-
1
-
-
0035409575
-
α-Synuclein and neurodegenerative diseases
-
Goedert M. α-Synuclein and neurodegenerative diseases. Nat. Rev. Neurosci. 2 (2001) 492-501
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, pp. 492-501
-
-
Goedert, M.1
-
2
-
-
0030882856
-
α-Synuclein in lewy bodies
-
Spillantini M.G., Schimdt M.L., Lee V.M., Trojanowski J.Q., Jakes R., and Goedert M. α-Synuclein in lewy bodies. Nature 388 (1997) 839-840
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schimdt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
3
-
-
0031941058
-
Aggregation of α-synuclein in lewy bodies of sporadic Parkinson's disease and dementia with lewy bodies
-
Baba M., Nakajo S., Tu P.H., Tomita T., Nakaya K., and Lee V.M. Aggregation of α-synuclein in lewy bodies of sporadic Parkinson's disease and dementia with lewy bodies. Am. J. Pathol. 152 (1998) 879-884
-
(1998)
Am. J. Pathol.
, vol.152
, pp. 879-884
-
-
Baba, M.1
Nakajo, S.2
Tu, P.H.3
Tomita, T.4
Nakaya, K.5
Lee, V.M.6
-
4
-
-
0032546895
-
Alpha synuclein immuno-reactivity in glial cytoplasmic inclusions in multiple system atrophy
-
Wakabayashi K., Yoshimoto M., Tsuji S., and Takahashi H. Alpha synuclein immuno-reactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci. Lett. 249 (1998) 180-182
-
(1998)
Neurosci. Lett.
, vol.249
, pp. 180-182
-
-
Wakabayashi, K.1
Yoshimoto, M.2
Tsuji, S.3
Takahashi, H.4
-
5
-
-
0024546234
-
The role of environmental toxins in the etiology of Parkinson's disease
-
Tanner C.M. The role of environmental toxins in the etiology of Parkinson's disease. Trends Neurosci. 12 (1989) 49-54
-
(1989)
Trends Neurosci.
, vol.12
, pp. 49-54
-
-
Tanner, C.M.1
-
6
-
-
0026034279
-
Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis
-
Hirsch E.C., Brandel J.P., Galle P., Javoy-Agid F., and Agid Y. Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis. J. Neurochem. 56 (1991) 446-451
-
(1991)
J. Neurochem.
, vol.56
, pp. 446-451
-
-
Hirsch, E.C.1
Brandel, J.P.2
Galle, P.3
Javoy-Agid, F.4
Agid, Y.5
-
7
-
-
0026746512
-
Neuromelanin-containing neurons of the substantia nigra accumulates iron and aluminium in Parkinson's disease: a LAMMA study
-
Good P.F., Olanow C.W., and Perl D.P. Neuromelanin-containing neurons of the substantia nigra accumulates iron and aluminium in Parkinson's disease: a LAMMA study. Brain Res. 593 (1992) 343-346
-
(1992)
Brain Res.
, vol.593
, pp. 343-346
-
-
Good, P.F.1
Olanow, C.W.2
Perl, D.P.3
-
8
-
-
0026454505
-
Calcium, magnesium aluminium concentrations in Parkinson's disease
-
Yasui M., Kihira T., and Ota K. Calcium, magnesium aluminium concentrations in Parkinson's disease. Neurotoxicology 13 (1992) 593-600
-
(1992)
Neurotoxicology
, vol.13
, pp. 593-600
-
-
Yasui, M.1
Kihira, T.2
Ota, K.3
-
9
-
-
0033037034
-
Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease
-
Gorell J.M., Johnson C.C., Rybicki B.A., Peterson E.L., Kortsha G.X., Brown G.G., and Richardson R.J. Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease. Neurotoxicology 20 (1999) 239-247
-
(1999)
Neurotoxicology
, vol.20
, pp. 239-247
-
-
Gorell, J.M.1
Johnson, C.C.2
Rybicki, B.A.3
Peterson, E.L.4
Kortsha, G.X.5
Brown, G.G.6
Richardson, R.J.7
-
10
-
-
0033153770
-
Aluminum containing antacids as a cause of idiopathic Parkinson's disease
-
Altschuler E. Aluminum containing antacids as a cause of idiopathic Parkinson's disease. Med. Hypotheses 53 (1999) 22-23
-
(1999)
Med. Hypotheses
, vol.53
, pp. 22-23
-
-
Altschuler, E.1
-
11
-
-
0033117146
-
Pesticides and Parkinson's disease
-
De Le Couteur D.G., McLean A.J., Taylor M.C., Woodham B.L., and Board P.G. Pesticides and Parkinson's disease. Biomed. Pharmacother. 53 (1999) 122-130
-
(1999)
Biomed. Pharmacother.
, vol.53
, pp. 122-130
-
-
De Le Couteur, D.G.1
McLean, A.J.2
Taylor, M.C.3
Woodham, B.L.4
Board, P.G.5
-
12
-
-
0024356620
-
Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease
-
Dexter D.T., Wells F.R., Lees A.J., Agid F.J., Agid Y., Jenner P., and Marsden C.D. Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J. Neurochem. 52 (1989) 1830-1836
-
(1989)
J. Neurochem.
, vol.52
, pp. 1830-1836
-
-
Dexter, D.T.1
Wells, F.R.2
Lees, A.J.3
Agid, F.J.4
Agid, Y.5
Jenner, P.6
Marsden, C.D.7
-
13
-
-
0025821265
-
Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia
-
Dexter D.T., Carayon A., Agid F.J., Agid Y., Wells F.R., Daniel S.E., Lees A.J., Jenner P., and Marsden C.D. Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain 114 (1991) 1953-1975
-
(1991)
Brain
, vol.114
, pp. 1953-1975
-
-
Dexter, D.T.1
Carayon, A.2
Agid, F.J.3
Agid, Y.4
Wells, F.R.5
Daniel, S.E.6
Lees, A.J.7
Jenner, P.8
Marsden, C.D.9
-
14
-
-
0024557734
-
Transition metals, ferritin, glutathione and ascorbic acid in Parkinsonian brains
-
Riederer P., Sofic E., Rausch W.D., Schimidt B., Reynolds G.P., Jellinger K., and Youdim M.B. Transition metals, ferritin, glutathione and ascorbic acid in Parkinsonian brains. J. Neurochem. 52 (1989) 515-520
-
(1989)
J. Neurochem.
, vol.52
, pp. 515-520
-
-
Riederer, P.1
Sofic, E.2
Rausch, W.D.3
Schimidt, B.4
Reynolds, G.P.5
Jellinger, K.6
Youdim, M.B.7
-
15
-
-
0032568534
-
α-Synuclein in filamentous inclusions of lewy bodies from Parkinson's disease and dementia with lewy bodies
-
Spillantini M.G., Crowther R.A., Jakes R., Hasegawa M., and Goedert M. α-Synuclein in filamentous inclusions of lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc. Nat. Acad. Sci. (USA) 95 (1998) 6469-6473
-
(1998)
Proc. Nat. Acad. Sci. (USA)
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goedert, M.5
-
16
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbe L.I., and Nussbaum R.L. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276 (1997) 2045-2047
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnson, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di Iorio, G.18
Golbe, L.I.19
Nussbaum, R.L.20
more..
-
17
-
-
0031990490
-
Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
-
Kruger R., Kuhn W., Muller T., Woitalla D., Graeder M., and Kosel S. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nature Genet. 18 (1998) 106-108
-
(1998)
Nature Genet.
, vol.18
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
Woitalla, D.4
Graeder, M.5
Kosel, S.6
-
18
-
-
14844335694
-
The E46K mutation in alpha-synuclein increases amyloid fibril formation
-
Greenbaum E.A., Graves C.L., Mishizen-Eberz A.J., Lupoli M.A., Lynch D.R., Englander S.W., Axelsen P.H., and Giasson B.I. The E46K mutation in alpha-synuclein increases amyloid fibril formation. J. Biol. Chem. 280 (2005) 7800-7807
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 7800-7807
-
-
Greenbaum, E.A.1
Graves, C.L.2
Mishizen-Eberz, A.J.3
Lupoli, M.A.4
Lynch, D.R.5
Englander, S.W.6
Axelsen, P.H.7
Giasson, B.I.8
-
19
-
-
30444457574
-
The alpha-synuclein mutation E46K promotes aggregation in cultured cells
-
Pandey N., Schmidt R.E., and Galvin J.E. The alpha-synuclein mutation E46K promotes aggregation in cultured cells. Exp. Neurol. 197 (2006) 515-520
-
(2006)
Exp. Neurol.
, vol.197
, pp. 515-520
-
-
Pandey, N.1
Schmidt, R.E.2
Galvin, J.E.3
-
20
-
-
6344228684
-
Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein
-
Choi W., Zibaee S., Jakes R., Serpell L.C., Davletov B., Crowther R.A., and Goedert M. Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein. FEBS Lett. 576 (2004) 363-368
-
(2004)
FEBS Lett.
, vol.576
, pp. 363-368
-
-
Choi, W.1
Zibaee, S.2
Jakes, R.3
Serpell, L.C.4
Davletov, B.5
Crowther, R.A.6
Goedert, M.7
-
21
-
-
0023722437
-
Synuclein: a neuron specific protein localized to the nucleus and presynaptic nerve terminal
-
Maroteaux L., Campanelli J.T., and Scheller R.H. Synuclein: a neuron specific protein localized to the nucleus and presynaptic nerve terminal. J. Neurosci. 8 (1998) 2804-2815
-
(1998)
J. Neurosci.
, vol.8
, pp. 2804-2815
-
-
Maroteaux, L.1
Campanelli, J.T.2
Scheller, R.H.3
-
22
-
-
0028277520
-
Identification of two distinct synucleins from human brain
-
Jakes R., Spillantini M.G., and Goedert M. Identification of two distinct synucleins from human brain. FEBS Lett. 345 (1994) 27-32
-
(1994)
FEBS Lett.
, vol.345
, pp. 27-32
-
-
Jakes, R.1
Spillantini, M.G.2
Goedert, M.3
-
23
-
-
0028985267
-
The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
-
Iwai A., Masliah E., Yoshimoto M., Ge N., Flanagan L., de Silva H.A., Kittel A., and Saitoh T. The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14 (1995) 467-475
-
(1995)
Neuron
, vol.14
, pp. 467-475
-
-
Iwai, A.1
Masliah, E.2
Yoshimoto, M.3
Ge, N.4
Flanagan, L.5
de Silva, H.A.6
Kittel, A.7
Saitoh, T.8
-
24
-
-
0029127954
-
Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
-
George J.M., Jin H., Woods W.S., and Clayton D.F. Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 15 (1995) 361-372
-
(1995)
Neuron
, vol.15
, pp. 361-372
-
-
George, J.M.1
Jin, H.2
Woods, W.S.3
Clayton, D.F.4
-
25
-
-
0036128797
-
Natively unfolded proteins: a point where biology waits where biology waits for physics
-
Uversky V.N. Natively unfolded proteins: a point where biology waits where biology waits for physics. Protein Sci. 11 (2002) 739-756
-
(2002)
Protein Sci.
, vol.11
, pp. 739-756
-
-
Uversky, V.N.1
-
26
-
-
0025440053
-
Fluorometric examination of tissue amyloid fibrils in murine senile amyloidosis: use of the fluorescent indicator, thioflavine T
-
Naiki H., Higuchi K., Matsushima K., Shimada A., Chen W.H., Hosokawa M., and Takeda T. Fluorometric examination of tissue amyloid fibrils in murine senile amyloidosis: use of the fluorescent indicator, thioflavine T. Lab Invest. 62 (1990) 768-773
-
(1990)
Lab Invest.
, vol.62
, pp. 768-773
-
-
Naiki, H.1
Higuchi, K.2
Matsushima, K.3
Shimada, A.4
Chen, W.H.5
Hosokawa, M.6
Takeda, T.7
-
27
-
-
0035941201
-
Metal-triggered structural transformation, aggregation and fibrillation of human α-synuclein, a possible molecular link between Parkinson's disease and heavy metal exposure
-
Uversky V.N., Li J., and Fink A.L. Metal-triggered structural transformation, aggregation and fibrillation of human α-synuclein, a possible molecular link between Parkinson's disease and heavy metal exposure. J. Biol. Chem. 276 (2001) 44284-44296
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 44284-44296
-
-
Uversky, V.N.1
Li, J.2
Fink, A.L.3
-
28
-
-
0033538541
-
Alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease
-
Wood S.J., Wypych J., Steavenson S., Louis J.C., Citron M., and Biere A.L. Alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease. J. Biol. Chem. 274 (1999) 19509-19512
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 19509-19512
-
-
Wood, S.J.1
Wypych, J.2
Steavenson, S.3
Louis, J.C.4
Citron, M.5
Biere, A.L.6
-
29
-
-
0027006436
-
Amyloid fibril formation requires a chemically discriminating nucleation event: studies of an amyloidogenic sequence from the bacterial protein
-
Jarrett J.T., and Lansbury Jr. P.T. Amyloid fibril formation requires a chemically discriminating nucleation event: studies of an amyloidogenic sequence from the bacterial protein. OsmB. Biochem. 31 (1992) 12345-12352
-
(1992)
OsmB. Biochem.
, vol.31
, pp. 12345-12352
-
-
Jarrett, J.T.1
Lansbury Jr., P.T.2
-
30
-
-
0027195933
-
Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?
-
Jarrett J.T., and Lansbury Jr. P.T. Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?. Cell 73 (1993) 1035-1058
-
(1993)
Cell
, vol.73
, pp. 1035-1058
-
-
Jarrett, J.T.1
Lansbury Jr., P.T.2
-
31
-
-
9044229145
-
On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants
-
Lomakin A., Chung D.S., Benedek G.B., Kirschner D.A., and Teplow D.B. On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants. Proc. Nat. Acad. Sci. (USA) 93 (1996) 1125-1129
-
(1996)
Proc. Nat. Acad. Sci. (USA)
, vol.93
, pp. 1125-1129
-
-
Lomakin, A.1
Chung, D.S.2
Benedek, G.B.3
Kirschner, D.A.4
Teplow, D.B.5
-
32
-
-
0033849811
-
Probing the kinetics of beta-amyloid self-association
-
Murphy R.M., and Pallitto M.M. Probing the kinetics of beta-amyloid self-association. J. Struct. Biol. 130 (2000) 109-122
-
(2000)
J. Struct. Biol.
, vol.130
, pp. 109-122
-
-
Murphy, R.M.1
Pallitto, M.M.2
-
33
-
-
0034875603
-
A mathematical model of the kinetics of beta-amyloid fibril growth from the denatured state
-
Murphy R.M., and Pallitto M.M. A mathematical model of the kinetics of beta-amyloid fibril growth from the denatured state. Biophys. J. 81 (2001) 1805-1822
-
(2001)
Biophys. J.
, vol.81
, pp. 1805-1822
-
-
Murphy, R.M.1
Pallitto, M.M.2
-
34
-
-
0029904487
-
NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
-
Weinreb P.H., Zhen W., Poon A.W., Conway K.A., and Lansbury P.T. NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35 (1996) 13709-13715
-
(1996)
Biochemistry
, vol.35
, pp. 13709-13715
-
-
Weinreb, P.H.1
Zhen, W.2
Poon, A.W.3
Conway, K.A.4
Lansbury, P.T.5
-
35
-
-
0034708767
-
Membrane association and protein conformation of α-synuclein in intact neurons, effect of Parkinson's disease-linked mutations
-
McLean P.J., Kawamata H., Ribich S., and Hyman B.T. Membrane association and protein conformation of α-synuclein in intact neurons, effect of Parkinson's disease-linked mutations. J. Biol. Chem. 275 (2000) 8812-8816
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8812-8816
-
-
McLean, P.J.1
Kawamata, H.2
Ribich, S.3
Hyman, B.T.4
-
36
-
-
0036943010
-
Patterns of protein nitration in dementia with lewy bodies and striato-nigral degeneration
-
Gomez-Tortosa E., Gonzalo I., Newell K., Garcia Y.J., Vonsattel P., and Hyman B.T. Patterns of protein nitration in dementia with lewy bodies and striato-nigral degeneration. Acta Neuropathol. (Berlin) 103 (2002) 495-500
-
(2002)
Acta Neuropathol. (Berlin)
, vol.103
, pp. 495-500
-
-
Gomez-Tortosa, E.1
Gonzalo, I.2
Newell, K.3
Garcia, Y.J.4
Vonsattel, P.5
Hyman, B.T.6
-
37
-
-
0035815664
-
Evidence for a partially folded intermediate in α-synuclein fibril formation
-
Uversky V.N., Li J., and Fink A.L. Evidence for a partially folded intermediate in α-synuclein fibril formation. J. Biol. Chem. 276 (2001) 10737-10744
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 10737-10744
-
-
Uversky, V.N.1
Li, J.2
Fink, A.L.3
-
38
-
-
0031571624
-
Aluminium induced structural alterations of the precursor of the non-Aβ component of Alzheimer disease amyloid
-
Paik S.R., Lee J.H., Kim D.H., Chang C.S., and Kim J. Aluminium induced structural alterations of the precursor of the non-Aβ component of Alzheimer disease amyloid. Arch. Biochem. Biophys. 344 (1997) 325-334
-
(1997)
Arch. Biochem. Biophys.
, vol.344
, pp. 325-334
-
-
Paik, S.R.1
Lee, J.H.2
Kim, D.H.3
Chang, C.S.4
Kim, J.5
-
39
-
-
0033564726
-
Copper (II)-induced self-oligomerisation of α-synuclein
-
Paik S.R., Shin H.J., Lee J.H., Chang C.S., and Kim J. Copper (II)-induced self-oligomerisation of α-synuclein. Biochem. J. 340 (1999) 821-828
-
(1999)
Biochem. J.
, vol.340
, pp. 821-828
-
-
Paik, S.R.1
Shin, H.J.2
Lee, J.H.3
Chang, C.S.4
Kim, J.5
-
40
-
-
34249669709
-
Thermodynamics imprinting reveals differential binding of metals to α-synuclein: relevance to Parkinson's disease
-
Bharathi, and Rao K.S.J. Thermodynamics imprinting reveals differential binding of metals to α-synuclein: relevance to Parkinson's disease. Biochem. Biophys. Res. Commun. 359 1 (2007) 115-120
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.359
, Issue.1
, pp. 115-120
-
-
Bharathi1
Rao, K.S.J.2
-
41
-
-
34548021006
-
Copper and Iron induced differential morphology of fibrils in α-synuclein: TEM study
-
Bharathi, Indi S.S., and Rao K.S.J. Copper and Iron induced differential morphology of fibrils in α-synuclein: TEM study. Neurosci. Lett. 424 2 (2007) 78-82
-
(2007)
Neurosci. Lett.
, vol.424
, Issue.2
, pp. 78-82
-
-
Bharathi1
Indi, S.S.2
Rao, K.S.J.3
-
42
-
-
0026708694
-
Kinetics of aggregation of synthetic beta-amyloid peptide
-
Tomski S.J., and Murphy R.M. Kinetics of aggregation of synthetic beta-amyloid peptide. Arch. Biochem. Biophys. 294 (1992) 630-638
-
(1992)
Arch. Biochem. Biophys.
, vol.294
, pp. 630-638
-
-
Tomski, S.J.1
Murphy, R.M.2
-
43
-
-
0030030956
-
First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro
-
Naiki H., and Nakakuki H. First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro. Lab Invest. 74 (1998) 374-383
-
(1998)
Lab Invest.
, vol.74
, pp. 374-383
-
-
Naiki, H.1
Nakakuki, H.2
-
44
-
-
0032830123
-
Monitoring protein assembly using quasielastic light scattering spectroscopy
-
Lomakin A., Teplow D.B., Kirschner D.A., and Benedek G.B. Monitoring protein assembly using quasielastic light scattering spectroscopy. Methods Enzymol. 309 (1999) 429-459
-
(1999)
Methods Enzymol.
, vol.309
, pp. 429-459
-
-
Lomakin, A.1
Teplow, D.B.2
Kirschner, D.A.3
Benedek, G.B.4
|