Phenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 19, 2012, Pages 6218-6223

  Du, Xiaohui ^a   Kim, Yong Jae ^a   Lai, Sujen ^a   Chen, Xi ^a   Lizarzaburu, Mike ^a   Turcotte, Simon ^a   Fu, Zice ^a   Liu, Qingxiang ^a   Zhang, Ying ^a   Motani, Alykhan ^a   Oda, Kozo ^b   Okuyama, Ryo ^b   Nara, Futoshi ^b   Murakoshi, Michiko ^b   Fu, Angela ^a   Reagan, Jeff D ^a   Fan, Peter ^a   Xiong, Yumei ^a   Shen, Wang ^a   Li, Leping ^a   Houze, Jonathan ^a   Medina, Julio C ^a   more..

^a AMGEN INC   (United States)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

Glucose lowering; GPR142 agonist; Insulin secretagogue; Type II diabetes

Indexed keywords

ANTIDIABETIC AGENT; G PROTEIN COUPLED RECEPTOR 142 AGONIST; GLUCOSE; INSULIN; PHENYLALANINE DERIVATIVE; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL MODIFICATION; CYCLIZATION; DEALKYLATION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; GLUCOSE BLOOD LEVEL; GLUCURONIDATION; HUMAN; HYPOGLYCEMIA; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; PROTEIN BINDING; SUZUKI REACTION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; GLUCOSE TOLERANCE TEST; HEK293 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICE; MICE, INBRED STRAINS; MICROSOMES; PHENYLALANINE; RATS; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 84866365022     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.015     Document Type: Article

References (8)

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7. Xiong, Y. Motani, A.; Reagan, J.; Gao, X.; Yang, H.; Ma, J.; Schwandner, R.; Zhang, Y.; Liu, q.; Miao, L.; Luo, J.; Tian, H.; Chen, J-L.; Murakoshi, M.; Nara, F.; Yeh, W-C.; Cao, Z. manuscript is in preparation.
8. Lizarzabura, M.; Turcotte, S.; Du, X.; Duquette, J.; Fu, A.; Houze, J.; Li, L.; Liu, J.; Oda, K.; Okuyama, R.; Yu, M.; Reagan, J.; Medina, J. C. in press,corrected proof, Bioorg. Med. Chem. Lett.