Chemically modified non-antimicrobial tetracyclines are multifunctional drugs against advanced cancers

Pharmacological Research

Volumn 63, Issue 2, 2011, Pages 146-150

  Lokeshwar, Bal L ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bone metastasis; Free radicals; Matrix metalloproteinase; Prostate cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; CMT 308; DOXYCYCLINE; GELATINASE A; GELATINASE B; INCYCLINIDE; TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG;

ADVANCED CANCER; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BONE METASTASIS; CANCER INHIBITION; CANCER INVASION; CELL CYCLE PROGRESSION; CELL PROLIFERATION; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BONE NEOPLASMS; CELL CYCLE; CELL PROLIFERATION; DOXYCYCLINE; ENZYME INHIBITORS; HUMANS; MALE; MATRIX METALLOPROTEINASES; MELANOMA; NEOPLASM METASTASIS; NEOPLASMS; OFF-LABEL USE; PROSTATIC NEOPLASMS; RATS; TETRACYCLINES;

EID: 79251636716     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2010.11.003     Document Type: Article

References (48)

1. A. Jemal, R. Siegel, J. Xu, and E. Ward Cancer statistics, 2010 CA Cancer J Clin 60 September-October (5) 2010 277 300
2. L.A. Liotta, and W.G. Stetler-Stevenson Metalloproteinases and cancer invasion Semin Cancer Biol 1 April (2) 1990 99 106
3. L.A. Liotta, P.S. Steeg, and W.G. Stetler-Stevenson Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation Cell 64 January (2) 1991 327 336
4. D. Bourboulia, and W.G. Stetler-Stevenson Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): positive and negative regulators in tumor cell adhesion Semin Cancer Biol 20 June (3) 2010 161 168
5. K. Kessenbrock, V. Plaks, and Z. Werb Matrix metalloproteinases: regulators of the tumor microenvironment Cell 141 April (1) 2010 52 67
6. T.A. Stamey, N. Yang, A.R. Hay, J.E. McNeal, F.S. Freiha, and E. Redwine Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate N Engl J Med 317 October (15) 1987 909 916
7. J.E. Oesterling Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate J Urol 145 May (5) 1991 907 923
8. G. Botchorishvili, M.P. Matikainen, and H. Lilja Early prostate-specific antigen changes and the diagnosis and prognosis of prostate cancer Curr Opin Urol 19 May (3) 2009 221 226
9. H. Van Poppel, S. Joniau, B. Van Cleynenbreugel, F.M. Mottaghy, and R. Oyen Diagnostic evaluation of PSA recurrence and review of hormonal management after radical prostatectomy Prostate Cancer Prostatic Dis 12 2 2009 116 123
10. G.D. Roodman Mechanisms of bone metastasis N Engl J Med 350 April (16) 2004 1655 1664
11. L.A. Kingsley, P.G. Fournier, J.M. Chirgwin, and T.A. Guise Molecular biology of bone metastasis Mol Cancer Ther 6 October (10) 2007 2609 2617
12. X.C. Ye, M. Choueiri, S.M. Tu, and S.H. Lin Biology and clinical management of prostate cancer bone metastasis Front Biosci 12 May 2007 3273 3286
13. B.L. Lokeshwar, M.G. Selzer, N.L. Block, and Z. Gunja-Smith Secretion of matrix metalloproteinases and their inhibitors (tissue inhibitor of metalloproteinases) by human prostate in explant cultures: reduced tissue inhibitor of metalloproteinase secretion by malignant tissues Cancer Res 53 October (19) 1993 4493 4498
14. M.E. Stearns, and M. Wang Type IV collagenase (M(r) 72,000) expression in human prostate: benign and malignant tissue Cancer Res 53 February (4) 1993 878 883
15. M.E. Stearns, and M. Stearns Autocrine factors, type IV collagenase secretion and prostatic cancer cell invasion Cancer Metastasis Rev 12 March (1) 1993 39 52
16. Z. Dong, J.A. Nemeth, M.L. Cher, K.C. Palmer, R.C. Bright, and R. Fridman Differential regulation of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression in co-cultures of prostate cancer and stromal cells Int J Cancer 93 August (4) 2001 507 515
17. J.A. Nemeth, R. Yousif, M. Herzog, M. Che, J. Upadhyay, and B. Shekarriz Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis J Natl Cancer Inst 94 January (1) 2002 17 25
18. L.M. Golub, N. Ramamurthy, T.F. McNamara, B. Gomes, M. Wolff, and A. Casino Tetracyclines inhibit tissue collagenase activity. A new mechanism in the treatment of periodontal disease J Periodontal Res 19 November (6) 1984 651 655
19. L.M. Golub, H.M. Lee, G. Lehrer, A. Nemiroff, T.F. McNamara, and R. Kaplan Minocycline reduces gingival collagenolytic activity during diabetes. Preliminary observations and a proposed new mechanism of action J Periodontal Res 18 September (5) 1983 516 526
20. B.R. Rifkin, A.T. Vernillo, L.M. Golub, and N.S. Ramamurthy Modulation of bone resorption by tetracyclines Ann N Y Acad Sci September (732) 1994 165 180
21. R.D. Bonfil, S. Chinni, R. Fridman, H.R. Kim, and M.L. Cher Proteases, growth factors, chemokines, and the microenvironment in prostate cancer bone metastasis Urol Oncol 25 September-October (5) 2007 407 411
22. T. Sasaki, N.S. Ramamurthy, and L.M. Golub Bone cells and matrix bind chemically modified non-antimicrobial tetracycline Bone 15 May-June (3) 1994 373 375
23. E. Viadana, I.D. Bross, and J.W. Pickren The metastatic spread of kidney and prostate cancers in man Neoplasma 23 3 1976 323 332
24. J.R. Gingrich, R.J. Barrios, R.A. Morton, B.F. Boyce, F.J. DeMayo, and M.J. Finegold Metastatic prostate cancer in a transgenic mouse Cancer Res 56 September (18) 1996 4096 4102
25. S. Wang, J. Gao, Q. Lei, N. Rozengurt, C. Pritchard, and J. Jiao Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer Cancer Cell 4 September (3) 2003 209 221
26. J.A. Nemeth, J.F. Harb, U. Barroso Jr., Z. He, D.J. Grignon, and M.L. Cher Severe combined immunodeficient-hu model of human prostate cancer metastasis to human bone Cancer Res 59 April (8) 1999 1987 1993
27. H.E. Zhau, C.L. Li, and L.W. Chung Establishment of human prostate carcinoma skeletal metastasis models Cancer 88 June (12 Suppl.) 2000 2995 3001
28. E. Corey, J.E. Quinn, F. Bladou, L.G. Brown, M.P. Roudier, and J.M. Brown Establishment and characterization of osseous prostate cancer models: intra-tibial injection of human prostate cancer cells Prostate 52 1 2002 Jun 1 20 33
29. M.G. Selzer, B. Zhu, N.L. Block, and B.L. Lokeshwar CMT-3, a chemically modified tetracycline, inhibits bony metastases and delays the development of paraplegia in a rat model of prostate cancer Ann N Y Acad Sci 878 June 1999 678 682
30. B. Zhu, N.L. Block, and B.L. Lokeshwar Interaction between stromal cells and tumor cells induce chemoresistance and matrix metalloproteinase secretion Ann N Y Acad Sci 878 June 1999 642 646
31. D.H. Shevrin, S.C. Kukreja, L. Ghosh, and T.E. Lad Development of skeletal metastasis by human prostate cancer in athymic nude mice Clin Exp Metastasis 6 September-October (5) 1988 401 409
32. A.A. Geldof, and B.R. Rao Prostate tumor (Dunning R3327) skeletal metastasis Prostate 16 1990 279 290
33. J.T. Isaacs, W.B. Isaacs, W.F. Feitz, and J. Scheres Establishment and characterization of seven Dunning rat prostatic cancer cell lines and their use in developing methods for predicting metastatic abilities of prostatic cancers Prostate 9 3 1986 261 281
34. B.L. Lokeshwar, M.G. Selzer, B.Q. Zhu, N.L. Block, and L.M. Golub Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model Int J Cancer 98 March (2) 2002 297 309
35. D.S. Dandekar, and B.L. Lokeshwar Inhibition of cyclooxygenase (COX)-2 expression by Tet-inducible COX-2 antisense cDNA in hormone-refractory prostate cancer significantly slows tumor growth and improves efficacy of chemotherapeutic drugs Clin Cancer Res 10 December (23) 2004 8037 8047
36. D.S. Dandekar, M. Lopez, R.I. Carey, and B.L. Lokeshwar Cyclooxygenase-2 inhibitor celecoxib augments chemotherapeutic drug-induced apoptosis by enhancing activation of caspase-3 and -9 in prostate cancer cells Int J Cancer 115 June (3) 2005 484 492
37. B.L. Lokeshwar, E. Escatel, and B. Zhu Cytotoxic activity and inhibition of tumor cell invasion by derivatives of a chemically modified tetracycline CMT-3 (COL-3) Curr Med Chem 8 February (3) 2001 271 279
38. B.L. Lokeshwar, H.L. Houston-Clark, M.G. Selzer, N.L. Block, and L.M. Golub Potential application of a chemically modified non-antimicrobial tetracycline (CMT-3) against metastatic prostate cancer Adv Dent Res 12 November (2) 1998 97 102
39. T. Onoda, T. Ono, D.K. Dhar, A. Yamanoi, and N. Nagasue Tetracycline analogues (doxycycline and COL-3) induce caspase-dependent and -independent apoptosis in human colon cancer cells Int J Cancer 118 March (5) 2006 1309 1315
40. R.S. Fife, and G.W. Sledge Jr. Effects of doxycycline on in vitro growth, migration, and gelatinase activity of breast carcinoma cells J Lab Clin Med 125 March (3) 1995 407 411
41. R.S. Fife, and G.W. Sledge Jr. Effects of doxycycline on cancer cells in vitro and in vivo Adv Dent Res 12 November (2) 1998 94 96
42. R.S. Fife, B.T. Rougraff, C. Proctor, and G.W. Sledge Jr. Inhibition of proliferation and induction of apoptosis by doxycycline in cultured human osteosarcoma cells J Lab Clin Med 130 November (5) 1997 530 534
43. R.E. Seftor, E.A. Seftor, J.E. De Larco, D.E. Kleiner, J. Leferson, and W.G. Stetler-Stevenson Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis Clin Exp Metastasis 16 April (3) 1998 217 225
44. Z. Saikali, and G. Singh Doxycycline and other tetracyclines in the treatment of bone metastasis Anticancer Drugs 14 November (10) 2003 773 778
45. W.C. Duivenvoorden, S.V. Popović, S. Lhoták, E. Seidlitz, H.W. Hirte, and R.G. Tozer Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer Cancer Res 62 March (6) 2002 1588 1591
46. W.C. Duivenvoorden, H.W. Hirte, and G. Singh Use of tetracycline as an inhibitor of matrix metalloproteinase activity secreted by human bone-metastasizing cancer cells Invasion Metastasis 17 6 1997 312 322
47. W.C. Duivenvoorden, S. Vukmirović-Popović, M. Kalina, E. Seidlitz, and G. Singh Effect of zoledronic acid on the doxycycline-induced decrease in tumor burden in a bone metastasis model of human breast cancer Br J Cancer 96 May (10) 2007 1526 1531
48. R.E. Seftor, E.A. Seftor, D.A. Kirschmann, and M.J. Hendrix Targeting the tumor microenvironment with chemically modified tetracyclines: inhibition of laminin 5 gamma2 chain promigratory fragments and vasculogenic mimicry Mol Cancer Ther 1 November (13) 2002 1173 1179