Interleukin 17A is an immune marker for chlamydial disease severity and pathogenesis in the koala (Phascolarctos cinereus)

Developmental and Comparative Immunology

Volumn 46, Issue 2, 2014, Pages 423-429

  Mathew, Marina ^a   Waugh, Courtney ^a,b   Beagley, Kenneth W ^a   Timms, Peter ^a,b   Polkinghorne, Adam ^a,b  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b UNIVERSITY OF THE SUNSHINE COAST   (Australia)

Author keywords

Chlamydia; IFN ; IL10; IL17A; Koala; TNF

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CHLAMYDIA PECORUM; CHLAMYDIA PECORUM INFECTION; CHLAMYDIASIS; CONTROLLED STUDY; CYTOKINE RESPONSE; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; KOALA; LONGITUDINAL STUDY; MALE; NONHUMAN; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; BLOOD; CELL CULTURE; CHLAMYDIA; GENETICS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MONONUCLEAR CELL; VETERINARY;

ANIMALS; BIOLOGICAL MARKERS; CELLS, CULTURED; CHLAMYDIA; CHLAMYDIA INFECTIONS; FEMALE; GENE EXPRESSION; INTERLEUKIN-17; LEUKOCYTES, MONONUCLEAR; MALE; PHASCOLARCTIDAE;

EID: 84902951243     PISSN: 0145305X     EISSN: 18790089     Source Type: Journal    
DOI: 10.1016/j.dci.2014.05.015     Document Type: Article

References (45)

1. Abraham E. Effects of stress on cytokine production. Methods Achiev. Exp. Pathol. 1991, 14:45-62.
2. Agrawal T., Gupta R., Dutta R., Srivastava P., Bhengraj A.R., Salhan S., Mittal A. Protective or pathogenic immune response to genital chlamydial infection in women - a possible role of cytokine secretion profile of cervical mucosal cells. Clin. Immunol. 2009, 130:347-354.
3. Andrew D.W., Cochrane M., Schripsema J.H., Ramsey K.H., Dando S.J., O'Meara C.P., Timms P., Beagley K.W. The duration of Chlamydia muridarum genital tract infection and associated chronic pathological changes are reduced in IL-17 knockout mice but protection is not increased further by immunization. PLoS One 2013, 8(9). 10.1371/journal.pone.0076664.
4. Bai H., Cheng J., Gao X., Joyee A.G., Fan Y., Wang S., Jiao L., Yao Z., Yang X. IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function. J. Immunol. 2009, 183:5886-5895. 5810.4049/jimmunol.0901584.
5. Barral R., Desai R., Zheng X., Frazer L.C., Sucato G.S., Haggerty C.L., O'Connell C.M., Zurenski M.A., Darville T. Frequency of Chlamydia trachomatis-specific T cell interferon-gamma and interleukin-17 responses in CD4-enriched peripheral blood mononuclear cells of sexually active adolescent females. J. Reprod. Immunol. 2014, 10.1016/j.jri.2014.01.002.
6. Cua D.J., Tato C.M. Innate IL-17-producing cells: the sentinels of the immune system. Nat. Rev. Immunol. 2010, 10:479-489.
7. Darville T., Hiltke T.J. Pathogenesis of genital tract disease due to Chlamydia trachomatis. J. Infect. Dis. 2010, 201:114-125.
8. Entrican G., Wattegedera S., Rocchi M., Fleming D.C., Kelly R.W., Wathne G., Magdalenic V., Howie S.E.M. Induction of inflammatory host immune responses by organisms belonging to the genera Chlamydia/Chlamydophila. Vet. Immunol. Immunopathol. 2004, 100:179-186.
9. Geisler W.M., Tang J., Wang C., Wilson C.M., Kaslow R.A. Epidemiological and genetic correlates of incident Chlamydia trachomatis infection in North American adolescents. J. Infect. Dis. 2004, 190:1723-1729.
10. Geisler W.M. Duration of untreated, uncomplicated Chlamydia trachomatis genital infection and factors associated with chlamydia resolution: a review of human studies. J. Infect. Dis. 2010, 201(Suppl. 2):104-113.
11. Griffith J.E., Dhand N.K., Krockenberger M.B., Higgins D.P. A retrospective study of admission trends of koalas to a rehabilitation facility over 30 years. J. Wildl. Dis. 2013, 49:18-28.
12. Hafner L., Beagley K., Timms P. Chlamydia trachomatis infection: host immune responses and potential vaccines. Mucosal Immunol. 2008, 10.1038/mi.2007.19.
13. Hemsley S., Canfield P.J. Histopathological and immunohistochemical investigation of naturally occurring chlamydial conjunctivitis and urogenital inflammation in koalas (Phascolarctos cinereus). J. Comp. Pathol. 1997, 116:273-290.
14. Hogan R.J., Mathews S.A., Mukhopadhyay S., Summersgill J.T., Timms P. Chlamydial persistence: beyond the biphasic paradigm. Infect. Immun. 2004, 72:1843-1855.
15. Jha R., Srivastava P., Salhan S., Finckh A., Gabay C., Mittal A., Bas S. Spontaneous secretion of interleukin-17 and -22 by human cervical cells in Chlamydia trachomatis infection. Microbes Infect. 2011, 13:167-178.
16. Jin W., Dong C. IL-17 cytokines in immunity and inflammation. Emerg. Microbes. Infect. 2013, 2. 10.1038/emi.2013.58.
17. Kollipara A., George C., Hanger J., Loader J., Polkinghorne A., Beagley K., Timms P. Vaccination of healthy and diseased koalas (Phascolarctos cinereus) with a Chlamydia pecorum multi-subunit vaccine: Evaluation of immunity and pathology. Vaccine 2012, 30:1875-1885.
18. Kollipara A., Polkinghorne A., Wan C., Kanyoka P., Hanger J., Loader J., Callaghan J., Bell A., Ellis W., Fitzgibbon S., Melzer A., Beagley K., Timms P. Genetic diversity of Chlamydia pecorum strains in wild koala locations across Australia and the implications for a recombinant C. pecorum major outer membrane protein based vaccine. Vet. Microbiol. 2013, 167:513-522.
19. Lee K.E., Seddon J.M., Johnston S., FitzGibbon S.I., Carrick F., Melzer A., Bercovitch F., Ellis W. Genetic diversity in natural and introduced island populations of koalas in Queensland. Aust. J. Zool. 2013, 60:303-310.
20. Lin Y., Ritchea S., Logar A., Slight S., Messmer M., Rangel-Moreno J., Guglani L., Alcorn J.F., Strawbridge H., Park S.M., Onishi R., Nyugen N., Walter M.J., Pociask D., Randall T.D., Gaffen S.L., Iwakura Y., Kolls J.K., Khader S.A. Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity 2009, 31:799-810.
21. -δδCT method. Methods 2001, 25:402-408.
22. Longbottom D., Coulter L.J. Animal chlamydioses and zoonotic implications. J. Comp. Pathol. 2003, 128:217-244.
23. Loomis W.P., Starnbach M.N. T cell responses to Chlamydia trachomatis. Curr. Opin. Microbiol. 2002, 5:87-91.
24. Maher I.E., Griffith J.E., Lau Q., Reeves T., Higgins D.P. Expression profiles of the immune genes CD4, CD8β, IFNγ, IL-4, IL-6 and IL-10 in mitogen-stimulated koala lymphocytes (Phascolarctos cinereus) by qRT-PCR. PeerJ 2014, 10.7717/peerj.280.
25. Mascellino M.T., Boccia P., Oliva A. Immunopathogenesis in Chlamydia trachomatis infected women. ISRN Obstet. Gynecol. 2011, 10.5402/2011/436936.
26. Mathew M., Beagley K.W., Timms P., Polkinghorne A. Preliminary characterisation of tumor necrosis factor alpha and interleukin-10 responses to Chlamydia pecorum infection in the koala (Phascolarctos cinereus). PLoS One 2013, 8. 10.1371/journal.pone.0059958.
27. Mathew M., Pavasovic A., Prentis P.J., Beagley K.W., Timms P., Polkinghorne A. Molecular characterisation and expression analysis of Interferon gamma in response to natural Chlamydia infection in the koala, Phascolarctos cinereus. Gene 2013, 527:570-577.
28. Miguel R.D.V., Harvey S.A., LaFramboise W.A., Reighard S.D., Matthews D.B., Cherpes T.L. Human female genital tract infection by the obligate intracellular bacterium Chlamydia trachomatis elicits robust Type 2 immunity. PLoS One 2013, 8. 10.1371/journal.pone.0058565.
29. Mohamad K.Y., Rodolakis A. Recent advances in the understanding of Chlamydophila pecorum infections, sixteen years after it was named as the fourth species of the Chlamydiaceae family. Vet. Res. 2010, 41. 10.1051/vetres/2009075.
30. Morris K., Prentis P., O'Meally D., Pavasovic A., Taylor-Brown A., Timms P., Belov K., Polkinghorne A. The koala immunological toolkit: sequence identification and comparison of key markers of the koala (Phascolarctos cinereus) immune response. Aust. J. Zool. 2014, 10.1071/ZO13105.
31. O'Meara C.P., Armitage C.W., Harvie M.C., Timms P., Lycke N.Y., Beagley K.W. (a). Immunization with a MOMP-based vaccine protects mice against a pulmonary Chlamydia challenge and identifies a disconnection between infection and pathology. PLoS One 2013, 8. 10.1371/journal.pone.0061962.
32. O'Meara C.P., Armitage C.W., Harvie M.C., Andrew D.W., Timms P., Lycke N.Y., Beagley K.W. Immunity against a Chlamydia infection and disease may be determined by a balance of IL-17 signaling. Immunol. Cell Biol. 2013, 10. 1038/icb.2013.92.
33. Polkinghorne A., Hanger J., Timms P. Recent advances in understanding the biology, epidemiology and control of chlamydial infections in koalas. Vet. Microbiol. 2013, 165:214-223.
34. Savarin C., Stohlman S.A., Hinton D.R., Ransohoff R.M., Cua D.J., Bergmann C.C. IFN-gamma protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils. J. Neuroinflammation 2012, 9. 10.1186/1742-2094-9-104.
35. Schneemilch C.E., Schilling T., Bank U. Effects of general anaesthesia on inflammation. Best Pract. Res. Clin. Anaesthesiol. 2004, 18:493-507.
36. Scurlock A.M., Frazer L.C., Andrews C.W., O'Connell C.M., Foote I.P., Bailey S.L., Chandra-Kuntal K., Kolls J.K., Darville T. Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection. Infect. Immun. 2011, 79:1349-1362.
37. Vats V., Agrawal T., Salhan S., Mittal A. Primary and secondary immune response of mucosal and peripheral lymphocytes during Chlamydia trachomatis infection. FEMS Immunol. Med. Microbiol. 2007, 49:280-287.
38. Wan C., Loader J., Hanger J., Beagley K.W., Timms P., Polkinghorne A. Using quantitative polymerase chain reaction to correlate Chlamydia pecorum infectious load with ocular, urinary and reproductive tract disease in the koala (Phascolarctos cinereus). Aust. Vet. J. 2011, 89:409-412.
39. Wang C., Tang J., Geisler W.M., Crowley-Nowick P.A., Wilson C.M., Kaslow R.A. Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescents. J. Infect. Dis. 2005, 191:1084-1092.
40. Yang X. Distinct function of Th1 and Th2 type delayed type hypersensitivity: protective and pathological reactions to chlamydial infection. Microsc. Res. Tech. 2001, 53:273-277.
41. Ye P., Garvey P.B., Zhang P., Nelson S., Bagby G., Summer W.R., Schwarzenberger P., Shellito J.E., Kolls J.K. Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am. J. Respir. Cell Mol. Biol. 2001, 25:335-340.
42. Yu H., Jiang X., Shen C., Karunakaran K.P., Jiang J., Rosin N.L., Brunham R.C. Chlamydia muridarum T-cell antigens formulated with the adjuvant DDA/TDB induce immunity against infection that correlates with a high frequency of gamma interferon (IFN-gamma)/tumor necrosis factor alpha and IFN-gamma/interleukin-17 double-positive CD4+ T cells. Infect. Immun. 2010, 78:2272-2282.
43. Zhang X., Gao L., Lei L., Zhong Y., Dube P., Berton M.T., Arulanandam B., Zhang J., Zhong G. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J. Immunol. 2009, 183:1291-1300.
44. Zhang Y., Wang H., Ren J., Tang X., Jing Y., Xing D., Zhao G., Yao Z., Yang X., Bai H. IL-17A synergizes with IFN-gamma to upregulate iNOS and NO production and inhibit chlamydial growth. PLoS One 2012, 7. 10.1371/journal.pone.0039214.
45. Zhou X., Chen Q., Moore J., Kolls J.K., Halperin S., Wang J. Critical role of the Interleukin-17/Interleukin-17 receptor axis in regulating host susceptibility to respiratory infection with Chlamydia species. Infect. Immun. 2009, 77:5059-5070.