Smoking decreases the level of circulating CD34+ progenitor cells in young healthy women - a pilot study

BMC Women's Health

Volumn 10, Issue , 2010, Pages

  Ludwig, Antje ^a   Jochmann, Nicoline ^a   Kertesz, Andras ^a   Kuhn, Claudia ^a   Mueller, Simone ^a   Gericke, Christine ^a   Baumann, Gert ^a   Stangl, Karl ^a   Stangl, Verena ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CARDIOVASCULAR RISK; CD133+ T LYMPHOCYTE; CD34+ T LYMPHOCYTE; COLONY FORMING UNIT; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOTHELIUM CELL; FEMALE; FLOW CYTOMETRY; FOLLICULAR PHASE; HUMAN; HUMAN CELL; LUTEAL PHASE; LYMPHOCYTE COUNT; LYMPHOCYTE CULTURE; LYMPHOID PROGENITOR CELL; NORMAL HUMAN; PILOT STUDY; PREMENOPAUSE; SMOKING; T LYMPHOCYTE; VASODILATATION; BLOOD; CYTOLOGY; METABOLISM; MONOCYTE; STEM CELL;

CD34 ANTIGEN;

ADULT; ANTIGENS, CD34; ENDOTHELIAL CELLS; FEMALE; FLOW CYTOMETRY; HUMANS; MONOCYTES; PILOT PROJECTS; SMOKING; STEM CELLS;

EID: 77952679727     PISSN: None     EISSN: 14726874     Source Type: Journal    
DOI: 10.1186/1472-6874-10-20     Document Type: Article

References (34)

1. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997, 275:964-967. 10.1126/science.275.5302.964, 9020076.
2. Hill JM, Finkel T, Quyyumi AA. Endothelial progenitor cells and endothelial dysfunction. Vox Sang 2004, 2:31-37.
3. Huang PH, Chen YH, Chen YL, Wu TC, Chen JW, Lin SJ. Vascular endothelial function and circulating progenitor cells in patients with cardiac syndrome X. Heart 2007, 93:1064-1070. 10.1136/hrt.2006.107763, 17488770.
4. Fadini GP, de Kreutzenberg SV, Coracina A, Baesso I, Agostini C, Tiengo A, Avogaro A. Circulating CD34 + cells, metabolic syndrome, and cardiovascular risk. Eur Heart J 2006, 27:2247-2255. 10.1093/eurheartj/ehl198, 16912055.
5. Müller-Ehmsen J, Braun D, Schneider T, Pfister R, Worm N, Wielckens K, Scheid C, Frommolt P, Flesch M. Decreased number of circulating progenitor cells in obesity: beneficial effects of weight reduction. Eur Heart J 2008, 29:1560-1568. 10.1093/eurheartj/ehn213, 18515295.
6. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003, 348:593-600. 10.1056/NEJMoa022287, 12584367.
7. Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H, Zeiher AM, Dimmeler S. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 2001, 89:E1-7. 10.1161/hh1301.093953, 11440984.
8. Wenger NK. Coronary heart disease: an older woman's major health risk. BMJ 1997, 315:1085-1090. 2127693, 9366743.
9. Mendelssohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med 1999, 340:1801-1811. 10.1056/NEJM199906103402306, 10362825.
10. Cignarella A, Paoletti R, Puglisi L. Direct effects of estrogen on the vessel wall. Med Res Rev 2001, 21:171-184. 10.1002/1098-1128(200103)21:2<171::AID-MED1005>3.0.CO;2-4, 11223864.
11. Strehlow K, Werner N, Berweiler J, Link A, Dirnagl U, Priller J, Laufs K, Ghaeni L, Milosevic M, Böhm M, Nickening G. Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation. Circulation 2003, 107:3059-3065. 10.1161/01.CIR.0000077911.81151.30, 12810616.
12. Iwakura A, Luedemann C, Shastry S, Hanley A, Kearney M, Aikawa R, Isner JM, Asahara T, Losordo DW. Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury. Circulation 2003, 108:3115-3121. 10.1161/01.CIR.0000106906.56972.83, 14676142.
13. Masuda H, Kalka C, Takahashi T, Yoshida M, Wada M, Kobori M, Itoh R, Iwaguro H, Eguchi M, Iwami Y, Tanaka R, Nakagawa Y, Sugimoto A, Ninomiva S, Hayashi S, Kato S, Asahara T. Estrogen-mediated endothelial progenitor cell biology and kinetics for physiological postnatal vasculogenesis. Circ Res 2007, 101:598-606. 10.1161/CIRCRESAHA.106.144006, 17656679.
14. Fadini GP, de Kreutzenberg S, Albiero M, Coracina A, Pagnin E, Baesso I, Cignarella A, Bolego C, Plebani M, Nardelli GB, Sartore S, Agostini C, Avogaro A. Gender differences in endothelial progenitor cells and cardiovascular risk profile: the role of female estrogens. Arterioscler Thromb Vasc Biol 2008, 28:997-1004. 10.1161/ATVBAHA.107.159558, 18276910.
15. Lemieux C, Cloutier I, Tanguay JF. Menstrual cycle influences endothelial progenitor cell regulation: A link to gender differences in vascular protection?. Int J Cardiol 2009, 136:200-210. 10.1016/j.ijcard.2008.04.054, 18644636.
16. Khot UN, Khot MB, Bajzer CT, Sapp SK, Ohman EM, Brener SJ, Ellis SG, Lincoff AM, Topol EJ. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA 2003, 290:898-904. 10.1001/jama.290.7.898, 12928466.
17. Mayhan WG, Scarpe GM. Effect of cigarette smoke extract on arteriolar dilatation in vivo. J Appl Physiol 1996, 81:1996-2003.
18. Neunteufl T, Heher S, Kostner K, Mitulovic G, Lehr S, Khoschsorur G, Schmid RW, Maurer G, Stefenelli T. Contribution of nicotine to acute endothelial dysfunction in long-term smokers. J Am Coll Cardiol 2002, 39:251-256. 10.1016/S0735-1097(01)01732-6, 11788216.
19. Yanbaeva DG, Dentener MA, Creutzberg EC, Wesseling G, Wouters EFM. Systemic effects of smoking. Chest 2007, 131:1557-1566. 10.1378/chest.06-2179, 17494805.
20. Kondo T, Hayashi M, Takeshita K, Numaguchi Y, Kobayashi K, Iino S, Inden Y, Murohara T. Smoking cessation rapidely increases circulating progenitor cells in peripheral blood in chronic smokers. Arterioscler Thromb Vasc Biol 2004, 24:1442-1447. 10.1161/01.ATV.0000135655.52088.c5, 15191940.
21. Lorenz M, Jochmann N, von Krosigk A, Martus P, Baumann G, Stangl K, Stangl V. Addition of milk prevents vascular protective effects of tea. Eur Heart J 2007, 2:219-223.
22. Corretti MC, Anderson TJ, Benjamin EJ. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002, 39:257-265. 10.1016/S0735-1097(01)01746-6, 11788217.
23. Pyke KE, Tschakovsky ME. The relationship between shear stress and flow-mediated dilation: implications for the assessment of endothelial function. J Physiol 2005, 568:357-369. 10.1113/jphysiol.2005.089755, 1474741, 16051630.
24. Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 2004, 10:145-147. 10.1038/nm988, 2693485, 14745444.
25. Boilson BA, Kiernan TJ, Harbuzariu A, Nelson RE, Lerman A, Simari RD. Circulating CD34 + cell subsets in patients with coronary endothelial dysfunction. Nat Clin Pract Cardiovasc Med 2008, 8:489-496.
26. Heeschen C, Aicher A, Lehmann R, Fichtlscherer S, Vasa M, Urbich C, Mildner-Rihm C, Martin H, Zeiher AM, Dimmeler S. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003, 108:2511-2516.
27. Umemura T, Higashi Y. Endothelial progenitor cells: therapeutic target for cardiovascular diseases. J Pharmacol Sci 2000, 108:1-6.
28. Aicher A, Zeiher AM, Dimmeler S. Mobilizing endothelial progenitor cells. Hypertension 2005, 45:321-325. 10.1161/01.HYP.0000154789.28695.ea, 15655116.
29. Imanishi T, Hano T, Nishio I. Estrogen reduces endothelial progenitor cell senescene through augmentation of telomerase acitvity. J Hypertens 2005, 23:1699-1706. 10.1097/01.hjh.0000176788.12376.20, 16093915.
30. Celermajer DS, Sorensen KE, Georgakopoulos D, Bull C, Thomas O, Robinson J, Deanfield JE. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelial-dependent dilation in healthy young adults. Circulation 1993, 88:2149-2155.
31. Jochmann N, Mueller S, Kuhn C, Gericke C, Baumann G, Stangl K, Stangl V. Chronic smoking prevents amelioration of endothelial function in the course of the menstrual cycle. Circ J 2009, 73:568-572. 10.1253/circj.CJ-08-0628, 19202305.
32. Raij L, DeMaster EG, Jaimes EA. Cigarette smoke-induced endothelium dysfunction: role of superoxide anion. J Hypertens 2001, 19:891-897. 10.1097/00004872-200105000-00009, 11393672.
33. Tsuchiya M, Asada A, Kasahara E, Sato EF, Shindo M, Inoue M. Smoking a single cigarette rapidly reduces combined concentrations of nitrate and nitrite and concentrations of antioxidants in plasma, Circulation. 2002, 105:1155-1157.
34. Michaud SE, Dussault S, Haddad P, Groleau J, Rivard A. Circulating endothelial progenitor cells from healthy smokers exhibit impaired functional activities. Atherosclerosis 2006, 187:423-432. 10.1016/j.atherosclerosis.2005.10.009, 16288934.