Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Ditte, Zuzana ^a   Ditte, Peter ^a   Labudova, Martina ^a   Simko, Veronika ^a   Iuliano, Filippo ^a   Zatovicova, Miriam ^a   Csaderova, Lucia ^a,b   Pastorekova, Silvia ^a   Pastorek, Jaromir ^a  

^a INSTITUTE OF VIROLOGY   (Slovakia)

^b INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

Carbonic anhydrase IX; Carnosine; Hypoxia; pH regulation

Indexed keywords

CARBONATE DEHYDRATASE IX; CARNOSINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; MULTIENZYME COMPLEX; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE; TUMOR ANTIGEN;

ACIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVE SITE; ENZYME INHIBITION; FLOW CYTOMETRY; GENE EXPRESSION; HELA CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PH MEASUREMENT; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED; DOG; GENETICS; MDCK CELL LINE; METABOLISM; NEOPLASMS; PATHOLOGY; XENOGRAFT;

ACIDOSIS; ANIMALS; ANTIGENS, NEOPLASM; CARBONIC ANHYDRASES; CARNOSINE; DOGS; HELA CELLS; HETEROGRAFTS; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; MICE; NEOPLASMS;

EID: 84902533515     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-358     Document Type: Article

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