Small intestinal intraepithelial lymphocytes expressing CD8 and T cell receptor γδ are involved in bacterial clearance during salmonella enterica serovar typhimurium infection

Infection and Immunity

Volumn 80, Issue 2, 2012, Pages 565-574

  Li, Zhiyuan ^a   Zhang, Cai ^a   Zhou, Zhixia ^a   Zhang, Jianhua ^a   Zhang, Jian ^a   Tian, Zhigang ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CD8 ANTIGEN; MURINE ULIB BINDING PROTEIN LIKE TRANSCRIPT 1; NATURAL KILLER CELL RECEPTOR NKG2D; QA 1 PROTEIN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR GAMMA DELTA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL GROWTH; BACTERIAL IMMUNITY; CELL EXPANSION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOLYSIS; DOWN REGULATION; ENTERITIS; EPITHELIUM CELL; INTESTINE CELL; LYMPHOCYTE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; LYMPHOCYTOTOXICITY; MALE; MOUSE; MOUTH INFECTION; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SALMONELLA ENTERICA; SMALL INTESTINE INTRAEPITHELIAL LYMPHOCYTE; TYPHOID FEVER; UPREGULATION;

ANIMALS; ANTIGENS, CD8; CELL LINE, TUMOR; ENTERITIS; GENE EXPRESSION REGULATION; INTESTINE, SMALL; LYMPHOCYTES; MALE; MICE; MICE, INBRED C57BL; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SALMONELLA INFECTIONS, ANIMAL; SALMONELLA TYPHIMURIUM;

EID: 84863152143     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.05078-11     Document Type: Article

References (30)

1. Bao S, Beagley K, France M, Shen J, Husband A. 2000. Interferon-γ plays a critical role in intestinal immunity against Salmonella typhimurium infection. Immunology 99:464-472.
2. + intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J. Clin. Invest. 118:281-293.
3. Carding SR, Egan PJ. 2002.γδT cells: functional plasticity and heterogeneity. Nat. Rev. Immunol. 2:336-345.
4. Coburn B, Li Y, Owen D, Vallance BA, Finlay BB. 2005. Salmonella enterica serovar Typhimurium pathogenicity island 2 is necessary for complete virulence in a mouse model of infectious enterocolitis. Infect. Immun. 73:3219-3227.
5. Das G, Janeway CA. 1999. Development of CD8α/α and CD8α/β T cells in major histocompatibility complex class I-deficient mice. J. Exp. Med. 190:881-884.
6. Davies A, et al. 2004. Infection-Induced Expansion of a MHC class Ibdependent intestinal intraepithelialγδT cell subset. J. Immunol. 172: 6828-6837.
7. Groh V, Steinle A, Bauser S, Spies T. 1998. Recognition of stress-induced MHC molecules by intestine epithelial γδ T cells. Science 279:1737-1740.
8. Hayday A, Theodoridis E, Ramsburg E, Shires J. 2001. Intraepithelial lymphocytes: exploring the third way in immunology. Nat. Immunol. 2:997-1003.
9. Hayday A, Tigelaar R. 2003. Immunoregulation in the tissues by γδ T cells. Nat. Rev. Immunol. 3:233-242.
10. Hiromatsu K, et al. 1992. A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice. J. Exp. Med. 175:49-56.
11. Hue S, et al. 2004. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity 21:367-377.
12. + intraepithelial lymphocytes: a unique model to study the regulation of effector cytotoxic T lymphocytes in tissue. Immunol. Rev. 215:202-214.
13. Jabri B, et al. 2002. TCR specificity dictates CD94/NKG2A expression by human CTL. Immunity 17:487-499.
14. Jensen PE, Sullivan BA, Reed-Loisel LM, Weber DA. 2004. Qa-1, a nonclassical class I histocompatibility molecule with roles in innate and adaptive immunity. Immunol. Res. 29:81-92.
15. Jiang H. 2005. The Qa-1 dependent CD8+ T cell mediated regulatory pathway. Cell. Mol. Immunol. 2:161-167.
16. Jiang H, Chess L. 2009. How the immune system achieves self-nonself discrimination during adaptive immunity. Adv. Immunol. 102:95-133.
17. Kunisawa J, Takahashi I, Kiyono H. 2007. Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine. Immunol. Rev. 215:136-153.
18. Liu X, Lu R, Xia Y, Sun J. 2010. Global analysis of the eukaryotic pathways and networks regulated by Salmonella typhimurium in mouse intestinal infection in vivo. BMC Genomics 11:722.
19. Macartney KK, Baumgart DC, Carding SR, Brubaker JO, Offit PA. 2000. Primary murine small intestinal epithelial cells, maintained in longterm culture, are susceptible to rotavirus infection. J. Virol. 74:5597-5603.
20. Mixter P, Camerini V, Stone B, Miller V, Kronenberg M. 1994. Mouse T lymphocytes that express a gamma delta T-cell antigen receptor contribute to resistance to Salmonella infection in vivo. Infect. Immun. 62:4618-4621.
21. Mombaerts P, Arnoldi J, Russ F, Tonegawa S, Kaufmann SH. 1993. Different roles of alpha beta and gamma delta T cells in immunity against an intracellular bacterial pathogen. Nature 365:53-56.
22. Montufar-Solis D, Klein JR. 2006. An improved method for isolating intraepithelial lymphocytes (IELs) from the murine small intestine with consistently high purity. J. Immunol. Methods 308:251-254.
23. Raulet DH. 2003. Roles of the NKG2D immunoreceptor and its ligands. Nat. Rev. Immunol. 3:781-790.
24. Saphra I, Winter J. 1957. Clinical manifestations of salmonellosis in man: an evaluation of 7779 human infections identified at the New York Salmonella Center. N. Engl. J. Med. 256:1128-1134.
25. + intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). Immunity 15:419-434.
26. van Hall T, Oliveira CC, Joosten SA, Ottenhoff TH. 2010. The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress. Microbes Infect. 12:910-918.
27. Varthaman A, et al. 2010. Control of T cell reactivation by regulatory Qa-1-restricted CD8+ T cells. J. Immunol. 184:6585-6591.
28. Yamamoto M, Fujihashi K, Kawabata K, McGhee JR, Kiyono H. 1998. A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes. J. Immunol. 160:2188-2196.
29. Yamamoto S, Russ F, Teixeira HC, Conradt P, Kaufmann SH. 1993. Listeria monocytogenes-induced gamma interferon secretion by intestinal intraepithelial gamma/delta T lymphocytes. Infect. Immun. 61:2154-2161.
30. Zhou R, Wei H, Sun R, Zhang J, Tian Z. 2007. NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice. Proc. Natl. Acad. Sci. U. S. A. 104:7512-7515.