Opposite effects of JNK and p38 MAPK signaling pathways on furazolidone-stimulated S phase cell cycle arrest of human hepatoblastoma cell line

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 755, Issue 1, 2013, Pages 24-29

  Sun, Yu ^a   Tang, Shusheng ^a   Jin, Xi ^a,b   Zhang, Chaoming ^a   Zhao, Wenxia ^a   Xiao, Xilong ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b BEIJING NORMAL UNIVERSITY   (China)

Author keywords

Cell growth suppression; Furazolidone; HepG2 cells; JNK; P38 MAPK; S phase cell cycle arrest

Indexed keywords

FURAZOLIDONE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION;

CELL GROWTH SUPPRESSION; FURAZOLIDONE; HEPG2 CELLS; JNK; P38 MAPK; S PHASE CELL CYCLE ARREST;

ANTITRICHOMONAL AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; FURAZOLIDONE; HEPATOBLASTOMA; HUMANS; LIVER NEOPLASMS; MAP KINASE KINASE 4; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; S PHASE; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84880041457     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2013.04.015     Document Type: Article

References (38)

1. Ali B.H. Pharmacological, therapeutic and toxicological properties of furazolidone: some recent research. Vet. Res. Commun. 1999, 23:343-360.
2. Jin X., Tang S.S., Chen Q. Furazolidone induced oxidative DNA damage via up-regulating ROS that caused cell cycle arrest in human hepatoma G2 cells. Toxicol. Lett. 2011, 201:205-212.
3. Barr R.K., Bogoyevitch M.A. The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs). Int. J. Biochem. Cell B 2001, 33:1047-1063.
4. Beatriz M., Ricardo P.T. The cytotoxic prodigiosin induces phosphorylation of p38-MAPK but not of SAPK/JNK. Toxicol. Lett. 2002, 1:93-98.
5. Fracasso M.E., Perbellini L., Soldà S., Talamini G., Franceschetti P. Lead induced DNA strand breaks in lymphocytes of exposed workers: role of reactive oxygen species and protein kinase C. Mutat. Res. 2002, 515:159-169.
6. Megan C., Alice G., Patricia W. A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Mol. Cell. Biol. 2010, 30:481-495.
7. Boisleve F., Kerdine-Romer S., Pallardy M. Implication of the MAPK pathways in the maturation of human dendritic cells induced by nickel and TNF-alpha. Toxicology 2005, 206:233-244.
8. Bulavin D., Kovalsky O., Hollander M.C., Fornace A. Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of GADD45a. Mol. Cell. Biol. 2003, 23:3859-3871.
9. Chang L., Karin M. Mammalian MAP kinase signaling cascades. Nature 2001, 410:37-40.
10. Eirini K., Catherine G., Isidoros B. ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-κB transactivation during oxidative stress in skeletal myoblasts. Cell Signal. 2006, 12:2238-2251.
11. Harkin D.P., Bean J., Miklos Y. Induction of GADD45 and JNK/SAPK dependent apoptosis following inducible expression of BRCA1. Cell 1999, 97:575-586.
12. Sarah J.H., Philip L.G. Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38. Cell Signal. 2001, 5:299-310.
13. Cheng H., Kartenbeck J., Kabsch K., Mao X., Marqués M., Alonso A. Stress kinase p38 mediates EGFR transactivation by hyperosmolar concentrations of sorbitol. J. Cell. Physiol. 2002, 192:234-243.
14. Gomez P., Martinez-Martinez S., Calvo V., Armesilla A.L., Redondo J.M. JNK c-Jun NH2-terminal kinase is a target for antioxidants in T lymphocytes. J. Biol. Chem. 1996, 271:26335-26340.
15. Landry J., Huot J. Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27. Biochem. Cell. Biol. 1995, 73:703-707.
16. Wozniak K., Blasiak J. Free radicals-mediated induction of oxidized DNA bases and DNA-protein cross-links by nickel chloride. Mutat. Res. 2002, 514:233-243.
17. Rousseau S., Houle F., Landry J., Huot J. p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells. Oncogene 1997, 15:2169-2177.
18. Yang B., Cao D.J., Sainz I., Colman R.W., Guo Y.L. Different roles of ERK and p38 MAP kinases during tube formation from endothelial cells cultured in 3-dimensional collagen matrices. J. Cell. Physiol. 2000, 200:360-369.
19. Eva M., Anke B.K., Wolfgang N., Fraek M.L., Josefine M., Klaus T., Beck F.X. Possible involvement of heat shock protein 25 in the angiotensin II-induced glomerular mesangial cell contraction via p38 MAP kinase. J. Cell. Physiol. 1999, 181:462-469.
20. Klemke R.L., Cai S., Giannini A.L., Gallagher P.J., Lanerolle P., Cheresh D.A. Regulation of cell motility by mitogen-activated protein kinase. J. Cell. Biol. 1997, 137:481-492.
21. Kummer J.L., Rao P.K., Heidenreich K.A. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J. Biol. Chem. 1997, 272:20490-20494.
22. Zou J.J., Chen Q., Tang S.S. Olaquindox-induced genotoxicity and oxidative DNA damage in human hepatoma G2 (HepG2) cells. Mutat. Res. 2009, 676:27-33.
23. Pietenpol J.A., Stewart Z.A. Cell cycle checkpoint signaling: Cell cycle arrest versus apoptosis. Toxicology 2002, 181:475-481.
24. Daly J.M., Olayioye M.A., Wong A.M., Neve R., Lane H.A., Maurer F.G., Hynes N.E. NDF/heregulin-induced cell cycle changes and apoptosis in breast tumour cells: role of PI3 kinase and p38 MAP kinase pathways. Oncogene 1999, 18:3440-3451.
25. Ming Z., Aiguo W., Tao X., Ping H. Effects of fluoride on DNA damage, S phase cell-cycle arrest and the expression of NF-κB in primary cultured rat hippocampal neurons. Toxicol. Lett. 2008, 179:1-5.
26. Guay J., Lambert H., Gingras G., Lavoie J.N., Huot J., Landry J. Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27. J. Cell. Sci. 1997, 110:357-368.
27. Hedges J.C., Dechert M.A., Yamboliev I.A., Martin J.L., Hickey E., Weber L.A., Gerthoffer W.T. A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration. J. Biol. Chem. 1999, 274:24211-24219.
28. Kramer R.M., Roberts E.F., Strifler B.A., Johnstone E.M. Thrombin induces activation of p38 MAP kinase in human platelets. J. Biol. Chem. 1995, 270:27395-27398.
29. Cuenda A., Rouse J., Doza Y.N., Meier R., Cohen P., Gallagher T.F., Young P.R., Lee J.C. SB203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 1995, 364:229-233.
30. Jiang Y., Chen C., Li Z., Guo W., Gegner J.A., Lin S., Han J. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J. Biol. Chem. 1996, 271:17920-17926.
31. Sanjay K., Bartholomew J.V., David J.R., Alison M.B., Maxine G., John C.L. IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase. J. Cell. Physiol. 2001, 187:294-303.
32. Ozaki I., Tani E., Ikemoto H., Kitagawa H., Fujikawa H. Activation of stress-activated protein kinase/c-Jun NH2-terminal kinase and p38 kinase in calphostin C-induced apoptosis requires caspase-3-like proteases but is dispensable for cell death. J. Biol. Chem. 1999, 274:5310-5317.
33. Saeki K., Kobayashi N., Inazawa Y., Zhang H., Nishitoh H., Ichijo H., Isemura M., Yuo A. Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis. Biochem. J. 2002, 368:705-720.
34. Kim J.Y., Choi J.A., Kim T.H., Yoo Y.D., Kim J.I., Lee Y.J., Yoo S.Y., Cho C.K., Lee Y.S., Lee S.J. Involvement of p38 mitogen-activated protein kinase in the cell growth inhibition by sodium arsenite. J. Cell. Physiol. 2002, 190:369-373.
35. Marra F., Arrighi M.C., Fazi M., Caligiuri A., Pinzani M., Romanelli R.G., Efsen E., Laffi G., Gentilini P. Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat. Hepatology 1999, 30:951-958.
36. Matsumoto T., Yokote K., Tamura K., Takemoto M., Ueno H., Saito Y., Mori S. Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration. J. Biol. Chem. 1999, 274:13954-13960.
37. Wenhong C., Kiefer W., Jacques R., Pere P. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol. Cell. Biol. 2004, 24:3057-3067.
38. Soh Y., Shin M.H., Lee J.S., Jang J.H., Kim O.H., Kang H., Surh Y.J. Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline. Mutat. Res. 2003, 544:129-142.