Hypermethylation of DDAH2 promoter contributes to the dysfunction of endothelial progenitor cells in coronary artery disease patients

Journal of Translational Medicine

Volumn 12, Issue 1, 2014, Pages

  Niu, Pan Pan ^a   Cao, Yu ^a   Gong, Ting ^a   Guo, Jin Hui ^b   Zhang, Bi Kui ^a   Jia, Su Jie ^a  

^a THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

^b XINXIANG MEDICAL UNIVERSITY   (China)

Author keywords

Atherosclerosis; Dimethylarginine dimethylaminohydrolase; DNA methylation; Endothelial progenitor cells; Homocysteine

Indexed keywords

AZACITIDINE; DIMETHYLARGININASE; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 2; HOMOCYSTEINE; MESSENGER RNA; UNCLASSIFIED DRUG; AMIDASE; PRIMER DNA;

ADULT; AGED; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DNA METHYLATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL PROGENITOR CELL; FEMALE; GENE EXPRESSION; GENE SEQUENCE; GENOME; HUMAN; HUMAN CELL; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; CASE CONTROL STUDY; CELL CULTURE; GENETICS; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOLOGY;

AGED; AMIDOHYDROLASES; BASE SEQUENCE; CASE-CONTROL STUDIES; CELL ADHESION; CELLS, CULTURED; CORONARY ARTERY DISEASE; DNA METHYLATION; DNA PRIMERS; ENDOTHELIAL PROGENITOR CELLS; FEMALE; HUMANS; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84902955674     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-12-170     Document Type: Article

References (31)

1. Wassmann S, Werner N, Czech T, Nickenig G. Improvement of endothelial function by systemic transfusion of vascular progenitor cells. Circ Res 2006, 99:e74-e83.
2. Bozdag-Turan I, Turan RG, Paranskaya L, Arsoy NS, Turan CH, Akin I, Kische S, Ortak J, Schneider H, Ludovicy S, Hermann T, D'Ancona G, Durdu S, Akar AR, Ince H, Nienaber CA. Correlation between the functional impairment of bone marrow-derived circulating progenitor cells and the extend of coronary artery disease. J Transl Med 2012, 10:143.
3. Kurtzman N, Zhang L, French B, Jonas R, Bantly A, Rogers WT, Moore JS, Rickels MR, Mohler ER. Personalized cytomic assessment of vascular health: Evaluation of the vascular health profile in diabetes mellitus. Cytometry B Clin Cytom 2013, 84:255-266.
4. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003, 348:593-600.
5. Moon JH, Chae MK, Kim KJ, Cha BS, Lee HC, Kim YJ, Lee BW. Decreased endothelial progenitor cells and increased serum glycated albumin are independently correlated with plaque-forming carotid artery atherosclerosis in type 2 diabetes patients without documented ischemic disease. Circ J 2012, 76:2273-2279.
6. Bakogiannis C, Tousoulis D, Androulakis E, Briasoulis A, Papageorgiou N, Vogiatzi G, Kampoli AM, Charakida M, Siasos G, Latsios G, Antoniades C, Stefanadis C. Circulating endothelial progenitor cells as biomarkers for prediction of cardiovascular outcomes. Curr Med Chem 2012, 19:2597-2604.
7. Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999, 99:3092-3095.
8. Fiedler LR, Bachetti T, Leiper J, Zachary I, Chen L, Renné T, Wojciak-Stothard B. The ADMA/DDAH pathway regulates VEGF-mediated angiogenesis. Arterioscler Thromb Vasc Biol 2009, 29:2117-2124.
9. Singh JP. Dimethylarginine dimethylaminohydrolase: a new therapeutic target for the modulation of nitric oxide and angiogenesis. Curr Opin Investig Drugs 2007, 8:736-741.
10. Antoniades C, Antonopoulos AS, Tousoulis D, Marinou K, Stefanadis C. Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J 2009, 30:6-15.
11. Zhu JH, Chen JZ, Wang XX, Xie XD, Sun J, Zhang FR. Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells. J Mol Cell Cardiol 2006, 40:648-652.
12. Jia SJ, Lai YQ, Zhao M, Gong T, Zhang BK. Homocysteine-induced hypermethylation of DDAH2 promoter contributes to apoptosis of endothelial cells. Pharmazie 2013, 68:282-286.
13. Zhang BK, Lai YQ, Niu PP, Zhao M, Jia SJ. Epigallocatechin-3-gallate inhibits homocysteine-induced apoptosis of endothelial cells by demethylation of the DDAH2 gene. Planta Med 2013, 79:1715-1719.
14. Walter DH, Rittig K, Bahlmann FH, Kirchmair R, Silver M, Murayama T, Nishimura H, Losordo DW, Asahara T, Isner JM. Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation 2002, 105:3017-3024.
15. Chen JZ, Zhu JH, Wang XX, Zhu JH, Xie XD, Sun J, Shang YP, Guo XG, Dai HM, Hu SJ. Effects of homocysteine on number and activity of endothelial progenitor cells from peripheral blood. J Mol Cell Cardiol 2004, 36:233-239.
16. Qi Y, Qian L, Sun B, Liu L, Wu P, Sun L. Inhaled NO contributes to lung repair in piglets with acute respiratory distress syndrome via increasing circulating endothelial progenitor cells. PLoS One 2012, 7:e33859.
17. Yao L, Heuser-Baker J, Herlea-Pana O, Iida R, Wang Q, Zou MH, Barlic-Dicen J. Bone marrow endothelial progenitors augment atherosclerotic plaque regression in a mouse model of plasma lipid lowering. Stem Cells 2012, 30:2720-2731.
18. Ludwig A, Jochmann N, Kertesz A, Kuhn C, Mueller S, Gericke C, Baumann G, Stangl K, Stangl V. Smoking decreases the level of circulating CD34+ progenitor cells in young healthy women-a pilot study. BMC Womens Health 2010, 10:20.
19. Haberzettl P, Lee J, Duggineni D, McCracken J, Bolanowski D, O'Toole TE, Bhatnagar A, Conklin DJ. Exposure to ambient air fine particulate matter prevents VEGF-induced mobilization of endothelial progenitor cells from the bone marrow. Environ Health Perspect 2012, 120:848-856.
20. Chen JZ, Zhang FR, Tao QM, Wang XX, Zhu JH, Zhu JH. Number and activity of endothelial progenitor cells from peripheral blood in patients with hypercholesterolaemia. Clin Sci (Lond) 2004, 107:273-280.
21. Kuliszewski MA, Ward MR, Kowalewski JW, Smith AH, Stewart DJ, Kutryk MJ, Leong-Poi H. A direct comparison of endothelial progenitor cell dysfunction in rat metabolic syndrome and diabetes. Atherosclerosis 2013, 226:58-66.
22. Tran CT, Fox MF, Vallance P, Leiper JM. Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins. Genomics 2000, 68:101-105.
23. Seo HA, Kim SW, Jeon EJ, Jeong JY, Moon SS, Lee WK, Kim JG, Lee IK, Park KG. Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension. Diabetes Res Clin Pract 2012, 98:125-131.
24. Xu AG, Xu RM, Lu CQ, Li DD, Xu QF, Guo J, Fu X, Zhao W, Yao MY. Association study of dimethylarginine dimethylaminohydrolase 2 gene polymorphisms and coronary heart disease. Mol Med Rep 2012, 6:1103-1106.
25. Lund G, Andersson L, Lauria M, Lindholm M, Fraga MF, Villar-Garea A, Ballestar E, Esteller M, Zaina S. DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E. J Biol Chem 2004, 279:29147-29154.
26. Yoo JH, Park JE, Hong KP, Lee SH, Kim DK, Lee WR, Park SC. Moderate hyperhomocyst (e) inemia is associated with the presence of coronary artery disease and the severity of coronary atherosclerosis in Koreans. Thromb Res 1999, 94:45-52.
27. Mangoni AA, Zinellu A, Carru C, Attia JR, McEvoy M. Serum thiols and cardiovascular risk scores: a combined assessment of transsulfuration pathway components and substrate/product ratios. J Transl Med 2013, 11:99. doi:10.1186/1479-5876-11-99.
28. Huang C, Zhang L, Wang Z, Pan H, Zhu J. Endothelial progenitor cells are associated with plasma homocysteine in coronary artery disease. Acta Cardiol 2011, 66:773-777.
29. Bao XM, Wu CF, Lu GP. Atorvastatin inhibits homocysteine-induced dysfunction and apoptosis in endothelial progenitor cells. Acta Pharmacol Sin 2010, 31:476-484.
30. Scott JM. Homocysteine and cardiovascular risk. Am J Clin Nutr 2000, 72:333-334.
31. Woo KS, Chook P, Lolin YI, Cheung AS, Chan LT, Sun YY, Sanderson JE, Metreweli C, Celermajer DS. Hyperhomocyst (e) inemia is a risk factor for arterial endothelial dysfunction in humans. Circulation 1997, 96:2542-2544.