Endostatin and kidney fibrosis in aging: A case for antagonistic pleiotropy?

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 306, Issue 12, 2014, Pages

  Sarah Lin, Chi Hua ^a   Chen, Jun ^a   Ziman, Bruce ^b   Marshall, Shannon ^b   Maizel, Julien ^c   Goligorsky, Michael S ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c AMIENS UNIVERSITY HOSPITAL   (France)

Author keywords

Aging; Antiangiogenesis; Dormant tumors; Endostatin

Indexed keywords

ENDOSTATIN; SIRTUIN 1; SIRTUIN 3;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; INTERSTITIAL NEPHRITIS; KIDNEY FIBROSIS; MICROANGIOPATHY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION;

AGING; ANTIANGIOGENESIS; DORMANT TUMORS; ENDOSTATIN;

AGING; ANIMALS; ENDOSTATINS; FIBROSIS; GENETIC PLEIOTROPY; KIDNEY; MICE; MICROVESSELS; MODELS, ANIMAL; NEOVASCULARIZATION, PHYSIOLOGIC; REGIONAL BLOOD FLOW; SIRTUIN 1; SIRTUIN 3;

EID: 84902668883     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00064.2014     Document Type: Article

References (50)

1. Ahluwalia A, Jones MK, Deng X, Sandor Z, Szabo S, Tarnawski AS. An imbalance between VEGF and endostatin underlies impaired angiogenesis in gastric mucosa of aging rats. Am J Physiol Gastrointest Liver Physiol 305: G325-G332, 2013.
2. Anderson S, Halter JB, Hazzard WR, Himmelfarb J, Horne FM, Kaysen GA, Kusek JW, Nayfield SG, Schmader K, Tian Y, Ashworth JR, Clayton CP, Parker RP, Tarver ED, Woolard NF, High KP. Prediction, progression, and outcomes of chronic kidney disease in older adults. J Am Soc Nephrol 20: 1199-1209, 2009.
3. Arenillas JF, Alvarez-Sabin J, Montaner J, Rosell A, Molina CA, Rovira A, Ribo M, Sanchez E, Quintana M. Angiogenesis in symptom-atic intracranial atherosclerosis: predominance of the inhibitor endostatin is related to a greater extent and risk of recurrence. Stroke 36: 92-97, 2005.
4. Aubert G, Lansdorp PM. Telomeres and aging. Physiol Rev 88: 557-579, 2008.
5. Benigni A, Corna D, Zoja C, Sonzogni A, Latini R, Salio M, Conti S, Rottoli D, Longaretti L, Cassis P, Morigi M, Coffman TM, Remuzzi G. Disruption of the Ang II type 1 receptor promotes longevity in mice. J Clin Invest 119: 524-530, 2009.
6. Blasco MA. Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet 6: 611-622, 2005.
7. Bruserud O, Grovan F, Lindas R, Blymke Moinichen C, Osterhus KK. Serum levels of angioregulatory mediators in healthy individuals depend on age and physical activity: studies of angiogenin, basic fibroblast growth factor, leptin and endostatin. Scand J Clin Lab Invest 65: 505-511, 2005.
8. Campisi J. Cancer and ageing: rival demons? Nat Rev Cancer 3: 339-349, 2003.
9. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120: 513-522, 2005.
10. Chen J, Xavier S, Moskowitz-Kassai E, Chen R, Lu CY, Sanduski K, Spes A, Turk B, Goligorsky MS. Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence. Am J Pathol 180: 973-983, 2012.
11. Donmez G, Guarente L. Aging and disease: connections to sirtuins. Aging Cell 9: 285-290, 2010.
12. Emerich DF, Schneider P, Bintz B, Hudak J, Thanos CG. Aging reduces the neuroprotective capacity, VEGF secretion, and metabolic activity of rat choroid plexus epithelial cells. Cell Transplant 16: 697-705, 2007.
13. Esposito C, He CJ, Striker GE, Zalups RK, Striker LJ. Nature and severity of the glomerular response to nephron reduction is strain-dependent in mice. Am J Pathol 154: 891-897, 1999.
14. Felbor U, Dreier L, Bryant RA, Ploegh HL, Olsen BR, Mothes W. Secreted cathepsin L generates endostatin from collagen XVIII. EMBO J 19: 1187-1194, 2000.
15. Ferreras M, Felbor U, Lenhard T, Olsen BR, Delaisse J. Generation and degradation of human endostatin proteins by various proteinases. FEBS Lett 486: 247-251, 2000.
16. Giaimo S, d'Adda di Fagagna F. Is cellular senescence an example of antagonistic pleiotropy? Aging Cell 11: 378-383, 2012.
17. Guarente L, Franklin H. Epstein Lecture: sirtuins L, aging, medicine. N Engl J Med 364: 2235-2244, 2011.
18. Guarente L. Mitochondria-a nexus for aging, calorie restriction, and sirtuins? Cell 132: 171-176, 2008.
19. Haigis MC, Yankner BA. The aging stress response. Mol Cell 40: 333-344, 2010.
20. Haines DC, Chattopadhyay S, Ward JM. Pathology of aging B6;129 mice. Toxicol Pathol 29: 653-661, 2001.
21. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460, 1990.
22. Kim YM, Hwang S, Pyun BJ, Kim TY, Lee ST, Gho YS, Kwon YG. Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/Flk-1. J Biol Chem 277: 27872-27879, 2002.
23. Lahteenvuo J, Rosenzweig A. Effects of aging on angiogenesis. Circ Res 110: 1252-1263, 2012.
24. Ma LJ, Fogo AB. Model of robust induction of glomerulosclerosis in mice: importance of genetic background. Kidney Int 64: 350-355, 2003.
25. Maeshima Y, Makino H. Angiogenesis and chronic kidney disease. Fibrogenesis Tissue Repair 3: 13, 2010.
26. Mahmoud M, Upton PD, Arthur HM. Angiogenesis regulation by TGFbeta signaling: clues from an inherited vascular disease. Biochem Soc Trans 39: 1659-1666, 2011.
27. Marzetti E, Csiszar A, Dutta D, Balagopal G, Calvani R, Leeuwenburgh C. Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics. Am J Physiol Heart Circ Physiol 305: H459-H476, 2013.
28. Masoro EJ. Aging: current concepts. Aging Clin Exp Res 9: 436-437, 1997.
29. Miled C, Pontoglio M, Garbay S, Yaniv M, Weitzman JB. A genomic map of p53 binding sites identifies novel p53 targets involved in an apoptotic network. Cancer Res 65: 5096-5104, 2005.
30. Miyazaki R, Ichiki T, Hashimoto T, Inanaga K, Imayama I, Sadoshima J, Sunagawa K. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 28: 1263-1269, 2008.
31. Morgan RG, Ives SJ, Lesniewski LA, Cawthon RM, Andtbacka RH, Noyes RD, Richardson RS, Donato AJ. Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries. Am J Physiol Heart Circ Physiol 305: H251-H258, 2013.
32. Musso O, Rehn M, Saarela J, Theret N, Lietard J, Hintikka Lotrian D, Campion JP, Pihlajaniemi T, Clement B. Collagen XVIII is localized in sinusoids and basement membrane zones and expressed by hepatocytes and activated stellate cells in fibrotic human liver. Hepatology 28: 98-107, 1998.
33. Naumov GN, Akslen LA, Folkman J. Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch. Cell Cycle 5: 1779-1787, 2006.
34. O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88: 277-285, 1997.
35. Oshikawa J, Kim SJ, Furuta E, Caliceti C, Chen GF, McKinney RD, Kuhr F, Levitan I, Fukai T, Ushio-Fukai M. Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells. Am J Physiol Heart Circ Physiol 302: H724-H732, 2012.
36. Paddenberg R, Faulhammer P, Goldenberg A, Kummer W. Hypoxiainduced increase of endostatin in murine aorta and lung. Histochem Cell Biol 125: 497-508, 2006.
37. Paez D, Labonte MJ, Bohanes P, Zhang W, Benhanim L, Ning Y, Wakatsuki T, Loupakis F, Lenz HJ. Cancer dormancy: a model of early dissemination and late cancer recurrence. Clin Cancer Res 18: 645-653, 2012.
38. Pili R, Guo Y, Chang J, Nakanishi H, Martin GR, Passaniti A. Altered angiogenesis underlying age-dependent changes in tumor growth. J Natl Cancer Inst 86: 1303-1314, 1994.
39. Ramchandran R, Dhanabal M, Volk R, Waterman MJ, Segal M, Lu H, Knebelmann B, Sukhatme VP. Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin. Biochem Biophys Res Commun 255: 735-739, 1999.
40. Rubinsztein DC, Marino G, Kroemer G. Autophagy and aging. Cell 146: 682-695, 2011.
41. Sahin E, DePinho RA. Axis of ageing: telomeres, p53 and mitochondria. Nat Rev Mol Cell Biol 13: 397-404, 2012.
42. Sasaki T, Larsson H, Tisi D, Claesson-Welsh L, Hohenester E, Timpl R. Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity. J Mol Biol 301: 1179-1190, 2000.
43. Skovseth DK, Veuger MJ, Sorensen DR, De Angelis PM, Haraldsen G. Endostatin dramatically inhibits endothelial cell migration, vascular morphogenesis, and perivascular cell recruitment in vivo. Blood 105: 1044-1051, 2005.
44. Teodoro JG, Parker AE, Zhu X, Green MR. p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase. Science 313: 968-971, 2006.
45. Tjin Tham Sjin RM, Satchi-Fainaro R, Birsner AE, Ramanujam VM, Folkman J, Javaherian K. A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity. Cancer Res 65: 3656-3663, 2005.
46. Vasko R, Xavier S, Chen J, Lin CH, Ratliff B, Rabadi M, Maizel J, Tanokuchi R, Zhang F, Cao J, Goligorsky MS. Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence. J Am Soc Nephrol 25: 276-291, 2014.
47. Vigneron A, Vousden KH. p53, ROS and senescence in the control of aging. Aging (Albany NY) 2: 471-474, 2010.
48. Williams CG. Pleiotropy, natural selection, and the evolution of senescence. Evolution 11: 398-411, 1957.
49. Yang H, Fogo AB. Cell senescence in the aging kidney. J Am Soc Nephrol 21: 1436-1439, 2010.
50. Zheng F, Plati AR, Potier M, Schulman Y, Berho M, Banerjee A, Leclercq B, Zisman A, Striker LJ, Striker GE. Resistance to glomerulosclerosis in B6 mice disappears after menopause. Am J Pathol 162: 1339-1348, 2003.