Carnosine inhibits ATP production in cells from malignant glioma

Neurological Research

Volumn 32, Issue 1, 2010, Pages 101-105

  Renner, Christof ^a   Asperger, Ansgar ^a   Seyffarth, Anne ^a   Meixensberger, Jürgen ^a   Gebhardt, Rolf ^a   Gaunitz, Frank ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Carnosine; Energy metabolism; Glycolysis; Malignant glioma; Oxamate; Potassium cyanide; Tumor growth

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARNOSINE; GLUCOSE; OXAMIC ACID; POTASSIUM CYANIDE;

ANAEROBIC GLYCOLYSIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL ENERGY; CELL METABOLISM; CONTROLLED STUDY; ENERGY METABOLISM; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; OXIDATIVE PHOSPHORYLATION;

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENTS; CARNOSINE; CELL LINE, TUMOR; CELLS, CULTURED; GLIOMA; GLUCOSE; GLYCOLYSIS; HUMANS; MITOCHONDRIA; ORGANIC CHEMICALS; POTASSIUM CYANIDE;

EID: 77949428731     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164109X12518779082237     Document Type: Article

References (20)

1. Gulewitsch W, Amiradzibi S. Ueber das Carnosin, eine neue organische Base des Fleischextraktes. Ber Deut Chem Ges 1900; 33: 1902-1903
2. Mannion AF, Jakeman PM, Dunnett M, et al. Carnosine and anserine concentrations in the quadriceps femoris muscle of healthy humans. Eur J Appl Physiol Occup Physiol 1992; 64: 47-50
3. Pisano JJ, Wilson JD, Cohen L, et al. Isolation of gammaaminobutyrylhistidine (homocarnosine) from brain. J Biol Chem 1961; 236: 499-502
4. Margolis FL. Carnosine: An olfactory neuropeptide. In: Barker JL, Smith TG, Jr, eds. The Role of Peptides in Neuronal Function, New York: Marcel Dekker, 1980: pp. 545-572
5. Kalyankar GD, Meistera A. Enzymatic synthesis of carnosine and related beta-alanyl and gamma-aminobutyryl peptides. J Biol Chem 1959; 234: 3210-3218
6. Teufel M, Saudek V, Ledig JP, et al. Sequence identification and characterization of human carnosinase and a closely related nonspecific dipeptidase. J Biol Chem 2003; 278: 6521-6531
7. Guiotto A, Calderan A, Ruzza P, et al. Carnosine and carnosinerelated antioxidants: A review. Curr Med Chem 2005; 12: 2293-2315
8. Boldyrev AA. Problems and perspectives in studying the biological role of carnosine. Biochemistry (Mosc) 2000; 65: 751-756
9. Smith EC. The buffering of muscle in rigor; protein, phosphate and carnosine. J Physiol 1938; 92: 336-343
10. Baran EJ. Metal complexes of carnosine. Biochemistry (Mosc) 2000; 65: 789-797
11. Nadi NS, Hirsch JD, Margolis FL. Laminar distribution of putative neurotransmitter amino acids and ligand binding sites in the dog olfactory bulb. J Neurochem 1980; 34: 138-146
12. Kohen R, Yamamoto Y, Cundy KC, et al. Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc Natl Acad Sci USA 1988; 85: 3175-3179
13. Gallant S, Semyonova M, Yuneva M. Carnosine as a potential anti-senescence drug. Biochemistry (Mosc) 2000; 65: 866-868
14. Holliday R, McFarland GA. Inhibition of the growth of transformed and neoplastic cells by the dipeptide carnosine. Br J Cancer 1996; 73: 966-971
15. Renner C, Seyffarth A, Garcia de Arriba S, et al. Carnosine inhibits growth of cells isolated from human glioblastoma multiforme. Int J Pept Res Ther 2008; 14: 127-135
16. Gaunitz F, Heise K. HTS compatible assay for antioxidative agents using primary cultured hepatocytes. Assay Drug Dev Technol 2003; 1: 469-477
17. Warburg O, Posener K, Negelein E. Ueber den Stoffwechsel der Carcinomzelle. Biochem Z 1924; 152: 309-344
18. Pelicano H, Martin DS, Xu RH, et al. Glycolysis inhibition for anticancer treatment. Oncogene 2006; 25: 4633-4646
19. Papaconstantinou J, Colowick SP. The role of glycolysis in the growth of tumor cells. II. The effect of oxamic acid on the growth of HeLa cells in tissue culture. J Biol Chem 1961; 236: 285-288
20. Papaconstantinou J, Colowick SP. The role of glycolysis in the growth of tumor cells. I. Effects of oxamic acid on the metabolism of Ehrlich ascites tumor cells in vitro. J Biol Chem 1961; 236: 278-284.