Testosterone deficiency accelerates neuronal and vascular aging of samp8 mice: Protective role of enos and sirt1

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Ota, Hidetaka ^a   Akishita, Masahiro ^a   Akiyoshi, Takuyu ^a   Kahyo, Tomoaki ^b   Setou, Mitsutoshi ^b   Ogawa, Sumito ^a   Iijima, Katsuya ^a   Eto, Masato ^a   Ouchi, Yasuyoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; HUMORAL ANTIBODY; MESSENGER RNA; SIRTUIN 1; TESTOSTERONE; BOLDENONE; DRUG DERIVATIVE; NOS3 PROTEIN, MOUSE; SIRT1 PROTEIN, MOUSE;

ANDROGEN DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCULTURE; COGNITIVE DEFECT; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HIPPOCAMPUS; HYPOGONADISM; MOUSE; MOUSE STRAIN; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; SENESCENCE ACCELERATED MOUSE; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; BLOOD VESSEL; CELL AGING; CELL CULTURE; COGNITION; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; MOUSE MUTANT; NERVE CELL; PATHOLOGY; PHYSIOLOGY; UMBILICAL VEIN ENDOTHELIAL CELL;

MUS;

ANIMALS; BLOOD VESSELS; CELL AGING; CELLS, CULTURED; COGNITION; COGNITION DISORDERS; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MICE; MICE, MUTANT STRAINS; MODELS, BIOLOGICAL; NEURONS; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; SIRTUIN 1; TESTOSTERONE;

EID: 84855409342     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029598     Document Type: Article

References (45)

1. Tanzi RE, Bertram L, (2005) Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 120: 545-55.
2. Evans DA, Funkenstein HH, Albert MS, Scherr PA, Cook NR, et al. (1989) Prevalence of Alzheimer's disease in a community population of older persons higher than previously reported. JAMA 262: 2551-6.
3. Kaufman JM, Vermeulen A, (2005) The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 26: 833-76.
4. Tan RS, Pu SJ, (2003) A pilot study on the effects of testosterone in hypogonadal aging male patients with Alzheimer's disease. Aging Male 6: 13-7.
5. Moffat SD, Zonderman AB, Metter EJ, Blackman MR, Harman SM, et al. (2002) Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. J Clin Endocrinol Metab 87: 5001-7.
6. Small SA, Duff K, (2008) Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron 60: 534-42.
7. Pimplikar SW, (2009) Reassessing the amyloid cascade hypothesis of Alzheimer's disease. Int J Biochem Cell Biol 41: 1261-8.
8. Guarente L, (2000) Sir2 links chromatin silencing, metabolism, and aging. Genes Dev 14: 1021-6.
9. Sinclair D, Mills K, Guarente L, (1998) Aging in Saccharomyces cerevisiae. Annu Rev Microbiol 52: 533-60.
10. Donmez G, Wang D, Cohen DE, Guarente L, (2010) SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 142: 320-32.
11. Hofman A, Ott A, Breteler MM, Bots ML, Slooter AJ, et al. (1997) Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet 349: 151-4.
12. Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, et al. (2007) SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev 21: 2644-58.
13. Ota H, Akishita M, Eto M, Iijima K, Kaneki M, et al. (2007) Sirt1 modulates premature senescence-like phenotype in human endothelial cells. J Mol Cell Cardiol 43: 571-9.
14. Menghini R, Casagrande V, Cardellini M, Martelli E, Terrinoni A, et al. (2009) MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation 120: 1524-32.
15. DeFries JC, Wilson JR, McClearn GE, (1970) Open-field behavior in mice: selection response and situational generality. Behav Genet 1: 195-211.
16. Tang BL, (2011) Sirt1's systemic protective roles and its promise as a target in antiagingmedicine. Transl Res 157: 276-84.
17. Mattson MP, (2004) Pathways towards and away from Alzheimer's disease. Nature 430: 631-9.
18. Yu J, Akishita M, Eto M, Ogawa S, Son BK, et al. (2010) Androgen receptor-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells: role of phosphatidylinositol 3-kinase/akt pathway. Endocrinology 151: 1822-8.
19. Goglia L, Tosi V, Sanchez AM, Flamini MI, Fu XD, et al. (2010) Endothelial regulation of eNOS, PAI-1 and t-PA by testosterone and dihydrotestosterone in vitro and in vivo. Mol Hum Reprod 16: 761-9.
20. Ota H, Eto M, Ogawa S, Iijima K, Akishita M, et al. (2010) SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis. J Atheroscler Thromb 17: 431-5.
21. Ota H, Eto M, Kano MR, Ogawa S, Iijima K, et al. (2008) Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells. Arterioscler Thromb Vasc Biol 28: 1634-9.
22. Coppé JP, Desprez PY, Krtolica A, Campisi J, (2010) The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 5: 99-118.
23. Holland J, Bandelow S, Hogervorst E, (2011) Testosterone levels and cognition in elderly men: A review. Maturitas 69: 322-37.
24. Simerly RB, Chang C, Muramatsu M, Swanson LW, (1990) Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J Comp Neurol 294: 76-95.
25. Del Valle J, Duran-Vilaregut J, Manich G, Casadesús G, Smith MA, et al. (2010) Early amyloid accumulation in the hippocampus of SAMP8 mice. J Alzheimers Dis 19: 1303-15.
26. Canudas AM, Gutierrez-Cuesta J, Rodríguez MI, Acuña-Castroviejo D, Sureda FX, et al. (2005) Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM). Mech Ageing Dev 126: 1300-4.
27. Tomobe K, Nomura Y, (2009) Neurochemistry, neuropathology, and heredity in SAMP8: a mouse model of senescence. Neurochem Res 34: 660-9.
28. Flood JF, Farr SA, Kaiser FE, La Regina M, Morley JE, (1995) Age-related decrease of plasma testosterone in SAMP8 mice: replacement improves age-related impairment of learning and memory. Physiol Behav 57: 669-73.
29. Białek M, Zaremba P, Borowicz KK, Czuczwar SJ, (2004) Neuroprotective role of testosterone in the nervous system. Pol J Pharmacol 56: 509-18.
30. Ramsden M, Shin TM, Pike CJ, (2003) Androgens modulate neuronal vulnerability to kainate lesion. Neuroscience 122: 573-8.
31. Gao J, Wang WY, Mao YW, Gräff J, Guan JS, et al. (2010) A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature 466: 1105-9.
32. Michán S, Li Y, Chou MM, Parrella E, Ge H, et al. (2010) SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci 30: 9695-707.
33. Casserly I, Topol E, (2004) Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins. Lancet 363: 1139-46.
34. Mahley RW, Weisgraber KH, Huang Y, (2006) Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc Natl Acad Sci U S A 103: 5644-51.
35. Maciag T, Hoover GA, Stemerman MB, Weinstein R, (1981) Serial propagation of human endothelial cells in vitro. J Cell Biol 91: 420-6.
36. Akishita M, Shirakami G, Iwai M, Wu L, Aoki M, et al. (2001) Angiotensin converting enzyme inhibitor restrains inflammation-induced vascular injury in mice. J Hypertens 19: 1083-8.
37. Jessup JA, Zhang L, Chen AF, Presley TD, Kim-Shapiro DB, et al. (2011) Neuronal nitric oxide synthase inhibition improves diastolic function and reduces oxidative stress in ovariectomized mRen2.Lewis rats. Menopause 18: 698-708.
38. Honaramooz A, Snedaker A, Boiani M, Schöler H, Dobrinski I, et al. (2002) Sperm from neonatal mammalian testes grafted in mice. Nature 418: 778-81.
39. Matsushita N, Takami Y, Kimura M, Tachiiri S, Ishiai M, et al. (2005) Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells. Genes Cells 10: 321-32.
40. Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, et al. (2001) hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159.
41. Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, et al. (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429: 771-6.
42. Dimri GP, Lee X, Basile G, Acosta M, Scott G, et al. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 92: 9363-7.
43. Cao D, Lu H, Lewis TL, Li L, (2007) Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease. J Biol Chem 282: 36275-82.
44. Lukacs H, Hiatt ES, Lei ZM, Rao CV, (1995) Peripheral and intracerebroventricular administration of human chorionic gonadotropin alters several hippocampus-associated behaviors in cycling female rats. Horm Behav 29: 42-58.
45. Zhang W, Koerner IP, Noppens R, Grafe M, Tsai HJ, et al. (2007) Soluble epoxide hydrolase: a novel therapeutic target in stroke. J Cereb Blood Flow Metab 27: 1931-1940.