Atovaquone derivatives as potent cytotoxic and apoptosis inducing agents

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 5091-5094

  Zhou, Jing ^a   Duan, Lei ^a   Chen, Huaming ^b   Ren, Xiaomei ^a   Zhang, Zhang ^a   Zhou, Fengtao ^a,c   Liu, Jinsong ^a   Pei, Duanqing ^a   Ding, Ke ^a  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Apoptosis; Atovaquone; Cytotoxic

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 PIPERAZINYLNAPHTHOQUINONE DERIVATIVE; 2 PIPERIDINYLNAPHTHOQUINONE DERIVATIVE; ATOVAQUONE; CASPASE 3; CASPASE 9; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ATOVAQUONE; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MALE; MOLECULAR CONFORMATION; NAPHTHOQUINONES; PROSTATIC NEOPLASMS;

EID: 68549097981     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.044     Document Type: Article

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