Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of rho and ROCK

Gastroenterology

Volumn 147, Issue 1, 2014, Pages

  Voorneveld, Philip W ^a   Kodach, Liudmila L ^a   Jacobs, Rutger J ^a   Liv, Nalan ^b   Christiaan Zonnevylle, A ^b   Hoogenboom, Jacob P ^b   Biemond, Izak ^a   Verspaget, Hein W ^a   Hommes, Daniel W ^a,c   De Rooij, Karien ^a,d   Van Noesel, Carel J M ^e   Morreau, Hans ^a   Van Wezel, Tom ^a   Offerhaus, G Johan A ^f   Van Den Brink, Gijs R ^e   Peppelenbosch, Maikel P ^g   Ten Dijke, Peter ^a   Hardwick, James C H ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^c UCLA MEDICAL CENTER   (United States)

^d PERCUROS B V   (Netherlands)

^e ACADEMIC MEDICAL CENTER   (Netherlands)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^g ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Colon Cancer; Signal Transduction; Transcription; Tumor Progression

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; BONE MORPHOGENETIC PROTEIN RECEPTOR 1B; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; LENTIVIRUS VECTOR; LIM KINASE; MESSENGER RNA; RHO FACTOR; RHO KINASE; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER PROGNOSIS; CELL INVASION; CELL MIGRATION; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; HCT116 CELL LINE; HT 29 CELL LINE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SURVIVAL TIME; TUMOR XENOGRAFT;

COLON CANCER; SIGNAL TRANSDUCTION; TRANSCRIPTION; TUMOR PROGRESSION;

AGED; AMIDES; ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HETEROGRAFTS; HUMANS; MALE; MICE; MICE, NUDE; MIDDLE AGED; NEOPLASM METASTASIS; PYRIDINES; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; SURVIVAL RATE;

EID: 84902990761     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.03.052     Document Type: Article

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