Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root bark

BMC Complementary and Alternative Medicine

Volumn 14, Issue , 2014, Pages

  Eo, Hyun J ^a   Park, Jae H ^b   Park, Gwang H ^a   Lee, Man H ^c   Lee, Jeong R ^c   Koo, Jin S ^a   Jeong, Jin B ^a  

^a Andong National University   (South Korea)

^b Jungwon University   (South Korea)

^c Gyeongbuk Institute for Bio industry   (South Korea)

Author keywords

Anti cancer; Anti inflammation; Medicinal plant; Morus alba L. Mulberry root bark

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; CYCLIN D1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MULBERRY EXTRACT; MULBERRY ROOT BARK EXTRACT; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL GROWTH; CELL VIABILITY; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DOWN REGULATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MORUS ALBA; MTT ASSAY; NONHUMAN; PLANT ROOT; PROTEIN EXPRESSION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACTIVATING TRANSCRIPTION FACTOR 3; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MORUS; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84902905688     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-200     Document Type: Article

References (57)

1. Nagata M. Inflammatory cells and oxygen radicals. Curr Drug Targets Inflamm Allergy 2005, 4(4):503-504.
2. Lee YG, Lee WM, Kim JY, Lee JY, Lee IK, Yun BS, Rhee MH, Cho JY. Src kinase-targeted anti-inflammatory activity of davallialactone from Inonotus xeranticus in lipopolysaccharide-activated RAW264.7 cells. Br J Pharm 2008, 154(4):852-863.
3. Ferencik M, Stvrtinova V, Hulin I, Novak M. Inflammation-a lifelong companion. Attempt at a non-analytical holistic view. Folia Microbiologica 2007, 52(2):159-173.
4. Hogg N. Free radicals in disease. Semin Reprod Endocrinol 1998, 16(4):241-248.
5. Kim HY, Goo JH, Joo YA, Lee HY, Lee SM, Oh CT, Ahn SM, Kim NH, Hwang JS. Impact on inflammation and recovery of skin barrier by nordihydroguaiaretic Acid as a protease-activated receptor 2 antagonist. Biomol Ther 2012, 20(5):463-469.
6. Mordan LJ, Burnett TS, Zhang LX, Tom J, Cooney RV. Inhibitors of endogenous nitrogen oxide formation block the promotion of neoplastic transformation in C3H 10 T1/2 fibroblasts. Carcinogenesis 1993, 14(8):1555-1559.
7. Ohshima H, Bartsch H. Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat Res 1994, 305(2):253-264.
8. Kroncke KD, Fehsel K, Kolb-Bachofen V. Inducible nitric oxide synthase in human diseases. Clin Exp Immunol 1998, 113(2):147-156.
9. Kwon OK, Lee MY, Yuk JE, Oh SR, Chin YW, Lee HK, Ahn KS. Anti-inflammatory effects of methanol extracts of the root of Lilium lancifolium on LPS-stimulated Raw264.7 cells. J Ethnopharmacol 2010, 130(1):28-34.
10. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow?. Lancet 2001, 357(9255):539-545.
11. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002, 420(6917):860-867.
12. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA-Cancer J Clin 2013, 63(1):11-30.
13. Wang S, Wu X, Tan M, Gong J, Tan W, Bian B, Chen M, Wang Y. Fighting fire with fire: poisonous Chinese herbal medicine for cancer therapy. J Ethnopharmacol 2012, 140(1):33-45.
14. Fukai T, Satoh K, Nomura T, Sakagami H. Antinephritis and radical scavenging activity of prenylflavonoids. Fitoterapia 2003, 74(7-8):720-724.
15. Bottone FG, Martinez JM, Alston-Mills B, Eling TE. Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells. Carcinogenesis 2004, 25(3):349-357.
16. Yan C, Lu D, Hai T, Boyd DD. Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J 2005, 24(13):2425-2435.
17. Wang H, Mo P, Ren S, Yan C. Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6. J Biol chem 2010, 285(17):13201-13210.
18. Lu D, Wolfgang CD, Hai T. Activating transcription factor 3, a stress-inducible gene, suppresses Ras-stimulated tumorigenesis. J Biol chem 2006, 281(15):10473-10481.
19. Alao JP. The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mole Cancer 2007, 6:24.
20. Bahnassy AA, Zekri AR, El-Houssini S, El-Shehaby AM, Mahmoud MR, Abdallah S, El-Serafi M. Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients. BMC gastroenterol 2004, 4:22.
21. Banskota AH, Tezuka Y, Nguyen NT, Awale S, Nobukawa T, Kadota S. DPPH radical scavenging and nitric oxide inhibitory activities of the constituents from the wood of Taxus yunnanensis. Planta Med 2003, 69(6):500-505.
22. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992, 6(12):3051-3064.
23. Sung MJ, Davaatseren M, Kim W, Sung Kwang P, Kim SH, Haeng Jeon H, Myung Sunny K, Kim YS, Dae Young K. Vitisin A suppresses LPS-induced NO production by inhibiting ERK, p38, and NF-kappaB activation in RAW 264.7 cells. Int Immunopharmacol 2009, 9(3):319-323.
24. Jeong JB, Yang X, Clark R, Choi J, Baek SJ, Lee SH. A mechanistic study of the proapoptotic effect of tolfenamic acid: involvement of NF-kappaB activation. Carcinogenesis 2013, 34(10):2350-2360.
25. Kikuchi T, Nihei M, Nagai H, Fukushi H, Tabata K, Suzuki T, Akihisa T. Albanol A from the root bark of Morus alba L. induces apoptotic cell death in HL60 human leukemia cell line. Chem Pharm Bull 2010, 58(4):568-571.
26. Nam SY, Yi HK, Lee JC, Kim JC, Song CH, Park JW, Lee DY, Kim JS, Hwang PH. Cortex mori extract induces cancer cell apoptosis through inhibition of microtubule assembly. Arch Pharm Res 2002, 25(2):191-196.
27. Wang Q, Kuang H, Su Y, Sun Y, Feng J, Guo R, Chan K. Naturally derived anti-inflammatory compounds from Chinese medicinal plants. J Ethnopharmacol 2013, 146(1):9-39.
28. Sharma JN, Al-Omran A, Parvathy SS. Role of nitric oxide in inflammatory diseases. Inflammopharmacology 2007, 15(6):252-259.
29. Anggard E. Nitric oxide: mediator, murderer, and medicine. Lancet 1994, 343(8907):1199-1206.
30. Lechner M, Lirk P, Rieder J. Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin. Semin Cancer Biol 2005, 15(4):277-289.
31. Chang H, Tsai SY, Chang Y, Chen TL, Chen RM. Therapeutic concentrations of propofol protects mouse macrophages from nitric oxide-induced cell death and apoptosis. Can J Anaesth 2002, 49(5):477-480.
32. Hobbs AJ, Higgs A, Moncada S. Inhibition of nitric oxide synthase as a potential therapeutic target. Ann Rev Pharm Toxicol 1999, 39:191-220.
33. Marletta MA. Nitric oxide synthase structure and mechanism. J Biol Chem 1993, 268(17):12231-12234.
34. Won JH, Kim JY, Yun KJ, Lee JH, Back NI, Chung HG, Chung SA, Jeong TS, Choi MS, Lee KT. Gigantol isolated from the whole plants of Cymbidium goeringii inhibits the LPS-induced iNOS and COX-2 expression via NF-kappaB inactivation in RAW 264.7 macrophages cells. Planta Med 2006, 72(13):1181-1187.
35. Lin CM, Huang ST, Liang YC, Lin MS, Shih CM, Chang YC, Chen TY, Chen CT. Isovitexin suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages. Planta Med 2005, 71(8):748-753.
36. Ko HC, Kuo YH, Wei BL, Chiou WF. Laxifolone A suppresses LPS/IFN-gamma-induced NO synthesis by attenuating NF-kappaB translocation: role of NF-kappaB p105 level. Planta Med 2005, 71(6):514-519.
37. Jin XY, Lee SH, Kim JY, Zhao YZ, Park EJ, Lee BS, Nan JX, Song KS, Ko G, Sohn DH. Polyozellin inhibits nitric oxide production by down-regulating LPS-induced activity of NF-kappaB and SAPK/JNK in RAW 264.7 cells. Planta Med 2006, 72(9):857-859.
38. Gilmore TD. Introduction to NF-kappaB: players, pathways, perspectives. Oncogene 2006, 25(51):6680-6684.
39. Mankan AK, Lawless MW, Gray SG, Kelleher D, McManus R. NF-kappaB regulation: the nuclear response. J Cell Mol Med 2009, 13(4):631-643.
40. Sarkar FH, Li Y, Wang Z, Kong D. NF-kappaB signaling pathway and its therapeutic implications in human diseases. Int Rev Immunol 2008, 27(5):293-319.
41. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 2001, 480-481:243-268.
42. Saxena A, Baliga MS, Ponemone V, Kaur K, Larsen B, Fletcher E, Greene J, Fayad R. Mucus and adiponectin deficiency: role in chronic inflammation-induced colon cancer. Int J Colorectal Dis 2013, 28(9):1267-1279.
43. Liang G, Wolfgang CD, Chen BP, Chen TH, Hai T. ATF3 gene. Genomic organization, promoter, and regulation. J Biol Chem 1996, 271(3):1695-1701.
44. Syed V, Mukherjee K, Lyons-Weiler J, Lau KM, Mashima T, Tsuruo T, Ho SM. Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling. Oncogene 2005, 24(10):1774-1787.
45. Hartman MG, Lu D, Kim ML, Kociba GJ, Shukri T, Buteau J, Wang X, Frankel WL, Guttridge D, Prentki M, Grey ST, Ron D, Hai T. Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mole Cell Biol 2004, 24(13):5721-5732.
46. Piyanuch R, Sukhthankar M, Wandee G, Baek SJ. Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells. Cancer Lett 2007, 258(2):230-240.
47. Lee SH, Yamaguchi K, Kim JS, Eling TE, Safe S, Park Y, Baek SJ. Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Carcinogenesis 2006, 27(5):972-981.
48. Yan C, Jamaluddin MS, Aggarwal B, Myers J, Boyd DD. Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin. Mole Cancer Ther 2005, 4(2):233-241.
49. Lee SH, Min KW, Zhang X, Baek SJ. 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells. Journal Nutr Biochem 2013, 24(4):664-671.
50. Kwon O, Soung NK, Thimmegowda NR, Jeong SJ, Jang JH, Moon DO, Chung JK, Lee KS, Kwon YT, Erikson RL, Ahn JS, Kim BY. Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation. Cell Signal 2012, 24(4):943-950.
51. Casanovas O, Miro F, Estanyol JM, Itarte E, Agell N, Bachs O. Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner. J Biol Chem 2000, 275(45):35091-35097.
52. Okabe H, Lee SH, Phuchareon J, Albertson DG, McCormick F, Tetsu O. A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PloS one 2006, 1:e128.
53. Diehl JA, Zindy F, Sherr CJ. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev 1997, 11(8):957-972.
54. Lim JH, Lee YM, Chun YS, Park JW. Reactive oxygen species-mediated cyclin D1 degradation mediates tumor growth retardation in hypoxia, independently of p21cip1 and hypoxia-inducible factor. Cancer Sci 2008, 99(9):1798-1805.
55. Cheon BS, Kim YH, Son KS, Chang HW, Kang SS, Kim HP. Effects of prenylated flavonoids and biflavonoids on lipopolysaccharide-induced nitric oxide production from the mouse macrophage cell line RAW 264.7. Planta Med 2000, 66(7):596-600.
56. Yang ZG, Matsuzaki K, Takamatsu S, Kitanaka S. Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3 T3-L1 cells and nitric oxide production in RAW264.7 cells. Molecules 2011, 16(7):6010-6022.
57. Lee JC, Won SJ, Chao CL, Wu FL, Liu HS, Ling P, Lin CN, Su CL. Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. Biochem Biophys Res Co 2008, 372(1):236-242.