Oxidative stress mediates radiation lung injury by inducing apoptosis

International Journal of Radiation Oncology Biology Physics

Volumn 83, Issue 2, 2012, Pages 740-748

  Zhang, Yu ^a   Zhang, Xiuwu ^a   Rabbani, Zahid N ^a   Jackson, Isabel L ^b   Vujaskovic, Zeljko ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

Apoptosis; Nox4; PTEN; Radiation; Reactive oxygen species

Indexed keywords

APOPTOTIC CELLS; LUNG INJURY; LUNG TISSUE; NOX4; PARENCHYMAL CELLS; PROTEIN LEVEL; PTEN; PTEN EXPRESSION; PULMONARY TOXICITY; RADIATION-INDUCED; REACTIVE OXYGEN AND NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; SIGNALING PATHWAYS; TRANSFORMING GROWTH FACTORS; TYPE II; UP-REGULATION;

BIOLOGICAL ORGANS; HEAT RADIATION; OXIDATIVE STRESS; OXYGEN; RADIATION; SIGNALING; TISSUE;

CELL DEATH;

[MANGNESE MESO TETRAKIS(N,N' DIETHYLIMIDAZOLIUM 2 YL)PORPHYRIN]; AEOL 10150; APOPTOSIS INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BAX; PROTEIN KINASE B; PROTEIN P53; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SCAVENGER; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWNSTREAM PROCESSING; ENDOTHELIUM; FEMALE; HYPOTHESIS; INTRACELLULAR SIGNALING; IRRADIATION; LUNG ALVEOLUS CELL TYPE 1; LUNG ALVEOLUS CELL TYPE 2; LUNG INJURY; LUNG PARENCHYMA; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION INJURY; UPREGULATION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; ENDOTHELIUM; FEMALE; IN SITU NICK-END LABELING; LUNG; LUNG INJURY; METALLOPORPHYRINS; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; NADPH OXIDASE; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PNEUMOCYTES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RADIATION INJURIES; RANDOM ALLOCATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84862796552     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.08.005     Document Type: Article

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