Involvement of histone H3 phosphorylation through p38 MAPK pathway activation in casticin-induced cytocidal effects against the human promyelocytic cell line HL-60

International Journal of Oncology

Volumn 43, Issue 6, 2013, Pages 2046-2056

  Kikuchi, Hidetomo ^a,b   Yuan, Bo ^a   Yuhara, Eisuke ^a   Takagi, Norio ^a   Toyoda, Hiroo ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b YASUDA WOMEN'S UNIVERSITY   (Japan)

Author keywords

Apoptosis; Casticin; G2 M phase arrest; Histone H3 phosphorylation; HL 60 cells; p38 MAPK

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 8; CASPASE 9; CASTICIN; FLAVONOID; HISTONE H3; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL STRAIN HL 60; CELL VIABILITY; CHROMOSOME CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANTHRACENES; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; HISTONES; HL-60 CELLS; HUMANS; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKEMIA, PROMYELOCYTIC, ACUTE; M PHASE CELL CYCLE CHECKPOINTS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PYRIDINES; REACTIVE OXYGEN SPECIES;

EID: 84891918211     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2106     Document Type: Article

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