Modulation of radiation-induced tumour necrosis factor-α and transforming growth factor β1 expression in the lung tissue by Shengqi Fuzheng injection

Molecular Medicine Reports

Volumn 3, Issue 4, 2010, Pages 621-627

  Dong, Xiao Rong ^a   Wang, Jing Na ^a   Liu, Li ^a   Chen, Xue ^a   Chen, Ming Shi ^a   Chen, Juan ^a   Ren, Jing Hua ^a   Li, Qin ^a   Han, Jun ^a  

^a UNION HOSPITAL   (China)

Author keywords

Radiation induced lung injury; Shenqi Fuzheng injection; Transforming growth factor 1; Tumour necrosis factor

Indexed keywords

CHINESE DRUG; CODONOPSIS EXTRACT; COLLAGEN; PHOSPHATE BUFFERED SALINE; RADIX ASTRAGALI EXTRACT; SHENGQI FUZHENG; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CHINESE MEDICINE; CODONOPSIS PILOSULA; CONTROLLED STUDY; FEMALE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IRRADIATION; LUNG FIBROSIS; LUNG INJURY; LUNG PARENCHYMA; LUNG STRUCTURE; MEDIATOR; MODULATION; MOUSE; NONHUMAN; PATHOGENESIS; PH; PNEUMONIA; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; TRADITIONAL MEDICINE;

CODONOPSIS PILOSULA; MUS;

EID: 77956654750     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr-00000306     Document Type: Article

References (49)

1. Ghafoori P, Marks LB, Vujaskovic Z and Kelsey CR: Radiation-induced lung injury. Assessment, management, and prevention. Oncology (Williston Park) 22: 37-47; 52-53, 2008.
2. Marks LB, Munley MT, Bentel GC, Zhou SM, Hollis D, Scarfone C and Sibley GS: Physical and biological predictors of changes in whole-lung function following thoracic irradiation. Int J Radiat Oncol Biol Phys 39: 563-570, 1997.
3. Kong FM, Hayman JA, Griffith KA, Kalemkerian GP, Arenberg D, Lyons S and Turrisi A: Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): predictors for radiation pneumonitis and fibrosis. Int J Radiat Oncol Biol Phys 65: 1075-1086, 2006.
4. Hope AJ, Lindsay PE, ElNaqa I, Alaly JR, Vicic M, Bradley JD and Deasy JO: Modeling radiation pneumonitis risk with clinical, dosimetric, and spatial parameters. Int J Radiat Oncol Biol Phys 65: 112-124, 2006.
5. Ohe Y, Yamamoto S, Suzuki K, Hojo F, Kakinuma R, Matsumoto T and Ohmatsu H: Risk factors of treatment-related death in chemotherapy and thoracic radiotherapy for lung cancer. Eur J Cancer 37: 54-63, 2001.
6. Mehta V: Radiation pneumonitis and pulmonary fibrosis in non-small cell lung cancer: pulmonary function, prediction, and prevention. Int J Radiat Oncol Biol Phys 63: 5-24, 2005.
7. Fan M, Marks LB, Hollis D, Bentel GG, Anscher MS, Sibley G and Coleman RE: Can we predict radiation-induced changes in pulmonary function based on the sum of predicted regional dysfunction? J Clin Oncol 19: 543-550, 2001.
8. Borst GR, Jaeger K, Belderbos JS, Burgers SA and Lebesque JV: Pulmonary function changes after radiotherapy in non-small-cell lung cancer patients with long-term disease-free survival. Int J Radiat Oncol Biol Phys 62: 639-644, 2005.
9. Epperly MW, Franicola D, Zhang X, Nie S, Wang H, Bahnson AB and Shields DS: Reduced irradiation pulmonary fibrosis and stromal cell migration in Smad3-/- marrow chimeric mice. In Vivo 20: 573-582, 2006.
10. Schallenkamp JM, Miller RC, Brinkmann DH, Foote T and Garces YI: Incidence of radiation pneumonitis after thoracic irradiation: dose volume correlates. Int J Radiat Oncol Biol Phys 67: 410-416, 2007.
11. Franko AJ and Sharplin J: Assessment of radiation-induced lung injury in mice using carbon monoxide uptake: correlation with histologically visible damage. Radiat Res 133: 245-251, 1993.
12. Rübe CE, Uthe D, Wilfert F, Ludwig D, Yang K, König J and Palm J: The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation. Int J Radiat Oncol Biol Phys 61: 1482-1492, 2005.
13. Tsoutsou PG and Koukourakis MI: Radiation pneumonitis and fibrosis: mechanisms underlying its pathogenesis and implications for future research. Int J Radiat Oncol Biol Phys 66: 1281-1293, 2006.
14. Rübe CE, Wilfert F, Uthe D, Schmid KW, Knoop R, Willich N and Schuck A: Modulation of radiation-induced tumour necrosis factor alpha (TNF-alpha) expression in the lung tissue by pentoxifylline. Radiother Oncol 64: 177-187, 2002.
15. Rübe CE, Wilfert F, Palm J, König J, Burdak-Rothkamm S, Liu L and Schuck A: Irradiation induces a biphasic expression of pro-inflammatory cytokines in the lung. Strahlenther Onkol 180: 442-448, 2004.
16. Sekine I, Sumi M, Ito Y, Nokihara H, Yamamoto N, Kunitoh H and Ohe Y: Retrospective analysis of steroid therapy for radiation-induced lung injury in lung cancer patients. Radiother Oncol 80: 93-97, 2006.
17. Kosaka Y, Mitsumori M, Araki N, Yamauchi C, Nagata Y, Hiraoka M and Kodama H: Avascular necrosis of bilateral femoral head as a result of long-term steroid administration for radiation pneumonitis after tangential irradiation of the breast. Int J Clin Oncol 11: 482-486, 2006.
18. Yu SZ, Yang GH and Feng JM: Clinical study on treatment of malignant neoplasms with Shenqi Fuzheng Injection and chemotherapy. J Chin Integr Med 4: 84-86, 2006.
19. Dai ZJ, Wang XJ, Kang HF, Ji ZZ, Liu L, Liu XX and Song LQ: Clinical effects of Shengqi Fuzheng Injection in the neoadjuvant chemotherapy for local advanced breast cancer and the effects on T-lymphocytes subsets. J Trad Chin Med 28: 34-38, 2008.
20. Liu L, Ding Q, Dai XF, Zhao YX, Ke Y and Wu G: Study on the controlling effect of Shengqi Fuzheng Injection on plasma cytokine network in patients with thoracic tumor undergoing radiotherapy. Chin J Integrated Trad Western Med 12: 1082-1085, 2007.
21. Sheng LS and Song Min: The component analysis of Shengqi injection. Chinese Prescribed Drug 29: 47-48, 2004.
22. Szapiel SV, Elson NA, Fulmer JD, Hunninghake GW and Crystal RG: Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse. Am Rev Respir Dis 12: 893-899, 1979.
23. Friedrichs K, Gluba S, Eidtmann H and Jonat W: Overexpression of P53 and prognosis in breast cancer. Cancer 72: 3641-3647, 1993.
24. Rübe CE, Uthe D, Schmid KW, Richter KD, Wessel J, Schuck A and Willich N: Dose-dependent induction of transforming growth factor β (TGF-β) in the lung tissue of fibrosis-prone mice after thoracic irradiation. Int J Radiat Oncol Biol Phys 47: 1033-1042, 2000.
25. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005.
26. Bülzebruck H, Bopp R, Drings P, Bauer E, Krysa S, Probst G and van Kaick G: New aspects in the staging of lung cancer. Prospective validation of the international union against cancer TNM classification. Cancer 70: 1102-1110, 1992.
27. Tyldesley S, Boyd C, Schulzem K, Walker H and Mackillop WJ: Estimating the need for radiotherapy for lung cancer: an evidence-based, epidemiologic approach. Int J Radiat Oncol Biol Phys 49: 973-985, 2001.
28. Yamada M, Kudoh S, Hirata K, Nakajima T and Yoshikawa J: Risk factors of pneumonitis following chemoradiotherapy for lung cancer. Eur J Cancer 34: 71-75, 1998.
29. Khan MA, Yeung IWT, Van Dyk J, Yeung IW and Hill RP: Partial volumer at lung irradiation: assessment of early DNA damage in different lung regions and effect of radical scavengers. Radiother Oncol 66: 95-102, 2003.
30. Moiseenko VV, Battista JJ, Hill RP, Travis EL and van Dyk J: In-field and out-of-field effects in partial volume lung irradiation in rodents: possible correlation between early DNA damage and functional endpoints. Int J Radiat Oncol Biol Phys 48: 1539-1548, 2000.
31. Jin H, Tucker SL, Liu HH, Wei X, Yom SS, Wang S and Komaki R: Dose-volume thresholds and smoking status for the risk of treatment-related pneumonitis in inoperable non-small cell lung cancer treated with definitive radiotherapy. Radiother Oncol 91: 427-432, 2009.
32. Robnett TJ, Machtay M, Vines EF, Mckenna MG, Algazy KM and Mckenna WG: Factors predicting severe radiation pneumonitis in patients receiving definitive chemoradiation for lung cancer. Int J Radiat Oncol Biol Phys 48: 89-94, 2000.
33. Hernando ML, Marks LB, Bentel GC, Zhou SM, Hollis D, Das SK and Fan M: Radiation-induced pulmonary toxicity: a dose-volume histogram analysis in 201 patients with lung cancer. Int J Radiat Oncol Biol Phys 51: 650-659, 2001.
34. Yorke ED, Jackson A, Rosenzweig KE, Merrick SA, Gabrys D, Venkatraman ES and Burman CM: Dose-volume factor contributing to the incidence of radiation pneumonitis in non-small- cell lung cancer patients treated with three-dimensional conformal radiationtherapy. Int J Radiat Oncol Biol Phys 54: 329-339, 2002.
35. Rancati T, Ceresoli GL, Gagliardi G, Schipani S and Cattaneo GM: Factors predicting radiation pneumonitis in lung cancer patients: a retrospective study. Radiother Oncol 67: 275-283, 2003.
36. Graham MV, Purdy JA, Emami B, Harms W, Bosch W, Lockett MA and Perez CA: Clinical dose volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys 45: 323-329, 1999.
37. Kwa SL, Lebesque JV, Theuws JC, Marks LB, Munley MT, Bentel G and Oetzel D: Radiation pneumonitis as a function of mean lung dose: ananalysis of pooled data of 540 patients. Int J Radiat Oncol Biol Phys 42: 1-9, 1998.
38. Rodrigues G, Lock M, D Souza D, Yu E and van Dyk J: Prediction of radiation pneumonitis by dose volume histogram parameters in lung cancer a systematic review. Radiother Oncol 71: 127-138, 2004.
39. Herrmann T, Kasper M and Kasper M: Target cells in radiation pneumopathy. Int J Radiat Oncol Biol Phys 2: 463-469, 2004.
40. Zhao L, Sheldon K, Chen M, Yin MS, Hayman JA, Kalemkerian GP and Arenberg D: The predictive role of plasma TGF-beta1 during radiation therapy for radiation-induced lung toxicity deserves further study in patients with non-small cell lung cancer. Lung Cancer 59: 232-239, 2008.
41. Leask A and Abraham DJ: TGF-beta signaling and the fibrotic response. FASEB J 18: 816-827, 2004.
42. Vujaskovic Z, Marks LB and Anscher MS: The physical parameters and molecular events associated with radiation-induced lung toxicity. Semin Radiat Oncol 10: 296-307, 2000.
43. Sanderson N, Factor V, Nagy P, Kopp J, Kondaiah P, Wakeeld L and Roberts AB: Hepatic expression of mature transforming growth factor beta1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci USA 92: 2572-2576, 1995.
44. Chen Y, Williams J, Ding I, Hernady E, Liu W, Smudzin T and Finkelstein JN: Radiation pneumonitis and early circulatory cytokine markers. Semin Radiat Oncol 12 (Suppl 1): 26-33, 2002.
45. Evans ES, Kocak Z, Zhou SM, Kahn DA, Huang H, Hollis DR and Light KL: Does transforming growth factor-1 predict for radiation-induced pneumonitis in patients treated for lung cancer? Cytokine 35: 186-192, 2006.
46. Fu XL, Huang H, Bentel G, Clough R, Jirtle RL, Kong FM and Marks LB: Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V (30) and transforming growth factor beta. Int J Radiat Oncol Biol Phys 50: 899-908, 2001.
47. Anscher MS, Thrasher B, Rabbani Z, Teicher B and Vujaskovic Z: Antitransforming growth factor antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation. Int J Radiat Oncol Biol Phys 65: 876-881, 2006.
48. Zheng W, Gao ZH and Wu LN: The clinical study of combination of Chinese and Western medicine in radiation pneumonitis. Chinese Journal of Integrated Traditional and Western Medicine 27: 1121-1127, 2007.
49. Wang JN and Liu L: The effects of Chinese medicine on radiation-induced lung injury. Modern Oncology 10: 1800-1803, 2008.