Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning

Chemico-Biological Interactions

Volumn 203, Issue 1, 2013, Pages 160-166

  Mumford, Helen ^a   Docx, Cerys J ^a   Price, Matthew E ^a   Green, A Christopher ^a   Tattersall, John E H ^a   Armstrong, Stuart J ^a  

^a Biomedical Sciences Department   (United Kingdom)

Author keywords

Chemical warfare nerve agents; Guinea pigs; Medical countermeasures; Microdialysis; Pharmacodynamics; Pharmacokinetics

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; ANTICONVULSIVE AGENT; ATROPINE; AVIZAFONE; CHOLINESTERASE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; MUSCARINIC RECEPTOR BLOCKING AGENT; ORGANOPHOSPHATE; OXIME; SCAVENGER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; CELL PROTECTION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG TARGETING; GUINEA PIG; LETHAL DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; ORGANOPHOSPHATE POISONING; STOICHIOMETRY; SURVIVAL TIME; TIME TO MAXIMUM PLASMA CONCENTRATION;

ACETYLCHOLINESTERASE; ANIMALS; ANTIDOTES; ATROPINE; BUTYRYLCHOLINESTERASE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE REACTIVATORS; DIAZEPAM; GUINEA PIGS; HUMANS; INJECTIONS, INTRAMUSCULAR; MALE; ORGANOPHOSPHATE POISONING; ORGANOTHIOPHOSPHORUS COMPOUNDS; OXIMES; PYRIDINIUM COMPOUNDS;

ANIMALIA; CAVIA;

EID: 84875810996     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.08.018     Document Type: Conference Paper

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