Serotonergic 5-HT7 receptors and cognition

Reviews in the Neurosciences

Volumn 25, Issue 3, 2014, Pages 311-323

  Gasbarri, Antonella ^a,b   Pompili, Assunta ^a,b  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

5 HT7receptor; Learning and memory; Serotonin

Indexed keywords

3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; AMISULPRIDE; AMPHETAMINE; ANTIDEPRESSANT AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIZOCILPINE; KETAMINE; LURASIDONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLEPTIC AGENT; PHENCYCLIDINE; SCOPOLAMINE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 5 RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN RECEPTOR;

ALZHEIMER DISEASE; AMNESIA; AMYGDALOID NUCLEUS; ANTIDEPRESSANT ACTIVITY; ANXIETY DISORDER; AVOIDANCE BEHAVIOR; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASE; COGNITION; COGNITIVE DEFECT; DEPRESSION; DOWN SYNDROME; EMOTION; EPILEPSY; EXTRAPYRAMIDAL SYNDROME; FEAR; FEEDING; HUMAN; HYPERACTIVITY; HYPOTHALAMUS; INSTRUMENTAL CONDITIONING; LEARNING; LONG TERM MEMORY; MEMORY; MEMORY CONSOLIDATION; MENTAL DISEASE; NEUROMODULATION; NONHUMAN; PAIN; PANIC; PARKINSON DISEASE; PREPULSE INHIBITION; REFERENCE MEMORY; REVIEW; SCHIZOPHRENIA; SENSORY GATING; SEXUAL BEHAVIOR; SINGLE NUCLEOTIDE POLYMORPHISM; SLEEP; SLEEP DISORDER; STATE DEPENDENT LEARNING; THALAMUS; WORKING MEMORY; ANIMAL; METABOLISM; PHYSIOLOGY;

ANIMALS; COGNITION; HUMANS; RECEPTORS, SEROTONIN; SEROTONIN;

EID: 84902584558     PISSN: 03341763     EISSN: 21910200     Source Type: Journal    
DOI: 10.1515/revneuro-2013-0066     Document Type: Review

References (141)

1. Abbas A. Hedlund P.B. Huang X.P. Tran T.B. Meltzer H.Y. and Roth B.L. (2009). Amisulpride is a potent 5-HT7 antagonist: relevance for antidepr essant actions in vivo. Psychopharmacology (Berl.) 205 119-128
2. Aghajanian G.K. and Sanders-Bush E. (2002). Serotonin. In: Neuropsychopharmacology: The Fifth Generation of Progress. Davis K.L. Charney D. Coyle J.T. and Nemeroff C.B. eds. (Philadelphia: Lippincott-Williams & Wilkins) pp. 15-34
3. Bard J.A. Zgombick J. Adham N. Vaysse P. Branchek T.A. and Weinshank R.L. (1993). Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J. Biol. Chem. 268 23422-23426
4. Barnes N.M. and Sharp T. (1999). A review of central 5-HT receptors and their function. Neuropharmacology 38 1083-1152
5. Barnes J.M. Costall B. Coughlan J. Domeney A.M. Gerrard P.A. Kelly M.E. Navlor R.J. Onaivi E.S. Tomkins D.M. and Tvers M. (1990). The effects of ondansetron a 5-HT3 receptor agonist on cognition in rodents and primates. Pharmacol. Biochem. Behav. 35 955-962
6. Barros M. and Tomaz C. (2002). Non-human primate models for investigating fea r and anxiety. Neurosci. Biobehav. Rev. 26 187-201
7. Barros M. De Souza Silva M.A. Huston J.P. and Tomaz C. (2002). Anxiolytic-like effects of substance P fragment (SP1-7) in non-human primates (Callithrix penicillata). Peptides 23 967-973
8. Bickerdike M.J. Fletcher A. and Marsden C.A. (1995). Attenuation of CCK-induced aversion in rats on the elevated X-maze by the selective 5-HT1A receptor antago nists (+) WAY 100135 and WAY 100635. Neuropharmacology 34 805-811
9. Bonaventure P. Nepomuceno D. Hein L. Sutcliffe J.G. Lovenberg T. and Hedlund P.B. (2004). Radioligand binding analy sis of knockout mice reveals 5-hydroxytryptamine7 receptor distribution and uncovers 8-hydroxy-2-(di-npropylamino) tetralin interaction with α2 adrenergic receptors. Neuroscience 124 901-911
10. Bradley P.B. Engle G. Feniuk W. Fozard J.R. Humphrey P.P.A. Middlemis D.N. Mylecharane E.J. Richardson B.P. and Saxena P.R. (1986). Proposals for the classification and nomenclature of functional receptors of 5-hydroxytryp tamine. Neuropharmacology 25 563-576
11. Bubser M. Backstrom J.R. Sanders-Bush E. Roth B.L. and Deutch A.Y. (2001). Distribution of serotonin 5-HT (2A) receptors in afferents of the rat striatum. Synapse 39 297-304
12. Buhot M.C. Patra S.K. and Naï li S. (1995). Spatial memory deficits following stimulation of hippocampal 5-HT1B receptors in the rat. Eur. J. Pharmacol. 285 221-228
13. Buhot M.C. Martin S. and Segu L. (2000). Role of serotonin in memory impairment. Ann. Med. 32 210-221.
14. Butkevich I.P.Mikhailenko V.A. and Leont'eva M.N. 2005 Sequelae of prenatal serotonin depletion and stress on pain sensitivity in rats. Neurosci. Behav. Physiol. 35 925-930
15. Cifariello A. Pompili A. and Gasbarri A. (2008). 5-HT7 receptors in the modulation of cognitive processes. Behav. Brain Res. 195 171-179
16. Clemett D.A. Cockett M.I. Marsden C.A. and Fone K.C.F. (1998) . Antisense oligonucleotide-induced reduction in 5-hydroxytryptamine7 receptors in the rat hypothalamus without alteration in exploratory behaviour or neuroendocrine function. J. Neurochem. 71 1271-1279
17. Consolo S. Amaboldi S. Ramponi S. Nannini L. Ladinsky H. and Baldi G. (1996). Endogenous serotonin facilitates in vivo acetylcholine release in rat frontal cortex through 5-HT1B receptors. J. Pharmacol. Exp. Ther. 277 823-830
18. Corcoran K.A. Lu Y. Turner R.S. and Maren S. (2002). Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease. Learn. Mem. 9 243-252
19. Dean B. Pavey G. Thomas D. and Scarr E. (2006). Cortical serotonin7 1D and 1F receptors: effects of schizophrenia suicide and antipsychotic drug treatment. Schizophr. Res. 88 265-274
20. Dineley K.T. Xia X. Bui D. Sweatt J.D. and Zheng H. (2002). Accelerated plaque accumulation associative learning deficits and up-regulation of alpha 7 nicotinic receptor protein in transgen ic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J. Biol. Chem. 277 22768-22780
21. Djaldetti R. Yust-Katz S. Kolianov V. Melamed E. and Dabby R. (2007). The effect of duloxetine on primary pain symptoms in Parkinson disease. Clin. Neuropharmacol. 30 201-205
22. Dourish C.T. (1987). 5-HT1A receptors and anxiety. In: Brain 5-HT1A Receptors. Dourish C.T. Ahlenius S. and Hutson P.H. eds. (Chichester: Ellis Horwood) pp. 261-277
23. Dourish C.T. Hutson P.H. and Curzon G. (1985a ). Characteristics of feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). Brain Res. Bull. 15 377-384
24. Dourish C.T. Hutson P.H. and Curzon G. (1985b ). Low doses of the putative serotonin agonist 8-hydroxy-2-(di-npropylamino) tetralin (8-OH-DPAT) elicit feeding in the rat. Psychopharmacology 86 197-204
25. East S.Z. Burnet P.W. Kerwin R.W. and Harrison P.J. (2002). An RT-PCR study of 5-HT(6) and 5-HT(7) receptor mRNAs in the hippocampal formation and prefrontal cortex in schizophrenia. Schizophr. Res. 57 15-26
26. Eglen R.M. Wong E.H.F. Dumuis A. and Bockaert J. (1995). Central 5-HT4 receptors. Trends Pharmacol. Sci. 16 391-398
27. Enomoto T. Ishibashi T. Tokuda K. Ishiyama T. Toma S. and Ito A. (2008). Lurasidone reverses MK-801-induced impairment of learning and memory in the Morris water maze and radial-arm maze test in rats. Behav. Brain Res. 186 197-207
28. Eriksson T.M. Golkar A. Ekström J.C. Svenningsson P. and Ö gren S.O. (2008). 5-HT7 receptor stimulation by 8-OH-DPAT counteracts the impairing effect of 5-HT1A receptor stimulation on contextual learning in mice. Eur. J. Pharmacol. 596 107-110
29. Galici R. Boggs J.D. Miller K.L. Bonaventure P. and Atack J.R. (2008). Effects of SB-269970 a 5-HT7 receptor antagonist in mouse models predictive of antipsychotic-like activity. Behav. Pharmacol. 19 153-159
30. García-Alcoce r G. Segura L.C.B. García Peña M. Martínez-Torres A. and Miledi R. (2006). Ontogenetic distribution of 5-HT2C 5-HT5A and 5-HT7 receptors in the rat hippocampus. Gene Expr. 13 53-57
31. Gasb arri A. Cifariello A. Pompili A. and Meneses A. (2008). Effect of 5-HT7 antagonist SB-269970 in the modulation of working and reference memory in the rat. Behav. Brain Res. 195 164-170
32. Ge J. and Barnes N.M. (1996). 5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo. Br. J. Pharmacol. 117 1475-1480
33. Gellynck E. Heyninck K. Andressen K.W. Haegeman G Levy F.O. Vanhoenacker P. and Van Craenenbroeck K. (2013). The serotonin 5-HT7 receptors: two decades of research. Exp. Brain Res. 230 555-568
34. Geyer M.A. Krebs-Thomson K. Braff D.L. and Swerdlow N.R. (2001). Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology (Berl.) 156 117-154
35. Glass J.D. Grossma n G.H. Farnbauch L. and Di Nardo L. (2003). Midbrain raphe modulation of nonphotic circadian clock resetting and 5-HT release in the mammalian suprachiasmatic nucleus. J. Neurosci. 23 7451-7460.
36. Gonzalez R.Chávez-Pascacio K.Meneses A.(2013). Role of 5-HT5A receptors in the consolidation of memory. Behav. Brain Res. 252 246-251
37. Graham-Smith D.G. (1971). Studies in-vivo on relationship betw een brain tryptophan brain 5-HT synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and L-tryptophan. J. Neurochem. 18 1053-1066
38. Griebel G. Rodgers R.J. Perrault G. and Sanger D.J. (2000). The effects of compounds varying in selectivity as 5-HT (1A) receptor antagonists in three rat models of anxiety. Neuropharmacology 39 1848-1857
39. Hannon J. and Hoyer D. (2002). Serotonin receptors and systems: endless of diversity? Acta Biol. Szeged. 46 1-12
40. Hannon J. and Hoyer D. (2008). Molecular biology of 5-HT receptors. Behav. Brain Res. 195 198-213
41. Harvey J.A. (1996). Serotonergic regulation of associative learning. Behav. Brain Res. 73 47-50
42. Hedlund P.B. (2009). The 5-HT7 receptor and disorders of the nervous system: an overview. Psychopharmacology (Berl.) 206 345-354
43. Hedlund P.B. and Sutcliffe J.G. (2004). Functional molecular and pharmacological advances in 5-HT7 receptor research. Trends Pharmacol. Sci. 25 481-486
44. Hedlund P.B. Kelly L. Mazur C. Lovenberg T. Sutcliffe J.G. and Bonaventure P. (2004). 8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents. Eur. J. Pharmacol. 487 125-132
45. Hedlund P.B. Huitron-Resendi z S. Henriksen S.J. and Sutcliffe J.G. (2005). 5-HT7 receptor inhibition and inactivation induce antidepressant-like behavior and sleep pattern. Biol. Psych. 58 831-837
46. Hensler J.G . Artigas F. Bortolozzi A. Daws L.C. De Deurwaerdère P. Milan L. Navailles S. and Koek W. (2013). Catecholamine/serotonin interactions: systems thinking for brain function and disease. Adv. Pharmacol. 68 167-197
47. Herremans A.H.J. Hijzen T.H. Olivier B. and Slangen J.L. (1995). Serotonergic drug effects on a delayed conditional discrimination task in the rat: involvement of the 5-HT1A receptor in working m emory. J. Psychopharmacol. 9 242-250
48. Hjorth S. Carlsson A. Lindberg P. Sanchez D. Wikstöm H. Arvidsson L.E. Hacksell U. and Nilsson J.L.G. (1982). 8-Hydroxy-2-(di-n-prop ylamino) tetralin 8-OH-DPAT a potent and selective simplified ergot congener with central 5-HT-receptor stimulating activity. J. Neural Transm. 55 169-188
49. Horiguchi M. Huang M. and Meltzer H.Y. (2011). The role of 5-HT7 receptors in the phencyclidine (PCP)-induced novel object recognition (NOR) deficit in rats. J. Pharmacol. Exp. Ther. 338 605-614
50. Hoyer D. and Martin G. (1997). 5-HT receptor classification an d nomenclature: towards a harmonization with the human genome. Neuropharmacology 36 419-428
51. Hoyer D. Clarke D.E. Fozard J.R. Hartig P.R. Martin G.R. Mylecharane E.J. Saxena P.R. and Humphrey P.P. (1994). International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46 157-203
52. Hoyer D. Hannon P.J. and Martin R.G. (2002). Molecular pharmacological and functional diversity of 5-HT receptors. Pharmacol. Biochem. Behav. 71 533-554
53. Ikeda M. Iwata N. Kitajima T. Suzuki T. Yamanouchi Y. Kinoshita Y. and Ozaki N. (2006). Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. Neuropsychopharmacology 31 866-871
54. Ishibashi T. Horisawa T. Tokuda K. Ishiyama T. Ogasa M. Tagashira R. Matsumoto K. Nishikawa H. Ueda Y. Toma S. et al. (2010). Pharmacological profile of lurasidone a novel antipsychotic agent with potent 5 hydroxytryptamine 7 (5-HT7) and 5-H T1A receptor activity. J. Pharmacol. Exp. Ther. 334 171-181
55. Izquierdo I. da Cunha C. Rosat R. Jerusalinsky D. Ferreira M.B. and Medina J.H. (1992). Neurotransmitter receptors involved in memory processing by the amygdala medial septum and hippocampus of rats. Behav. Neural Biol. 58 16-25
56. Jacobs B.L. and Klemfuss H. (1975). Brain stem and spinal cord mediation of a serotonergic behavioral syndrome. Brain Res. 100 450-457
57. Jones B.J. and Blackburn T.P. (2002). The medical benefit of 5-HT research. Pharmacol. Biochem. Behav. 71 555-568.
58. Jørgensen H.S., 2007, Studies on the neuroendocrine role of serotonin. Dan. Med. Bull., 54, 266-288
59. Jovanovska A. and Prosser R.A. (2002). Translational and transcriptional inhibitors block serotonergic p hase advances of the suprachiasmatic nucleus circadian pacemaker in vitro. J. Biol. Rhythms 17 137-146
60. Kandel E.R. (2001). The molecular biology of memory storage: a dialogue between genes and synapses. Science 294 1030-1038
61. Lai M.K. Tsang S.W. Alder J.T. Keene J. Hope T. Esiri M.M. Francis P.T. and Chen C.P. (2005). Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer's disease. Psychopharmacology (Berl.) 179 673-677
62. Lamprecht R. and LeDoux J. (2004). Structural plasticity and memory. Nat. Rev. Neurosci. 5 45-54
63. Lanctô t K.L. Hussey D.F. Herrmann N. Black S.E. Rusjan P.M. Wilson A.A. Houle S. Kozloff N. Verhoeff N.P. and Kapur S. (2007). A positron emission tomography study of 5-hydroxytryptamine-1A receptors in Alzheimer disease. Am. J. Geriatr. Psychiatry 15 888-898
64. Leopoldo M. Berardi F. Colabufo N.A. Contino M. Lacivita E. Perrone R. and Tortorella V . (2004). Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors. J. Pharm. Pharmacol. 56 247-255
65. Leopoldo M. Lacivita E. Berardi F. Perrone R. and Hedlund P. B. (2011). Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders. Pharmacol. Ther. 129 120-148
66. Lieberman J.A. Mailman R.B. Duncan G. Sikich L. Chakos M. Nichols D.E. and Kraus J.E. (1998). Serotonergic basis of antipsychotic drug effects in schizophrenia. Biol. Psychiatry 44 1099-1117
67. Liy-Salmeron G. and Meneses A. (2007). Role of 5-HT1-7 receptors in short-and long-term memory for an autoshaping task: intrahippocampal manipulations. Brain Res. 1147 140-147
68. Lovell P.J. Bromidge S.M. Dabbs S. Duckworth D.M. Forbes I.T. Jennings A.J King F.D. Middlemiss D.N. Rahman S.K. Saunders D.V. et al. (2000). A novel potent and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)eth yl) pyrrolidine-1-sulfonyl) phenol (SB-269970). J. Med. Chem. 43 342-345
69. Lovenberg T.W. Baron B.M. de Lece a L. Miller J.D. Prosser R.A. Rea M.A. Foye P.E. Racke M. Slone A.L. Siegel B.W. et al. (1993). A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammali an circadian rhythms. Neuron 11 449-458
70. Lucki I. and Wieland S. (1990). 5-Hydroxytryptamine1A receptors and behavioural responses. Neuropsychopharmacology 3 481-493
71. Lucki I. Nobler M.S. and Frazer A. (1984). Differential actions of serotonin antagonists on 2 behavioral models of serotonin receptor activation in the rat. J. Pharmacol. Exp. Ther. 228 133-139
72. L una-Munguia H. Manuel-Apolinar L. Rocha L. and Meneses A. (2005). 5-HT1A receptor expression during memory formation. Psychopharmacology 181 309-318
73. Mahgoub M.A. Sara Y. Kavalali E .T. and Monteggia L.M. (2005). Reciprocal interaction of 5-HT and neuronal activity in regulation of CRE-dependent gene expression. J. Pharmacol. Exp. Ther. 163 820-823
74. Manuel-Apolinar L. and Meneses A. (2004). 8-OH-DPAT facilitated memory consolidation and increased hippocampal and cortical cAMP production. Behav. Brain Res. 148 179-184
75. Martikainen I.K. Hirvonen J. Kajander J. Hagelberg N. Mansikka H. Någren K. Hietala J. and Pertovaara A. (2007). Correlation of human cold pressor pain responses with 5-HT(1A) receptor binding in the brain. Brain Res. 1172 21-31
76. Martin-Cora F.J. and Pazos A. (2004). Autoradiographic distribution of 5-HT7 receptors in the human brain using [3H]mesulergine: comparison to other mammalian species. Br. J. Pharmacol. 141 92-104
77. Matthys A. Haegman G. Va n Craenenbroeck K. and Vanhoenacker P. (2011). Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives. Mol. Neurobiol. 43 228-253
78. McGaugh J.L. (2000). Memory: a century of consolidation. Science 287 248-251.
79. McGaugh J.L.,Izquierdo I., 2000, The contribution of pharmacology to research on the mechanisms of memory formation. Trends Pharmacol. Sci., 21, 208-210
80. McLean S.L. Woolley M.L. Thomas D. and Neill J.C. (2009). Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat. Psychopharmacology 206 403-414
81. Meltzer H.Y. Rajagopal L. Huang M. Oyamada Y. Kwon S. and Horiguchi M. (2013). Translating the N-methyl-Daspartate receptor antagonist model of schizophrenia to treatments for cognitive impai rment in schizophrenia. Int. J. Neuropsychopharmacol. 16 2181-2194
82. Meneses A. (1999). 5-HT system and cognition. Neurosci. Biobehav. Rev. 23 1111-1125
83. Meneses A. (2001). Effect s of the 5-HT6 receptor antagonist Ro 04-6790 on learning consolidation. Behav. Brain Res. 118 107-110
84. Meneses A. (2002). Involvement of 5-HT2A/2B/2C receptors on memory formation: simple agonism antagonism or inverse agonism? Cell. Mol. Neurobiol. 22 675-688
85. Meneses A. (2003). A pharmacological analysis of an associative learning task: function of 5-HT1 to 5-HT7 receptor subtypes on a Pavlovian/instrumental autoshaped memory. Learn. Mem. 10 363-372
86. Meneses A. ( 2004). Effects of the 5-HT7 receptor antagonists SB-269970 and DR 4004 in autoshaping Pavlovian/instrumental learning task. Behav. Brain Res. 155 275-282
87. Meneses A. (2007). Do serotonin (1-7) rece ptors modulate short and long-term memory? Neurobiol Learn. Mem. 87 561-572
88. Meneses A. (2013). 5-HT systems: emergent targets for memory formation and memory alterations. Rev. Neurosci. 24 629-664
89. Meneses A. Manuel-Apolinar L. Rocha L. Castello E. and Castello C. (2004). Expression of the 5-HT receptors in rat brain during memory consolidation. Behav. Brain Res. 152 425-436
90. Meyer hof W. Obermüller F. Fehr S. and Richter D. (1993). A novel rat serotonin receptor: primary structure pharmacology and expression pattern in distinct brain regions. DNA Cell. Biol. 12 401-409
91. Mizu ta E. Yamaguchi M. and Kuno S. (1990). Behavioural effects of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in monkeys. Eur. J. Pharmacol. 178 125-127
92. Monsma F.J. Shen Y. Ward R.P. Hamblin M.W. and Sibley D.R. (1993). Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol. Pharmacol. 43 320-327
93. Motofei I.G. (2008). A dual p hysiological character for sexual function: the role of serotonergic receptors. BJU Int. 101 531-534
94. Müller C.P. and Huston J.P. (2006). Determining the region-specific contributions of 5-HT receptors to the psychostimulant effects of cocaine. Trends Pharmacol. Sci. 27 105-112
95. Mü ller C.P. Carey R.J. Huston J.P. and De Souza Silva M.A. (2007). Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors. Prog. Neurobiol. 81 133-178
96. Mullins U.L. Gianutsos G. and Eison A.S. (1999). Effects of ant idepressants on 5-HT7 receptor regulation in the rat hypothalamus. Neuropsychopharmacology 21 352-367
97. Nandam L.S. Jhaveri D. and Bartlett P. (2007). 5-HT7 neurogenesis and antidepressants: a promising therapeutic axis treating depression. Clin. Exp. Physiol. 34 546-551
98. Natestan S. Reckless G.E. Barlow K.E. Nobrega J.N. and Kapur S. (2008). Amisulpride the ?atypical' atypical antipsychoti c-comparison to haloperidol risperidone and clozapine. Schizopr. Res. 105 224-235
99. Nelson D.L. (2004). 5-HT5 receptors. Curr. Drug Targets CNS Neurol. Disord. 3 53-58
100. Ng N.K. Lee H.S. and Wong P.T. (1999). Regulation of striatal dopamine release through 5-HT1 and 5-HT2 receptors. J. Neurosci. Res. 55 600-607.
101. Ohno Y.,Shimizu S.,Tokudome K., 2013, Pathophysiological roles of serotonergic system in regulating extrapyramidal motor functions, Biol. Pharm. Bull., 36, 1396-1400
102. O'Keefe J. and Nadel L. (1978). The Hippocampus as a Cognitive Map (Oxford: Oxford University Press
103. Page I.H. Rapport M.M. and Green A.A. (1948). The crystallization of serotonin. J. Lab. Clin. Med. 33 1606
104. Pérez-Garcí a G.S. and Meneses A. (2005). Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav. Brain Res. 163 136-140
105. Pérez-Garcí a G. and Meneses A. (2008). Ex vivo study of 5-HT1A and 5-HT7 receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia. Behav. Brain Res. 195 139-146
106. Pérez-Garcí a G. and Meneses A. (2009). Memory time-course: mRNA 5-HT1A and 5-HT7 receptors. Behav. Brain Res. 24 102-113
107. Pérez-Garcí a G. Gonzales-Espinosa C. and Meneses A. (2006). An m-RNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation. Behav. Brain Res. 169 83-92
108. Peroutka S.J. and Snyder S.H. (1983). Multiple serotonin receptors and their physiological significance. Fed. Proc. 42 213-217
109. Plassat J.L. Amlaiky N. and Hen R. (1993). Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol. Pharmacol. 44 229-236
110. Pouzet B. (2002). SB-258741: a 5-HT7 receptor antagonist of potential clinical interest. CNS Drug Rev. 8 90-100
111. Pouzet B. Didriksen M. and Arnt J. (2002). Effects of the 5-HT(7) receptor antagonist SB-258741 in animal models for schizophrenia. Pharmacol. Biochem. Behav. 71 655-65
112. Prado-Alcalà R.A. (1995). Serial and parallel processing during memory consolidation. McGaugh G.L. Bermúdez-Rattoni F. and Prado-Alcalà R.A. eds. Plasticity in the Central Nervous System: Learning and Me mory (Mahwah NJ: Erlbaum) pp. 57-65
113. Prado-Alcalà R.A. Solana-Figueroa R. Galindo L.E. Medina A.C. and Quirarte GL. (2003). Blockade of striatal 5-HT2 receptors produces retrograde amnesia in rats. Life Sci. 74 481-488
114. Pritchard A.L. Pritchard C.W. Bentham P. and Lendon C.L. (2007). Ro le of serotonin transporter polymorphisms in the behavioural and psychological symptoms in probable Alzheimer disease patients. Dement. Geriatr. Cogn. Disord. 24 201-206
115. Ramage A.G. (2006). The role of central 5-hydroxytryptamine (5-HT serotonin) receptors in the control of micturition. Br. J. Pharmacol. 147 S120-S131
116. Ramage A.G. and Villaló n C.B. (2008). 5-Hydroxytryptamine (serotonin) and cardiovascular regulation. Trends Pharmacol. Sci. 29 472-481
117. Ramí rez M.J. Cenarruzabeitia E. Lasheras B. and Del Rio J. (1997). 5-HT2 receptor regulation of acetylcholine release induced by dopaminergic stimulation in rat striatal slices. Brain Res. 757 17-23
118. Rapport M.M. Green A.A. and Page I.H. (1948). Serum vasoconstrictor serotonin; isolation and characterization. J. Biol. Chem. 176 1243-1251
119. Raymond J.R. Mukhin Y.V. Gelasco A. Turner J. Collinsworth G. Gettys T.W. Grewal J.S. and Garnovskaya M.N. (2001). Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacol. Ther. 92 179-212
120. Roberts A.J. and Hedlund P.B. (2012). The 5-HT7 receptor in learning and memory. Importance of the hippocampus. 22 762-771
121. Roberts A.J. Krucker T. Levy C.L. Slanina K.A. Sutcliffe J.G. and Hedlund P.B. (2004). Mice lacking 5-HT7 receptors show specific impairments in contextual learning. Eur. J. Neurosci. 19 1913-1922.
122. Roth B.,Craigo S.,Choudhary M.,Uluer A.,Monsma F.J.,Shen Y.,Meltzer H.,Sibley D., 1994, Binding of typi cal and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J. Pharmacol. Exp. Ther., 268, 1403-1410
123. Roth B.L. Hanizavareh S.M. and Blum A.E. (2004). Serotonin recept ors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders. Psychopharmacology 174 17-24
124. Ruat M. Traiffort E. Leurs R. Tardivel-Lacombe J. Diaz J. Schwartz J.M. and Schwartz J.C. (1993). Molecular cloning characterization and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. Proc. Natl. Acad. Sci. USA 90 8547-8551
125. Sarkisyan G. and Hedlund P.B. (2009). The 5-HT7 receptor is involved in allocentric spatial memory information processing. Behav. Brain Res. 202 26-31
126. Sarkisyan G. Roberts A.J. and Hedlund P.B . (2010). The 5-HT7 receptor as a mediator and modulator of antidepressant-like behavior. Behav. Brain Res. 209 99-108
127. Sarnyai Z. Sibille E.L. Pavlides C. Fenster R.J. McEwen B.S. and Toth M. (2000). Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin1A receptors. Proc. Natl. Acad. Sci. USA 97 14731-14736
128. Schechter L.E. Dawso n L.A. and Harder J.A. (2002). The potential utility of 5-HT1A receptor antagonists in the treatment of cognitive dysfunction associated with Alzheimer's disease. Curr. Pharm. Des. 8 139-145
129. Semenova S. G eyer M.A. Sutcliffe J.G. Markou A. and Hedlund P.B. (2008). Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition. Biol. Psychiatry 63 98-105
130. Shen Y. Monsma F.J. Metcalf M.A. Jose P.A. Hamblin M.W. and Sibley D.R. (1993). Molecular cloning and expression of a 5-hydroxytryptamine 7 serotonin receptor subtype. J. Biol. Chem. 268 18200-18204
131. Shireman B.T. Bonaventure P. and Carruthers N.I. (2008). Recent advances on the 5-HT5A 5-HT6 and 5-HT7 receptors. In: Annual Reports in Medicinal Chemistry (New York: Academic Press). Vol. 43 p. 25-42
132. Slassi A. Isaac M. and Xin T. (2004). Recent progress in 5-HT7 receptors: potential treatment of central and peripheral nervous system diseases. Expert Opin. Ther. Pat. 14 1009-1027
133. Sodhi M.S. and Sanders-Bush E. (2004). Serotonin and brain development. Int. Rev. Neurobiol. 59 111-174
134. Tekes K. Hantos M. Gyenge M. Karabélyos C. and Csaba G. (2006). Prolonged effect of stress at weaning on the brain serotonin metabolism and sexuality of female rats. Horm. Metab. Res. 38 799-802
135. Thomas D.R. and Hagan J.J. (2004). 5-HT7 receptors. Curr. Drug Targets CNS Neurol. Disord. 3 81-90
136. Tricklebank M.D. Forler C. and Fozard J.R. (1984). The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propyla mino) tetralin in the rat. Eur. J. Pharmacol. 106 271-282
137. Ullmer C. Schmuck K. Kalkman H.O. and Luebbert H. (1995). Expression of serotonin receptor mRNA in blood vessels. FEBS Lett. 370 215-221
138. Varnä s K. Thomas D.R. Tupala E. Tiihonen J. and Hall H. (2004). Distribution of 5-HT7 receptors in the human brain: a preliminary autoradiographic study using [3H]-SB-269970. Neurosci. Lett. 367 313-316
139. Waters K.A. Stean T.O. Hammond B. Virley D.J. Neil Upton N. Kew J.N.C. and Hussain I. (2012). Effects of the selective 5-HT7 receptor antagonist SB-269970 in animal models of psychosis and cognition. Behav. Brain Res. 228 211-218
140. Woolley M.L. Ma rsden C.A. and Fone K.C.F. (2004). 5-HT6 receptors. Curr. Drug Targets CNS Neurol. Dis. 3 81-90
141. Yau J.L.W. Noble J. and Seckl J.R. (2001). Acute restraint stress increases 5-HT7 receptor mRNA expression in the rat hippocampus. Neurosci. Lett. 309 141-144