The biological actions of 11,12-epoxyeicosatrienoic acid in endothelial cells are specific to the R/S-enantiomer and require the Gs proteins

Journal of Pharmacology and Experimental Therapeutics

Volumn 350, Issue 1, 2014, Pages 14-21

  Ding, Yindi ^a   Frömel, Timo ^a   Popp, Rüdiger ^a   Falck, John R ^b   Schunck, Wolf Hagen ^c   Fleming, Ingrid ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

11,12 EPOXY 5,8,14 ICOSATRIENOIC ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; EPOXYICOSATRIENOIC ACID; G PROTEIN COUPLED RECEPTOR; HYBRID PROTEIN; RNA; SMALL INTERFERING RNA; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 5; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL MEMBRANE; CELL MIGRATION; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; ENANTIOMER; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; UMBILICAL VEIN ENDOTHELIAL CELL;

8,11,14-EICOSATRIENOIC ACID; ANGIOGENESIS INDUCING AGENTS; CELL MOVEMENT; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOWN-REGULATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; PRIMARY CELL CULTURE; RNA, SMALL INTERFERING; STEREOISOMERISM; TRPC CATION CHANNELS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84903529376     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.214254     Document Type: Article

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