Characterization of TLX Expression in Neural Stem Cells and Progenitor Cells in Adult Brains

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Li, Shengxiu ^a   Sun, Guoqiang ^a   Murai, Kiyohito ^a   Ye, Peng ^a   Shi, Yanhong ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; PROTEIN TLX; TRANSCRIPTION FACTOR MASH1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL DIVISION; CELL RENEWAL; CELL TYPE; MOUSE; NEURAL STEM CELL; NONHUMAN; PROTEIN EXPRESSION; SUBVENTRICULAR ZONE;

ANIMALS; BETA-GALACTOSIDASE; BRAIN; BRAIN MAPPING; BROMODEOXYURIDINE; CELL PROLIFERATION; FLUORESCENT DYES; GENE EXPRESSION REGULATION; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEURAL STEM CELLS; NEURODEGENERATIVE DISEASES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STEM CELLS;

EID: 84865603437     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043324     Document Type: Article

References (39)

1. Yu RT, McKeown M, Evans RM, Umesono K, (1994) Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor TLX. Nature 370: 375-379.
2. Monaghan AP, Bock D, Gass P, Schwager A, Wolfer DP, et al. (1997) Defective limbic system in mice lacking the tailless gene. Nature 390: 515-517.
3. Shi Y, Lie CD, Taupin P, Nakashima K, Ray J, et al. (2004) Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature 427: 78-83.
4. Sun G, Yu RT, Evans RM, Shi Y, (2007) Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. Proc Natl Acad Sci USA 104: 15282-15287.
5. Sun G, Alzayady K, Stewart R, Ye P, Yang S, et al. (2010) Histone demethylase LSD1 regulates neural stem cell proliferation. Molecular and Cellular Biology 30: 1997-2005.
6. Sun G, Ye P, Murai K, Lang MF, Li S, et al. (2011) miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells. Nature Communications 2: 529.
7. Qu Q, Sun G, Li W, Yang S, Ye P, et al. (2010) Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal. Nature Cell Biology 12: 31-40; sup pp 31-39.
8. Elmi M, Matsumoto Y, Zeng ZJ, Lakshminarasimhan P, Yang W, et al. (2010) TLX activates MASH1 for induction of neuronal lineage commitment of adult hippocampal neuroprogenitors. Molecular and Cellular Neurosciences 45: 121-131.
9. Chavali PL, Saini RK, Matsumoto Y, Agren H, Funa K, (2010) Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia. The Journal of Biological Chemistry 286: 9393-9404.
10. Obernier K, Simeonova I, Fila T, Mandl C, Holzl-Wenig G, et al. (2011) Expression of Tlx in both stem cells and transit amplifying progenitors regulates stem cell activation and differentiation in the neonatal lateral subependymal zone. Stem Cells 29: 1415-1426.
11. Zhao C, Sun G, Li S, Lang M, Yang S, et al. (2010) microRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling. Proc Natl Acad Sci USA 107: 1876-1881.
12. Zhao C, Sun G, Li S, Shi Y, (2009) A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. Nature Struct Mol Biol 16: 365-371.
13. Zhang CL, Zou Y, He W, Gage FH, Evans RM, (2008) A role for adult TLX-positive neural stem cells in learning and behaviour. Nature 451: 1004-1007.
14. Liu HK, Belz T, Bock D, Takacs A, Wu H, et al. (2008) The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone. Genes & Development 22: 2473-2478.
15. Liu HK, Wang Y, Belz T, Bock D, Takacs A, et al. (2010) The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation. Genes & Development 24: 683-695.
16. Roy K, Kuznicki K, Wu Q, Sun Z, Bock D, et al. (2004) The Tlx gene regulates the timing of neurogenesis in the cortex. J Neurosci 24: 8333-8345.
17. Stenman JM, Wang B, Campbell K, (2003) Tlx controls proliferation and patterning of lateral telencephalic progenitor domains. J Neurosci 23: 10568-10576.
18. Li W, Sun G, Yang S, Qu Q, Nakashima K, et al. (2008) Nuclear Receptor TLX Regulates Cell Cycle Progression in Neural Stem Cells of the Developing Brain. Molecular Endocrinology 22: 56-64.
19. Gage FH, (2000) Mammalian neural stem cells. Science 287: 1433-1438.
20. Morshead CM, Reynolds BA, Craig CG, McBurney MW, Staines WA, et al. (1994) Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells. Neuron 13: 1071-1082.
21. Doetsch F, Caille I, Lim DA, Garcia-Verdugo JM, Alvarez-Buylla A, (1999) Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97: 703-716.
22. Angevine JB Jr, Sidman RL, (1961) Autoradiographic study of cell migration during histogenesis of cerebral cortex in the mouse. Nature 192: 766-768.
23. Altman J, (1962) Are new neurons formed in the brains of adult mammals? Science 135: 1127-1128.
24. Gratzner HG, (1982) Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. Science 218: 474-475.
25. Miller MW, Nowakowski RS, (1988) Use of bromodeoxyuridine-immunohistochemistry to examine the proliferation, migration and time of origin of cells in the central nervous system. Brain Res 457: 44-52.
26. Takahashi T, Nowakowski RS, Caviness VS Jr, (1992) BUdR as an S-phase marker for quantitative studies of cytokinetic behaviour in the murine cerebral ventricular zone. Journal of Neurocytology 21: 185-197.
27. Kempermann G, Kuhn HG, Gage FH, (1997) More hippocampal neurons in adult mice living in an enriched environment. Nature 386: 493-495.
28. Burns KA, Kuan CY, (2005) Low doses of bromo- and iododeoxyuridine produce near-saturation labeling of adult proliferative populations in the dentate gyrus. The European Journal of Neuroscience 21: 803-807.
29. Vega CJ, Peterson DA, (2005) Stem cell proliferative history in tissue revealed by temporal halogenated thymidine analog discrimination. Nature Methods 2: 167-169.
30. Thomas RM, Hotsenpiller G, Peterson DA, (2007) Acute psychosocial stress reduces cell survival in adult hippocampal neurogenesis without altering proliferation. J Neurosci 27: 2734-2743.
31. Dupret D, Fabre A, Dobrossy MD, Panatier A, Rodriguez JJ, et al. (2007) Spatial learning depends on both the addition and removal of new hippocampal neurons. PLoS Biology 5: e214.
32. Leuner B, Glasper ER, Gould E, (2009) Thymidine analog methods for studies of adult neurogenesis are not equally sensitive. The Journal of Comparative Neurology 517: 123-133.
33. Jackson EL, Garcia-Verdugo JM, Gil-Perotin S, Roy M, Quinones-Hinojosa A, et al. (2006) PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron 51: 187-199.
34. Mirzadeh Z, Merkle FT, Soriano-Navarro M, Garcia-Verdugo JM, Alvarez-Buylla A, (2008) Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain. Cell Stem Cell 3: 265-278.
35. Wojtowicz JM, Kee N, (2006) BrdU assay for neurogenesis in rodents. Nature protocols 1: 1399-1405.
36. Maslov AY, Barone TA, Plunkett RJ, Pruitt SC, (2004) Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice. J Neurosci 24: 1726-1733.
37. Bauer S, Patterson PH, (2006) Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain. J Neurosci 26: 12089-12099.
38. Doetsch F, Garcia-Verdugo JM, Alvarez-Buylla A, (1997) Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J Neurosci 17: 5046-5061.
39. Mira H, Andreu Z, Suh H, Lie DC, Jessberger S, et al. (2010) Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. Cell Stem Cell 7: 78-89.