Quantification of biliary excretion and sinusoidal excretion of 5(6)-carboxy-2',7'-dichlorofluorescein (CDF) in cultured hepatocytes isolated from Sprague Dawley, Wistar and Mrp2-deficient Wistar (TR-) rats

Toxicology in Vitro

Volumn 28, Issue 6, 2014, Pages 1165-1175

  Ellis, L C J ^a   Grant, M H ^b   Hawksworth, G M ^a   Weaver, R J ^c  

^a Section of Translational Medicine   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

Canalicular efflux; Drug transporters; Membranes and vesicles expressing rat Mrp2; Primary rat hepatocytes; Sinusoidal efflux

Indexed keywords

5(6) CARBOXY 2',7' DICHLOROFLUORESCEIN; DICHLOROFLUORESCEIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 6; MULTIDRUG RESISTANCE PROTEIN 5; UNCLASSIFIED DRUG; 5(6)-CARBOXY-2',7'-DICHLOROFLUORESCEIN; ABC TRANSPORTER; FLUORESCEIN DERIVATIVE;

ABCC1 GENE; ABCC2 GENE; ABCC3 GENE; ABCC4 GENE; ABCC5 GENE; ABCC6 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HYDROLYSIS KINETICS; IN VITRO STUDY; LIVER CELL CULTURE; LIVER CELL MEMBRANE; MALE; NONHUMAN; RAT; TRANSPORT KINETICS; UPREGULATION; URINARY EXCRETION; ANIMAL; CELL CULTURE; GENETICS; KNOCKOUT MOUSE; LIVER; LIVER CELL; METABOLISM; SPRAGUE DAWLEY RAT; WISTAR RAT;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELLS, CULTURED; FLUORESCEINS; HEPATOCYTES; LIVER; MALE; MICE, KNOCKOUT; RATS, SPRAGUE-DAWLEY; RATS, WISTAR;

EID: 84902958090     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.05.010     Document Type: Article

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