Frequency of Chlamydia trachomatis-specific T cell interferon-γ and interleukin-17 responses in CD4-enriched peripheral blood mononuclear cells of sexually active adolescent females

Journal of Reproductive Immunology

Volumn 103, Issue 1, 2014, Pages 29-37

  Barral, Romina ^a   Desai, Ruchi ^a   Zheng, Xiaojing ^a   Frazer, Lauren C ^a   Sucato, Gina S ^a   Haggerty, Catherine L ^b   O'Connell, Catherine M ^a   Zurenski, Matthew A ^a   Darville, Toni ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Antigen; Genital; Immunity; Pelvic inflammatory disease; Th1; Th17

Indexed keywords

ANTIBODY; AZITHROMYCIN; BACTERIAL VACCINE; CHAPERONIN 60; CONCANAVALIN A; GAMMA INTERFERON; INTERLEUKIN 17; MAJOR OUTER MEMBRANE PROTEIN; MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN; POLYMORPHIC MEMBRANE PROTEIN F; POLYMORPHIC MEMBRANE PROTEIN G; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; BACTERIUM ANTIBODY; OMP1 PROTEIN, CHLAMYDIA TRACHOMATIS; PMPG PROTEIN, CHLAMYDIA TRACHOMATIS; PORIN;

ADOLESCENT; ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; CD4+ T LYMPHOCYTE; CHLAMYDIA TRACHOMATIS; CLINICAL ARTICLE; COMPARATIVE STUDY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HUMAN; IMMUNOGENICITY; NERVE CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REINFECTION; SEXUAL BEHAVIOR; BIOSYNTHESIS; BLOOD; CHLAMYDIASIS; IMMUNOLOGY; MONONUCLEAR CELL; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; FEMALE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-17; LEUKOCYTES, MONONUCLEAR; PORINS; SEXUAL BEHAVIOR; YOUNG ADULT;

EID: 84900327326     PISSN: 01650378     EISSN: 18727603     Source Type: Journal    
DOI: 10.1016/j.jri.2014.01.002     Document Type: Article

References (36)

1. Arno J., Ricker V., Batteiger B., Katz B., Caine V., Jones R. Interferon-gamma in endocervical secretions of women infected with Chlamydia trachomatis. J. Infect. Dis. 1990, 162:1385-1389.
2. Arno J., Katz B., McBride R., Carty G., Batteiger B., Caine V., et al. Age and clinical immunity to infections with Chlamydia trachomatis. Sex. Transm. Dis. 1994, 21:47-52.
3. Batteiger B., Tu W., Ofner S., Van Der Pol B., Stothard D., Orr D., et al. Repeated Chlamydia trachomatis genital infections in adolescent women. J. Infect. Dis. 2010, 201:42-51.
4. Bom R., Christerson L., Schim van der Loeff M., Coutinho R., Herrmann B., Bruisten S., et al. Evaluation of high-resolution typing methods for Chlamydia trachomatis in samples from heterosexual couples. J. Clin. Microbiol. 2011, 49:2844-2853.
5. Brunham R., Kuo C., Cles L., Holmes K. Correlation of host immune response with quantitative recovery of Chlamydia trachomatis from the human endocervix. Infect. Immun. 1983, 39:1491-1494.
6. Cerrone M., Ma J., Stephens R. Cloning and sequence of the gene for heat shock protein 60 from Chlamydia trachomatis and immunological reactivity of the protein. Infect. Immun. 1991, 59:79-90.
7. Cohen C., Koochesfahani K., Meier A., Shen C., Karunakaran K., Ondondo B., et al. Immunoepidemiologic profile of Chlamydia trachomatis infection: importance of heat-shock protein 60 and interferon-gamma. J. Infect. Dis. 2005, 192:591-599.
8. Coler R., Bhatia A., Maisonneuve J., Probst P., Barth B., Ovendale P., et al. Identification and characterization of novel recombinant vaccine antigens for immunization against genital Chlamydia trachomatis. FEMS Immunol. Med. Microbiol. 2009, 55:258-270.
9. Cong Y., Jupelli M., Guentzel M., Zhong G., Murthy A., Arulanandam B. Intranasal immunization with chlamydial protease-like activity factor and cpg deoxynucleotides enhances protective immunity against genital Chlamydia muridarum infection. Vaccine 2007, 25:3773-3780.
10. Crane D., Carlson J., Fischer E., Bavoil P., Hsia R., Tan C., et al. Chlamydia trachomatis polymorphic membrane protein D is a species-common pan-neutralizing antigen. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:1894-1899.
11. Finco O., Frigimelica E., Buricchi F., Petracca R., Galli G., Faenzi E., et al. Approach to discover T- and B-cell antigens of intracellular pathogens applied to the design of Chlamydia trachomatis vaccines. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:9969-9974.
12. Geisler W. Diagnosis and management of uncomplicated Chlamydia trachomatis infections in adolescents and adults: summary of evidence reviewed for the 2010 Centers for Disease Control and Prevention Sexually Transmitted Diseases treatment guidelines. Clin. Infect. Dis. 2011, 53(Suppl. (3)):S92-S98.
13. Igietseme J., Rank R. Susceptibility to reinfection after a primary chlamydial genital infection is associated with a decrease of antigen-specific T cells in the genital tract. Infect. Immun. 1991, 59:1346-1351.
14. Jha R., Srivastava P., Salhan S., Finckh A., Gabay C., Mittal A., et al. Spontaneous secretion of interleukin-17 and -22 by human cervical cells in Chlamydia trachomatis infection. Microbes Infect. 2011, 13:167-178.
15. Kalman S., Mitchell W., Marathe R., Lammel C., Fan J., Hyman R., et al. Comparative genomes of Chlamydia pneumoniae and C. trachomatis. Nat. Genet. 1999, 4:385-389.
16. Karunakaran K., Rey-Ladino J., Stoynov N., Berg K., Shen C., Jiang X., et al. Immunoproteomic discovery of novel T cell antigens from the obligate intracellular pathogen Chlamydia. J. Immunol. 2008, 180:2459-2465.
17. Morrison S.G., Morrison R.P. A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection. J. Immunol. 2005, 175:7536-7542.
18. Morrison S.G., Su H., Caldwell H., Morrison R. Immunity to murine Chlamydia trachomatis genital tract reinfection involves B cells and CD4(+) T cells but not CD8(+) T cells. Infect. Immun. 2000, 68:6979-6987.
19. O'Connell C., AbdelRahman Y., Green E., Darville H., Saira K., Smith B., et al. Toll-like receptor 2 activation by Chlamydia trachomatis is plasmid dependent, and plasmid-responsive chromosomal loci are coordinately regulated in response to glucose limitation by C. trachomatis but not by C. muridarum. Infect. Immun. 2011, 79:1044-1056.
20. Ondondo B., Brunham R., Harrison W., Kinyari T., Sheth P., Mugo N., et al. Frequency and magnitude of Chlamydia trachomatis elementary body- and heat shock protein 60-stimulated interferon gamma responses in peripheral blood mononuclear cells and endometrial biopsy samples from women with high exposure to infection. J. Infect. Dis. 2009, 199:1771-1779.
21. Ortiz L., Demick K., Petersen J., Polka M., Rudersdorf R., Van der Pol B., et al. Chlamydia trachomatis major outer membrane protein (momp) epitopes that activate HLA class ii-restricted T cells from infected humans. J. Immunol. 1996, 157:4554-4567.
22. Peipert J.F. Clinical practice genital chlamydial infections. N. Engl. J. Med. 2003, 349:2424-2430.
23. Perry L., Feilzer K., Caldwell H. Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through ifn-gamma-dependent and -independent pathways. J. Immunol. 1997, 158:3344-3352.
24. Ramsey K., Rank R. Resolution of chlamydial genital infection with antigen-specific T-lymphocyte lines. Infect. Immun. 1991, 59:925-931.
25. Rank R.G., Soderberg L., Sanders M., Batteiger B. Role of cell-mediated immunity in the resolution of secondary chlamydial genital infection in guinea pigs infected with the agent of guinea pig inclusion conjunctivitis. Infect. Immun. 1989, 57:706-710.
26. Riley M., Zurenski M., Frazer L., O'Connell C., Andrews C., Mintus M., et al. The recall response induced by genital challenge with Chlamydia muridarum protects the oviduct from pathology but not from reinfection. Infect. Immun. 2012, 80:2194-2203.
27. Scurlock A., Frazer L., Andrews C., O'Connell C., Foote I., Bailey S., et al. Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection. Infect. Immun. 2011, 79:1349-1362.
28. Stephens R., Kalman S., Lammel C., Fan J., Marathe R., Aravind L., et al. Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science 1998, 282:754-759.
29. Su H., Messer R., Whitmire W., Hughes S., Caldwell H. Subclinical chlamydial infection of the female mouse genital tract generates a potent protective immune response: implications for development of live attenuated chlamydial vaccine strains. Infect. Immun. 2000, 68:192-196.
30. Voigt A., Schofl G., Saluz H. The Chlamydia psittaci genome: a comparative analysis of intracellular pathogens. PLoS ONE 2012, 7:e35097.
31. Wang S., Grayston J. Human serology in Chlamydia trachomatis infection with microimmunofluorescence. J. Infect. Dis. 1974, 130:388-397.
32. Workowski K., Berman S. Centers for disease control and prevention sexually transmitted disease treatment guidelines. Clin. Infect. Dis. 2011, 53(Suppl. (3)):S59-S63.
33. Yi Y., Zhong G., Brunham R. Continuous B-cell epitopes in Chlamydia trachomatis heat shock protein 60. Infect. Immun. 1993, 61:1117-1120.
34. Yu H., Jiang X., Shen C., Karunakaran K., Brunham R. Novel Chlamydia muridarum T cell antigens induce protective immunity against lung and genital tract infection in murine models. J. Immunol. 2009, 182:1602-1608.
35. Yu H., Jiang X., Shen C., Karunakaran K., Jiang J., Rosin N., et al. Chlamydia muridarum T-cell antigens formulated with the adjuvant dda/tdb induce immunity against infection that correlates with a high frequency of interferon-gamma)/tumor necrosis factor alpha and interferon-gamma/interleukin-17 double-positive CD4+ T cells. Infect. Immun. 2010, 78:2272-2282.
36. Yu H., Karunakaran K., Jiang X., Shen C., Andersen P., Brunham R. Chlamydia muridarum T cell antigens and adjuvants that induce protective immunity in mice. Infect. Immun. 2012, 80:1510-1518.