Adoptive Transfer of Regulatory T Cells Protects against Coxsackievirus B3-Induced Cardiac Fibrosis

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Cao, Yanxia ^a   Xu, Wei ^b   Xiong, Sidong ^a,b  

^a FUDAN UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BASILIXIMAB; COLLAGEN TYPE 1; INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; INTERSTITIAL COLLAGENASE; NEUTRALIZING ANTIBODY; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; COXSACKIE VIRUS; COXSACKIE VIRUS INFECTION; COXSACKIEVIRUS B3; COXSACKIEVIRUS B3 INFECTION; DISEASE EXACERBATION; DISEASE SEVERITY; DOWN REGULATION; FIBROBLAST; HEART MUSCLE FIBROSIS; HEART PROTECTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T CELL DEPLETION; THERAPY EFFECT; VIRUS MYOCARDITIS;

ADOPTIVE TRANSFER; ANIMALS; CELL COUNT; ENTEROVIRUS B, HUMAN; FIBROSIS; INTERLEUKIN-10; MALE; MICE; MICE, INBRED BALB C; MYOCARDIUM; T-LYMPHOCYTES, REGULATORY;

EID: 84883383379     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074955     Document Type: Article

References (38)

1. Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, et al. (2007) Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 13: 952-961. doi:10.1038/nm1613. PubMed: 17660828.
2. Langd C, Sauter M, Szalay G, Racchi G, Grassi G, et al. (2008) Connective tissue growth factor: a crucial cytokine-mediating cardiac fibrosis in ongoing enterovirus myocarditis. J Mol Med (Berl) 86: 49-60. doi:10.1007/s00109-007-0249-3.
3. Assomull RG, Prasad SK, Lyne J, Smith G, Burman ED, et al. (2006) Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy. J Am Coll Cardiol 48: 1977-1985. doi:10.1016/j.jacc.2006.07.049. PubMed: 17112987.
4. Esfandiarei M, McManus BM, (2008) Molecular biology and pathogenesis of viral myocarditis. Annu Rev Pathol 3: 127-155. doi:10.1146/annurev.pathmechdis.3.121806.151534. PubMed: 18039131.
5. Feldman AM, McNamara D, (2000) Myocarditis. N Engl J Med 343: 1388-1398. doi:10.1056/NEJM200011093431908. PubMed: 11070105.
6. Jefferies JL, Towbin JA, (2010) Dilated cardiomyopathy. Lancet 375: 752-762. doi:10.1016/S0140-6736(09)62023-7. PubMed: 20189027.
7. Weber KT, Brilla CG, (1991) Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation 83: 1849-1865. doi:10.1161/01.CIR.83.6.1849. PubMed: 1828192.
8. Khan R, Sheppard R, (2006) Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia. Immunology 118: 10-24. doi:10.1111/j.1365-2567.2006.02336.x. PubMed: 16630019.
9. Leslie KO, Schwarz J, Simpson K, Huber SA, (1990) Progressive interstitial collagen deposition in Coxsackievirus B3-induced murine myocarditis. Am J Pathol 136: 683-693. PubMed: 2156433.
10. Gibbons MA, MacKinnon AC, Ramachandran P, Dhaliwal K, Duffin R, et al. (2011) Ly6C(hi) Monocytes Direct Alternatively Activated rofibrotic Macrophage Regulation of Lung Fibrosis. Am J Respir Crit Care Med 184: 569-581. doi:10.1164/rccm.201010-1719OC. PubMed: 21680953.
11. Brodlie M, McKean MC, Johnson GE, Anderson AE, Hilkens CM, et al. (2011) Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease. Eur Resrir J 37: 1378-1385. doi:10.1183/09031936.00067110. PubMed: 21109552.
12. Wehling HM, Jordan MC, Gotoh T, Grody WW, Roos KP, et al. (2010) Arginine Metabolism by Macrophages Promotes Cardiac and Muscle Fibrosis in mdx Muscular Dystrophy. PLOS ONE 5: e10763. doi:10.1371/journal.pone.0010763. PubMed: 20505827.
13. Tapmeier TT, Fearn A, Brown K, Chowdhury P, Sacks SH, et al. (2010) Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction. Kidney Int 78: 351-362. doi:10.1038/ki.2010.177. PubMed: 20555323.
14. Wei L, (2011) Immunological aspect of cardiac remodeling: T lymphocyte subsets in inflammation-mediated cardiac fibrosis. Exp Mol Pathol 90: 74-78. doi:10.1016/j.yexmp.2010.10.004. PubMed: 20965166.
15. Marra F, Aleffi S, Galastri S, Provenzano A, (2009) Mononuclear cells in liver fibrosis. Semin Immunopathol 31: 345-358. doi:10.1007/s00281-009-0169-0. PubMed: 19533130.
16. Sakaguchi S, Vignali DA, Rudensky AY, Niec RE, Waldmann H, (2013) The plasticity and stability of regulatory T cells. Nat Rev Immunol 13: 461-467. doi:10.1038/nri3464. PubMed: 23681097.
17. Liu F, Liu J, Weng D, Song L, He Q, et al. (2010) CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in mice. PLOS ONE 5: e15404. doi:10.1371/journal.pone.0015404. PubMed: 21072213.
18. Li J, Qiu SJ, She WM, Wang FP, Gao H, et al. (2012) Significance of the Balance between Regulatory T (Treg) and T Helper 17 (Th17) Cells during Hepatitis B Virus Related Liver Fibrosis. PLOS ONE 7: e39307. doi:10.1371/journal.pone.0039307. PubMed: 22745730.
19. Claassen MA, de Knegt RJ, Tilanus HW, Janssen HL, Boonstra A, (2010) Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis. J Hepatol 52: 315-321. doi:10.1016/j.jhep.2009.12.013. PubMed: 20129690.
20. Samarakoon R, Overstreet JM, Higgins PJ, (2013) TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities. Cell Signal 25: 264-268. doi:10.1016/j.cellsig.2012.10.003. PubMed: 23063463.
21. O'Reilly S, (2013) Role of interleukin-13 in fibrosis, particularly systemic sclerosis. Biofactors. doi:10.1002/biof.1117.
22. Kong X, Feng D, Mathews S, Gao B, (2013) Hepatoprotective and anti-fibrotic functions of interleukin-22: Therapeutic potential for the treatment of alcoholic liver disease. J Gastroenterol Hepatol 28 (Suppl 1):: 56-60. doi:10.1111/jgh.12032. PubMed: 23855297.
23. Ghosh AK, Quaggin SE, Vaughan DE, (2013) Molecular basis of organ fibrosis: Potential therapeutic approaches. Exp Biol Med (Maywood) 238: 461-481. doi:10.1177/1535370213489441. PubMed: 23856899.
24. Huber SA, Sartini D, (2005) Roles of tumor necrosis factor alpha (TNF-alpha) and the p55 TNF receptor in CD1d induction and coxsackievirus B3-induced myocarditis. J Virol 79: 2659-2665. doi:10.1128/JVI.79.5.2659-2665.2005. PubMed: 15708985.
25. D'Alessio FR, Tsushima K, Aggarwal NR, West EE, Willett MH, et al. (2009) CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J Clin Invest 119: 2898-2913. doi:10.1172/JCI36498. PubMed: 19770521.
26. Yu M, Wen S, Wang M, Liang W, Li HH, et al. (2013) TNF-α-Secreting B Cells Contribute to Myocardial Fibrosis in Dilated Cardiomyopathy. J Clin Immunol 33: 1002-1008. doi:10.1007/s10875-013-9889-y. PubMed: 23558825.
27. Kotsianidis I, Nakou E, Bouchliou I, Tzouvelekis A, Spanoudakis E, et al. (2009) Treg Global Impairment of CD4(+)CD25(+)FOXP3(+) Regulatory T Cells in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med 179: 1121-1130. doi:10.1164/rccm.200812-1936OC. PubMed: 19342412.
28. Heda K, (2009) Regulatory T cells ameliorate angiotensin II induced cardiac damage. Circulation 119: 2904-2912. doi:10.1161/CIRCULATIONAHA.108.832782. PubMed: 19470887.
29. Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F, (1999) An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 190: 995-1004. doi:10.1084/jem.190.7.995. PubMed: 10510089.
30. Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, et al. (2008) Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28: 546-558. doi:10.1016/j.immuni.2008.02.017. PubMed: 18387831.
31. Shi JH, Guan H, Shi S, Cai WX, Bai XZ, et al. (2013) Protection against TGF-β1-induced fibrosis effects of IL-10 on dermal fibroblasts and its potential therapeutics for the reduction of skin scarring. Arch Dermatol Res 305: 341-352. doi:10.1007/s00403-013-1314-0. PubMed: 23321694.
32. Yuan C, Chen WX, Zhu JS, Chen NW, Lu YM, et al. (2013) IL-10 treatment is associated with prohibitin expression in the Crohn's disease intestinal fibrosis mouse model. Mediat Inflamm,(2013): pp. 617145. PubMed: 23690666.
33. Zimmermann O, Homann JM, Bangert A, Müller AM, Hristov G, et al. (2012) Successful use of mRNA-nucleofection for overexpression of interleukin-10 in murine monocytes/macrophages for anti-inflammatory therapy in a murine model of autoimmune myocarditis. J AM Heart Assoc 1: e003293. doi:10.1161/JAHA.112.003293. PubMed: 23316321.
34. Sun L, Louie MC, Vannella KM, Wilke CA, LeVine AM, et al. (2011) New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis. Am J Physiol Lung Cell Mol Physiol 300: L341-L353. doi:10.1152/ajplung.00122.2010. PubMed: 21131395.
35. Krishnamurthy P, Rajasingh J, Lambers E, Qin G, Losordo DW, et al. (2009) IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR. Circ Res 104: e9-18. doi:10.1161/CIRCRESAHA.108.188243. PubMed: 19096025.
36. Verma SK, Krishnamurthy P, Barefield D, Singh N, Gupta R, et al. (2012) Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB. Circulation 126: 418-429. doi:10.1161/CIRCULATIONAHA.112.112185. PubMed: 22705886.
37. Tu CT, Li J, Wang FP, Li L, Wang JY, et al. (2012) Glycyrrhizin regulates CD4+T cell response during liver fibrogenesis via JNK, ERK and PI3K/AKT pathway. Int Immunopharmacol 14: 410-421. doi:10.1016/j.intimp.2012.08.013. PubMed: 22940540.
38. Thum T, Gross C, Fiedler J, Fischer T, Kissler S, et al. (2008) MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456: 980-984. doi:10.1038/nature07511. PubMed: 19043405.