Involvement of histone H3 phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract

International Journal of Oncology

Volumn 45, Issue 2, 2014, Pages 843-852

  Kikuchi, Hidetomo ^a,b,d   Yuan, Bo ^a   Yuhara, Eisuke ^a   Imai, Masahiko ^a   Furutani, Ryota ^a   Fukushima, Shin ^a   Hazama, Shingo ^a   Hirobe, Chieko ^c   Ohyama, Kunio ^a   Takagi, Norio ^a   Toyoda, Hiroo ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b YASUDA WOMEN'S UNIVERSITY   (Japan)

^c Seisen University   (Japan)

^d JOSAI UNIVERSITY   (Japan)

Author keywords

Apoptosis; Histone H3 phosphorylation; HL 60 cells; Intracellular redox status; p38 MAPK; Vitex angus castus

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTINEOPLASTIC AGENT; GLYCOPROTEIN GP 91; HEME OXYGENASE 1; HISTONE H3; PROTOPORPHYRIN TIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; VITEX AGNUS CASTUS EXTRACT; HERBACEOUS AGENT; HISTONE;

APOPTOSIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HISTONE PHOSPHORYLATION; HL 60 CELL LINE; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; FRUIT; METABOLISM; OXIDATION REDUCTION REACTION; PHOSPHORYLATION; PHYTOTHERAPY; PROCEDURES; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VITEX;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CELL SURVIVAL; DNA FRAGMENTATION; DRUGS, CHINESE HERBAL; FRUIT; HISTONES; HL-60 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; OXIDATION-REDUCTION; PHOSPHORYLATION; PHYTOTHERAPY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VITEX;

EID: 84902585242     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2454     Document Type: Article

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