메뉴 건너뛰기




Volumn 13, Issue 6, 2014, Pages 1503-1513

Immunotherapy for hepatoma using a dual-function vector with both immunostimulatory and Pim-3-silencing effects

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; PROTEIN DERIVATIVE; PROTEIN KINASE PIM 3; SHORT HAIRPIN RNA; SINGLE STRANDED RNA; TOLL LIKE RECEPTOR 7; UNCLASSIFIED DRUG; ONCOPROTEIN; PIM3 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA;

EID: 84902659434     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-13-0722     Document Type: Article
Times cited : (23)

References (45)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70. (Pubitemid 30046295)
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 33645745475 scopus 로고    scopus 로고
    • Targeting PIM kinases impairs survival of hematopoietic cells transformed by kinase inhibitor-sensitive and kinase inhibitor-resistant forms of Fms-Like tyrosine kinase 3 and BCR/ABL
    • Adam M, Pogacic V, Bendit M, Chappuis R, Nawijn MC, Duyster J, et al. Targeting PIM kinases impairs survival of hematopoietic cells transformed by kinase inhibitor-sensitive and kinase inhibitor-resistant forms of Fms-Like tyrosine kinase 3 and BCR/ABL. Cancer Res 2006;66:7-14.
    • (2006) Cancer Res , vol.66 , pp. 7-14
    • Adam, M.1    Pogacic, V.2    Bendit, M.3    Chappuis, R.4    Nawijn, M.C.5    Duyster, J.6
  • 3
    • 77953180976 scopus 로고    scopus 로고
    • PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers
    • Brault L, Gasser C, Bracher F, Huber K, Knapp S, Schwaller J. PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. Haematologica 2010;95:1004-15.
    • (2010) Haematologica , vol.95 , pp. 1004-1015
    • Brault, L.1    Gasser, C.2    Bracher, F.3    Huber, K.4    Knapp, S.5    Schwaller, J.6
  • 4
    • 79960411328 scopus 로고    scopus 로고
    • Roles of Pim-3, a novel survival kinase, in tumorigenesis
    • Mukaida N, Wang YY, Li YY. Roles of Pim-3, a novel survival kinase, in tumorigenesis. Cancer Sci 2011;102:1437-42.
    • (2011) Cancer Sci , vol.102 , pp. 1437-1442
    • Mukaida, N.1    Wang, Y.Y.2    Li, Y.Y.3
  • 5
    • 33746122005 scopus 로고    scopus 로고
    • Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines
    • DOI 10.1158/0008-5472.CAN-05-4272
    • Li YY, Popivanova BK, Nagai Y, Ishikura H, Fujii C, Mukaida N. Pim-3, a proto-oncogene with serine/threonine kinase is aberrantly expressed in human pancreatic cancer and phosphorylates Bad to block Badmediate apoptosis in human pancreatic cancer cell lines activity. Cancer Res 2006;66:6741-7. (Pubitemid 44085632)
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6741-6747
    • Li, Y.-Y.1    Popivanova, B.K.2    Nagai, Y.3    Ishikura, H.4    Fujii, C.5    Mukaida, N.6
  • 6
    • 33846701190 scopus 로고    scopus 로고
    • Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis
    • DOI 10.1111/j.1349-7006.2007.00390.x
    • Popivanova BK, Li YY, Zheng H, Omura K, Fujii C, Tsuneyama K, et al. Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis. Cancer Sci 2007;98:321-8. (Pubitemid 46195601)
    • (2007) Cancer Science , vol.98 , Issue.3 , pp. 321-328
    • Popivanova, B.K.1    Li, Y.-Y.2    Zheng, H.3    Omura, K.4    Fujii, C.5    Tsuneyama, K.6    Mukaida, N.7
  • 7
    • 13244284663 scopus 로고    scopus 로고
    • Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines
    • DOI 10.1002/ijc.20719
    • Fujii C, Nakamoto Y, Lu P. Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. Int J Cancer 2005;114:209-18. (Pubitemid 40194286)
    • (2005) International Journal of Cancer , vol.114 , Issue.2 , pp. 209-218
    • Fujii, C.1    Nakamoto, Y.2    Lu, P.3    Tsuneyama, K.4    Popivanova, B.K.5    Kaneko, S.6    Mukaida, N.7
  • 8
    • 33847650413 scopus 로고    scopus 로고
    • Cancer immunosurveillance, immunoediting and inflammation: Independent or interdependent processes?
    • DOI 10.1016/j.coi.2007.02.001, PII S095279150700009X, Lymphocyte development/Tumour immunology
    • Bui JD, Schreiber RD. Cancer immunosurveillance, immunoediting and in.ammation: independent or interdependent processes? Curr Opin Immunol 2007;19:203-8. (Pubitemid 46356963)
    • (2007) Current Opinion in Immunology , vol.19 , Issue.2 , pp. 203-208
    • Bui, J.D.1    Schreiber, R.D.2
  • 9
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 11
    • 84855371207 scopus 로고    scopus 로고
    • New immune therapy targets tumor-associated environment: From bone marrow to tumor site
    • Fu YX. New immune therapy targets tumor-associated environment: from bone marrow to tumor site. Cell Mol Immunol 2012;9:1-2.
    • (2012) Cell Mol Immunol , vol.9 , pp. 1-2
    • Fu, Y.X.1
  • 12
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010, 11:373-84.
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 13
    • 34548430160 scopus 로고    scopus 로고
    • The role of type I interferons in TLR responses
    • DOI 10.1038/sj.icb.7100099, PII 7100099
    • Noppert SJ, Fitzgerald KA, Hertzog PJ. The role of type I interferons in TLR responses. Immunol Cell Biol 2007;85:446-57. (Pubitemid 47367509)
    • (2007) Immunology and Cell Biology , vol.85 , Issue.6 , pp. 446-457
    • Noppert, S.J.1    Fitzgerald, K.A.2    Hertzog, P.J.3
  • 17
    • 50649093779 scopus 로고    scopus 로고
    • The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy
    • Smits EL, Ponsaerts P, Berneman ZN, Van Tendeloo VF. The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy. Oncologist 2008;13:859-75.
    • (2008) Oncologist , vol.13 , pp. 859-875
    • Smits, E.L.1    Ponsaerts, P.2    Berneman, Z.N.3    Van Tendeloo, V.F.4
  • 18
    • 84863152143 scopus 로고    scopus 로고
    • Small intestinal intraepithelial lymphocytes expressing CD8 and T cell receptor γδ are involved in bacterial clearance during Salmonella enterica serovar Typhimurium infection
    • Li Z, Zhang C, Zhou Z, Zhang J, Zhang J, Tian Z. Small intestinal intraepithelial lymphocytes expressing CD8 and T cell receptor γδ are involved in bacterial clearance during Salmonella enterica serovar Typhimurium infection. Infect Immun 2012;80:565-74.
    • (2012) Infect Immun , vol.80 , pp. 565-574
    • Li, Z.1    Zhang, C.2    Zhou, Z.3    Zhang, J.4    Zhang, J.5    Tian, Z.6
  • 19
    • 84879601220 scopus 로고    scopus 로고
    • Therapeutic recovery of HBV-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance
    • Lan P, Zhang C, Han Q, Zhang J, Tian Z. Therapeutic recovery of HBV-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance. Hepatology 2013;58:73-85.
    • (2013) Hepatology , vol.58 , pp. 73-85
    • Lan, P.1    Zhang, C.2    Han, Q.3    Zhang, J.4    Tian, Z.5
  • 20
    • 0028111256 scopus 로고
    • Liposome mediated depletion of macrophages: Mechanism of action, preparation of liposomes and applications
    • Van Rooijen N, Sanders A. Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J Immunol Methods 1994;174:83-93.
    • (1994) J Immunol Methods , vol.174 , pp. 83-93
    • Van Rooijen, N.1    Sanders, A.2
  • 22
  • 24
    • 3343007095 scopus 로고    scopus 로고
    • 112 gatekeeper site
    • DOI 10.1016/j.febslet.2004.06.050, PII S0014579304008026
    • Aho TL, Sandholm J, Peltola KJ, Mankonen HP, Lilly M, Koskinen PJ. Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site. FEBS Lett 2004;571:43-9. (Pubitemid 38992921)
    • (2004) FEBS Letters , vol.571 , Issue.1-3 , pp. 43-49
    • Aho, T.L.T.1    Sandholm, J.2    Peltola, K.J.3    Mankonen, H.P.4    Lilly, M.5    Koskinen, P.J.6
  • 27
    • 1542317550 scopus 로고    scopus 로고
    • Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA
    • DOI 10.1126/science.1093616
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innateantiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004;303:1529-31. (Pubitemid 38314425)
    • (2004) Science , vol.303 , Issue.5663 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis E, S.C.5
  • 30
    • 77951092205 scopus 로고    scopus 로고
    • Accelerated hepatocellular carcinoma development in mice expressing expressing the Pim-3 transgene selectively in the liver
    • Wu Y, Wang YY, Nakamoto Y, Li YY, Baba T, Kaneko S, et al. Accelerated hepatocellular carcinoma development in mice expressing expressing the Pim-3 transgene selectively in the liver. Oncogene 2010; 29:2228-37.
    • (2010) Oncogene , vol.29 , pp. 2228-2237
    • Wu, Y.1    Wang, Y.Y.2    Nakamoto, Y.3    Li, Y.Y.4    Baba, T.5    Kaneko, S.6
  • 31
    • 23944469591 scopus 로고    scopus 로고
    • Expression of human pim family genes is selectively up-regulated by cytokines promoting T helper type 1, but not T helper type 2, cell differentiation
    • DOI 10.1111/j.1365-2567.2005.02201.x
    • Aho TL, Lund RJ, Ylikoski EK, Matikainen S, Lahesmaa R, Koskinen PJ. Expression of human pim family genes is selectively up-regulated by cytokines promoting T helper type 1, but not T helper type 2, cell differentiation. Immunology 2005;116:82-8. (Pubitemid 41208355)
    • (2005) Immunology , vol.116 , Issue.1 , pp. 82-88
    • Aho, T.L.T.1    Lund, R.J.2    Ylikoski, E.K.3    Matikainen, S.4    Lahesmaa, R.5    Koskinen, P.J.6
  • 32
    • 0033560095 scopus 로고    scopus 로고
    • Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Rα, c-myc, and pim-1 genes in human T cells
    • Matikainen S, Sareneva T, Ronni T, Lehtonen A, Koskinen PJ, Julkunen I. Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Rα, c-myc, and pim-1 genes in human T cells. Blood 1999;93:1980-91. (Pubitemid 29128500)
    • (1999) Blood , vol.93 , Issue.6 , pp. 1980-1991
    • Matikainen, S.1    Sareneva, T.2    Ronni, T.3    Lehtonen, A.4    Koskinen, P.J.5    Julkunen, I.6
  • 33
    • 62849113353 scopus 로고    scopus 로고
    • Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells
    • Li YY, Wu Y, Tsuneyama K, Baba T, Mukaida N. Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells. Cancer Sci 2009;100:396-404.
    • (2009) Cancer Sci , vol.100 , pp. 396-404
    • Li, Y.Y.1    Wu, Y.2    Tsuneyama, K.3    Baba, T.4    Mukaida, N.5
  • 34
    • 77954229780 scopus 로고    scopus 로고
    • Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7
    • Bourquin C, Schmidt L, Lanz AL, Storch B, Wurzenberger C, Anz D, et al. Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7. J Immunol 2009;183:6078-86.
    • (2009) J Immunol , vol.183 , pp. 6078-6086
    • Bourquin, C.1    Schmidt, L.2    Lanz, A.L.3    Storch, B.4    Wurzenberger, C.5    Anz, D.6
  • 35
  • 36
    • 84875226194 scopus 로고    scopus 로고
    • Down-regulation of Toll-like receptor 7 expression in hepatitis-virus-related human hepatocellular carcinoma
    • Lin KJ, Lin TM, Wang CH, Liu HC, Lin YL, Eng HL. Down-regulation of Toll-like receptor 7 expression in hepatitis-virus-related human hepatocellular carcinoma. Hum Pathol 2013;44:534-41.
    • (2013) Hum Pathol , vol.44 , pp. 534-541
    • Lin, K.J.1    Lin, T.M.2    Wang, C.H.3    Liu, H.C.4    Lin, Y.L.5    Eng, H.L.6
  • 37
    • 73449145993 scopus 로고    scopus 로고
    • Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells
    • Chang S, Kodys K, Szabo G. Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells. Hepatology 2010;51:35-42.
    • (2010) Hepatology , vol.51 , pp. 35-42
    • Chang, S.1    Kodys, K.2    Szabo, G.3
  • 38
    • 84857033446 scopus 로고    scopus 로고
    • siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo
    • Khairuddin N, Gantier MP, Blake SJ, Wu SY, Behlke MA, Williams BR, et al. siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo. Immunol Cell Biol 2012;90:187-96.
    • (2012) Immunol Cell Biol , vol.90 , pp. 187-196
    • Khairuddin, N.1    Gantier, M.P.2    Blake, S.J.3    Wu, S.Y.4    Behlke, M.A.5    Williams, B.R.6
  • 39
    • 78650640612 scopus 로고    scopus 로고
    • Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity
    • Fotin-Mleczek M, Duchardt KM, Lorenz C, Pfeiffer R, Ojkić-Zrna S, Probst J, et al. Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity. J Immunother 2011;34:1-15.
    • (2011) J Immunother , vol.34 , pp. 1-15
    • Fotin-Mleczek, M.1    Duchardt, K.M.2    Lorenz, C.3    Pfeiffer, R.4    Ojkić-Zrna, S.5    Probst, J.6
  • 40
    • 67449108173 scopus 로고    scopus 로고
    • TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA
    • Berger M, Ablasser A, Kim S, Bekeredjian-Ding I, Giese T, Endres S, et al. TLR8-driven IL-12-dependent reciprocal and synergistic activation of NK cells and monocytes by immunostimulatory RNA. J Immunother 2009;32:262-71.
    • (2009) J Immunother , vol.32 , pp. 262-271
    • Berger, M.1    Ablasser, A.2    Kim, S.3    Bekeredjian-Ding, I.4    Giese, T.5    Endres, S.6
  • 41
    • 22544473593 scopus 로고    scopus 로고
    • TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-γ production
    • Hart OM, Athie-Morales V, O'Connor GM, Gardiner CM. TLR7/8- mediated activation of human NK cells results in accessory celldependent IFN-γ production. J Immunol 2005;175:1636-42. (Pubitemid 41023066)
    • (2005) Journal of Immunology , vol.175 , Issue.3 , pp. 1636-1642
    • Hart, O.M.1    Athie-Morales, V.2    O'Connor, G.M.3    Gardiner, C.M.4
  • 43
    • 34548654133 scopus 로고    scopus 로고
    • Cross-talk between T cells and innate immune cells is crucial for IFN-γ-dependent tumor rejection
    • Li Z, Pradera F, Kammertoens T, Li B, Liu S, Qin Z. Cross-talk between T cells and innate immune cells is crucial for IFN-γ-dependent tumor rejection. J Immunol 2007;179:1568-76.
    • (2007) J Immunol , vol.179 , pp. 1568-1576
    • Li, Z.1    Pradera, F.2    Kammertoens, T.3    Li, B.4    Liu, S.5    Qin, Z.6
  • 45
    • 79960956913 scopus 로고    scopus 로고
    • Systemic cancer therapy with a small molecule agonist of toll-like receptor 7 can be improved by circumventing TLR tolerance
    • Bourquin C, Hotz C, Noerenberg D, Voelkl A, Heidegger S, Roetzer LC, et al. Systemic cancer therapy with a small molecule agonist of toll-like receptor 7 can be improved by circumventing TLR tolerance. Cancer Res 2011;71:5123-33.
    • (2011) Cancer Res , vol.71 , pp. 5123-5133
    • Bourquin, C.1    Hotz, C.2    Noerenberg, D.3    Voelkl, A.4    Heidegger, S.5    Roetzer, L.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.