The isoflavone equol mediates rapid vascular relaxation: Ca 2+-independent activation of endothelial nitric-oxide synthase/Hsp90 involving ERK1/2 and Akt phosphorylation in human endothelial cells

Journal of Biological Chemistry

Volumn 281, Issue 37, 2006, Pages 27335-27345

  Joy, Sheeja ^a   Siow, Richard C M ^a   Rowlands, David J ^a   Becker, Marko ^a   Wyatt, Amanda W ^a   Aaronson, Philip I ^a   Coen, Clive W ^a   Kallo, Imre ^a,b   Jacob, Ron ^a   Mann, Giovanni E ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; CARDIOLOGY; CELLS; ENZYME INHIBITION; ENZYMES; TOXIC MATERIALS;

CARDIOVASCULAR DISEASE; ESTROGEN RECEPTORS; PHOSPHORYLATION; VASCULAR RELAXATION;

BIOCHEMISTRY;

ANTIESTROGEN; CALCIUM ION; CYCLIC AMP; DAIDZEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EQUOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENISTEIN; HEAT SHOCK PROTEIN 90; ICI 182750; ISOFLAVONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TAMOXIFEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION;

ANIMALS; CALCIUM; ENDOPLASMIC RETICULUM; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ESTROGEN ANTAGONISTS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; ISOFLAVONES; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE SYNTHASE TYPE III; PHYTOESTROGENS; RATS; RATS, WISTAR;

EID: 33748744767     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M602803200     Document Type: Article

References (68)

1. Valverde, M. A., and Parker, M. G. (2002) Trends Biochem. Sci. 27, 172-173
2. McDonnell, D. P., and Norris, J. D. (2002) Science 296, 642-1644
3. Hisamoto, K., and Bender, J. R. (2005) Steroids 70, 382-387
4. Sumi, D., and Ignarro, L. J. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 14451-14456
5. Borras, C., Gambini, J., Gomez-Cabrera, M. C., Sastre, J., Pallardo, F. V., Mann, G. E., and Vina, J. (2005) Aging Cell 4, 113-118
6. Chen, Z., Yuhanna, I. S., Galcheva-Gargova, Z., Karas, R. H., Mendelsohn, M. E., and Shaul, P. W. (1999) J. Clin. Investig. 103, 401-406
7. Kim, H. P., Lee, J. Y., Jeong, J. K., Bae, S. W., Lee, H. K., and Jo, I. (1999) Biochem. Biophys. Res. Commun. 263, 257-262
8. Chambliss, K. L., Yuhanna, I. S., Mineo, C., Liu, P., German, Z., Sherman, T. S., Mendelsohn, M. E., Anderson, R. G., and Shaul, P. W. (2000) Circ. Res. 87, E44-E52
9. Simoncini, T., Hafezi-Moghadam, A., Brazil, D. P., Ley, K., Chin, W. W., and Liao, J. K. (2000) Nature 407, 538-541
10. Kim-Schulze, S., Lowe, W. L., Jr., and Schnaper, H. W. (1998) Circulation 98, 413-421
11. Hisamoto, K., Ohmichi, M., Kurachi, H., Hayakawa, J., Kanda, Y., Nishio, Y., Adachi, K., Tasaka, K., Miyoshi, E., Fujiwara, N., Taniguchi, N., and Murata, Y. (2001) J. Biol. Chem. 276, 3459-3467
12. Chen, D. B., Bird, I. M., Zheng, J., and Magness, R. R. (2004) Endocrinology 145, 113-125
13. Wyckoff, M. H., Chambliss, K. L., Mineo, C., Yuhanna, I. S., Mendelsohn, M. E., Mumby, S. M., and Shaul, P. W. (2001) J. Biol. Chem. 276, 27071-27076
14. Russell, K. S., Haynes, M. P., Sinha, D., Clerisme, E., and Bender, J. R. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 5930-5935
15. Fleming, I., Bauersachs, J., Fisslthaler, B., and Busse, R. (1998) Circ. Res. 82, 686-695
16. Caulin-Glaser, T., Garcia-Cardena, G., Sarrel, P., Sessa, W. C., and Bender, J. R. (1997) Circ. Res. 81, 885-892
17. Goetz, R. M., Thatte, H. S., Prabhakar, P., Cho, M. R., Michel, T., and Golan, D. E. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 2788-2793
18. Stefano, G. B., Prevot, V., Beauvillain, J. C., Cadet, P., Fimiani, C., Welters, I., Fricchione, G. L., Breton, C., Lassalle, P., Salzet, M., and Bilfinger, T. V. (2000) Circulation 101, 1594-1597
19. Adlercreutz, H., Markkanen, H., and Watanabe, S. (1993) Lancet 342, 1209-1210
20. Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., and Gustafsson, J.-A. (1998) Endocrinology 139, 4252-4263
21. Setchell, K. D. R., and Cassidy, A. (1999) J. Nutr. 129, S758-S767
22. de Kleijn, M. J., van der Schouw, Y. T., Verbeek, A. L., Peeters, P. H., Banga, J. D., and van der Graaf, Y. (2002) Am. J. Epidemiol. 155, 339-345
23. Cassidy, A., Albertazzi, P., Nielsen, L. I., Hall, W., Williamson, G., Tetens, I., Atkins, S., Cross, H., Manios, Y., Wolk, A., Steiner, C., and Branca, F. (2006) Proc. Nutr. Soc. 65, 76-92
24. Squadrito, F., Altavilla, D., Squadrito, G., Saitta, A., Cucinotta, D., Minutoli, L., Deodato, B., Ferlito, M., Campo, G. M., Bova, A., and Caputi, A. P. (2000) Cardiovasc. Res. 45, 454-462
25. Rivas, M., Garay, R. P., Escanero, J. F., Cia, P., Jr., Cia, P., and Alda, J. O. (2002) J. Nutr. 132, 1900-1902
26. Teede, H. J., McGrath, B. P., DeSilva, L., Cehun, M., Fassoulakis, A., and Nestel, P. J. (2003) Arterioscler. Thromb. Vasc. Biol. 23, 1066-1071
27. Vera, R., Galisteo, M., Villar, I. C., Sanchez, M., Zarzuelo, A., Perez-Vizcaino, F., and Duarte, J. (2005) J. Pharmacol. Exp. Ther. 314, 1300-1309
28. Walker, H. A., Dean, T. S., Sanders, T. A., Jackson, G., Ritter, J. M., and Chowienczyk, P. J. (2001) Circulation 103, 258-262
29. Cuevas, A. M., Irribarra, V. L., Castillo, O. A., Yanez, M. D., and Germain, A. M. (2003) Eur. J. Clin. Nutr. 57, 889-894
30. Squadrito, F., Altavilla, D., Crisafulli, A., Saitta, A., Cucinotta, D., Morabito, N., D'Anna, R., Corrado, F., Ruggeri, P., Frisina, N., and Squadrito, G. (2003) Am. J. Med. 114, 470-476
31. Mishra, S. K., Abbot, S. E., Choudhury, Z., Cheng, M., Khatab, N., Maycock, N. J. R., Zavery, A., and Aaronson, P. I. (2000) Cardiovasc. Res. 46, 539-546
32. Figtree, G. A., Griffiths, H., Lu, Y.-Q., Webb, C., MacLeod, K., and Collins, P. (2000) J. Am. Coll. Cardiol. 35, 1977-1985
33. Lissin, L. W., and Cooke, J. P. (2000) J. Am. Coll. Cardiol. 35, 1403-1410
34. Mahn, K., Borras, C., Knock, G. A., Taylor, P., Khan, I. Y., Sugden, D., Poston, L., Ward, J. P., Sharpe, R. M., Viña, J., Aaronson, P. I., and Mann, G. E. (2005) FASEB J. 19, 1755-1757
35. Jaffe, E. A., Nachman, R. L., Becker, G. C., and Minick, C. R. (1973) J. Clin. Investig. 52, 2745-2756
36. Wyatt, A. W., Steinert, J. R., Wheeler-Jones, C. P., Morgan, A. J., Sugden, D., Pearson, J. D., Sobrevia, L., and Mann, G. E. (2002) FASEB J. 16, 1584-1594
37. Hrabovszky, E., Kallo, I., Steinhauser, A., Merchenthaler, I., Coen, C. W., Petersen, S. L., and Liposits, Z. (2004) J. Comp. Neurol. 473, 315-333
38. Jacob, R. (1990) J. Physiol. (Lond.) 421, 55-77
39. Garcia-Cardena, G., Fan, R., Shah, V., Sorrentino, R., Cirino, G., Papapetropoulos, A., and Sessa, W. C. (1998) Nature 392, 821-824
40. Schulz, E., Anter, E., Zou, M. H., and Keaney, J. F. Jr. (2005) Circulation 111, 3473-3480
41. Haynes, M. P., Li, L., Sinha, D., Russell, K. S., Hisamoto, K., Baron, R., Collinge, M., Sessa, W. C., and Bender, J. R. (2003) J. Biol. Chem. 278, 2118-2123
42. Venkov, C. D., Rankin, A. B., and Vaughan, D. E. (1996) Circulation 94, 727-733
43. Razandi, M., Alton, G., Pedram, A., Ghonshani, S., Webb, P., and Levin, E. R. (2003) Mol. Cell. Biol. 23, 1633-1646
44. Cowley, S. M., Hoare, S., Mosselman, S., and Parker, M. G. (1997) J. Biol. Chem. 272, 19858-19862
45. Dan, P., Cheung, J. C., Scriven, D. R., and Moore, E. D. (2003) Am. J. Physiol. 284, H1295-H1306
46. Chambliss, K. L., Simon, L., Yuhanna, I. S., Mineo, C., and Shaul, P. W. (2005) Mol. Endocrinol. 19, 277-289
47. Chambliss, K. L., Yuhanna, I. S., Anderson, R. G., Mendelsohn, M. E., and Shaul, P. W. (2002) Mol. Endocrinol. 16, 938-946
48. Figtree, G. A., McDonald, D., Watkins, H., and Channon, K. M. (2003) Circulation 107, 120-126
49. Pappas, T. C., Gametchu, B., and Watson, C. S. (1995) FASEB J. 9, 404-410
50. Evinger, A. J., and Levin, E. R. (2005) Steroids 70, 361-363
51. McCabe, T. J., Fulton, D., Roman, L. J., and Sessa, W. C. (2000) J. Biol. Chem. 275, 6123-6128
52. Fulton, D., Gratton, J. P., McCabe, T. J., Fontana, J., Fujio, J., Walsh, K., Franke, T. K., Papapetropoulos, A., and Sessa, W. C. (1999) Nature 399, 597-601
53. Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., and Zeiher, A. M. (1999) Nature 399, 601-605
54. Ou, J., Fontana, J. T., Ou, Z., Jones, D. W., Ackerman, A. W., Oldham, K. T., Yu, J., Sessa, W. C., and Pritchard, K. A., Jr. (2004) Am. J. Physiol. 286, H561-H569
55. Kuppusamy, U. R., and Das, N. P. (1992) Biochem. Pharmacol. 44, 1307-1315
56. Liu, D., Homan, L. L., and Dillon, J. S. (2004) Endocrinology 145, 5532-5539
57. Nakashima, S., Koike, T., and Nozawa, Y. (1991) Mol. Pharmacol. 39, 475-480
58. Lorenz, M., Wessler, S., Follmann, E., Michaelis, W., Dusterhoft, T., Baumann, G., Stangl, K., and Stangl, V. (2004) J. Biol. Chem. 279, 6190-6195
59. Anter, E., Thomas, S. R., Schulz, E., Shapira, O. M., Vita, J. A., and Keaney, J. F., Jr. (2004) J. Biol. Chem. 279, 46637-46643
60. Klinge, C. M., Blankenship, K. A., Risinger, K. E., Bhatnagar, S., Noisin, E. L., Sumanasekera, W. K., Zhao, L., Brey, D. M., and Keynton, R. S. (2005) J. Biol. Chem. 280, 7460-7468
61. Ndiaye, M., Chataigneau, M., Lobysheva, I., Chataigneau, T., and Schini-Kerth, V. B. (2005) FASEB J. 19, 455-457
62. Quattrone, S., Chiappini, L., Scapagnini, G., Bigazzi, B., and Bani, D. (2004) Mol. Hum. Reprod. 10, 325-330
63. Bachetti, T., Comini, L., Curello, S., Bastianon, D., Palmieri, M., Bresciani, G., Callea, F., and Ferrari, R. (2004) J. Mol. Cell. Cardiol. 37, 939-945
64. Hwang, J., Wang, J., Morazzoni, P., Hodis, H. N., and Sevanian, A. (2003) Free Radic. Biol. Med. 34, 1271-1282
65. Chin-Dusting, J. P., Fisher, L. J., Lewis, T. V., Piekarska, A., Nestel, P. J., and Husband, A. (2001) Br. J. Pharmacol. 133, 595-605
66. Chin-Dusting, J. P., Boak, L., Husband, A., and Nestel, P. J. (2004) Atherosclerosis 176, 45-48
67. Setchell, K. D., Clerici, C., Lephart, E. D., Cole, S. J., Heenan, C., Castellani, D., Wolfe, B. E., Nechemias-Zimmer, L., Brown, N. M., Lund, T. D., Handa, R. J., and Heubi, J. E. (2005) Am. J. Clin. Nutr. 81, 1072-1079
68. Cassidy, A., Brown, J. E., Hawdon, A., Faughnan, M. S., King, L. J., Millward, J., Zimmer-Nechemias, L., Wolfe, B., and Setchell, K. D. (2006) J. Nutr. 136, 45-51