메뉴 건너뛰기




Volumn 45, Issue 2, 2014, Pages 795-803

Oridonin inhibits the proliferation of human osteosarcoma cells by suppressing Wnt/β-catenin signaling

Author keywords

Dkk 1; Oridonin; Osteosarcoma; Proliferation inhibition; Wnt catenin signaling

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; DICKKOPF 1 PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; MYC PROTEIN; ORIDONIN; KAURANE DERIVATIVE;

EID: 84902594810     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2456     Document Type: Article
Times cited : (36)

References (50)
  • 1
    • 33748156545 scopus 로고    scopus 로고
    • Primary bone osteosarcoma in the pediatric age: State of the art
    • DOI 10.1016/j.ctrv.2006.05.005, PII S0305737206001125
    • Longhi A, Errani C, De Paolis M, Mercuri M and Bacci G: Primary bone osteosarcoma in the pediatric age: state of the art. Cancer Treat Rev 32: 423-436, 2006. (Pubitemid 44309249)
    • (2006) Cancer Treatment Reviews , vol.32 , Issue.6 , pp. 423-436
    • Longhi, A.1    Errani, C.2    De Paolis, M.3    Mercuri, M.4    Bacci, G.5
  • 3
    • 0025137138 scopus 로고
    • Medicine from plants
    • Abelson PH: Medicine from plants. Science 247: 513, 1990.
    • (1990) Science , vol.247 , pp. 513
    • Abelson, P.H.1
  • 4
    • 33748354274 scopus 로고    scopus 로고
    • Fas/FasL signaling allows extracelluar-signal regulated kinase to regulate cytochrome c release in oridonin-induced apoptotic U937 cells
    • DOI 10.1248/bpb.29.1873
    • Liu YQ, Mu ZQ, You S, Tashiro S, Onodera S and Ikejima T: Fas/FasL signaling allows extracelluar-signal regulated kinase to regulate cytochrome c release in oridonin-induced apoptotic U937 cells. Biol Pharm Bull 29: 1873-1879, 2006. (Pubitemid 44338410)
    • (2006) Biological and Pharmaceutical Bulletin , vol.29 , Issue.9 , pp. 1873-1879
    • Liu, Y.-Q.1    Mu, Z.-Q.2    You, S.3    Tashiro, S.-I.4    Onodera, S.5    Ikejima, T.6
  • 5
    • 34250847036 scopus 로고    scopus 로고
    • Effects of oridonin on proliferation of HT29 human colon carcinoma cell lines both in vitro and in vivo in mice
    • DOI 10.1691/ph.2007.6.6691
    • Zhu Y, Xie L, Chen G, Wang H and Zhang R: Effects of oridonin on proliferation of HT29 human colon carcinoma cell lines both in vitro and in vivo in mice. Pharmazie 62: 439-444, 2007. (Pubitemid 46975266)
    • (2007) Pharmazie , vol.62 , Issue.6 , pp. 439-444
    • Zhu, Y.1    Xie, L.2    Chen, G.3    Wang, H.4    Zhang, R.5
  • 6
    • 25844511169 scopus 로고    scopus 로고
    • Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the Chinese herb Rabdosia rubescens
    • DOI 10.1016/j.bbrc.2005.09.040, PII S0006291X05020413
    • Hsieh TC, Wijeratne EK, Liang JY, Gunatilaka AL and Wu JM: Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens. Biochem Biophys Res Commun 337: 224-231, 2005. (Pubitemid 41393783)
    • (2005) Biochemical and Biophysical Research Communications , vol.337 , Issue.1 , pp. 224-231
    • Hsieh, T.-C.1    Wijeratne, E.K.2    Liang, J.-Y.3    Gunatilaka, A.L.4    Wu, J.M.5
  • 8
    • 34247388477 scopus 로고    scopus 로고
    • Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells
    • Jin S, Shen JN, Wang J, Huang G and Zhou JG: Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. Cancer Biol Ther 6: 261-268, 2007. (Pubitemid 46641633)
    • (2007) Cancer Biology and Therapy , vol.6 , Issue.2 , pp. 261-268
    • Jin, S.1    Shen, J.-N.2    Wang, J.3    Huang, G.4    Zhou, J.-G.5
  • 9
    • 5444265502 scopus 로고    scopus 로고
    • The Wnt connection to tumorigenesis
    • DOI 10.1387/ijdb.041815jb, Invasion in Cancer and Embryonic Development
    • Behrens J and Lustig B: The Wnt connection to tumorigenesis. Int J Dev Biol 48: 477-487, 2004. (Pubitemid 39360398)
    • (2004) International Journal of Developmental Biology , vol.48 , Issue.5-6 , pp. 477-487
    • Behrens, J.1    Lustig, B.2
  • 10
    • 33751530490 scopus 로고    scopus 로고
    • Mining the Wnt pathway for cancer therapeutics
    • DOI 10.1038/nrd2154, PII NRD2154
    • Barker N and Clevers H: Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov 5: 997-1014, 2006. (Pubitemid 44835127)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.12 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 15
    • 0029096787 scopus 로고
    • Aberrant expression of the growth factor Wnt-5A in human malignancy
    • Iozzo RV, Eichstetter I and Danielson KG: Aberrant expression of the growth factor Wnt-5A in human malignancy. Cancer Res 55: 3495-3499, 1995.
    • (1995) Cancer Res , vol.55 , pp. 3495-3499
    • Iozzo, R.V.1    Eichstetter, I.2    Danielson, K.G.3
  • 16
    • 84863270637 scopus 로고    scopus 로고
    • Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma
    • Lu BJ, Wang YQ, Wei XJ, et al: Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma. Mol Med Rep 5: 1033-1036, 2012.
    • (2012) Mol Med Rep , vol.5 , pp. 1033-1036
    • Lu, B.J.1    Wang, Y.Q.2    Wei, X.J.3
  • 17
    • 84873430058 scopus 로고    scopus 로고
    • Inhibition of the Wnt-beta-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy
    • Ma Y, Ren Y, Han EQ, et al: Inhibition of the Wnt-beta-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. Biochem Biophys Res Commun 431: 274-279, 2013.
    • (2013) Biochem Biophys Res Commun , vol.431 , pp. 274-279
    • Ma, Y.1    Ren, Y.2    Han, E.Q.3
  • 18
    • 65249167488 scopus 로고    scopus 로고
    • Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
    • Kansara M, Tsang M, Kodjabachian L, et al: Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. J Clin Invest 119: 837-851, 2009.
    • (2009) J Clin Invest , vol.119 , pp. 837-851
    • Kansara, M.1    Tsang, M.2    Kodjabachian, L.3
  • 19
    • 78049385776 scopus 로고    scopus 로고
    • Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc
    • Gao FH, Hu XH, Li W, et al: Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc. BMC Cancer 10: 610, 2010.
    • (2010) BMC Cancer , vol.10 , pp. 610
    • Gao, F.H.1    Hu, X.H.2    Li, W.3
  • 20
    • 77951021015 scopus 로고    scopus 로고
    • Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma
    • He BC, Chen L, Zuo GW, et al: Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma. Clin Cancer Res 16: 2235-2245, 2010.
    • (2010) Clin Cancer Res , vol.16 , pp. 2235-2245
    • He, B.C.1    Chen, L.2    Zuo, G.W.3
  • 21
    • 84861683233 scopus 로고    scopus 로고
    • Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/beta-catenin signaling
    • Wu K, Yang Q, Mu Y, et al: Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/beta-catenin signaling. Int J Oncol 41: 292-298, 2012.
    • (2012) Int J Oncol , vol.41 , pp. 292-298
    • Wu, K.1    Yang, Q.2    Mu, Y.3
  • 23
    • 72949110602 scopus 로고    scopus 로고
    • BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling
    • Tang N, Song WX, Luo J, et al: BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling. J Cell Mol Med 13: 2448-2464, 2009.
    • (2009) J Cell Mol Med , vol.13 , pp. 2448-2464
    • Tang, N.1    Song, W.X.2    Luo, J.3
  • 24
    • 78651246162 scopus 로고    scopus 로고
    • Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/β-catenin signaling
    • He BC, Gao JL, Luo X, et al: Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/β-catenin signaling. Int J Oncol 38: 437-445, 2011.
    • (2011) Int J Oncol , vol.38 , pp. 437-445
    • He, B.C.1    Gao, J.L.2    Luo, X.3
  • 25
    • 0029382452 scopus 로고
    • Expression of p53 protein, PCNA, and Ki-67 in osteosarcomas of bone
    • Park HR and Park YK: Expression of p53 protein, PCNA, and Ki-67 in osteosarcomas of bone. J Korean Med Sci 10: 360-367, 1995.
    • (1995) J Korean Med Sci , vol.10 , pp. 360-367
    • Park, H.R.1    Park, Y.K.2
  • 26
    • 77955317205 scopus 로고    scopus 로고
    • Emerging links between CDK cell cycle regulators and Wnt signaling
    • Davidson G and Niehrs C: Emerging links between CDK cell cycle regulators and Wnt signaling. Trends Cell Biol 20: 453-460, 2010.
    • (2010) Trends Cell Biol , vol.20 , pp. 453-460
    • Davidson, G.1    Niehrs, C.2
  • 28
    • 0031813650 scopus 로고    scopus 로고
    • Axin, an inhibitor of the Wnt signalling pathway, interacts with beta- catenin, GSK-3beta and APC and reduces the beta-catenin level
    • Nakamura T, Hamada F, Ishidate T, et al: Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. Genes Cells 3: 395-403, 1998. (Pubitemid 28387083)
    • (1998) Genes to Cells , vol.3 , Issue.6 , pp. 395-403
    • Nakamura, T.1    Hamada, F.2    Ishidate, T.3    Anai, K.-I.4    Kawahara, K.5    Toyoshima, K.6    Akiyama, T.7
  • 29
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • DOI 10.1038/378785a0
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M and Hemmings BA: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789, 1995. (Pubitemid 26004411)
    • (1995) Nature , vol.378 , Issue.6559 , pp. 785-789
    • Cross, D.A.E.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 30
    • 59149098536 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3beta
    • Bikkavilli RK, Feigin ME and Malbon CC: p38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3beta. J Cell Sci 121: 3598-3607, 2008.
    • (2008) J Cell Sci , vol.121 , pp. 3598-3607
    • Bikkavilli, R.K.1    Feigin, M.E.2    Malbon, C.C.3
  • 31
    • 79953029230 scopus 로고    scopus 로고
    • Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics
    • Li CY, Wang EQ, Cheng Y and Bao JK: Oridonin: an active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics. Int J Biochem Cell Biol 43: 701-704, 2011.
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 701-704
    • Li, C.Y.1    Wang, E.Q.2    Cheng, Y.3    Bao, J.K.4
  • 32
    • 7944229670 scopus 로고    scopus 로고
    • Cytochrome c release from oridonin-treated apoptotic A375-S2 cells is dependent on p53 and extracellular signal-regulated kinase activation
    • DOI 10.1254/jphs.FPJ04008X
    • Zhang CL, Wu LJ, Zuo HJ, Tashiro S, Onodera S and Ikejima T: Cytochrome c release from oridonin-treated apoptotic A375-S2 cells is dependent on p53 and extracellular signal-regulated kinase activation. J Pharmacol Sci 96: 155-163, 2004. (Pubitemid 39469606)
    • (2004) Journal of Pharmacological Sciences , vol.96 , Issue.2 , pp. 155-163
    • Zhang, C.-L.1    Wu, L.-J.2    Zuo, H.-J.3    Tashiro, S.-I.4    Onodera, S.5    Ikejima, T.6
  • 33
    • 70349469564 scopus 로고    scopus 로고
    • Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells
    • Cheng Y, Qiu F, Ye YC, Tashiro S, Onodera S and Ikejima T: Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells. Arch Biochem Biophys 490: 70-75, 2009.
    • (2009) Arch Biochem Biophys , vol.490 , pp. 70-75
    • Cheng, Y.1    Qiu, F.2    Ye, Y.C.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 34
    • 35648937054 scopus 로고    scopus 로고
    • Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line
    • Hu HZ, Yang YB, Xu XD, et al: Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line. Acta Pharmacol Sin 28: 1819-1826, 2007.
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 1819-1826
    • Hu, H.Z.1    Yang, Y.B.2    Xu, X.D.3
  • 35
    • 84863811994 scopus 로고    scopus 로고
    • Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells
    • Li X, Li X, Wang J, Ye Z and Li JC: Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells. Int J Biol Sci 8: 901-912, 2012.
    • (2012) Int J Biol Sci , vol.8 , pp. 901-912
    • Li, X.1    Li, X.2    Wang, J.3    Ye, Z.4    Li, J.C.5
  • 36
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis P: Wnt signaling and cancer. Genes Dev 14: 1837-1851, 2000.
    • (2000) Genes Dev , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 37
    • 84873558051 scopus 로고    scopus 로고
    • WNT signaling in bone homeostasis and disease: From human mutations to treatments
    • Baron R and Kneissel M: WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat Med 19: 179-192, 2013.
    • (2013) Nat Med , vol.19 , pp. 179-192
    • Baron, R.1    Kneissel, M.2
  • 38
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • DOI 10.1038/nature03319
    • Reya T and Clevers H: Wnt signalling in stem cells and cancer. Nature 434: 843-850, 2005. (Pubitemid 40558990)
    • (2005) Nature , vol.434 , Issue.7035 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 40
    • 77949667984 scopus 로고    scopus 로고
    • Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma
    • Rubin EM, Guo Y, Tu K, Xie J, Zi X and Hoang BH: Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. Mol Cancer Ther 9: 731-741, 2010.
    • (2010) Mol Cancer Ther , vol.9 , pp. 731-741
    • Rubin, E.M.1    Guo, Y.2    Tu, K.3    Xie, J.4    Zi, X.5    Hoang, B.H.6
  • 41
    • 50649124475 scopus 로고    scopus 로고
    • Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model
    • Guo Y, Rubin EM, Xie J, Zi X and Hoang BH: Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model. Clin Orthop Relat Res 466: 2039-2045, 2008.
    • (2008) Clin Orthop Relat Res , vol.466 , pp. 2039-2045
    • Guo, Y.1    Rubin, E.M.2    Xie, J.3    Zi, X.4    Hoang, B.H.5
  • 42
    • 77953312514 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 beta: Can it be a target for oral cancer
    • Mishra R: Glycogen synthase kinase 3 beta: can it be a target for oral cancer. Mol Cancer 9: 144, 2010.
    • (2010) Mol Cancer , vol.9 , pp. 144
    • Mishra, R.1
  • 43
    • 84899928773 scopus 로고    scopus 로고
    • TWIST interacts with beta-catenin signaling on osteosarcoma cell survival against cisplatin
    • Dec 31, Epub ahead of print. doi: 10.1002/mc.21991
    • Wu J, Liao Q, He H, Zhong D and Yin K: TWIST interacts with beta-catenin signaling on osteosarcoma cell survival against cisplatin. Mol Carcinog: Dec 31, 2012(Epub ahead of print). doi: 10.1002/mc.21991.
    • (2012) Mol Carcinog
    • Wu, J.1    Liao, Q.2    He, H.3    Zhong, D.4    Yin, K.5
  • 44
    • 77957734800 scopus 로고    scopus 로고
    • Celecoxib inhibits beta-catenin-dependent survival of the human osteosarcoma MG-63 cell line
    • Xia JJ, Pei LB, Zhuang JP, et al: Celecoxib inhibits beta-catenin- dependent survival of the human osteosarcoma MG-63 cell line. J Int Med Res 38: 1294-1304, 2010.
    • (2010) J Int Med Res , vol.38 , pp. 1294-1304
    • Xia, J.J.1    Pei, L.B.2    Zhuang, J.P.3
  • 46
    • 84861307078 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta, NF-kappaB signaling, and tumorigenesis of human osteosarcoma
    • Tang QL, Xie XB, Wang J, et al: Glycogen synthase kinase-3beta, NF-kappaB signaling, and tumorigenesis of human osteosarcoma. J Natl Cancer Inst 104: 749-763, 2012.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 749-763
    • Tang, Q.L.1    Xie, X.B.2    Wang, J.3
  • 47
    • 0035822594 scopus 로고    scopus 로고
    • Wnt signalling: Antagonistic Dickkopfs
    • Zorn AM: Wnt signalling: antagonistic Dickkopfs. Curr Biol 11: R592-R595, 2001.
    • (2001) Curr Biol , vol.11
    • Zorn, A.M.1
  • 48
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the Wnt signalling pathway
    • DOI 10.1242/jcs.00623
    • Kawano Y and Kypta R: Secreted antagonists of the Wnt signalling pathway. J Cell Sci 116: 2627-2634, 2003. (Pubitemid 36857216)
    • (2003) Journal of Cell Science , vol.116 , Issue.13 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 49
    • 84891926867 scopus 로고    scopus 로고
    • Dkk-3, a secreted wnt antagonist, suppresses tumorigenic potential and pulmonary metastasis in osteosarcoma
    • Lin CH, Guo Y, Ghaffar S, et al: Dkk-3, a secreted wnt antagonist, suppresses tumorigenic potential and pulmonary metastasis in osteosarcoma. Sarcoma 2013: 147541, 2013.
    • (2013) Sarcoma , vol.2013 , pp. 147541
    • Lin, C.H.1    Guo, Y.2    Ghaffar, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.