Synthesis and anticancer activity of some novel 5,6-fused hybrids of juglone based 1,4-naphthoquinones

European Journal of Medicinal Chemistry

Volumn 83, Issue , 2014, Pages 84-91

  Mallavadhani, Uppuluri Venkata ^a   Prasad, Chakka Vara ^a   Shrivastava, Shweta ^b   Naidu, V G M ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Anticancer activity; Apoptosis; Cell cycle arrest; Juglone; Plumbagin

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 METHYLNAPHTHOL[1,2 B]FURAN 6,9 DIONE; 2,3 DIHYDRO 2 (IODOMETHYL) 7 METHYLNAPHTHO[1,2 B]FURAN 6,9 DIONE; 2,3 DIHYDRO 2 (IODOMETHYL) NAPHTHO[1,2 B] FURAN 6,9 DIONE; 2,7 DIMETHYLNAPHTHO[1,2 B]FURAN 6,9 DIONE; 2H BENZO[H]CHROMENE 7,10 DIONE; 5 (ALLYLOXY) 2 METHYLNAPHTHALENE 1,4 DIONE; 5 (ALLYLOXY) NAPHTHALENE 1,4 DIONE; 6 ALLYL 5 HYDROXY 2 METHYLNAPHTHALENE 1,4 DIONE; 6 ALLYL 5 HYDROXYNAPHTHALENE 1,4 DIONE; 8 METHYL 2H BENZO[H]CHROMENE 7,10 DIONE; ANTINEOPLASTIC AGENT; DOXORUBICIN; ETOPOSIDE; JUGLONE; PLUMBAGIN; UNCLASSIFIED DRUG; 2 METHYLNAPHTHO[ 1,2 B]FURAN 6,9 DIONE; 2,3 DIHYDRO 2 (IODOMETHYL) 7 METHYLNAPHTHO[ 1,2 B]FURAN 6,9 DIONE; 2,3 DIHYDRO 2 (IODOMETHYL)NAPHTHO[ 1,2 B]FURAN 6,9 DIONE; 2,7 DIMETHYLNAPHTHO[ 1,2 B]FURAN 6,9 DIONE; BENZOFURAN DERIVATIVE; CHROMENE DERIVATIVE; DIHYDROBENZOFURAN DERIVATIVE; PHENOL; QUINONE DERIVATIVE; 1,4-NAPHTHOQUINONE; NAPHTHOQUINONE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIZATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HELA CELL LINE; HT 29 CELL LINE; HUMAN; HUMAN CELL; HYBRID; IC 50; IN VITRO STUDY; M PHASE CELL CYCLE CHECKPOINT; MALE; MCF 7 CELL LINE; MTT ASSAY; PROSTATE CANCER; UTERINE CERVIX CANCER; BREAST CANCER CELL LINE; CANCER CELL LINE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CYTOTOXICITY; HUMAN CELL CULTURE; IC50; PROSTATE CANCER CELL LINE; CELL CYCLE; CHEMISTRY; DRUG EFFECTS; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NAPHTHOQUINONES;

EID: 84903172276     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.06.012     Document Type: Article

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