The TATA-containing core promoter of the type II collagen gene (COL2A1) is the target of interferon-γ-mediated inhibition in human chondrocytes: Requirement for Stat1α, Jak1 and Jak2

Biochemical Journal

Volumn 369, Issue 1, 2003, Pages 103-115

  Osaki, Makoto ^a,c   Tan, Lujian ^a   Choy, Bob K ^a   Yoshida, Yasuhiro ^a   Cheah, Kathryn S E ^b   Auron, Philip E ^a   Goldring, Mary B ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c NAGASAKI ROSAI HOSPITAL   (Japan)

Author keywords

DNA binding protein; Dominant negative Stat1 ; Janus kinase (JAK); Janus kinase inhibitor; Transcription

Indexed keywords

CELLS; PROTEINS; SYNTHESIS (CHEMICAL);

NUCLEAR EXTRACTS;

BIOCHEMISTRY;

AGGRECAN; BINDING PROTEIN; COLLAGEN TYPE 2; GAMMA INTERFERON; JANUS KINASE; LUCIFERASE; STAT1 PROTEIN;

ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE DELETION; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTRON; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; TATA BOX; TRANSCRIPTION REGULATION;

BASE SEQUENCE; CELL LINE, TRANSFORMED; CHONDROCYTES; COLLAGEN TYPE II; DNA; HUMANS; INTERFERON TYPE II; INTERFERON-STIMULATED GENE FACTOR 3; JANUS KINASE 1; JANUS KINASE 2; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS (GENETICS); PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; TATA BOX; TRANSCRIPTION FACTORS;

JANUS;

EID: 0037269828     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020928     Document Type: Article

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