The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Benod, Cindy ^a   Villagomez, Rosa ^a   Filgueira, Carly S ^a   Hwang, Peter K ^b   Leonard, Paul G ^c   Poncet Montange, Guillaume ^c   Rajagopalan, Senapathy ^a   Fletterick, Robert J ^b   Gustafsson, Jan Åke ^d   Webb, Paul ^a  

^a HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d University of Houston   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1,5 DIMETHYLPYRAZOLE 3 CARBONYL) 4 (DIPHENYLMETHYL)PIPERAZINE; DYDROGESTERONE; FAMPROFAZONE; NUCLEAR RECEPTOR TAILLESS; ORPHAN NUCLEAR RECEPTOR; PIPERAZINE DERIVATIVE; PROTEIN NR2E1; PROTEIN TLX; PYRIDAZINE DERIVATIVE; RECOMBINANT PROTEIN; RECOMBINANT TLX PROTEIN; UNCLASSIFIED DRUG; CELL RECEPTOR; CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR 2; ESTROGEN RECEPTOR BETA; LIGAND; NR2E1 PROTEIN, HUMAN; PROTEIN BINDING; PYRAZOLE DERIVATIVE; RENILLA LUCIFERIN 2 MONOOXYGENASE; RETINOID X RECEPTOR ALPHA;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; HIGH THROUGHPUT SCREENING; HUMAN; LIGAND BINDING; LUCIFERASE ASSAY; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN INTERACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; TRANSCRIPTION TERMINATION; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; BINDING SITE; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETICS; HELA CELL LINE; IC50; MOLECULAR GENETICS; PHYSIOLOGY; REPORTER GENE; TRANSCRIPTION INITIATION;

AMINO ACID SEQUENCE; BINDING SITES; COUP TRANSCRIPTION FACTOR II; DYDROGESTERONE; ESTROGEN RECEPTOR BETA; GENES, REPORTER; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; LUCIFERASES, RENILLA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PIPERAZINES; PROTEIN BINDING; PYRAZOLES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RETINOID X RECEPTOR ALPHA; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84903289490     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099440     Document Type: Article

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