The oncoprotein BCL11A binds to orphan nuclear receptor TLX and potentiates its transrepressive function

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Estruch, Sara B ^a   Buzón, Víctor ^a   Carbó, Laia R ^a   Schorova, Lenka ^a   Lüders, Jens ^b   Estébanez Perpiñá, Eva ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPHIN 1; BINDING PROTEIN; COMPLEMENTARY DNA; ONCOPROTEIN; ORPHAN NUCLEAR RECEPTOR; ORPHAN NUCLEAR RECEPTOR TLX; TRANSCRIPTION FACTOR BCL11A; UNCLASSIFIED DRUG; ATROPHIN-1; BCL11A PROTEIN, HUMAN; CARRIER PROTEIN; CELL RECEPTOR; COREPRESSOR PROTEIN; NERVE PROTEIN; NR2E1 PROTEIN, HUMAN; NUCLEAR PROTEIN; REPRESSOR PROTEIN;

ARTICLE; CONTROLLED STUDY; GENETIC ANALYSIS; GENETIC REGULATION; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; SUBVENTRICULAR ZONE; TRANSCRIPTION REGULATION; ADULT; CELL STRAIN HEK293; METABOLISM;

ADULT; CARRIER PROTEINS; CO-REPRESSOR PROTEINS; HEK293 CELLS; HUMANS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REPRESSOR PROTEINS;

EID: 84861853813     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037963     Document Type: Article

References (42)

1. Yu RT, McKeown M, Evans RM, Umesono K, (1994) Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx. Nature 370: 375-379.
2. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, et al. (1995) The Nuclear Receptor Superfamily: the Second Decade. Cell 83: 835-839.
3. Gui H, Li ML, Tsai CC, (2011) A tale of tailless. Dev Neurosci 33: 1-13.
4. Monaghan A, Grau E, Bock D, Schütz G, (1995) The mouse homolog of the orphan nuclear receptor tailless is expressed in the developing forebrain. Development 121: 839-853.
5. Monaghan A, Bock D, Gass P, Schwäger A, Wolfer DP, et al. (1997) Defective limbic system in mice lacking the tailless gene. 1997 122: 1751-1758.
6. Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, et al. (2004) Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature 427: 78-83.
7. Roy K, Kuznicki K, Wu Q, Sun Z, Bock D, et al. (2004) The Tlx gene regulates the timing of neurogenesis in the cortex. J Neurosci 24: 8333-8345.
8. Li W, Sun G, Yang S, Qu Q, Nakashima K, et al. (2008) Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain. Mol Endocrinol 22: 56-64.
9. Liu H, Belz T, Bock D, Takacs A, Wu H, et al. (2008) The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone. Genes Dev 22: 2473-2478.
10. Liu H, Wang Y, Belz T, Bock D, Takacs A, et al. (2010) The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation. Genes Dev 24: 683-695.
11. Roy K, Thiels E, Monaghan AP, (2002) Loss of the tailless gene affects forebrain development and emotional behavior. Physiol Behav 77: 595-600.
12. Young K, Berry ML, Mahaffey CL, Saionz JR, Hawes NL, et al. (2002) Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent. Behav Brain Res 132: 145-158.
13. Zhang CL, Zou Y, He W, Gage FH, Evans RM, (2008) A role for adult TLX-positive neural stem cells in learning and behaviour. Nature 451: 1004-1007.
14. Qu Q, Shi Y, (2009) Neural stem cells in the developing and adult brains. J Cell Physiol 221: 5-9.
15. Shi Y, Sun, G, Zhao, C, Stewart, R, (2008) Neural stem cell self-renewal. Crit Rev Oncol Hematol 65: 43-53.
16. Zhang CL, Zou Y, Yu RT, Gage FH, Evans RM, (2006) Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. Genes Dev 20: 1308-1320.
17. Yu R, Chiang MY, Tanabe T, Kobayashi M, Yasuda K, et al. (2000) The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision. Proc Natl Acad Sci USA 97: 2621-2625.
18. Yokoyama A, Takezawa S, Schüle R, Kitagawa H, Kato S, (2008) Transrepressive function of TLX requires the histone demethylase LSD1. Mol Cell Biol 28: 3995-4003.
19. Sun G, Alzayady K, Stewart R, Ye P, Yang S, et al. (2010) Histone demethylase LSD1 regulates neural stem cell proliferation. Mol Cell Biol 30: 1997-2005.
20. Sun G, Yu RT, Evans RM, Shi Y, (2007) Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. Proc Natl Acad Sci U S A 104: 15282-15287.
21. Wang L, Rajan H, Pitman JL, McKeown M, Tsai CC, (2006) Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors. Genes Dev 20: 525-530.
22. Zhang S, Xu L, Lee J, Xu T, (2002) Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes. Cell 108: 45-56.
23. Shen Y, Lee G, Choe Y, Zoltewicz JS, Peterson AS, (2007) Functional architecture of atrophins. J Biol Chem 282: 5037-5044.
24. Wang L, Tsai CC, (2008) Atrophin proteins: an overview of a new class of nuclear receptor corepressors. Nucl Recept Signal 6.
25. Shen Y, Peterson AS, (2009) Atrophins emerging roles in development and neurodegenerative disease. 2009 66: 437-446.
26. Suzuki Y, Yazawa I, (2011) Pathological accumulation of atrophin-1 in dentatorubralpallidoluysian atrophy. Int J Clin Exp Pathol 4: 378-384.
27. Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, et al. (2000) Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. J Biol Chem 275: 10315-10322.
28. Avram D, Fields A, Senawong T, Topark-Ngarm A, Leid M, (2002) COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein. Biochem J 368: 555-563.
29. Estébanez-Perpiñá E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, et al. (2007) A surface on the androgen receptor that allosterically regulates coactivator binding. Proc Natl Acad Sci U S A 104: 16074-16079.
30. Kruse S, Suino-Powell K, Zhou XE, Kretschman JE, Reynolds R, et al. (2008) Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. PLoS Biol 6: e227.
31. Ingraham H, Redinbo MR, (2005) Orphan nuclear receptors adopted by crystallography. Curr Opin Struct Biol 15: 708-715.
32. Sankaran V, Xu J, Orkin SH, (2010) Transcriptional silencing of fetal hemoglobin by BCL11A. Ann N Y Acad Sci 1202: 64-68.
33. Xu J, Sankaran VG, Ni M, Menne TF, Puram RV, et al. (2010) Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev 24: 783-798.
34. Liu H, Ippolito GC, Wall JK, Niu T, Probst L, et al. (2006) Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells. Mol Cancer 16: 18.
35. Leid M, Ishmael JE, Avram D, Shepherd D, Fraulob V, et al. (2004) CTIP1 and CTIP2 are differentially expressed during mouse embryogenesis. Gene Expr Patterns 4: 733-739.
36. Liu P, Keller JR, Ortiz M, Tessarollo L, Rachel RA, et al. (2003) Bcl11a is essential for normal lymphoid development. Nat Immunol 4: 525-532.
37. Gunnersen J, Augustine C, Spirkoska V, Kim M, Brown M, et al. (2002) Global analysis of gene expression patterns in developing mouse neocortex using serial analysis of gene expression. Mol Cell Neurosci 19: 560-573.
38. Kuo T, Hsueh YP, (2007) Expression of zinc finger transcription factor Bcl11A/Evi9/CTIP1 in rat brain. J Neurosci Res 85: 1628-1636.
39. Kuo T, Hong CJ, Chien HL, Hsueh YP, (2010) X-linked mental retardation gene CASK interacts with Bcl11A/CTIP1 and regulates axon branching and outgrowth. J neurosci Res 88: 2364-2373.
40. Jackson A, Panayiotidis P, Foroni L, (1998) The human homologue of the Drosophila tailless gene (TLX): characterization and mapping to a region of common deletion in human lymphoid leukemia on chromosome 6q21. Genomics 50: 24-43.
41. Metzger E, Wissmann M, Yin N, Müller JM, Schneider R, et al. (2005) LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437: 436-439.
42. Teixidó-Travesa N, Villén J, Lacasa C, Bertran MT, Archinti M, et al. (2010) The gammaTuRC revisited: a comparative analysis of interphase and mitotic human gammaTuRC redefines the set of core components and identifies the novel subunit GCP8. Mol Biol Cell 21: 3963-3972.