On the calcium hypothesis of brain aging;ZUR KALZIUMHYPOTHESE DER HIRNALTERUNG

Nervenarzt

Volumn 67, Issue 1, 1996, Pages 15-24

  Muller W E ^a,b   Eckert, A ^a   Hartmann, H ^a   Velbinger, K ^a   Forstl H ^a  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b Abteilung Psychopharmakologie   (Germany)

Author keywords

amyloid; aging; Alzheimer's disease; free intracellular calcium

Indexed keywords

CALCIUM;

AGING; BRAIN; HUMAN; REVIEW; STRESS; THEORY;

AGED; AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; CALCIUM; CALCIUM CHANNELS; HOMEOSTASIS; HUMANS; NEURONS;

EID: 0030050170     PISSN: 00282804     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (59)

1. Adunsky A, Baram D, Hershkowitz M, Mekori YA (1991) Increased cytosolic free calcium in lymphocytes of Alzheimer patients. J Neuroimmunol 33: 167-172
2. 2+] in mononuclear blood cells from demented patients and healthy controls. Eur Arch Psychiatry Clin Neurosci 243: 224-228
3. Bondy B, Hoffmann M, Müller-Spahn F, Witzko M, Hock C (1994) Störungen der intrazellulären Kalziumregulation und Dysfunktion der Kaliumkanäle in Lymphozyten: Ein Marker für die Alzheimersche Erkrankung? Fortschr Neurol Psychiatrie 62: 78 (Abstr)
4. Carney JM, Carney AM (1994) Role of protein oxidation in aging and in age-associated neurodegenerative diseases. Life Sci 55: 2097-2103
5. Chandler LJ, Crews FT (1989) Calcium-versus G-protein activated phosphoinositide hydrolysis in synaptosomes from young and old rats. Ann NY Acad Sci 568: 187-192
6. Davies T, Fine RE, Johnson RJ, Levesque CA, Rathbun WH, Seetoo KF, Smith SJ, Strohmeier G, Volicer L, Delva L, Simons ER (1993) Non-age related differences in thrombin responses by platelets from male patients with advanced Alzheimer's disease. Biochem Biophys Res Commun 194: 537-543
7. Disterhoft JF, Moyer JR, Thompson LT, Kowalska M (1993) Functional aspects of calcium-channel modulation. Clin Neuropharmacol 16: S12-S24
8. Dumais-Huber C, Aldenhoff JB (1994) Mitogen-induzierter Kalziumanstieg in einzelnen T-Lymphozyten bei Patienten mit Alzheimerscher Erkrankung sowie bei jungen und alten Gesunden. Fortschr Neurol Psychiatrie 62: 77 (Abstr.)
9. Eckert A, Förstl H, Hartmann H, Müller WE (1993) Decreased β-amyloid sensitivity in Alzheimer's disease. Lancet 342: 805-806
10. Eckert A, Hartmann H, Müller WE (1993) β-Amyloid protein enhances the mitogen-induced calcium response in circulating human lymphocytes. FEBS Lett 330: 49-52
11. Eckert A, Hartmann H, Förstl H, Müller WE (1994) Alterations of intracellular calcium régulation during aging and Alzheimei's disease in nonneuronal cells. Life Sci 55: 2019-2029
12. Eckert A, Förstl H, Hartmann H, Czech C, Mönning U, Beyreuther K, Müller WE (1995) The amplifying effect of β-amyloid on cellular calcium signalling is reduced in Alzheimer's disease. Neuro Rep 6: 1199-1202
13. Etcheberrigaray R, Ito E, Oka K, Tofel-Grehl B, Gibson GE, Alkon DL (1993) Potassisum channel dysfunction in fibroblasts identifies aptients with Alzheimer's disease. Proc Natl Acad Sci USA 90: 8209-8213
14. + channels. Science 264: 276-279
15. Farrar RP, Rezaradeh SM, Morris JL, Lildy JE, Guan R, Leslie SW (1989) Aging does not alter cyclosolic calcium levels of cortical synaptosomes in Fisher 344 rats. Neurosci Lett 100: 319-325
16. Gibson GE, Peterson C (1987) Calcium and the aging nervous system. Neurobiol Aging 8: 329-343
17. Gibson GE, Toral-Borza L (1992) Cytosolic free calcium in lymphoblasts from young aged and Alzheimer subjects. Mech Ageing Dev 63: 1-9
18. 2+ changes in rat cortical synaptosomes. J Neurochem 53: 392-398
19. + subset. Exp Cell Res 180: 367-382
20. + lymphocytes in Alzheimer's disease and in older persons with Down's syndrome. Neurobiol Agine 14: 177-185
21. Hartmann H, Müller WE (1993) Age-related changes in receptor-mediated and depolarization-induced phosphatidylinositol turnover in mouse brain. Brain Res 622: 86-92
22. Hartmann H, Eckert A, Müller WE (1993) Aging enhances the calcium sensitivity of central neurons of the mouse as an adaptive response to reduced free intracellular calcium. Neurosci Lett 152: 181-184
23. Hartmann H, Eckert A, Müller WE (1993) β-amyloid protein amplifies calcium signalling in central neurons from the adult mouse. Biochem Biophys Res Commun 194: 1216-1220
24. Hartmann H, Eckert A, Förstl H, Müller WE (1994) Similar age-related changes of free intracellular calcium in lymphocytes and central neurons: effects of Alzheimer's disease. Eur Arch Psychiatr Clin Neurosci 243: 218-223
25. Hartmann H, Eckert A, Müller WE (1994) Apoliprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to β-amyloid neurotoxicity. Biochem Biophys Res Commun 200: 1185-1192
26. Hartmann H, Eckert A, Müller WE (1994) Disturbances of the neuronal calcium homeostasis in the aging nervous system. Life Sci 55: 2011-2018
27. Hartmann H, Velbinger K, Eckert A, Müller WE (1995) Region specific downregulation of free intracellular calcium in the aged rat brain. Neurobiol Aging (in press)
28. Herrschaft H (1992) Nimodipin. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuropsychopharmaka, Bd 5, Parkinsonmittel und Nootropika. Springer, Wien New York, S 261-289
29. Huang HM, Toral-Borza L, Thaler H, Tofel-Grehl B, Gibson GE (1991) Inositol phosphates and intracellular calcium after bradykinin stimulation in fibroblasts from young, aged and Alzheimer donors. Neurobiol Aging 12: 469-473
30. Huidobro A, Blanco P, Villalba M, Gomes-Puertas P, Villa A, Pereira R, Bogonez E, Martinez-Serrano A, Aparicia JJ, Satrustegui J (1993) Age-realted changes in calcium homeostatic mechanisms in synaptosomes in relation with working memory deficiency. Neurobiol Aging 14:479-486
31. Khachaturian ZS (1989) The role of calcium regulation in brain aging: reexamination of a hypothesis. Aging 1: 17-34
32. Landfield PW (1989) Nimodipine modulation of age-related increases in hippocampal calcium currents. In: Traber J, Gipsen WH (eds) Nimodipine and central nervous system function: new vistas. Schattauer, Stuttgart, pp 227-238
33. 2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats. Science 226: 1089-1091
34. Landfield PW, Pitler TA (1987) Calcium spike duration: prolongation on hippocampal neurons of aged rats. Soc Neurosci Abstr 13: 718
35. LeQuan Sang KH, Mignot E, Gilbert JC, Huguet R, Aquino JP, Regnier O, Devynck MA (1993) Platelet cytosolic free-calcium concenlration is decreased in aging and Alzheimer's disease. Biol Psychiatry 33: 391-393
36. Lustyk G, O'Leary JJ (1989) Aging and the mobilization of intracellular calcium by phytohemagglutinin in human T-cells. J Gerontol 44: B30-36
37. Manger T, Bowers J, Gibson GE (1987) Assessment of cytosolic-free calcium in synaptosomes with fura-2 in the presence of fura-2 AM. Effects of hypoglycemia and aging. Soc Neurosci Abstr 13: 1238
38. Martinez A, Vitorica J, Bogonez E, Satruslegui J (1987) Differential effects of age on the pathways of calcium influx into nerve terminals. Brain Res 435: 249-257
39. 45Ca-influx in synaptosomes with age involves inactivating and noninactivating calcium channels and is correlated with temporal modifications in protein phosphorylation. J Neurochem 52: 576-584
40. Mattson MP, Cheng B, Davies D, Bryant K, Liederburg I, Rydel RE (1992) β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to exocitotoxicity. J Neurosci 12: 376-389
41. Mattson MP, Rydel RE, Lieberburg I, Smith-Swintosky VL (1993) Altered calcium signalling and neuronal injury: stroke and Alzheimer's disease as examples. Ann NY Acad Sci 679: 1-21
42. Michaelis ML, Foster CT, Yajawickrcme C (1992) Regulation of calcium levels in brain tissue from adult and aged rats. Mech Ageing Dev 62: 291-306
43. Miller RA (1994) Aging and immune function. Cellular and biochemical analyses. Exp Gerontol 29: 21-35
44. Moyer JR, Disterhoft JF (1994) Nimodipine decreases calcium action potentials in rabbit hippocampal CA1 neurons in age-dependent and concentration-dependent manner. Hippocampus 4: 11-18
45. Müller WE, Eckert A, Hartmann H, Forstl H (1994) Free intracellular calcium in aging and Alzheimer's disease. In: Giacobini E, Becker R (eds) Advances in Alzheimer's therapy. Birkhäuser, Boston, pp 299-303
46. Müller WE, Koch S, Eckert A, Hartmann H, Scheuer K (1995) β-amyloid peptide decreases membrane fluidity. Brain Res 674: 133-136
47. 2- fluxes and responses to phorbol ester in T-lymphocytes from healthy elderly subjects. Clin Exp Immunol 89: 158-163
48. Peterson C, Ratan RR, Shelanski ML, Goldman JE (1986) Cytosolic free calcium and cell spreading decrease in fibroblasts from aged and Alzheimer donors. Proc Natl Acad Sci USA 83: 7999-8001
49. Peterson C (1993) Changes in calcium's role as a messenger during aging in neuronal and nonneuronal cells. Ann NY Acad Sci 279-293
50. 2+-currents in mammalian brain neurons. Brain Res 410: 147-153
51. Pitler TA, Landfield PW (1990) Agingrelated prolongation of calcium spike duration in rat hippocampal slice neurons. Brain Res 508: 1-6
52. Potier B, Rascol O, Jazat F, Lamour Y, Dutar P (1992) Alterations in the properties of hippocampal pyramidal neurons in the aged rat. Neurosci 48: 793-806
53. Reynolds JN, Carlen PL (1989) Diminished calcium currents in aged hippocampal dentate gyrus granule neurons. Brain Res 348-390
54. Strosznajder J, Samochocki, Wikie H, Melecki A (1994) Aging modulates calcium-de pendent phosphatidylinositol degradation by cerebral cortex synaptic plasma membrane phospholipases. Mol Chem Neuropathol 21: 95-107
55. Toth S, Csermely P, Beregi E, Szkladanyi A, Szabo LD (1989) Decreased cytosolic free calcium concentration of aged human lymphocytes in resting state. Compr Gerontol [Suppl A, B] 3: 16-22
56. 2+ uptake in acutely dissociated brain cells derived from adult rats. Brain Res 570: 347-353
57. Yankner BA, Duffy LK, Kirschner DA (1990) Neurotrophic and neurotoxic effects of amyloid β protein: Reversal by tachykinin neuropeptides. Science 256: 184-185
58. Bondy B, Hofmann M, Müller-Spahn F, Witzko M, Hock CH (1995) Reduced β-amyloid response in lymphocytes of patients with Alzheimer's disease. Pharmacopsychiat 28: 143-146
59. 2+ signalling. Pharmacopsychiat 28: 206