The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs

Toxicology Mechanisms and Methods

Volumn 21, Issue 1, 2011, Pages 53-62

  Shih, Tsung Ming ^a   Guarisco, John A ^a   Myers, Todd M ^a   Kan, Robert K ^a   McDonough, John H ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Acetylcholinesterase; Brain; Central nervous system; Cholinesterase inhibitors; Cholinesterase reactivation; Cyclosarin; Guinea pig; Nerve agents; Organophosphorus compounds; Oximes; Pralidoxime; Pro 2 PAM; Sarin; VX.

Indexed keywords

1 METHYL 1,6 DIHYDROPYRIDINE 2 CARBALDOXIME; CHOLINESTERASE; CYCLOSARIN; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; PRALIDOXIME; SARIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; CONTROLLED STUDY; DRUG EFFECT; ELECTROENCEPHALOGRAPHY; GUINEA PIG; HEART; MALE; NONHUMAN; PRIORITY JOURNAL; SEIZURE; SPINAL CORD;

ANIMALS; CHOLINESTERASE REACTIVATORS; GUINEA PIGS; MALE; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTHIOPHOSPHORUS COMPOUNDS; PRALIDOXIME COMPOUNDS; PRODRUGS; SARIN; SEIZURES;

ANIMALIA; CAVIA;

EID: 78650479046     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2010.529190     Document Type: Article

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