Anti-inflammatory effects of methanol extracts of the root of Lilium lancifolium on LPS-stimulated Raw264.7 cells

Journal of Ethnopharmacology

Volumn 130, Issue 1, 2010, Pages 28-34

  Kwon, Ok Kyoung ^a   Lee, Mee Young ^b   Yuk, Ji Eun ^a   Oh, Sei Ryang ^a   Chin, Young Won ^a   Lee, Hyeong Kyu ^a   Ahn, Kyung Seop ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

COX 2; IL 13; IL 4; Inflammation; INOS; Lilium lancifolium; NF B; TNF alpha

Indexed keywords

CONCANAVALIN A; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 6; LILIUM LANCIFOLIUM EXTRACT; LIPOPOLYSACCHARIDE; METHANOL; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; CYTOKINE; PROTEIN KINASE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRONCHITIS; CYTOKINE PRODUCTION; DRUG INDICATION; ENZYME PHOSPHORYLATION; LILIUM LANCIFOLIUM; LILY; MOUSE; NONHUMAN; PLANT ROOT; PNEUMONIA; ANIMAL; CELL LINE; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; METABOLISM; PHOSPHORYLATION; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CELL LINE; CYCLOOXYGENASE 2; CYTOKINES; DINOPROSTONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; LILIUM; LIPOPOLYSACCHARIDES; METHANOL; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PLANT EXTRACTS; PLANT ROOTS; PROTEIN KINASES;

LILIUM TIGRINUM;

EID: 77953807452     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.04.002     Document Type: Article

References (26)

1. Aggarwal B.B., Shishodia S., Sandur S.K., Pandey M.K., Sethi G. Inflammation and cancer: how hot is the link?. Biochemical Pharmacology 2006, 72:1605-1621.
2. Bosca L., Zeini M., Traves P.G., Hortelano S. Nitric oxide and cell viability in inflammatory cells: a role for NO in macrophage function and fate. Toxicology 2005, 208:249-258.
3. Breitbach K., Klocke S., Tschernig T., van Rooijen N., Baumann U., Steinmetz I. Role of inducible nitric oxide synthase and NADPH oxidase in early control of Burkholderia pseudomallei infection in mice. Infection and Immunity 2006, 74:6300-6309.
4. Choi C.R. Dongeebokam-Jabbeongpyun 2003, Pooreunsasang, Seoul.
5. Cunha I.W., Lopes A., Falzoni R., Soares F.A. Sarcomas often express constitutive nitric oxide synthases (NOS) but infrequently inducible NOS. Applied Immunohistochemistry & Molecular Morphology 2006, 14:404-410.
6. Farley K.S., Wang L.F., Razavi H.M., Law C., Rohan M., McCormack D.G., Mehta S. Effects of macrophage inducible nitric oxide synthase in murine septic lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology 2006, 290:L1164-L1172.
7. Gao Y.T., Panda S.P., Roman L.J., Martasek P., Ishimura Y., Masters B.S. Oxygen metabolism by neuronal nitric-oxide synthase. Journal of Biological Chemistry 2007, 282:7921-7929.
8. Geng Y., Zhang B., Lotz M. Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes. Journal of Immunology 1993, 151:6692-6700.
9. Geppert T.D., Whitehurst C.E., Thompson P., Beutler B. Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway. Molecular Medicine 1994, 1:93-103.
10. Hambleton J., Weinstein S.L., Lem L., DeFranco A.L. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proceedings of the National Academy of Sciences of the United States of America-Physical Sciences 1996, 93:2774-2778.
11. Han J., Lee J.D., Bibbs L., Ulevitch R.J. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 1994, 265:808-811.
12. Hortelano S., Zeini M., Bosca L. Nitric oxide and resolution of inflammation. Methods Enzymology 2002, 359:459-465.
13. Joung Y.M., Park S.J., Lee K.Y., Lee J.Y., Suh J.K., Hwang S.Y., Park K.E., Kang M.H. Antioxidative and antimicrobial activities of Lilium species extracts prepared from different aerial parts. Korean Journal of Food Science and Technology 2007, 39.
14. Kim H.S., Ye S.K., Cho I.H., Jung J.E., Kim D.H., Choi S., Kim Y.S., Park C.G., Kim T.Y., Lee J.W., Chung M.H. 8-hydroxydeoxyguanosine suppresses NO production and COX-2 activity via Rac1/STATs signaling in LPS-induced brain microglia. Free Radical Biology and Medicine 2006, 41:1392-1403.
15. Korhonen R., Lahti A., Kankaanranta H., Moilanen E. Nitric oxide production and signaling in inflammation. Current Drug Targets Inflammatory Allergy 2005, 4:471-479.
16. Locksley R.M., Killeen N., Lenardo M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001, 104:487-501.
17. Moncada S. Nitric oxide: discovery and impact on clinical medicine. Journal of the Royal Society of Medicine 1999, 92:164-169.
18. Nakano H., Shindo M., Sakon S., Nishinaka S., Mihara M., Yagita H., Okumura K. Differential regulation of IκB kinase alpha and beta by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proceedings of the National Academy of Sciences of the United States of America-Physical Sciences 1998, 95:3537-3542.
19. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB Journal 1992, 6:3051-3064.
20. Paige J.S., Jaffrey S.R. Pharmacologic manipulation of nitric oxide signaling: targeting NOS dimerization and protein-protein interactions. Current Topics in Medical Chemistry 2007, 7:97-114.
21. Park H.J., Kim I.T., Won J.H., Jeong S.H., Park E.Y., Nam J.H., Choi J., Lee K.T. Anti-inflammatory activities of ent-16alphaH,17-hydroxy-kauran-19-oic acid isolated from the roots of Siegesbeckia pubescens are due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-κB inactivation. European Journal of Pharmacology 2007, 558:185-193.
22. Rahman A., Yatsuzuka R., Jiang S., Ueda Y., Kamei C. Involvement of cyclooxygenase-2 in allergic nasal inflammation in rats. International Journal of Immunopharmacology 2006, 6:1736-1742.
23. Rose-John S., Waetzig G.H., Scheller J., Grotzinger J., Seegert D. The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opinion on Therapeutic Targets 2007, 11:613-624.
24. Sacco R.E., Waters W.R., Rudolph K.M., Drew M.L. Comparative nitric oxide production by LPS-stimulated monocyte-derived macrophages from Ovis canadensis and Ovis aries. Comparative Immunological and Microbiological Infectious Disease 2006, 29:1-11.
25. Tsatsanis C., Androulidaki A., Venihaki M., Margioris A.N. Signalling networks regulating cyclooxygenase-2. International Journal of Biochemical Cell Biology 2006, 38:1654-1661.
26. Zhang X., Wang H., Ng T.B. Isolation and characterization of a novel trypsin inhibitor from fresh lily bulbs. Planta Medica 2008, 74:546-550.