Juglone: A therapeutic phytochemical from Juglans regia L.

Journal of Medicinal Plant Research

Volumn 5, Issue 22, 2011, Pages 5324-5330

  Thakur, Ajay ^a  

^a FOREST RESEARCH INSTITUTE   (India)

Author keywords

Allelopathic; Anticarcinogenic; Antitumor; Medicinal; Phytochemical

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; HAIR DYE; JUGLONE; PEPTIDYLPROLYL ISOMERASE PIN1; TRANSCRIPTION FACTOR E2F4;

ALLELOPATHY; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; APOPTOSIS; BACTERIAL INFECTION; CANCER RESEARCH; CELL DEATH; DRUG ANALYSIS; DRUG ISOLATION; DRUG STRUCTURE; DRY WEIGHT; ENZYME INHIBITION; HEAT STROKE; HUMAN; INTESTINE TUMOR; JUGLANS REGIA; MYCOSIS; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; PROTEIN EXPRESSION; REVIEW; VIRUS INFECTION;

EID: 80055060628     PISSN: None     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Review

References (43)

1. Babich H, Stern A (1993). In vitro cytotoxicities of 1, 4-napthoquinone and hydroxylated 1, 4-napthoquiones to replicating cells. J. Appl. Toxicol., 13(5): 353-358.
2. Bode HR (1958). Contributions to the knowledge of allelopathic phenomena in some Juglandaceen. Planta, 51: 440-480.
3. Cai LW, Bijl G, Vander P, Wu CD (2000). Namibian chewing stick, Diospyros lycioides, contains antibacterial compounds against oral pathogens. J. Agric. Food Chem., 48(3): 909-914.
4. Chao SH, Greenleaf AL, Price DH (2001). Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription. Nucleic Acids Res., 29(3): 767-773.
5. Dama LB (2002). Effect of naturally occurring napthoquinones on rootknot nematode Meloidogyne javanica Ind. Phytopathol., 55(1): 67-69.
6. Doherty MD, Rodgers A, Cohen GM (1987). Mechanisms of toxicity of 2-and 5-hydroxy-1, 4-napthoquinone; absence of a role for redox cycling in the toxicity of 2-hydroxy-1, 4-napthoquinone to isolated hepatocytes. J. Appl. Toxicol., 7(2): 123-129.
7. Edenharder R, Tang X (1997). Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds. Food Chem. Toxicol., 35(3-4): 357-372.
8. Erdemoglu N, Küpeli E, Yesilada E (2003). Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine. J. Ethnopharmacol., 89: 123-129.
9. Finn G, Lu KP (2008). Phosphorylation-specific prolyl isomerase Pin1 as a new diagnostic and therapeutic target for cancer. Curr. Cancer Drug Targets, 8(3): 223-229.
10. Funk DT, Case PJ, Rietveld WJ, Phares RE (1979). Effects of juglone on the growth of coniferous seedlings. For. Sci., 25(3): 452-454.
11. Gamble JS (1902). A Manual of Indian Timber. Sampson Low, Martson and Company Ltd. London.
12. Gant TW, Doherty MD, Odowole D, Sales KD, Cohen GM (1986). Semiquinone anion radicals formed by the reaction of quinones with glutathione or amino acids. FEBS Lett., 201(2): 296-300.
13. Gîrzu M, Fraisse D, Carnat AP, Carnat A, Lamaison JL (1998). Highperformance liquid chromatographic method for the determination of juglone in fresh walnut leaves. J. Chromatogr., 805: 315-318.
14. Gleeson SK (1982). Heterodichogamy in walnuts: inheritance and stable ratios. Evolution, 36: 892-902.
15. Harborne JB (1988). Introduction to Ecological Biochemistry. London-New York, Acad. Press.
16. Hemery GE (2000). Genetic Variation in Juglans regia. D.Phil. Thesis. Department of Plant Sciences. Univ. Oxford. Oxford. UK.
17. Huntley B, Birks HJB (1983). An Atlas of Past and Present Pollen Maps for Europe: 0-13000 years ago. Cambridge Univ. Press, Cambridge.
18. Jackson D, McNeil D (1999). Walnuts. Temperate and Subtropical Fruit Production. 2nd edition (Eds Jackson and Looney), CABI Pub. Oxford.
19. Jalas J, Suominen J (1976). Atlas Florae Europeae, Vol. 3. The Committee for mapping the Flora of Europe, Helsinki.
20. Kolov O (1998). Ecological characteristics of the walnut-fruit forests in Kyrgyzstan. In Biodiversity and Sustainable Use of Kyrgyzstan's Walnut-Fruit Forests (eds. J. Blaser, J.Carter and D. Gilmour), IUCN, Gland, Switzerland and Cambridge, UK and INTERCOOPERATION, Bern, Switzerland. pp. 59-62.
21. Manning WE (1978). The classification within the Juglandaceae. Ann. Miss. Bot. Gard., 65: 1058-1087.
22. Manos PS, Stone DS (2001). Evolution, phylogeny and systematics of the Juglandaceae. Ann. Miss. Bot. Gard., 88(2): 231-269.
23. Namgoong GM, Khanal P, Cho HG, Lim SC, Oh YK, Kang BS, Shim JH, Yoo JC, Choi HS, (2010). The Prolyl Isomerase Pin1 Induces LC-3 Expression and Mediates Tamoxifen Resistance in Breast Cancer. J. Biol. Chem., 285(31): 23829-23841.
24. NLM (2005). Registry of Toxic Effects of Chemical Substances (RTECS), Bethesda, MD, Nat. Lib. Med.
25. Okada TA, Roberts E, Brodie AF (1967). Mitotic abnormalities produced by juglone in Ehrlich ascities tumor cells. Proc. Soc. Expt. Biol. Med., 126: 583-588.
26. Öllinger K, Brunmark A (1991). Effect of hydroxy substituent position on 1, 4-napthoquinone toxicity to rat hepatocytes. J. Biol. Chem., 266(32): 21496-21503.
27. Polunin O (1977). Trees and Bushes of Britain and Europe. Granada Pub. Ltd, Paladin Frogmore, St Albans Herts. pp. 204.
28. Reitveld WJ (1983). Allelopathic effects of juglone on germination and growth of several herbaceous and woody species. J. Chem. Ecol., 9(2): 295-308.
29. Roach FA (1985). Cultivated Fruits of Britain: Their Origin and History. Blackwell Pub., Oxford. Schneiderhan FJ (1927). The black walnut (Juglans nigra L.) as a cause of death of apple trees. Phytopathology, 17: 529-540.
30. Scisciolo B, De LDJ, Walton DC (1990). Seasonal patterns of juglone in soil beneath Juglans nigra (black walnut) and influence of J. nigra on understory vegetation. J. Chem. Ecol., 16 (4): 1111-1130.
31. Segura-Aguilar J, Jönsson K, Tidefelt U, Paul C (1992). The cytotoxic effects of 5-OH-1, 4-napthoquinone and 5,8-diOH-1, 4-napthoquinone on doxorubicin-resistant human leukemia cells (HL-60). Leuk. Res., 16(6-7): 631-637.
32. Sugie S, Okamoto K, Rahman KMW, Tanaka T, Kawai K, Yamahara J, Mori H (1998). Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats. Cancer Lett., 127(1-2): 177-183.
33. Thakur Ajay (2006). Genetic Variation in Juglans regia. Ph.D. Thesis. School of Agric. For. Univ. Wales, Bangor, UK.
34. Thakur A, Cahalan C (2011). Geographical Variation of Juglans regia L. in Juglone Content: Rapid Analysis Using micro plate reader. Curr. Sci., 100(10): 1483-1485.
35. Thomson RH (1957). Naturally Occuring Quinines. Butterworth Scientific Pub., London.
36. Townsend CC (1980). Juglandaceae. In Flora of Iraq, Vol. 8 (eds C.C. Townsend and E. Guest), Ministry of Agric. Agrar. Reform, Baghdad, pp. 56-61.
37. Tutin TG, Burges NA, Chater AO, Edmondson JR, Heywood VH, Moore DM (1993). Juglandaceae. In Fl. Europ., (2nd edn.) Vol. 1. (ed. D.M. Moore). Cambridge Univ. Press, Cambridge.
38. Van DBL, Segal A, Tseng SS, Rusch GM, Loewengart G, Maté U, Roth D, Smith A, Melchionne S, Seidman I (1978). Structure and tumor promoting activity of analogues of anthralin (1,8-dihydroxy-9-anthrone). J. Med. Chem., 21(1): 26-31.
39. Varga Z, Bene L, Pieri C, Damjanovich S, Gáspár R (1996). The effect of juglone on the membrane potential and whole-cell K+ currents of human lymphocytes. Biochem. Biophy. Res. Comm., 218(3): 828-832.
40. Westfall BA, Russell RL, Auyong TK (1961). Depressant agent from walnut hulls. Science, 134: 1617.
41. Westwood MN (1977). Temperate Zone Pomology. W.H. Freeman and Co., San Francisco.
42. Zhang CJ, Zhang ZH, Xu BL, Wang YL (2008). Recent advances in the study of pin1 and its inhibitors. Acta, Pharm. Sin., 43(1): 9-17.
43. Zohary D (1993). Domestication of Plants In Old World: The Origin and Spread of Cultivated Plants In West Asia, Europe And Nile Valley. Oxford Univ. Press, Oxford.