Evaluation of the prognostic value of pSMAD immunohistochemistry in colorectal cancer

European Journal of Cancer Prevention

Volumn 22, Issue 5, 2013, Pages 420-424

  Voorneveld, Philip W ^a   Jacobs, Rutger J ^a   De Miranda, Noel F C C ^a   Morreau, Hans ^a   Van Noesel, Carel J M ^b   Offerhaus, G Johan A ^c   Kodach, Liudmila L ^a   Hardwick, James C H ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c Utrecht Medical Center   (Netherlands)

Author keywords

BMP signalling; Colorectal cancer; Prognosis; pSMAD1,5,8,pSMAD2,3; SMAD4; TGF signalling

Indexed keywords

BONE MORPHOGENETIC PROTEIN; SMAD PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CANCER; COLORECTAL LIVER METASTASIS; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TISSUE MICROARRAY;

ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PHOSPHORYLATION; PREDICTIVE VALUE OF TESTS; PROTEIN KINASES; SMAD PROTEINS; TISSUE ARRAY ANALYSIS;

EID: 84882247176     PISSN: 09598278     EISSN: 14735709     Source Type: Journal    
DOI: 10.1097/CEJ.0b013e32835e88e2     Document Type: Article

References (20)

1. Alazzouzi H, Alhopuro P, Salovaara R, Sammalkorpi H, Jarvinen H, Mecklin JP, et al. (2005). SMAD4 as a prognostic marker in colorectal cancer. Clin Cancer Res 11:2606-2611
2. Howe JR, Bair JL, Sayed MG, Anderson ME, Mitros FA, Petersen GM, et al. (2001). Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet 28:184-187
3. Isaksson-Mettavainio M, Palmqvist R, Forssell J, Stenling R, Oberg A (2006). SMAD4/DPC4 expression and prognosis in human colorectal cancer. Anticancer Res 26:507-510
4. Itoh S, Itoh F, Goumans MJ, Ten DP (2000). Signaling of transforming growth factor-beta family members through Smad proteins. Eur J Biochem 267:6954-6967
5. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D, et al. (2011). Global cancer statistics. CA Cancer J Clin 61:69-90
6. Kodach LL, Bleuming SA, Musler AR, Peppelenbosch MP, Hommes DW, van den Brink GR, et al. (2008a). The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer. Cancer 112:300-306
7. Kodach LL, Wiercinska E, de Miranda NF, Bleuming SA, Musler AR, Peppelenbosch MP, et al. (2008b). The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers. Gastroenterology 134:1332-1341
8. Kouvidou C, Latoufis C, Lianou E, Kouvatseas G, Kakouri E, Anagnostakis D, et al. (2006). Expression of Smad4 and TGF-beta2 in colorectal carcinoma. Anticancer Res 26:2901-2907
9. Lampropoulos P, Zizi-Sermpetzoglou A, Rizos S, Kostakis A, Nikiteas N, Papavassiliou AG, et al. (2012a). Prognostic significance of transforming growth factor beta (TGF-beta) signaling axis molecules and E-cadherin in colorectal cancer. Tumour Biol 2012:1005-1014
10. Lampropoulos P, Zizi-Sermpetzoglou A, Rizos S, Kostakis A, Nikiteas N, Papavassiliou AG, et al. (2012b). TGF-beta signalling in colon carcinogenesis. Cancer Lett 314:1-7
11. Liu F, Pouponnot C, Massague J (1997). Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev 11:3157-3167
12. Markowitz S,Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, et al. (1995). Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268:1336-1338
13. Pinhel IF, Macneill FA, Hills MJ, Salter J, Detre S, A'hern R, et al. (2010). Extreme loss of immunoreactive p-Akt and p-Erk1/2 during routine fixation of primary breast cancer. Breast Cancer Res 12:R76
14. Pritchard CC, Grady WM (2011). Colorectal cancer molecular biology moves into clinical practice. Gut 60:116-129
15. Ten DP, Goumans MJ, Itoh F, Itoh S (2002). Regulation of cell proliferation by Smad proteins. J Cell Physiol 191:1-16
16. Thiagalingam S, Lengauer C, Leach FS, Schutte M, Hahn SA, Overhauser J, et al. (1996). Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet 13:343-346
17. Tomlinson IP, Carvajal-Carmona LG, Dobbins SE, Tenesa A, Jones AM, Howarth K, et al. (2011). Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer. PLoS Genet 7:e1002105
18. Walther A, Johnstone E, Swanton C, Midgley R, Tomlinson I, Kerr D, et al. (2009). Genetic prognostic and predictive markers in colorectal cancer. Nat Rev Cancer 9:489-499
19. Xie W, Rimm DL, Lin Y, Shih WJ, Reiss M (2003). Loss of Smad signaling in human colorectal cancer is associated with advanced disease and poor prognosis. Cancer J 9:302-312
20. Zlobec I, Lugli A (2008). Prognostic and predictive factors in colorectal cancer. J Clin Pathol 61:561-569