Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 4, 2012, Pages 1482-1493

  McCracken, Stephen T ^a   Kaiser, Marcel ^b,c   Boshoff, Helena I ^d   Boyd, Peter D W ^a   Copp, Brent R ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Malaria; Natural product; Photochemical dimerisation; Pyran 2 one; Tuberculosis

Indexed keywords

11,12,11'12' TETRAMETHOXY ANIBA DIMER; 4 METHOXY 6 (3 (4 TERT BUTYL PHENOXY) STYRYL) 2H PYRAN 2 ONE; 4 METHOXY 6 (3 NITROSTYRYL) 2H PYRAN 2 ONE; 4 METHOXY 6 (3 PHENOXY STYRYL) 2H PYRAN 2 ONE; 4 METHOXY 6 (4 (4 DIMETHYLAMINOPHENYL) 1,3 BUTADIENYL) 2H PYRAN 2 ONE; 4 METHOXY 6 (4 NITROSTYRYL) 2H PYRAN 2 ONE; 4 METHOXY 6 (4 PHENYL 1,3 BUTADIENYL) 2H PYRAN 2 ONE; 4 METHOXY 6 (4 TERT BUTYL STYRYL) 2H PYRAN 2 ONE; 4 METHOXY 6 [2 (1 NAPHTHYL)ETHENYL] 2H PYRAN 2 ONE; 4 METHOXY 6 [2 (1 NAPHTHYL)ETHYL]2H PYRAN 2 ONE; 4 METHOXY 6 [2 (2 FURYL)ETHENYL] 2H PYRAN 2 ONE; 4 METHOXY 6 [2 (2 NAPHTHYL)ETHENYL] 2H PYRAN 2 ONE; 4 METHOXY 6 [2 (2 NAPHTHYL)ETHYL]2H PYRAN 2 ONE; 4 METHOXY 6 [2 (4 TERT BUTYLPHENYL)ETHYL] 2H PYRAN 2 ONE; 4 METHOXY 6 STYRYL 2H PYRAN 2 ONE; 4 METHOXY 6 STYRYL PYRAN 2 ONE DERIVATIVE; 6 [2 (1,3 BENZODIOXO 5 YL)ETHENYL] 4 METHOXY 2H PYRAN 2 ONE; 6 [2 (1,3 BENZODIOXO 5 YL)ETHYL] 4 METHOXY 2H PYRAN 2 ONE; 6 [2 (3 (4 TERT BUTYLPHENOXY)PHENYL)ETHYL]2H PYRAN 2 ONE; 6 [2 (3,4 DIMEHOXYPHENYL)ETHENYL] 4 METHOXY 2H PYRAN 2 ONE; 6 [2 (3,4 DIMETHOXYPHENYL)ETHYL] 4 METHOXY 2H PYRAN 2 ONE; 6,6' (2,2' (1,4 PHENYLENE)BIS(ETHANE 2,1 DIYL))BIS (4 METHOXY 2H PYRAN 2 ONE); 6,6' (2,4 BIS (3,4 DIMETHOXYPHENYL)CYCLOBUTANE 1,3 DIYL)BIS (4 METHOXY 2H PYRAN 2 ONE); 6,6' (3,4 DIPHENYLCYCLOBUTANE 1,2 DIYL)BIS (4 METHOXY 2H PYRAN 2 ONE); 6,6' 2,2' (1,4 PHENYLENE)BIS(ETHENE 2,1 DIYL)BIS (4 METHOXY 2H PYRAN 2 ONE); 7,8 DIHYDRO 4 METHOXY 6 STYRYL 2H PYRAN 2 ONE; ANTIMALARIAL AGENT; NATURAL PRODUCT; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ANTITUBERCULOSIS ACTIVITY; ARTICLE; CYCLOADDITION; DIMERIZATION; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; LEISHMANIA DONOVANI; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOTOCHEMISTRY; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE;

ANTIMALARIALS; ANTITUBERCULAR AGENTS; COUMARINS; DIMERIZATION; FATTY ACIDS, MONOUNSATURATED; INHIBITORY CONCENTRATION 50; LEISHMANIA DONOVANI; LIGHT; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; PYRONES;

ANIBA; LEISHMANIA DONOVANI; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM FALCIPARUM; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI;

EID: 84857035404     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.12.053     Document Type: Article

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