Homocysteine-induced hypermethylation of DDAH2 promoter contributes to apoptosis of endothelial cells

Pharmazie

Volumn 68, Issue 4, 2013, Pages 282-286

  Jia, Su Jie ^a   Lai, Yong Quan ^a   Zhao, Ming ^b   Gong, Ting ^a   Zhang, Bi Kui ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; DIMETHYLARGININASE; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 2; DNA METHYLTRANSFERASE 1; HOMOCYSTEINE; MESSENGER RNA; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PROMOTER REGION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

AMIDOHYDROLASES; ANNEXIN A5; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; AZACITIDINE; CELL SURVIVAL; COLORING AGENTS; ENDOTHELIAL CELLS; HOMOCYSTEINE; METHYLATION; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; TETRAZOLIUM SALTS; THIAZOLES;

EID: 84876222176     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2013.2755     Document Type: Article

References (26)

1. Bao XM, Wu CF, Lu GP (2009) Atorvastatin attenuates homocysteineinduced apoptosis in human umbilical vein endothelial cells via inhibiting NADPH oxidase-related oxidative stress-triggered p38MAPK signaling. Acta Pharmacol Sin 30: 1392-1398.
2. Bao XM,Wu CF, LuGP (2010) Atorvastatin inhibits homocysteine-induced oxidative stress and apoptosis in endothelial progenitor cells involving Nox4 and p38MAPK. Atherosclerosis 210: 114-121.
3. Cedar H (1988) DNA methylation and gene activity. Cell 53: 3-4.
4. Chang PY, Lu SC, Lee CM, Chen YJ, Dugan TA, Huang WH, Chang SF, Liao WS, Chen CH, Lee YT (2008) Homocysteine inhibits arterial endothelial cell growth through transcriptional downregulation of fibroblast growth factor-2 involving G protein and DNA methylation. Circ Res 102: 933-941.
5. Chao CL, Kuo TL, Lee YT (2000) Effects of methionine-induced hyperhomocysteinemia on endothelium-dependent vasodilation and oxidative status in healthy adults. Circulation 101: 485-490.
6. Clarke S (1993) Protein methylation. Curr Opin Cell Biol 5: 977-983.
7. Dayal S, Bottiglieri T, Arning E, Maeda N, Malinow MR, Sigmund CD, Heistad DD, Faraci FM, Lentz SR (2001) Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthasedeficient mice. Circ Res 88: 1203-1209.
8. Dinavahi R, Falkner B (2004) Relationship of homocysteine with cardiovascular disease and blood pressure. J Clin Hypertens (Greenwich) 6: 494-298; quiz 499-500.
9. Fiedler LR, Bachetti T, Leiper J, Zachary I, Chen L, Renne T, Wojciak-Stothard B (2009) The ADMA/DDAH pathway regulates VEGF-mediated angiogenesis. Arterioscler Thromb Vasc Biol 29: 2117-2124.
10. Heil SG, De Vriese AS, Kluijtmans LA, Mortier S, Den Heijer M, Blom HJ (2004) The role of hyperhomocysteinemia in nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilatation. Cell Mol Biol (Noisy-le-grand) 50: 911-916.
11. Huang YS, Zhi YF, Wang SR (2009) Hypermethylation of estrogen receptor-alpha gene in atheromatosis patients and its correlation with homocysteine. Pathophysiology 16: 259-265.
12. Jia SJ, Jiang DJ, Hu CP, Zhang XH, Deng HW, Li YJ (2006) Lysophosphatidylcholine-induced elevation of asymmetric dimethylarginine level by the NADPH oxidase pathway in endothelial cells. Vascul Pharmacol 44: 143-148.
13. Jiang DJ, Jia SJ, Dai Z, Li YJ (2006) Asymmetric dimethylarginine induces apoptosis via p38 MAPK/caspase-3-dependent signaling pathway in endothelial cells. J Mol Cell Cardiol 40: 529-539.
14. Lee SJ, Kim KM, Namkoong S, Kim CK, Kang YC, Lee H, Ha KS, Han JA, Chung HT, Kwon YG, Kim YM (2005) Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of S-nitrosohomocysteine. J Biol Chem 280: 5781-5788.
15. Newell-Price J, Clark AJ, King P (2000) DNA methylation and silencing of gene expression. Trends Endocrinol Metab 11: 142-148.
16. Palm F, Onozato ML, Luo Z,Wilcox CS (2007) Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems. Am J Physiol Heart Circ Physiol 293: H3227-3245.
17. Post WS, Goldschmidt-Clermont PJ, Wilhide CC, Heldman AW, Sussman MS, Ouyang P, Milliken EE, Issa JP (1999) Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system. Cardiovasc Res 43: 985-991.
18. Rountree MR, Bachman KE, Herman JG, Baylin SB (2001) DNA methylation, chromatin inheritance, and cancer. Oncogene 20: 3156-3165.
19. Tomikawa J, Fukatsu K, Tanaka S, Shiota K (2006) DNA methylationdependent epigenetic regulation of dimethylarginine dimethylaminohydrolase 2 gene in trophoblast cell lineage. J Biol Chem 281: 12163-12169.
20. Turunen MP, Aavik E, Yla-Herttuala S (2009) Epigenetics and atherosclerosis. Biochim Biophys Acta 1790: 886-891.
21. Wang H, Yoshizumi M, Lai K, Tsai JC, Perrella MA, Haber E, Lee ME (1997) Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine. J Biol Chem 272: 25380-25385.
22. Wang X, Cui L, Joseph J, Jiang B, Pimental D, Handy DE, Liao R, Loscalzo J (2012) Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress. J Mol Cell Cardiol 52: 753-760.
23. Yi-Deng J, Tao S, Hui-Ping Z, Jian-Tuan X, Jun C, Gui-Zhong L, Shu-Ren W (2007) Folate and ApoE DNA methylation induced by homocysteine in human monocytes. DNA Cell Biol 26: 737-744.
24. Yideng J, Zhihong L, Jiantuan X, Jun C, Guizhong L, Shuren W (2008) Homocysteine-mediated PPARalpha,gamma DNA methylation and its potential pathogenic mechanism in monocytes. DNA Cell Biol 27: 143-150.
25. Zhang JG, Liu JX, Li ZH,Wang LZ, Jiang YD,Wang SR (2007) Dysfunction of endothelialNOsystem originated from homocysteine-induced aberrant methylation pattern in promoter region of DDAH2 gene. Chin Med J (Engl) 120: 2132-2137.
26. Zhu S, Goldschmidt-Clermont PJ, Dong C (2005) Inactivation of monocarboxylate transporter MCT3 by DNA methylation in atherosclerosis. Circulation 112: 1353-1361.