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Volumn 22, Issue 14, 2014, Pages 3654-3669

Synthesis and evaluation of (E)-2-(acrylamido)cyclohex-1-enecarboxylic acid derivatives as HCA1, HCA2, and HCA3 receptor agonists

(10) Bobileva, Olga a Bokaldere, Rasma a Gailite, Vija a Kaula, Ilze a Ikaunieks, Martins a Duburs, Gunars a Petrovska, Ramona b Mandrika, Ilona b Klovins, Janis b Loza, Einars a

a LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (Latvia)

b LATVIAN BIOMEDICAL RESEARCH AND STUDY CENTRE (Latvia)

Author keywords

2 Acrylamidocyclohex 1 ene; Agonist; cAMP; Dyslipidemia; GPR109A; HCA2; Niacin

Indexed keywords

2 (ACRYLAMIDO)CYCLOHEX 1 ENECARBOXYLIC ACID DERIVATIVE; 2 AMIDOCYCLOHEX 1 ENE CARBOXYLIC ACID DERIVATIVE; 2 [3 (NAPHTHALEN 2 YL)PROPANAMIDO]CYCLOHEX 1 ENECARBOXYLIC ACID; 6 HYDROXYNAPHTHALEN 2 YL DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CYCLIC AMP; ETHYL 2 [3 (2 CHLORO 3,4 DIMETHOXYPHENYL)ACRYLAMIDO]CYCLOHEX 1 ENECARBOXYLATE; ETHYL 2 [3 (2 CHLORO 6 METHOXYQUINOLIN 3 YL)ACRYLAMIDO]CYCLOHEX 1 ENECARBOXYLATE; ETHYL 2 [3 (2 CHLOROQUINOLIN 3 YL)ACRYLAMIDO]CYCLOHEX 1 ENECARBOXYLATE; ETHYL 2 [3 (2 METHYLQUINOLIN 6 YL)ACRYLAMIDO]CYCLOHEX 1 ENECARBOXYLATE; ETHYL 2 [3 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL)ACRYLAMIDO]CYCLOHEX 1 ENECARBOXYLATE; ETHYL 2 [3 (3 BROMO 4,5 DIMETHOXYPHENYL)ACRYLAMIDO]CYCLOHEX 1 ENECARBOXYLATE; ETHYL 2 [3 (5,6,7 TRIMETHOXYQUINOLIN 2 YL)ACRYLAMIDO]CYCLOHEX 1 ENECARBOXYLATE; ETHYL 2 [3 (6 BROMOBENZO[D][1,3]DIOXOL 5 YL)ACRYLAMIDO]CYCLOHEX 1 ENECARBOXYLATE; ETHYL 2 [3 (6 CHLOROBENZO[D][1,3]DIOXOL 5 YL)ACRYLAMIDO]CYCLOHEX 1 ENECARBOXYLATE; ETHYL 2 [3 (6 METHOXYNAPHTHALEN 2 YL)ACRYLAMIDO]CYCLOHEX 1 ENECARBOXYLATE; ETHYL 2 [3 (NAPHTHALENE 2 YL)ACRYLAMIDE]CYCLOHEX 1 ENECARBOXYLATE; ETHYL 2 [3 (QUINOLIN 2 YL)ACRYLAMIDO]CYCLOHEX 1 ENECARBOXYLATE; ETHYL 2 [3 (QUINOLIN 4 YL)ACRYLAMIDO]CYCLOHEX 1 ENECARBOXYLATE; ETHYL 2 [3 (QUINOLIN 6 YL)ACRYLAMIDO]CYCLOHEX 1 ENECARBOXYLATE; ETHYL 2 [3 (QUINOLIN 8 YL)ACRYLAMIDO]CYCLOHEX 1 ENECARBOXYLATE; HYDROXYLCARBOXYLIC ACID RECEPTOR 1; HYDROXYLCARBOXYLIC ACID RECEPTOR 1 AGONIST; HYDROXYLCARBOXYLIC ACID RECEPTOR 2; HYDROXYLCARBOXYLIC ACID RECEPTOR 2 AGONIST; HYDROXYLCARBOXYLIC ACID RECEPTOR 3; HYDROXYLCARBOXYLIC ACID RECEPTOR 3 AGONIST; NICOTINIC ACID; RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; ACRYLAMIDE DERIVATIVE; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; G PROTEIN COUPLED RECEPTOR; GPR81 PROTEIN, HUMAN; HCAR2 PROTEIN, HUMAN; HCAR3 PROTEIN, HUMAN; NICOTINIC RECEPTOR;

ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; AGONISTS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; SYNTHESIS;

ACRYLAMIDES; CELL LINE; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84902532493 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2014.05.011 Document Type: Article

Times cited : (10)

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