메뉴 건너뛰기




Volumn , Issue , 2014, Pages 145-155

S-Equol, an Antioxidant Metabolite of Soy Daidzein, and Oxidative Stress in Aging: A Focus on Skin and on the Cardiovascular System

Author keywords

Aging skin; Cardiovascular diseases; Estrogen; Estrogen receptor ; Isoflavones; Oxidative stress; S equol; Soy

Indexed keywords


EID: 84903014435     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-405933-7.00015-9     Document Type: Chapter
Times cited : (2)

References (58)
  • 1
    • 79959969392 scopus 로고    scopus 로고
    • Testosterone levels and cognition in elderly men: a review
    • Holland J., Bandelow S., Hogervorst E. Testosterone levels and cognition in elderly men: a review. Maturitas 2011, 69:322-337.
    • (2011) Maturitas , vol.69 , pp. 322-337
    • Holland, J.1    Bandelow, S.2    Hogervorst, E.3
  • 2
    • 84855409342 scopus 로고    scopus 로고
    • Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 mice: protective role of eNOS and SIRT1
    • Ota H., Akishita M., Akiyoshi T., et al. Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 mice: protective role of eNOS and SIRT1. PLoS One 2012, 10.1371/journal/pone.0029598.
    • (2012) PLoS One
    • Ota, H.1    Akishita, M.2    Akiyoshi, T.3
  • 3
    • 0037125379 scopus 로고    scopus 로고
    • For the Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial
    • Rossouw J.E. For the Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002, 288:321-333.
    • (2002) JAMA , vol.288 , pp. 321-333
    • Rossouw, J.E.1
  • 4
    • 77950350596 scopus 로고    scopus 로고
    • Postmenopausal hormone therapy and cognitive outcomes: the Women's Health Initiative Memory Study (WHIMS)
    • Coker L.H., Espeland M.A., Rapp S.R., et al. Postmenopausal hormone therapy and cognitive outcomes: the Women's Health Initiative Memory Study (WHIMS). J Steroid Biochem Mol Biol 2010, 118:304-310.
    • (2010) J Steroid Biochem Mol Biol , vol.118 , pp. 304-310
    • Coker, L.H.1    Espeland, M.A.2    Rapp, S.R.3
  • 5
    • 2942755831 scopus 로고    scopus 로고
    • Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study
    • Shumaker S.A., Legault C., Kuller L., et al. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study. JAMA 2004, 291:2947-2958.
    • (2004) JAMA , vol.291 , pp. 2947-2958
    • Shumaker, S.A.1    Legault, C.2    Kuller, L.3
  • 6
    • 80255126813 scopus 로고    scopus 로고
    • Hip fracture in postmenopausal women after cessation of hormone therapy: results from a prospective study in a large health management organization
    • Karim R., Dell R.M., Greene D.F., Mack W.J., Gallagher J.C., Hodis H.N. Hip fracture in postmenopausal women after cessation of hormone therapy: results from a prospective study in a large health management organization. Menopause 2011, 18:1172-1177.
    • (2011) Menopause , vol.18 , pp. 1172-1177
    • Karim, R.1    Dell, R.M.2    Greene, D.F.3    Mack, W.J.4    Gallagher, J.C.5    Hodis, H.N.6
  • 7
    • 79952311372 scopus 로고    scopus 로고
    • A 'window of opportunity': the reduction of coronary heart disease and total mortality with menopausal therapies is age - and time-dependent
    • Hodis H.N., Mack W.J. A 'window of opportunity': the reduction of coronary heart disease and total mortality with menopausal therapies is age - and time-dependent. Brain Res 2011, 1379:244-252.
    • (2011) Brain Res , vol.1379 , pp. 244-252
    • Hodis, H.N.1    Mack, W.J.2
  • 8
    • 79952311053 scopus 로고    scopus 로고
    • Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunity
    • Rocca W.A., Grossardt B.R., Shuster L.T. Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunity. Brain Res 2011, 1379:188-198.
    • (2011) Brain Res , vol.1379 , pp. 188-198
    • Rocca, W.A.1    Grossardt, B.R.2    Shuster, L.T.3
  • 9
    • 70350304150 scopus 로고    scopus 로고
    • Estrogen therapy: is time of initiation critical for neuroprotection?
    • Sherwin B.B. Estrogen therapy: is time of initiation critical for neuroprotection?. Nat Rev Endocrinol 2009, 5:620-627.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 620-627
    • Sherwin, B.B.1
  • 10
    • 84871328175 scopus 로고    scopus 로고
    • Hormone therapy and Alzheimer disease dementia: new findings from the Cache County Study
    • Shao H., Breitner J.C., Whitmer R.A., et al. Hormone therapy and Alzheimer disease dementia: new findings from the Cache County Study. Neurology 2012, 79:1846-1852.
    • (2012) Neurology , vol.79 , pp. 1846-1852
    • Shao, H.1    Breitner, J.C.2    Whitmer, R.A.3
  • 11
    • 80053260556 scopus 로고    scopus 로고
    • In search of estrogen alternative for the brain
    • Cambridge University Press, Cambridge, E. Hogervorst, V.W. Henderson, R.B. Gibbs, R.D. Brinton (Eds.)
    • Zhao L., Brinton R.D. In search of estrogen alternative for the brain. Hormones, cognition and dementia: state of the art and emergent therapeutic strategies 2009, 93-100. Cambridge University Press, Cambridge. E. Hogervorst, V.W. Henderson, R.B. Gibbs, R.D. Brinton (Eds.).
    • (2009) Hormones, cognition and dementia: state of the art and emergent therapeutic strategies , pp. 93-100
    • Zhao, L.1    Brinton, R.D.2
  • 12
    • 20544476987 scopus 로고    scopus 로고
    • S-equol, a potent ligand for estrogen receptor β, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora
    • Setchell K.D.R., Clerici C., Lephart E.D., et al. S-equol, a potent ligand for estrogen receptor β, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr 2005, 81:1072-1079.
    • (2005) Am J Clin Nutr , vol.81 , pp. 1072-1079
    • Setchell, K.D.R.1    Clerici, C.2    Lephart, E.D.3
  • 13
    • 79960722812 scopus 로고    scopus 로고
    • Emerging evidence on the health benefits of S-equol, an estrogen receptor β agonist
    • Jackson R.L., Greiwe J.S., Schwen R.J. Emerging evidence on the health benefits of S-equol, an estrogen receptor β agonist. Nutr Rev 2011, 69:432-438.
    • (2011) Nutr Rev , vol.69 , pp. 432-438
    • Jackson, R.L.1    Greiwe, J.S.2    Schwen, R.J.3
  • 14
    • 64049088510 scopus 로고    scopus 로고
    • New equol supplement for relieving menopausal symptoms: randomized, placebo-controlled trial of Japanese women
    • Ishiwata N., Melby M., Mizuno S., Watanabe S. New equol supplement for relieving menopausal symptoms: randomized, placebo-controlled trial of Japanese women. Menopause 2009, 16:141-148.
    • (2009) Menopause , vol.16 , pp. 141-148
    • Ishiwata, N.1    Melby, M.2    Mizuno, S.3    Watanabe, S.4
  • 15
    • 84860127103 scopus 로고    scopus 로고
    • Elucidation of the metabolic pathway of S-equol in rat, monkey and man
    • Schwen R.J., Nguyen L., Jackson R.L. Elucidation of the metabolic pathway of S-equol in rat, monkey and man. Food Chem Toxicol 2012, 50:2074-2083.
    • (2012) Food Chem Toxicol , vol.50 , pp. 2074-2083
    • Schwen, R.J.1    Nguyen, L.2    Jackson, R.L.3
  • 16
    • 79951563454 scopus 로고    scopus 로고
    • Single-dose and multi-dose 14 day pharmacokinetics studies of S-equol, a potent non hormonal, estrogen receptor β agonist being developed for the treatment of menopausal symptoms
    • Jackson R.L., Greiwe J.S., Desai P.B., Schwen R.J. Single-dose and multi-dose 14 day pharmacokinetics studies of S-equol, a potent non hormonal, estrogen receptor β agonist being developed for the treatment of menopausal symptoms. Menopause 2011, 18:185-193.
    • (2011) Menopause , vol.18 , pp. 185-193
    • Jackson, R.L.1    Greiwe, J.S.2    Desai, P.B.3    Schwen, R.J.4
  • 17
    • 84859483420 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
    • Velarde M.C., Flynn J.M., Day N.U., et al. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging 2012, 4:3-12.
    • (2012) Aging , vol.4 , pp. 3-12
    • Velarde, M.C.1    Flynn, J.M.2    Day, N.U.3
  • 18
    • 84873451022 scopus 로고    scopus 로고
    • Tissue-specific effects of loss of estrogen during menopause and aging
    • Wend K., Wend P., Krum S.A. Tissue-specific effects of loss of estrogen during menopause and aging. Front Endocrinol (Lausanne) 2012, 3:1-19.
    • (2012) Front Endocrinol (Lausanne) , vol.3 , pp. 1-19
    • Wend, K.1    Wend, P.2    Krum, S.A.3
  • 19
    • 84866530061 scopus 로고    scopus 로고
    • Postmenopausal skin and estrogen
    • Archer D.F. Postmenopausal skin and estrogen. Gynecol Endocrinol 2012, 28:2-6.
    • (2012) Gynecol Endocrinol , vol.28 , pp. 2-6
    • Archer, D.F.1
  • 20
    • 80054114421 scopus 로고    scopus 로고
    • Aging skin: estrogen receptor β agonists offer a new approach to change the outcome
    • Jackson R.L., Greiwe J.S., Schwen R.J. Aging skin: estrogen receptor β agonists offer a new approach to change the outcome. Exp Dermatol 2011, 20:879-882.
    • (2011) Exp Dermatol , vol.20 , pp. 879-882
    • Jackson, R.L.1    Greiwe, J.S.2    Schwen, R.J.3
  • 21
    • 84863678384 scopus 로고    scopus 로고
    • Age and skin site related differences in steroid metabolism in male skin point to a key role of sebocytes in cutaneous hormone metabolism
    • Hang M., Hamann T., Kulle A.E., et al. Age and skin site related differences in steroid metabolism in male skin point to a key role of sebocytes in cutaneous hormone metabolism. Dermatoendocrinol 2012, 4:58-64.
    • (2012) Dermatoendocrinol , vol.4 , pp. 58-64
    • Hang, M.1    Hamann, T.2    Kulle, A.E.3
  • 22
    • 84872180219 scopus 로고    scopus 로고
    • A role for estrogen receptorŁ and estrogen receptorŁ in collagen biosynthesis in mouse skin
    • Markiewicz M., Znoyko S., Stawski L., et al. A role for estrogen receptorŁ and estrogen receptorŁ in collagen biosynthesis in mouse skin. J Invest Dermatol 2013, 133:120-127.
    • (2013) J Invest Dermatol , vol.133 , pp. 120-127
    • Markiewicz, M.1    Znoyko, S.2    Stawski, L.3
  • 23
    • 77951068465 scopus 로고    scopus 로고
    • Estrogen receptor beta is a novel therapeutic target for photoaging
    • Chang K.C., Wang Y., Oh I.G., et al. Estrogen receptor beta is a novel therapeutic target for photoaging. Mol Pharmacol 2010, 77:744-750.
    • (2010) Mol Pharmacol , vol.77 , pp. 744-750
    • Chang, K.C.1    Wang, Y.2    Oh, I.G.3
  • 25
    • 29844433589 scopus 로고    scopus 로고
    • Protection against photoaging in the hairless mouse by the isoflavone equol
    • Reeve V.E., Widyarini S., Domanski D., et al. Protection against photoaging in the hairless mouse by the isoflavone equol. Photochem Photobiol 2005, 81:1548-1553.
    • (2005) Photochem Photobiol , vol.81 , pp. 1548-1553
    • Reeve, V.E.1    Widyarini, S.2    Domanski, D.3
  • 26
    • 84856532348 scopus 로고    scopus 로고
    • The effects of natural S-equol supplementation on skin aging in postmenopausal women: a pilot randomized placebo-controlled trial
    • Oyama A., Ueno T., Uchiyama S., et al. The effects of natural S-equol supplementation on skin aging in postmenopausal women: a pilot randomized placebo-controlled trial. Menopause 2012, 19:202-210.
    • (2012) Menopause , vol.19 , pp. 202-210
    • Oyama, A.1    Ueno, T.2    Uchiyama, S.3
  • 27
    • 79954573147 scopus 로고    scopus 로고
    • Photoaging and chronological aging profile: understanding oxidation of the skin
    • Peres P.S., Terra V.A., Guarnier F.A., et al. Photoaging and chronological aging profile: understanding oxidation of the skin. J Photochem Photobiol B 2011, 103:93-97.
    • (2011) J Photochem Photobiol B , vol.103 , pp. 93-97
    • Peres, P.S.1    Terra, V.A.2    Guarnier, F.A.3
  • 28
    • 57749120460 scopus 로고    scopus 로고
    • Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes
    • Ohtsuji M., Katsuoka F., Kobayashi A., et al. Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. J Biol Chem 2008, 283:33554-33562.
    • (2008) J Biol Chem , vol.283 , pp. 33554-33562
    • Ohtsuji, M.1    Katsuoka, F.2    Kobayashi, A.3
  • 29
    • 80051474217 scopus 로고    scopus 로고
    • Soy isoflavones increase quinone reductase in hepa-1c1c7 cells via estrogen receptor beta and nuclear factor erythroid 2-related factor 2 binding to the antioxidant response element
    • Froyen E.B., Steinberg F.M. Soy isoflavones increase quinone reductase in hepa-1c1c7 cells via estrogen receptor beta and nuclear factor erythroid 2-related factor 2 binding to the antioxidant response element. J Nutr Biochem 2011, 22:843-848.
    • (2011) J Nutr Biochem , vol.22 , pp. 843-848
    • Froyen, E.B.1    Steinberg, F.M.2
  • 30
    • 62549086961 scopus 로고    scopus 로고
    • Evaluation of equol function on anti - or prooxidant status in vivo
    • Choi E.J. Evaluation of equol function on anti - or prooxidant status in vivo. J Food Sci 2009, 74:H65-H71.
    • (2009) J Food Sci , vol.74
    • Choi, E.J.1
  • 31
    • 36249025809 scopus 로고    scopus 로고
    • Isoflavones, equol and cardiovascular disease: pharmacological and therapeutic insights
    • Jackman K.A., Woodman O.L., Sobey C.G. Isoflavones, equol and cardiovascular disease: pharmacological and therapeutic insights. Curr Med Chem 2007, 14:2824-2830.
    • (2007) Curr Med Chem , vol.14 , pp. 2824-2830
    • Jackman, K.A.1    Woodman, O.L.2    Sobey, C.G.3
  • 32
    • 79960729749 scopus 로고    scopus 로고
    • CARDIAC study and dietary intervention studies, Chapter 6
    • CRC Press, New York, M. Sugano (Ed.)
    • Yamori Y. CARDIAC study and dietary intervention studies, Chapter 6. Soy in health and disease prevention 2005, 107-119. CRC Press, New York. M. Sugano (Ed.).
    • (2005) Soy in health and disease prevention , pp. 107-119
    • Yamori, Y.1
  • 33
    • 84867605310 scopus 로고    scopus 로고
    • Urinary isoflavonoids and risk of coronary heart disease
    • Zhang X., Gao Y.T., Yang G., et al. Urinary isoflavonoids and risk of coronary heart disease. Int J Epidemiol 2012, 41:1367-1375.
    • (2012) Int J Epidemiol , vol.41 , pp. 1367-1375
    • Zhang, X.1    Gao, Y.T.2    Yang, G.3
  • 34
    • 80055019073 scopus 로고    scopus 로고
    • Isoflavone soy protein supplementation and atherosclerosis progression in healthy postmenopausal women: a randomized controlled trial
    • Hodis H.N., Mack W.J., Kono N., et al. Isoflavone soy protein supplementation and atherosclerosis progression in healthy postmenopausal women: a randomized controlled trial. Stroke 2011, 42:3168-3175.
    • (2011) Stroke , vol.42 , pp. 3168-3175
    • Hodis, H.N.1    Mack, W.J.2    Kono, N.3
  • 35
    • 85031253456 scopus 로고    scopus 로고
    • Soya isoflavone consumption in relation to carotid intima-media thickness in Chinese equol excretors aged 40-65 years
    • Cai Y., Guo K., Chen C., et al. Soya isoflavone consumption in relation to carotid intima-media thickness in Chinese equol excretors aged 40-65 years. Br J Nutr 2012, 29:1-7.
    • (2012) Br J Nutr , vol.29 , pp. 1-7
    • Cai, Y.1    Guo, K.2    Chen, C.3
  • 36
    • 34948847705 scopus 로고    scopus 로고
    • Pasta naturally enriched with isoflavone aglycons from soy germ reduces serum lipids and improves markers of cardiovascular risk
    • Clerici C., Setchell K.D., Battezzati P.M., et al. Pasta naturally enriched with isoflavone aglycons from soy germ reduces serum lipids and improves markers of cardiovascular risk. J Nutr 2007, 137:2270-2278.
    • (2007) J Nutr , vol.137 , pp. 2270-2278
    • Clerici, C.1    Setchell, K.D.2    Battezzati, P.M.3
  • 37
    • 84863252380 scopus 로고    scopus 로고
    • Equol status and blood lipid profile in hyperlipidemia after consumption of diets containing soy foods
    • Wong J.M., Kendall C.W., Marchie A., et al. Equol status and blood lipid profile in hyperlipidemia after consumption of diets containing soy foods. Am J Clin Nutr 2012, 95:564-571.
    • (2012) Am J Clin Nutr , vol.95 , pp. 564-571
    • Wong, J.M.1    Kendall, C.W.2    Marchie, A.3
  • 38
    • 33644693570 scopus 로고    scopus 로고
    • Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production
    • Hall W.L., Vafeiadou K., Hallund J., et al. Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production. Am J Clin Nutr 2005, 82:1260-1268.
    • (2005) Am J Clin Nutr , vol.82 , pp. 1260-1268
    • Hall, W.L.1    Vafeiadou, K.2    Hallund, J.3
  • 39
    • 56449087038 scopus 로고    scopus 로고
    • Reduction of C-reactive protein with isoflavone supplement reverses endothelial dysfunction in patients with ischaemic stroke
    • Chan Y.H., Lau K.K., Yiu K.H., et al. Reduction of C-reactive protein with isoflavone supplement reverses endothelial dysfunction in patients with ischaemic stroke. Eur Heart J 2008, 29:2800-2807.
    • (2008) Eur Heart J , vol.29 , pp. 2800-2807
    • Chan, Y.H.1    Lau, K.K.2    Yiu, K.H.3
  • 40
    • 0037448074 scopus 로고    scopus 로고
    • The phytoestrogen equol increases nitric oxide availability by inhibiting superoxide production: an antioxidant mechanism for cell-mediated LDL modification
    • Hwang J., Wang J., Morazzoni P., et al. The phytoestrogen equol increases nitric oxide availability by inhibiting superoxide production: an antioxidant mechanism for cell-mediated LDL modification. Free Radic Bio Med 2003, 34:1271-1282.
    • (2003) Free Radic Bio Med , vol.34 , pp. 1271-1282
    • Hwang, J.1    Wang, J.2    Morazzoni, P.3
  • 41
    • 84876388115 scopus 로고    scopus 로고
    • R- and S-Equol have equivalent cytoprotective effects in Friedreich's ataxia
    • Richardson T.E., Simpkins J.W. R- and S-Equol have equivalent cytoprotective effects in Friedreich's ataxia. BMC Pharmacol Toxicol 2012, 13. 10.1186/2050-6411-13-12.
    • (2012) BMC Pharmacol Toxicol , vol.13
    • Richardson, T.E.1    Simpkins, J.W.2
  • 42
    • 50849105401 scopus 로고    scopus 로고
    • Antioxidant effects of equol on bovine aortic endothelial cells
    • Chung J.E., Kim S.Y., Jo H.H., et al. Antioxidant effects of equol on bovine aortic endothelial cells. Biochem Biophys Res Comm 2008, 375:420-424.
    • (2008) Biochem Biophys Res Comm , vol.375 , pp. 420-424
    • Chung, J.E.1    Kim, S.Y.2    Jo, H.H.3
  • 43
    • 80052567031 scopus 로고    scopus 로고
    • Estrogen signaling and cardiovascular disease
    • Murphy E. Estrogen signaling and cardiovascular disease. Circ Res 2011, 109:687-696.
    • (2011) Circ Res , vol.109 , pp. 687-696
    • Murphy, E.1
  • 44
    • 80051781308 scopus 로고    scopus 로고
    • The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function
    • Meyer M.R., Prossnitz E.R., Barton M. The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function. Vascul Pharmacol 2011, 55:17-25.
    • (2011) Vascul Pharmacol , vol.55 , pp. 17-25
    • Meyer, M.R.1    Prossnitz, E.R.2    Barton, M.3
  • 45
    • 82155173499 scopus 로고    scopus 로고
    • The G-protein-coupled estrogen receptor GPER in health and disease
    • Prossnitz E.R., Barton M. The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol 2011, 7:715-726.
    • (2011) Nat Rev Endocrinol , vol.7 , pp. 715-726
    • Prossnitz, E.R.1    Barton, M.2
  • 46
    • 33748744767 scopus 로고    scopus 로고
    • The isoflavone equol mediates rapid vascular relaxation: Ca2+-independent activation of endothelial nitric-oxide synthase/Hsp90 involving ERK1/2 and Akt phosphorylation in human endothelial cells
    • Joy S., Siow R.C., Rowlands D.J., et al. The isoflavone equol mediates rapid vascular relaxation: Ca2+-independent activation of endothelial nitric-oxide synthase/Hsp90 involving ERK1/2 and Akt phosphorylation in human endothelial cells. J Biol Chem 2006, 281:27335-27345.
    • (2006) J Biol Chem , vol.281 , pp. 27335-27345
    • Joy, S.1    Siow, R.C.2    Rowlands, D.J.3
  • 47
    • 84861464050 scopus 로고    scopus 로고
    • Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging
    • Chapple S.J., Siow R.C., Mann G.E. Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging. Int J Biochem Cell Biol 2012, 44:1315-1320.
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 1315-1320
    • Chapple, S.J.1    Siow, R.C.2    Mann, G.E.3
  • 48
    • 33847634280 scopus 로고    scopus 로고
    • Cardiovascular targets for estrogens and phytoestrogens: transcriptional regulation of nitric oxide synthase and antioxidant defense genes
    • Siow R.C., Li F.Y., Rowlands D.J., et al. Cardiovascular targets for estrogens and phytoestrogens: transcriptional regulation of nitric oxide synthase and antioxidant defense genes. Free Radic Biol Med 2007, 42:909-925.
    • (2007) Free Radic Biol Med , vol.42 , pp. 909-925
    • Siow, R.C.1    Li, F.Y.2    Rowlands, D.J.3
  • 49
    • 62249089498 scopus 로고    scopus 로고
    • Targeting the redox sensitive Nrf2-Keap 1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones
    • Mann G.E., Bonacasa B., Ishii T., Sio R.C.M. Targeting the redox sensitive Nrf2-Keap 1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones. Curr Opin Pharmacol 2009, 9:139-145.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 139-145
    • Mann, G.E.1    Bonacasa, B.2    Ishii, T.3    Sio, R.C.M.4
  • 50
    • 78649636576 scopus 로고    scopus 로고
    • Dietary isoflavones and vascular protection: activation of cellular antioxidant defenses by SERMs or hormesis?
    • Siow R.C., Mann G.E. Dietary isoflavones and vascular protection: activation of cellular antioxidant defenses by SERMs or hormesis?. Mol Aspects Med 2010, 31:468-477.
    • (2010) Mol Aspects Med , vol.31 , pp. 468-477
    • Siow, R.C.1    Mann, G.E.2
  • 51
    • 84864008286 scopus 로고    scopus 로고
    • 17β-estradiol regulates the expression of antioxidant enzymes in myocardial cells by increasing Nrf2 translocation
    • Yu J., Zhao Y., Li B., et al. 17β-estradiol regulates the expression of antioxidant enzymes in myocardial cells by increasing Nrf2 translocation. J Biochem Mol Toxicol 2012, 26:264-269.
    • (2012) J Biochem Mol Toxicol , vol.26 , pp. 264-269
    • Yu, J.1    Zhao, Y.2    Li, B.3
  • 52
    • 84862278246 scopus 로고    scopus 로고
    • Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge
    • Donovan E.L., McCord J.M., Reuland D.J., et al. Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge. Oxid Med Cell Longev 2012, 10.1155/2012/132931.
    • (2012) Oxid Med Cell Longev
    • Donovan, E.L.1    McCord, J.M.2    Reuland, D.J.3
  • 53
    • 34249062039 scopus 로고    scopus 로고
    • Reduced expression of heme oxygenase-1 in patients with coronary atherosclerosis
    • Brydun A., Watari Y., Yamamoto Y., et al. Reduced expression of heme oxygenase-1 in patients with coronary atherosclerosis. Hypertens Res 2007, 30:341-348.
    • (2007) Hypertens Res , vol.30 , pp. 341-348
    • Brydun, A.1    Watari, Y.2    Yamamoto, Y.3
  • 54
    • 84890554973 scopus 로고    scopus 로고
    • Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for hypoxic preconditioning-mediated delayed cardioprotection
    • Huang X.S., Chen H.P., Yu H.H., et al. Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for hypoxic preconditioning-mediated delayed cardioprotection. Mol Cell Biochem 2013, 10.1007/s11010-013-1812-6.
    • (2013) Mol Cell Biochem
    • Huang, X.S.1    Chen, H.P.2    Yu, H.H.3
  • 55
    • 79953205141 scopus 로고    scopus 로고
    • Equol-stimulated mitochondrial reactive oxygen species activate endothelial nitric oxide synthase and redox signaling in endothelial cells: roles for F-actin and GPR30
    • Rowlands D.J., Chapple S., Siow R.C., Mann G.E. Equol-stimulated mitochondrial reactive oxygen species activate endothelial nitric oxide synthase and redox signaling in endothelial cells: roles for F-actin and GPR30. Hypertension 2011, 57:833-840.
    • (2011) Hypertension , vol.57 , pp. 833-840
    • Rowlands, D.J.1    Chapple, S.2    Siow, R.C.3    Mann, G.E.4
  • 56
    • 84875193419 scopus 로고    scopus 로고
    • Relationship between serum isoflavone levels and disability-free survival among community-dwelling elderly individuals: nested case-control study of the Tsurugaya Project
    • Hozawa A., Sugawara Y., Tomata Y., et al. Relationship between serum isoflavone levels and disability-free survival among community-dwelling elderly individuals: nested case-control study of the Tsurugaya Project. J Gerontol A Biol Sci Med Sci 2013, 68:465-472.
    • (2013) J Gerontol A Biol Sci Med Sci , vol.68 , pp. 465-472
    • Hozawa, A.1    Sugawara, Y.2    Tomata, Y.3
  • 57
    • 23744472139 scopus 로고    scopus 로고
    • Fetal exposure to phytoestrogens-the difference in phytoestrogen status between mother and fetus
    • Todaka E., Sakurai K., Fukata H., et al. Fetal exposure to phytoestrogens-the difference in phytoestrogen status between mother and fetus. Environ Res 2005, 99:195-203.
    • (2005) Environ Res , vol.99 , pp. 195-203
    • Todaka, E.1    Sakurai, K.2    Fukata, H.3
  • 58
    • 84872191509 scopus 로고    scopus 로고
    • Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype
    • Hong K.W., Ko K.P., Ahn Y., et al. Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype. Genes Nutr 2012, 7:567-574.
    • (2012) Genes Nutr , vol.7 , pp. 567-574
    • Hong, K.W.1    Ko, K.P.2    Ahn, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.