17β-Estradiol regulates the expression of antioxidant enzymes in myocardial cells by increasing Nrf2 translocation

Journal of Biochemical and Molecular Toxicology

Volumn 26, Issue 7, 2012, Pages 264-269

  Yu, Jiajia ^a   Zhao, Yueliu ^a   Li, Bingjin ^a   Sun, Lili ^a   Huo, Hongliang ^a  

^a NORTHEAST NORMAL UNIVERSITY   (China)

Author keywords

17 Estradiol; Antioxidant; Hypoxia; Nrf2; Reoxygenation

Indexed keywords

ESTRADIOL; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; MESSENGER RNA; OXIDOREDUCTASE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; CELL HYPOXIA; CONTROLLED STUDY; CYTOSOL; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; RAT; REOXYGENATION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

EID: 84864008286     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.21417     Document Type: Article

References (20)

1. Nilsson S, Makela S, Treuter E, Tujague M, Thomsen J, Andersson G, Enmark E, Pettersson K, Warner M, Gustafsson JA. Mechanisms of estrogen action. Physiol Rev. 2001;81(4):1535-1565.
2. Bjornstrom L, Sjobger M. Signal transducers and activators of transcription as down-stream targets of nongenomic estrogen receptor actions. Mol Endocrinol. 2002;16(10):2202-2214.
3. Kolodgie FD, Farb A, Litovsky SH, Narula J, Jeffers LA, Lee SJ, Virmani R. Myocardial protection of contractile function after global ischemia by physiologic estrogen replacement in the ovariectomized rat. J Mol Cell Cardiol. 1997;29(9):2403-2414.
4. Glinka YY, Youdim MB. Inhibition of mitochondrial complexes I and IV by 6-hydroxyl-dopamine. Eur J Pharmacol. 1995;292(3-4):329-332.
5. Wasserman WW, Fahl WE. Functional antioxidant responsive elements. Proc Natl Acad Sci U S A. 1997;94(10):5361-5366.
6. Nguyen T, Sherratt PJ, Pickett CB. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol. 2003;43:233-260.
7. Chan K, Kan YW. Nrf2 is essential for protection against acute pulmonary injury in mice. Proc Natl Acad Sci U S A. 1999;96(22):12731-12736.
8. Chan K, Han XD, Kan YW. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci U S A. 2001;98(8):4611-4616.
9. Ramos-Gomez M, Kwak MK, Dolan PM, Ken Itoh, Masayuki Yamamoto, Paul Talalay, Thomas W Kensler. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A 2001;98(6):3410-3415.
10. Baranano DE, Rao M, Ferris CD, Snyder SH. Biliverdin reductase: a major physiologic cytoprotectant. Proc Natl Acad Sci U S A. 2002;99(25):16093-16098.
11. Ferris CD, Jaffrey SR, Sawa A, Takahashi M, Brady SD, Barrow RK, Tysoe SA, Wolosker H, Barañano DE, Doré S, Poss KD, Snyder SH. Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol. 1999;1(3):152-157.
12. Didion SP, Ryan MJ, Didion LA, Fegan PE, Sigmund CD, Faraci FM. Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circ Res. 2002;91(10):938-944.
13. Singer CA, Figueroa-Masot XA, Batchelor RH, Dorsa DM. The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. J Neurosci. 1999;19(7):2455-2463.
14. Montano MM, Wittmann BM, Bianco NR. Identification and characterization of a novel factor that regulates quinone reductase gene transcriptional activity. J Biol Chem. 2000;275(44):34306-34313.
15. Moosmann B, Behl C. The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties. Proc Natl Acad Sci U S A. 1999;96(16):8867-8872.
16. Lee JM, Anderson PC, Padgitt JK, Hanson JM, Waters CM, Johnson JA. Nrf2, not the estrogen receptor, mediates catechol estrogen-induced activation of the antioxidant responsive element. Biochem Biophys Acta. 2003;1629(1-3):92-101.
17. 2+-independent activation of endothelial nitric-oxide synthase/Hsp90 involving ERK1/2 and Akt phosphorylation in human endothelial cells. J Biol Chem. 2006;281(37):27335-27345.
18. Stumpf WE, Sar M, Aumueller G. The heart: a target organ for estradiol. Science. 1977;196(4287):319-321.
19. Krieg M, Smith K, Bartsch W. Demonstration of a specific androgen receptor in rat heart muscle: relationship between binding, metabolism, and tissue levels of androgens. Endocrinology. 1978;103(5):1686-1694.
20. McGill HC Jr, Anselmo VC, Buchanan JM, Sheridan PJ. The heart is a target organ for androgen. Science. 1980;207(4432):775-777.