Human IGF1 Regulates Midgut Oxidative Stress and Epithelial Homeostasis to Balance Lifespan and Plasmodium falciparum resistance in Anopheles stephensi

PLoS Pathogens

Volumn 10, Issue 6, 2014, Pages

  Drexler, Anna L ^a   Pietri, Jose E ^a   Pakpour, Nazzy ^a   Hauck, Eric ^a   Wang, Bo ^a   Glennon, Elizabeth K K ^a   Georgis, Martha ^a   Riehle, Michael A ^b   Luckhart, Shirley ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CASPASE 3; LUCIFERASE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C; STRESS ACTIVATED PROTEIN KINASE; IGF1 PROTEIN, HUMAN; INSECT PROTEIN; RECOMBINANT PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANOPHELES STEPHENSI; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENETIC TRANSFECTION; HOMEOSTASIS; HUMAN CELL; IMMUNE RESPONSE; LIFESPAN; LUCIFERASE ASSAY; MIDGUT; NONHUMAN; OOCYST; OXIDATIVE STRESS; PHOSPHORYLATION; PLASMODIUM FALCIPARUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; ANOPHELES; DISEASE CARRIER; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; HORMESIS; HOST PARASITE INTERACTION; HUMAN; INFECTION CONTROL; INTESTINE; INTESTINE MUCOSA; ISOLATION AND PURIFICATION; LONGEVITY; MALARIA, FALCIPARUM; METABOLISM; MITOCHONDRION; PARASITOLOGY; PATHOGENICITY; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TRANSMISSION;

ANIMALS; ANOPHELES; COMMUNICABLE DISEASE CONTROL; FEMALE; HOMEOSTASIS; HORMESIS; HOST-PARASITE INTERACTIONS; HUMANS; INSECT PROTEINS; INSECT VECTORS; INSULIN-LIKE GROWTH FACTOR I; INTESTINAL MUCOSA; INTESTINES; LONGEVITY; MALARIA, FALCIPARUM; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; OXIDATIVE STRESS; PHOSPHORYLATION; PLASMODIUM FALCIPARUM; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS;

EID: 84903475604     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004231     Document Type: Article

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