Fully activated MEK1 exhibits compromised affinity for binding of allosteric inhibitors U0126 and PD0325901

Biochemistry

Volumn 50, Issue 37, 2011, Pages 7964-7976

  Sheth, Payal R ^a   Liu, Yuqi ^a   Hesson, Thomas ^a   Zhao, Jia ^a   Vilenchik, Lev ^a   Liu, Yan Hui ^a   Mayhood, Todd W ^a   Le, Hung V ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC INHIBITOR; BINDING AFFINITIES; CELLULAR EVENTS; CO-EXPRESSION; IN-SITU; IN-VITRO; INSECT CELLS; LIGAND BINDING PROPERTIES; PROTEIN SUBSTRATE; SIGNALING PATHWAYS; SPECIFIC ACTIVITY; SUBSTRATE PROTEINS; WESTERN BLOTTING;

AMINO ACIDS; BINDING ENERGY; ENZYMES; LIGANDS; MASS SPECTROMETRY; PHOSPHORYLATION; PROTEINS; SUBSTRATES;

BINDING SITES;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; RAF PROTEIN;

ARTICLE; BINDING AFFINITY; CALORIMETRY; ENZYME ACTIVATION; LIGAND BINDING; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ALLOSTERIC REGULATION; ANIMALS; BENZAMIDES; BUTADIENES; CELL LINE; DIPHENYLAMINE; ENZYME ACTIVATION; INSECTS; MITOGEN-ACTIVATED PROTEIN KINASE 1; NITRILES; PROTEIN BINDING; PROTEIN KINASE INHIBITORS;

HEXAPODA;

EID: 80052727104     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200542r     Document Type: Article

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