Caerulomycin A enhances Transforming Growth Factor-β (TGF-β)-Smad3 protein signaling by suppressing interferon-γ (IFN-γ)-signal transducer and activator of transcription 1 (STAT1) protein signaling to expand regulatory T cells (Tregs)

Journal of Biological Chemistry

Volumn 289, Issue 25, 2014, Pages 17515-17528

  Gurram, Rama Krishna ^a   Kujur, Weshely ^a   Maurya, Sudeep K ^a   Agrewala, Javed N ^b  

^a NATIONAL CHEMICAL LABORATORY   (India)

^b INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CYTOLOGY; PROTEINS; T-CELLS;

BIPYRIDYL; CYTOKINES; PROTEIN SIGNALING; REGULATORY T CELLS; SIGNAL TRANSDUCERS; SMAD3 PROTEINS; TRANSFORMING GROWTH FACTORS;

CELL SIGNALING;

BIPYRIDINE DERIVATIVE; CERULOMYCIN; FAS LIGAND; GAMMA INTERFERON; INTERLEUKIN 17; SMAD3 PROTEIN; SMAD7 PROTEIN; STAT1 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CD4 LYMPHOCYTE COUNT; CELL EXPANSION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG POTENCY; EFFECTOR CELL; FEMALE; INTRACELLULAR SIGNALING; LYMPHOCYTE SUBPOPULATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; REGULATORY T LYMPHOCYTE; TH1 CELL; TH17 CELL; UPREGULATION;

IMMUNOLOGY; IMMUNOSUPPRESSION; IMMUNOTHERAPY; SMAD TRANSCRIPTION FACTOR; STAT TRANSCRIPTION FACTOR; T CELL;

ANIMALS; FEMALE; GENE EXPRESSION REGULATION; INTERFERON-GAMMA; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; PYRIDINES; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; STAT1 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 84903485811     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.545871     Document Type: Article

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