메뉴 건너뛰기




Volumn 49, Issue 3, 2014, Pages 1350-1363

(-)-Epigallocatechin-3-gallate ameliorates learning and memory deficits by adjusting the balance of TrkA/p75NTR signaling in APP/PS1 transgenic mice

Author keywords

APP PS1 transgenic mouse; EGCG; Learning and memory deficits; NGF

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CASPASE 3; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EPIGALLOCATECHIN GALLATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROTROPHIN RECEPTOR P75; PRESENILIN 1; PROTEIN TYROSINE KINASE A; RAF PROTEIN; CATECHIN; NERVE GROWTH FACTOR RECEPTOR; TNFRSF16 PROTEIN, MOUSE;

EID: 84902551030     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-013-8608-2     Document Type: Article
Times cited : (102)

References (50)
  • 1
    • 34248190279 scopus 로고    scopus 로고
    • A beta oligomers - A decade of discovery
    • Walsh DM, Selkoe DJ (2007) A beta oligomers - a decade of discovery. J Neurochem 101(5):1172-1184
    • (2007) J Neurochem , vol.101 , Issue.5 , pp. 1172-1184
    • Walsh, D.M.1    Selkoe, D.J.2
  • 3
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • DOI 10.1126/science.274.5284.99
    • Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274(5284):99-102 (Pubitemid 26332733)
    • (1996) Science , vol.274 , Issue.5284 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6    Yang, F.7    Cole, G.8
  • 4
    • 33846633336 scopus 로고    scopus 로고
    • Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
    • DOI 10.1523/JNEUROSCI.3501-06.2007
    • Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL (2007) Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci 27(4):796-807 (Pubitemid 46174498)
    • (2007) Journal of Neuroscience , vol.27 , Issue.4 , pp. 796-807
    • Lacor, P.N.1    Buniel, M.C.2    Furlow, P.W.3    Clemente, A.S.4    Velasco, P.T.5    Wood, M.6    Viola, K.L.7    Klein, W.L.8
  • 5
    • 34648859471 scopus 로고    scopus 로고
    • Oxidative damage in mild cognitive impairment and early Alzheimer's disease
    • DOI 10.1002/jnr.21346
    • Lovell MA, Markesbery WR (2007) Oxidative damage in mild cognitive impairment and early Alzheimer's disease. J Neurosci Res 85(14):3036-3040 (Pubitemid 350057358)
    • (2007) Journal of Neuroscience Research , vol.85 , Issue.14 , pp. 3036-3040
    • Lovell, M.A.1    Markesbery, W.R.2
  • 7
    • 0028019105 scopus 로고
    • Possible role of neuronal apoptosis in Alzheimer's disease
    • Johnson EM Jr (1994) Possible role of neuronal apoptosis in Alzheimer's disease. Neurobiol Aging 15(Suppl 2):S187-S189
    • (1994) Neurobiol Aging , vol.15 , Issue.SUPPL. 2
    • Johnson Jr., E.M.1
  • 8
    • 79959886270 scopus 로고    scopus 로고
    • Amyloid precursor protein processing and Alzheimer's disease
    • O'Brien RJ, Wong PC (2011) Amyloid precursor protein processing and Alzheimer's disease. Annu Rev Neurosci 34:185-204
    • (2011) Annu Rev Neurosci , vol.34 , pp. 185-204
    • O'Brien, R.J.1    Wong, P.C.2
  • 9
    • 16844377812 scopus 로고    scopus 로고
    • The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease
    • Counts SE, Mufson EJ (2005) The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease. J Neuropathol Exp Neurol 64:263-272 (Pubitemid 40489553)
    • (2005) Journal of Neuropathology and Experimental Neurology , vol.64 , Issue.4 , pp. 263-272
    • Counts, S.E.1    Mufson, E.J.2
  • 10
    • 79958110929 scopus 로고    scopus 로고
    • Targeting NGF-pathway for developing neuroprotective therapies for multiple sclerosis and other neurological diseases
    • Colafrancesco V, Villoslada P (2011) Targeting NGF-pathway for developing neuroprotective therapies for multiple sclerosis and other neurological diseases. Arch Ital Biol 149(2):183-192
    • (2011) Arch Ital Biol , vol.149 , Issue.2 , pp. 183-192
    • Colafrancesco, V.1    Villoslada, P.2
  • 11
    • 0041488911 scopus 로고    scopus 로고
    • Trk receptors: Roles in neuronal signal transduction
    • DOI 10.1146/annurev.biochem.72.121801.161629
    • Huang EJ, Reichardt LF (2003) Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem 72:609-642 (Pubitemid 36930455)
    • (2003) Annual Review of Biochemistry , vol.72 , pp. 609-642
    • Huang, E.J.1    Reichardt, L.F.2
  • 12
    • 1242295155 scopus 로고    scopus 로고
    • Deficient p75 low-affinity neurotrophin receptor expression exacerbates experimental allergic encephalomyelitis in C57/BL6 mice
    • DOI 10.1016/j.jneuroim.2003.11.008
    • Copray S, Kust B, Emmer B, Lin MY, Liem R, Amor S, de Vries H, Floris S, Boddeke E (2004) Deficient p75 low-affmity neurotrophin receptor expression exacerbates experimental allergic encephalomyelitis in C57/BL6 mice. J NeuroimmunoI 148(1-2):41-53 (Pubitemid 38229557)
    • (2004) Journal of Neuroimmunology , vol.148 , Issue.1-2 , pp. 41-53
    • Copray, S.1    Kust, B.2    Emmer, B.3    Lin, M.Y.4    Liem, R.5    Amor, S.6    De Vries, H.7    Floris, S.8    Boddeke, E.9
  • 13
    • 22244466071 scopus 로고    scopus 로고
    • Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in beta-amyloid peptide-dependent cell death
    • DOI 10.1385/JMN:25:2:141
    • Costantini C, Rossi F, Formaggio E, Bernardoni R, Cecconi D, Della-Bianca V (2005) Characterization of the signaling pathway down-stream p75 neurotrophin receptor involved in beta-amyloid peptide-dependent cell death. J Mol Neurosci 25(2):141-156 (Pubitemid 41389355)
    • (2005) Journal of Molecular Neuroscience , vol.25 , Issue.2 , pp. 141-156
    • Costantini, C.1    Rossi, F.2    Formaggio, E.3    Bernardoni, R.4    Cecconi, D.5    Della-Bianca, V.6
  • 14
    • 78449258688 scopus 로고    scopus 로고
    • ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons
    • Song W, Volosin M, Cragnolini AB, Hempstead BL, Friedman WJ (2010) ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons. J Neurosci 30(46):15608-15615
    • (2010) J Neurosci , vol.30 , Issue.46 , pp. 15608-15615
    • Song, W.1    Volosin, M.2    Cragnolini, A.B.3    Hempstead, B.L.4    Friedman, W.J.5
  • 15
    • 84859269517 scopus 로고    scopus 로고
    • Cholingergic degeneration and alterations in the TrkA and p75NTR balance as a result of pro-NGF injection into aged rats
    • doi:10.4061/2011/460543
    • Fortress AM, Buhusi M, Helke KL, Granholm AC (2011) Cholingergic degeneration and alterations in the TrkA and p75NTR balance as a result of pro-NGF injection into aged rats. J Aging Res 2011:460543. doi:10.4061/2011/ 460543
    • (2011) J Aging Res , vol.2011 , pp. 460543
    • Fortress, A.M.1    Buhusi, M.2    Helke, K.L.3    Granholm, A.C.4
  • 16
    • 23044488902 scopus 로고    scopus 로고
    • The yin and yang of neurotrophin action
    • DOI 10.1038/nrn1726
    • Lu B, Pang PT, Woo NH (2005) The yin and yang of neurotrophin action. Nat Rev Neurosci 6(8):603-614 (Pubitemid 41059335)
    • (2005) Nature Reviews Neuroscience , vol.6 , Issue.8 , pp. 603-614
    • Lu, B.1    Pang, P.T.2    Woo, N.H.3
  • 17
    • 0242500949 scopus 로고    scopus 로고
    • Factors affecting the levels of tea polyphenols and caffeine in tea leaves
    • Lin YS, Tsai YJ, Tsay JS, Lin JK (2003) Factors affecting the levels of tea polyphenols and caffeine in tea leaves. J Agric Food Chem 51(7):1864-1873
    • (2003) J Agric Food Chem , vol.51 , Issue.7 , pp. 1864-1873
    • Lin, Y.S.1    Tsai, Y.J.2    Tsay, J.S.3    Lin, J.K.4
  • 18
    • 35348914727 scopus 로고    scopus 로고
    • Effects of green tea and EGCG on cardiovascular and metabolic health
    • Wolfram S (2007) Effects of green tea and EGCG on cardiovascular and metabolic health. J Am Coll Nutr 26(4):373S-388S
    • (2007) J Am Coll Nutr , vol.26 , Issue.4
    • Wolfram, S.1
  • 19
    • 0036239325 scopus 로고    scopus 로고
    • Tea as a functional food for oral health
    • DOI 10.1016/S0899-9007(02)00763-3, PII S0899900702007633
    • Wu CD, Wei GX (2002) Tea as a functional food for oral health. Nutrition 18(5):443-444 (Pubitemid 34414981)
    • (2002) Nutrition , vol.18 , Issue.5 , pp. 443-444
    • Wu, C.D.1    Wei, G.-X.2
  • 20
    • 33747015294 scopus 로고    scopus 로고
    • Regulation of interleukin-1beta-induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts
    • DOI 10.1002/art.22023
    • Ahmed S, Pakozdi A, Koch AE (2006) Regulation of interleukin-1beta- induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 54(8):2393-2401 (Pubitemid 44204999)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.8 , pp. 2393-2401
    • Ahmed, S.1    Pakozdi, A.2    Koch, A.E.3
  • 21
    • 0037291505 scopus 로고    scopus 로고
    • Inhibitory activity of epigallocatechin gallate (EGCg) in paraquat-induced microsomal lipid peroxidation - A mechanism of protective effects of EGCg against paraquat toxicity
    • DOI 10.1016/S0300-483X(02)00512-7, PII S0300483X02005127
    • Higuchi A, Yonemitsu K, Koreeda A, Tsunenari S (2003) Inhibitory activity of epigallocatechin gallate (EGCg) in paraquat-induced microsomal lipid peroxidation-a mechanism of protective effects of EGCg against paraquat toxicity. Toxicology 183(1-3):143-149 (Pubitemid 36005394)
    • (2003) Toxicology , vol.183 , Issue.1-3 , pp. 143-149
    • Higuchi, A.1    Yonemitsu, K.2    Koreeda, A.3    Tsunenari, S.4
  • 22
    • 34249299083 scopus 로고    scopus 로고
    • A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3- gallate as a potential anticancer agent
    • DOI 10.1158/0008-5472.CAN-06-4699
    • Landis-Piwowar KR, Huo C, Chen D, Milacic V, Shi G, Chan TH, Dou QP (2007) A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3- gallate as a potential anticancer agent. Cancer Res 67(9):4303-4310 (Pubitemid 46815078)
    • (2007) Cancer Research , vol.67 , Issue.9 , pp. 4303-4310
    • Landis-Piwowar, K.R.1    Huo, C.2    Chen, D.3    Milacic, V.4    Shi, G.5    Tak, H.C.6    Dou, Q.P.7
  • 23
    • 0347416986 scopus 로고    scopus 로고
    • Epigallocatechin 3-gallate attenuates neuronal damage induced by 3-hydroxykynurenine
    • DOI 10.1016/j.tox.2003.08.007
    • Jeong JH, Kim HJ, Lee TJ, Kim MK, Park ES, Choi BS (2004) Epigallocatechin 3-gallate attenuates neuronal damage induced by 3-hydroxykynurenine. Toxicology 195(1):53-60 (Pubitemid 38036982)
    • (2004) Toxicology , vol.195 , Issue.1 , pp. 53-60
    • Jeong, J.H.1    Kim, H.J.2    Lee, T.J.3    Kim, M.K.4    Park, E.S.5    Choi, B.S.6
  • 25
    • 70349336861 scopus 로고    scopus 로고
    • Green tea (-)-epigallocatechin-3-Gallate inhibits β-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-κB Pathways in Mice
    • Lee JW, Lee YK, Ban JO, Ha TY, Yun YP, Han SB, Oh KW, Hong JT (2009) Green tea (-)-epigallocatechin-3-Gallate inhibits β-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-κB Pathways in Mice. J Nutr 139(10):1987-1993
    • (2009) J Nutr , vol.139 , Issue.10 , pp. 1987-1993
    • Lee, J.W.1    Lee, Y.K.2    Ban, J.O.3    Ha, T.Y.4    Yun, Y.P.5    Han, S.B.6    Oh, K.W.7    Hong, J.T.8
  • 26
    • 44249116000 scopus 로고    scopus 로고
    • Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice
    • Rezai-Zadeh K, Arendash GW, Hou H, Fernandez F, Jensen M, Runfeldt M, Shytle RD, Tan J (2008) Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain Res 12(1214):177-187
    • (2008) Brain Res , vol.12 , Issue.1214 , pp. 177-187
    • Rezai-Zadeh, K.1    Arendash, G.W.2    Hou, H.3    Fernandez, F.4    Jensen, M.5    Runfeldt, M.6    Shytle, R.D.7    Tan, J.8
  • 27
    • 59949093248 scopus 로고    scopus 로고
    • Neuroprotective effects of (-)-epigallocatechin-3-gallate on aging mice induced by D-galactose
    • He M, Zhao L, Wei MJ, Yao WF, Zhao HS, Chen FJ (2009) Neuroprotective effects of (-)-epigallocatechin-3-gallate on aging mice induced by D-galactose. Biol Pharm Bull 32(1):55-60
    • (2009) Biol Pharm Bull , vol.32 , Issue.1 , pp. 55-60
    • He, M.1    Zhao, L.2    Wei, M.J.3    Yao, W.F.4    Zhao, H.S.5    Chen, F.J.6
  • 29
    • 33747153860 scopus 로고    scopus 로고
    • Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice
    • DOI 10.1016/j.nbd.2006.05.010, PII S0969996106001240
    • van Groen T, Kiliaan AJ, Kadish I (2006) Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice. Neurobiol Dis 23(3):653-662 (Pubitemid 44234102)
    • (2006) Neurobiology of Disease , vol.23 , Issue.3 , pp. 653-662
    • Van Groen, T.1    Kiliaan, A.J.2    Kadish, I.3
  • 32
    • 0038388951 scopus 로고    scopus 로고
    • Modulation of passive avoidance in mice by the 5-HT1A receptor agonist flesinoxan: Comparison with the benzodiazepine receptor agonist diazepam
    • Tsuji M, Takeda H, Matsumiya T (2003) Modulation of passive avoidance in mice by the 5-HT1A receptor agonist flesinoxan: comparison with the benzodiazepine receptor agonist diazepam. Neuropharmacology 28(4):664-674
    • (2003) Neuropharmacology , vol.28 , Issue.4 , pp. 664-674
    • Tsuji, M.1    Takeda, H.2    Matsumiya, T.3
  • 33
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11(1):47-60
    • (1984) J Neurosci Methods , vol.11 , Issue.1 , pp. 47-60
    • Morris, R.1
  • 34
    • 33846461062 scopus 로고    scopus 로고
    • Morris water maze: Procedures for assessing spatial and related forms of learning and memory
    • Vorhees CV, Williams MT (2006) Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 1(2):848-858
    • (2006) Nat Protoc , vol.1 , Issue.2 , pp. 848-858
    • Vorhees, C.V.1    Williams, M.T.2
  • 35
    • 79955727727 scopus 로고    scopus 로고
    • The cholinergic system in aging and neuronal degeneration
    • Schliebs R, Arendt T (2011) The cholinergic system in aging and neuronal degeneration. Behav Brain Res 221(2):555-563
    • (2011) Behav Brain Res , vol.221 , Issue.2 , pp. 555-563
    • Schliebs, R.1    Arendt, T.2
  • 36
    • 77957339512 scopus 로고    scopus 로고
    • Transgenic mice with chronic NGF deprivation and Alzheimer's disease-like pathology display hippocampal region-specific impairments in short- and long-term plasticities
    • Houehand G, Romani A, Marchetti C, Amato G, Capsoni S, Cattaneo A, Marie H (2010) Transgenic mice with chronic NGF deprivation and Alzheimer's disease-like pathology display hippocampal region-specific impairments in short- and long-term plasticities. J Neurosci 30(39):13089-13094
    • (2010) J Neurosci , vol.30 , Issue.39 , pp. 13089-13094
    • Houehand, G.1    Romani, A.2    Marchetti, C.3    Amato, G.4    Capsoni, S.5    Cattaneo, A.6    Marie, H.7
  • 37
    • 0030833055 scopus 로고    scopus 로고
    • Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
    • DOI 10.1016/S0896-6273(00)80974-5
    • Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS (1997) Accelerated amyloid deposition in t he brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19(4):939-945 (Pubitemid 27471397)
    • (1997) Neuron , vol.19 , Issue.4 , pp. 939-945
    • Borchelt, D.R.1    Ratovitski, T.2    Van Lare, J.3    Lee, M.K.4    Gonzales, V.5    Jenkins, N.A.6    Copeland, N.G.7    Price, D.L.8    Sisodia, S.S.9
  • 38
    • 84879795488 scopus 로고    scopus 로고
    • -Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus
    • Jia N, Han K, Kong JJ, Zhang XM, Sha S, Ren GR, Cao YP (2013) (-)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus. Mol Cell Biochem 380:211-218
    • (2013) Mol Cell Biochem , vol.380 , pp. 211-218
    • Jia, N.1    Han, K.2    Kong, J.J.3    Zhang, X.M.4    Sha, S.5    Ren, G.R.6    Cao, Y.P.7
  • 39
    • 34548027316 scopus 로고    scopus 로고
    • Protective effect of (-)-epigallocatechin gallate against advanced glycation endproducts-induced injury in neuronal cells
    • Lee SJ, Lee KW (2007) Protective effect of (-)-epigallocatechin gallate against advanced glycation endproducts-induced injury in neuronal cells. Biol Pharm Bull 30(8):1369-1373
    • (2007) Biol Pharm Bull , vol.30 , Issue.8 , pp. 1369-1373
    • Lee, S.J.1    Lee, K.W.2
  • 40
    • 10744223843 scopus 로고    scopus 로고
    • Epigallocatechin gallate protects nerve growth factor differentiated PC12 cells from oxidative-radical-stress-induced apoptosis through its effect on phosphoinositide 3-kinase/Akt and glycogen synthase kinase-3
    • DOI 10.1016/j.molbrainres.2003.07.003
    • Koh SH, Kim SH, Kwon H, Park Y, Kim KS, Song CW, Kim J, Kim MH, Yu HJ, Henkel JS, Jung HK (2003) Epigallocatechin gallate protects nerve growth factor differentiated PC12 cells from oxidative-radical-stress-induced apoptosis through its effect on phosphoinositide 3-kinase/Akt and glycogen synthase kinase-3. Mol Brain Res 118(1-2):72-81 (Pubitemid 37238989)
    • (2003) Molecular Brain Research , vol.118 , Issue.1-2 , pp. 72-81
    • Koh, S.-H.1    Kim, S.H.2    Kwon, H.3    Park, Y.4    Kim, K.S.5    Song, C.W.6    Kim, J.7    Kim, M.-H.8    Yu, H.-J.9    Henkel, J.S.10    Jung, H.K.11
  • 42
    • 79959985280 scopus 로고    scopus 로고
    • A dual mechanism linking NGF/proNGF imbalance and early inflammation to Alzheimer's disease neurodegeneration in the AD11 anti-NGF mouse model
    • Capsoni S, Brandi R, Arisi I, D'Onofrio M, Cattaneo A (2011) A dual mechanism linking NGF/proNGF imbalance and early inflammation to Alzheimer's disease neurodegeneration in the AD11 anti-NGF mouse model. CNS Neurol Disord Drug Targets 10(5):635-647
    • (2011) CNS Neurol Disord Drug Targets , vol.10 , Issue.5 , pp. 635-647
    • Capsoni, S.1    Brandi, R.2    Arisi, I.3    D'Onofrio, M.4    Cattaneo, A.5
  • 43
    • 33846574233 scopus 로고    scopus 로고
    • Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation
    • DOI 10.1016/j.neulet.2006.11.040, PII S0304394006012717
    • Williams B, Granholm AC, Sambamurti K (2007) Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation. Neurosci Lett 413(2):110-114 (Pubitemid 46177399)
    • (2007) Neuroscience Letters , vol.413 , Issue.2 , pp. 110-114
    • Williams, B.1    Granholm, A.-C.2    Sambamurti, K.3
  • 46
    • 85047694516 scopus 로고    scopus 로고
    • Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment
    • DOI 10.1172/JCI200422831
    • Gong B, Vitolo OV, Trinchese F, Liu S, Shelanski M, Arancio O (2004) Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. J Clin Invest 114:1624-1634 (Pubitemid 40385553)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.11 , pp. 1624-1634
    • Gong, B.1    Vitolo, O.V.2    Trinchese, F.3    Liu, S.4    Shelanski, M.5    Arancio, O.6
  • 47
    • 79551473183 scopus 로고    scopus 로고
    • 5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo
    • Chu J, Praticò D (2011) 5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo. Ann Neurol 69(1):34-46
    • (2011) Ann Neurol , vol.69 , Issue.1 , pp. 34-46
    • Chu, J.1    Praticò, D.2
  • 48
    • 0035907325 scopus 로고    scopus 로고
    • β-amyloid-(1-42) impairs acivity-dependent cAMP-response-elment- binding protein signaling in neurons at concentrations in which cell survival is not compromised
    • Tong LQ, Thornton PL, Balazs R, Cotman CW (2001) β-amyloid-(1-42) impairs acivity-dependent cAMP-response-elment-binding protein signaling in neurons at concentrations in which cell survival is not compromised. J Biol Chem 276(20):17301-17306
    • (2001) J Biol Chem , vol.276 , Issue.20 , pp. 17301-17306
    • Tong, L.Q.1    Thornton, P.L.2    Balazs, R.3    Cotman, C.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.