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Volumn 14, Issue 1, 2012, Pages 49-59

Niacin: The evidence, clinical use, and future directions

Author keywords

Apolipoprotein B; Atherosclerosis; Atherosclerosis imaging; Combination lipid therapy; HDL cholesterol; Laropiprant; Lipids; Lipoprotein (a); Niacin; Nicotinic acid; Statin

Indexed keywords

CLOFIBRATE; COLESTIPOL; COLESTYRAMINE; EZETIMIBE; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LAROPIPRANT PLUS NICOTINIC ACID; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; NICOTINIC ACID; PLACEBO; SIMVASTATIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

EID: 84857629402     PISSN: 15233804     EISSN: 15346242     Source Type: Journal    
DOI: 10.1007/s11883-011-0212-1     Document Type: Article
Times cited : (41)

References (77)
  • 1
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins
    • DOI 10.1016/S0140-6736(05)67394-1, PII S0140673605673941
    • C Baigent A Keech PM Kearney, et al. 2005 Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins Lancet 366 1267 1278 16214597 10.1016/S0140-6736(05)67394-1 1:CAS:528:DC%2BD2MXhtVOlu7fM (Pubitemid 41416582)
    • (2005) Lancet , vol.366 , Issue.9493 , pp. 1267-1278
  • 2
    • 33746355566 scopus 로고    scopus 로고
    • Meta-Analysis of Cardiovascular Outcomes Trials Comparing Intensive Versus Moderate Statin Therapy
    • DOI 10.1016/j.jacc.2006.04.070, PII S0735109706011752
    • CP Cannon BA Steinberg SA Murphy, et al. 2006 Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy J Am Coll Cardiol 48 438 445 16875966 10.1016/j.jacc.2006.04.070 1:CAS:528:DC%2BD28XntlWjsLo%3D (Pubitemid 44109954)
    • (2006) Journal of the American College of Cardiology , vol.48 , Issue.3 , pp. 438-445
    • Cannon, C.P.1    Steinberg, B.A.2    Murphy, S.A.3    Mega, J.L.4    Braunwald, E.5
  • 3
    • 33749002873 scopus 로고    scopus 로고
    • The effect of early, intensive statin therapy on acute coronary syndrome: A meta-analysis of randomized controlled trials
    • DOI 10.1001/archinte.166.17.1814
    • E Hulten JL Jackson K Douglas, et al. 2006 The effect of early, intensive statin therapy on acute coronary syndrome: a meta-analysis of randomized controlled trials Arch Intern Med 166 1814 1821 17000936 10.1001/archinte.166. 17.1814 1:CAS:528:DC%2BD28XhtFShu7jI (Pubitemid 44455162)
    • (2006) Archives of Internal Medicine , vol.166 , Issue.17 , pp. 1814-1821
    • Hulten, E.1    Jackson, J.L.2    Douglas, K.3    George, S.4    Villines, T.C.5
  • 4
    • 56749106312 scopus 로고    scopus 로고
    • Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    • 18997196 10.1056/NEJMoa0807646 1:CAS:528:DC%2BD1cXhtl2gurnL
    • PM Ridker E Danielson FA Fonseca, et al. 2008 Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein N Engl J Med 359 2195 2207 18997196 10.1056/NEJMoa0807646 1:CAS:528:DC%2BD1cXhtl2gurnL
    • (2008) N Engl J Med , vol.359 , pp. 2195-2207
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.3
  • 5
    • 45849096068 scopus 로고    scopus 로고
    • Prevalence and extent of dyslipidemia and recommended lipid levels in US adults with and without cardiovascular comorbidities: The National Health and Nutrition Examination Survey 2003-2004
    • 18585505 10.1016/j.ahj.2008.03.005 1:CAS:528:DC%2BD1cXnvVGksro%3D
    • H Ghandehari S Kamal-Bahl ND Wong 2008 Prevalence and extent of dyslipidemia and recommended lipid levels in US adults with and without cardiovascular comorbidities: the National Health and Nutrition Examination Survey 2003-2004 Am Heart J 156 112 119 18585505 10.1016/j.ahj.2008.03.005 1:CAS:528:DC%2BD1cXnvVGksro%3D
    • (2008) Am Heart J , vol.156 , pp. 112-119
    • Ghandehari, H.1    Kamal-Bahl, S.2    Wong, N.D.3
  • 6
    • 0037126526 scopus 로고    scopus 로고
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143-421.
    • (2002) Circulation , vol.106 , pp. 3143-421
  • 7
    • 0000808276 scopus 로고
    • Influence of nicotinic acid on serum cholesterol in man
    • 14350806 10.1016/0003-9861(55)90070-9 1:CAS:528:DyaG2MXktVCrtA%3D%3D
    • R Altschul A Hoffer JD Stephen 1955 Influence of nicotinic acid on serum cholesterol in man Arch Biochem 54 558 559 14350806 10.1016/0003-9861(55)90070-9 1:CAS:528:DyaG2MXktVCrtA%3D%3D
    • (1955) Arch Biochem , vol.54 , pp. 558-559
    • Altschul, R.1    Hoffer, A.2    Stephen, J.D.3
  • 8
    • 0023029454 scopus 로고
    • Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study
    • DOI 10.1001/jama.256.20.2835
    • WP Castelli RJ Garrison PW Wilson, et al. 1986 Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study JAMA 256 2835 2838 3773200 10.1001/jama.1986.03380200073024 1:STN:280: DyaL2s%2FjslWktA%3D%3D (Pubitemid 17178361)
    • (1986) Journal of the American Medical Association , vol.256 , Issue.20 , pp. 2835-2838
    • Castelli, W.P.1    Garrison, R.J.2    Wilson, P.W.F.3
  • 10
    • 78751640788 scopus 로고    scopus 로고
    • Meta-analysis: Statin therapy does not alter the association between low levels of high-density lipoprotein cholesterol and increased cardiovascular risk
    • 21173414
    • H Jafri AA Alsheikh-Ali RH Karas 2010 Meta-analysis: statin therapy does not alter the association between low levels of high-density lipoprotein cholesterol and increased cardiovascular risk Ann Intern Med 153 800 808 21173414
    • (2010) Ann Intern Med , vol.153 , pp. 800-808
    • Jafri, H.1    Alsheikh-Ali, A.A.2    Karas, R.H.3
  • 11
    • 77951483195 scopus 로고    scopus 로고
    • Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids
    • 20167660 10.1161/ATVBAHA.109.201129 1:CAS:528:DC%2BC3cXkslKqsrk%3D
    • BJ Wu L Yan F Charlton, et al. 2010 Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids Arterioscler Thromb Vasc Biol 30 968 975 20167660 10.1161/ATVBAHA.109.201129 1:CAS:528:DC%2BC3cXkslKqsrk%3D
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 968-975
    • Wu, B.J.1    Yan, L.2    Charlton, F.3
  • 12
    • 84948007950 scopus 로고
    • Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts
    • DOI 10.1001/jama.257.23.3233
    • DH Blankenhorn SA Nessim RL Johnson, et al. 1987 Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts JAMA 257 3233 3240 3295315 10.1001/jama.1987.03390230069027 1:STN:280:DyaL2s3is1GrtQ%3D%3D (Pubitemid 17078320)
    • (1987) Journal of the American Medical Association , vol.257 , Issue.23 , pp. 3233-3240
    • Blankenhorn, D.H.1    Nessim, S.A.2    Johnson, R.L.3
  • 13
    • 77952397461 scopus 로고    scopus 로고
    • Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis
    • 20079494 10.1016/j.atherosclerosis.2009.12.023 1:CAS:528: DC%2BC3cXmslGnu78%3D This work is a recent meta-analysis that evaluates the impact of niacin, alone or in combination treatment, on all cardiovascular events and atherosclerosis progression from among 11 randomized controlled trials
    • E Bruckert J Labreuche P Amarenco 2010 Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis Atherosclerosis 210 353 361 20079494 10.1016/j.atherosclerosis. 2009.12.023 1:CAS:528:DC%2BC3cXmslGnu78%3D This work is a recent meta-analysis that evaluates the impact of niacin, alone or in combination treatment, on all cardiovascular events and atherosclerosis progression from among 11 randomized controlled trials
    • (2010) Atherosclerosis , vol.210 , pp. 353-361
    • Bruckert, E.1    Labreuche, J.2    Amarenco, P.3
  • 14
    • 0025678697 scopus 로고
    • Beneficial effects of colestipol-niacin on coronary atherosclerosis. A 4-year follow-up
    • 2243429 10.1001/jama.1990.03450230049028 1:STN:280:DyaK3M%2Fls1Kmsg%3D%3D
    • L Cashin-Hemphill WJ Mack JM Pogoda, et al. 1990 Beneficial effects of colestipol-niacin on coronary atherosclerosis. A 4-year follow-up JAMA 264 3013 3017 2243429 10.1001/jama.1990.03450230049028 1:STN:280:DyaK3M%2Fls1Kmsg%3D%3D
    • (1990) JAMA , vol.264 , pp. 3013-3017
    • Cashin-Hemphill, L.1    MacK, W.J.2    Pogoda, J.M.3
  • 15
    • 77951928738 scopus 로고    scopus 로고
    • Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease
    • 20208032 10.1177/1074248410361337 1:CAS:528:DC%2BC3cXnsVOqt7o%3D
    • JK Duggal M Singh N Attri, et al. 2010 Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease J Cardiovasc Pharmacol Ther 15 158 166 20208032 10.1177/1074248410361337 1:CAS:528: DC%2BC3cXnsVOqt7o%3D
    • (2010) J Cardiovasc Pharmacol Ther , vol.15 , pp. 158-166
    • Duggal, J.K.1    Singh, M.2    Attri, N.3
  • 17
    • 10044281651 scopus 로고    scopus 로고
    • Arterial Biology for the Investigation of the Treatment Effects of Reducing cholesterol (ARBITER) 2: A double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins
    • DOI 10.1161/01.CIR.0000148955.19792.8D
    • AJ Taylor LE Sullenberger HJ Lee, et al. 2004 Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins Circulation 110 3512 3517 15537681 10.1161/01.CIR.0000148955.19792.8D 1:CAS:528:DC%2BD2MXhtVGnt7s%3D (Pubitemid 39612564)
    • (2004) Circulation , vol.110 , Issue.23 , pp. 3512-3517
    • Taylor, A.J.1    Sullenberger, L.E.2    Lee, H.J.3    Lee, J.K.4    Grace, K.A.5
  • 18
    • 33751217682 scopus 로고    scopus 로고
    • The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3
    • DOI 10.1185/030079906X148508
    • AJ Taylor HJ Lee LE Sullenberger 2006 The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3 Curr Med Res Opin 22 2243 2250 17076985 10.1185/030079906X148508 1:CAS:528:DC%2BD28XhtlCku7jK (Pubitemid 44789989)
    • (2006) Current Medical Research and Opinion , vol.22 , Issue.11 , pp. 2243-2250
    • Taylor, A.J.1    Lee, H.J.2    Sullenberger, L.E.3
  • 19
    • 72049129430 scopus 로고    scopus 로고
    • Extended-release niacin or ezetimibe and carotid intima-media thickness
    • 19915217 10.1056/NEJMoa0907569 1:CAS:528:DC%2BD1MXhsFSnsLzP This work evaluates the comparative efficacy of niacin extended-release versus ezetimibe when added to chronic, stable statin therapy among high-risk patients for the endpoint of change in CIMT over 14 months
    • AJ Taylor TC Villines EJ Stanek, et al. 2009 Extended-release niacin or ezetimibe and carotid intima-media thickness N Engl J Med 361 2113 2122 19915217 10.1056/NEJMoa0907569 1:CAS:528:DC%2BD1MXhsFSnsLzP This work evaluates the comparative efficacy of niacin extended-release versus ezetimibe when added to chronic, stable statin therapy among high-risk patients for the endpoint of change in CIMT over 14 months
    • (2009) N Engl J Med , vol.361 , pp. 2113-2122
    • Taylor, A.J.1    Villines, T.C.2    Stanek, E.J.3
  • 20
    • 35348902493 scopus 로고    scopus 로고
    • The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome
    • DOI 10.1111/j.1742-1241.2007.01597.x
    • M Thoenes A Oguchi S Nagamia, et al. 2007 The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome Int J Clin Pract 61 1942 1948 17935553 10.1111/j.1742-1241.2007.01597.x 1:CAS:528: DC%2BD2sXhtl2gtLzN (Pubitemid 47573105)
    • (2007) International Journal of Clinical Practice , vol.61 , Issue.11 , pp. 1942-1948
    • Thoenes, M.1    Oguchi, A.2    Nagamia, S.3    Vaccari, C.S.4    Hammoud, R.5    Umpierrez, G.E.6    Khan, B.V.7
  • 21
    • 77953121328 scopus 로고    scopus 로고
    • The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): Final results and the impact of medication adherence, dose, and treatment duration
    • 20399059 10.1016/j.jacc.2010.03.017 This work reports the final results of the ARBITER 6-HALTS trial and investigated the impact of niacin and ezetimibe cumulative drug exposure on change in CIMT
    • TC Villines EJ Stanek PJ Devine, et al. 2010 The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration J Am Coll Cardiol 55 2721 2726 20399059 10.1016/j.jacc.2010.03.017 This work reports the final results of the ARBITER 6-HALTS trial and investigated the impact of niacin and ezetimibe cumulative drug exposure on change in CIMT
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2721-2726
    • Villines, T.C.1    Stanek, E.J.2    Devine, P.J.3
  • 22
    • 71649101609 scopus 로고    scopus 로고
    • Effects of combination lipid therapy on coronary stenosis progression and clinical cardiovascular events in coronary disease patients with metabolic syndrome: A combined analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclerosis Treatment Study (HATS), and the Armed Forces Regression Study (AFREGS)
    • 19932775 10.1016/j.amjcard.2009.07.035 1:CAS:528:DC%2BD1MXhsVGlt7zO
    • XQ Zhao RA Krasuski J Baer, et al. 2009 Effects of combination lipid therapy on coronary stenosis progression and clinical cardiovascular events in coronary disease patients with metabolic syndrome: a combined analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclerosis Treatment Study (HATS), and the Armed Forces Regression Study (AFREGS) Am J Cardiol 104 1457 1464 19932775 10.1016/j.amjcard.2009.07.035 1:CAS:528:DC%2BD1MXhsVGlt7zO
    • (2009) Am J Cardiol , vol.104 , pp. 1457-1464
    • Zhao, X.Q.1    Krasuski, R.A.2    Baer, J.3
  • 23
    • 77952955394 scopus 로고    scopus 로고
    • Niacin and fibrates in atherogenic dyslipidemia: Pharmacotherapy to reduce cardiovascular risk
    • 20153365 10.1016/j.pharmthera.2010.01.008 1:CAS:528:DC%2BC3cXmsVeis7c%3D
    • MJ Chapman JS Redfern ME McGovern, et al. 2010 Niacin and fibrates in atherogenic dyslipidemia: pharmacotherapy to reduce cardiovascular risk Pharmacol Ther 126 314 345 20153365 10.1016/j.pharmthera.2010.01.008 1:CAS:528:DC%2BC3cXmsVeis7c%3D
    • (2010) Pharmacol Ther , vol.126 , pp. 314-345
    • Chapman, M.J.1    Redfern, J.S.2    McGovern, M.E.3
  • 24
    • 38149033577 scopus 로고    scopus 로고
    • Nicotinic acid: Pharmacological effects and mechanisms of action
    • DOI 10.1146/annurev.pharmtox.48.113006.094746
    • A Gille ET Bodor K Ahmed, et al. 2008 Nicotinic acid: pharmacological effects and mechanisms of action Annu Rev Pharmacol Toxicol 48 79 106 17705685 10.1146/annurev.pharmtox.48.113006.094746 1:CAS:528:DC%2BD1cXisFynurY%3D (Pubitemid 351738150)
    • (2008) Annual Review of Pharmacology and Toxicology , vol.48 , pp. 79-106
    • Gille, A.1    Bodor, E.T.2    Ahmed, K.3    Offermanns, S.4
  • 25
    • 79959479456 scopus 로고    scopus 로고
    • Future of GPR109A agonists in the treatment of dyslipidemia
    • Wanders D, Judd RL. Future of GPR109A agonists in the treatment of dyslipidemia. Diabetes Obes Metabol. 2011.
    • (2011) Diabetes Obes Metabol.
    • Wanders, D.1    Judd, R.L.2
  • 26
    • 1242322495 scopus 로고    scopus 로고
    • Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin
    • DOI 10.1016/j.bcp.2003.09.014
    • T Rubic M Trottmann RL Lorenz 2004 Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin Biochem Pharmacol 67 411 419 15037193 10.1016/j.bcp.2003.09.014 1:CAS:528:DC%2BD2cXhtVaht7o%3D (Pubitemid 38236129)
    • (2004) Biochemical Pharmacology , vol.67 , Issue.3 , pp. 411-419
    • Rubic, T.1    Trottmann, M.2    Lorenz, R.L.3
  • 27
    • 79952240405 scopus 로고    scopus 로고
    • Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells
    • 21317532 10.1172/JCI41651 1:CAS:528:DC%2BC3MXjtVWku74%3D
    • M Lukasova C Malaval A Gille, et al. 2011 Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells J Clin Invest 121 1163 1173 21317532 10.1172/JCI41651 1:CAS:528:DC%2BC3MXjtVWku74%3D
    • (2011) J Clin Invest , vol.121 , pp. 1163-1173
    • Lukasova, M.1    Malaval, C.2    Gille, A.3
  • 28
    • 57649219453 scopus 로고    scopus 로고
    • Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells
    • 18550065 10.1016/j.atherosclerosis.2008.04.044 1:CAS:528: DC%2BD1cXhsFajsb3K This work reports potential pleiotropic mechanisms of niacin on the atherosclerosis process
    • SH Ganji S Qin L Zhang, et al. 2009 Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells Atherosclerosis 202 68 75 18550065 10.1016/j.atherosclerosis.2008.04.044 1:CAS:528:DC%2BD1cXhsFajsb3K This work reports potential pleiotropic mechanisms of niacin on the atherosclerosis process
    • (2009) Atherosclerosis , vol.202 , pp. 68-75
    • Ganji, S.H.1    Qin, S.2    Zhang, L.3
  • 29
    • 33744517651 scopus 로고    scopus 로고
    • Accumulation of chylomicron remnants and impaired vascular reactivity occur in subjects with isolated low HDL cholesterol: Effects of niacin treatment
    • DOI 10.1016/j.atherosclerosis.2005.08.025, PII S0021915005005459
    • AM Benjo RC Maranhao SR Coimbra, et al. 2006 Accumulation of chylomicron remnants and impaired vascular reactivity occur in subjects with isolated low HDL cholesterol: effects of niacin treatment Atherosclerosis 187 116 122 16458316 10.1016/j.atherosclerosis.2005.08.025 1:CAS:528:DC%2BD28XltlentLw%3D (Pubitemid 43817002)
    • (2006) Atherosclerosis , vol.187 , Issue.1 , pp. 116-122
    • Benjo, A.M.1    Maranhao, R.C.2    Coimbra, S.R.3    Andrade, A.C.M.4    Favarato, D.5    Molina, M.S.6    Brandizzi, L.I.V.7    Da Luz, P.L.8
  • 30
    • 79551717222 scopus 로고    scopus 로고
    • Niacin improves small artery vasodilatory function and compliance in statin-treated type 2 diabetic patients
    • 20667937 10.1177/1479164110376206
    • SJ Hamilton GT Chew TM Davis, et al. 2010 Niacin improves small artery vasodilatory function and compliance in statin-treated type 2 diabetic patients Diab Vasc Dis Res 7 296 299 20667937 10.1177/1479164110376206
    • (2010) Diab Vasc Dis Res , vol.7 , pp. 296-299
    • Hamilton, S.J.1    Chew, G.T.2    Davis, T.M.3
  • 31
    • 67349209273 scopus 로고    scopus 로고
    • Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: Results of the randomized, double-blind, placebo-controlled INEF study
    • 18822413 10.1016/j.atherosclerosis.2008.08.003 1:CAS:528: DC%2BD1MXlsVKgtb0%3D
    • A Warnholtz P Wild MA Ostad, et al. 2009 Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: results of the randomized, double-blind, placebo-controlled INEF study Atherosclerosis 204 216 221 18822413 10.1016/j.atherosclerosis.2008.08.003 1:CAS:528: DC%2BD1MXlsVKgtb0%3D
    • (2009) Atherosclerosis , vol.204 , pp. 216-221
    • Warnholtz, A.1    Wild, P.2    Ostad, M.A.3
  • 32
    • 0016630250 scopus 로고
    • Clofibrate and niacin in coronary heart disease
    • Clofibrate and niacin in coronary heart disease. JAMA. 1975;231:360-81.
    • (1975) JAMA , vol.231 , pp. 360-81
  • 33
    • 0023001772 scopus 로고
    • Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin
    • PL Canner KG Berge NK Wenger, et al. 1986 Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin J Am Coll Cardiol 8 1245 1255 3782631 10.1016/S0735-1097(86)80293-5 1:STN:280: DyaL2s%2FlvVCqtQ%3D%3D (Pubitemid 17208898)
    • (1986) Journal of the American College of Cardiology , vol.8 , Issue.6 , pp. 1245-1255
    • Canner, P.L.1    Berge, K.G.2    Wenger, N.K.3
  • 36
    • 19944426989 scopus 로고    scopus 로고
    • A randomized trial of a strategy for increasing high-density lipoprotein cholesterol levels: Effects on progression of coronary heart disease and clinical events
    • 15657157
    • EJ Whitney RA Krasuski BE Personius, et al. 2005 A randomized trial of a strategy for increasing high-density lipoprotein cholesterol levels: effects on progression of coronary heart disease and clinical events Ann Intern Med 142 95 104 15657157
    • (2005) Ann Intern Med , vol.142 , pp. 95-104
    • Whitney, E.J.1    Krasuski, R.A.2    Personius, B.E.3
  • 37
    • 79952446880 scopus 로고    scopus 로고
    • The Atherothrombosis Intervention in Metabolic syndrome with low HDL/high triglycerides: Impact on Global Health outcomes (AIM-HIGH) trial
    • This work describes the methods of the AIM-HIGH trial
    • • The role of niacin in raising high-density lipoprotein cholesterol to reduce cardiovascular events in patients with atherosclerotic cardiovascular disease and optimally treated low-density lipoprotein cholesterol: baseline characteristics of study participants. The Atherothrombosis Intervention in Metabolic syndrome with low HDL/high triglycerides: impact on Global Health outcomes (AIM-HIGH) trial. Am Heart J. 2011;161:538-43. This work describes the methods of the AIM-HIGH trial.
    • (2011) Am Heart J. , vol.161 , pp. 538-43
  • 38
    • 84857626368 scopus 로고    scopus 로고
    • Accessed June 5, 2011
    • NHLBI Press Release on Stopping AIM-HIGH Trial. Available at http://public.nhlbi.nih.gov/newsroom/home/GetPressRelease.aspx?id=2792. Accessed June 5, 2011.
    • NHLBI Press Release on Stopping AIM-HIGH Trial
  • 40
    • 79952745060 scopus 로고    scopus 로고
    • Extended-release niacin/laropiprant lipid-altering consistency across patient subgroups
    • 21401833 10.1111/j.1742-1241.2010.02620.x 1:CAS:528:DC%2BC3MXktFeht7c%3D
    • H Bays A Shah Q Dong, et al. 2011 Extended-release niacin/laropiprant lipid-altering consistency across patient subgroups Int J Clin Pract 65 436 445 21401833 10.1111/j.1742-1241.2010.02620.x 1:CAS:528:DC%2BC3MXktFeht7c%3D
    • (2011) Int J Clin Pract , vol.65 , pp. 436-445
    • Bays, H.1    Shah, A.2    Dong, Q.3
  • 41
    • 53149118030 scopus 로고    scopus 로고
    • Lipid-modifying efficacy and tolerability of extended-release niacin/laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia
    • 19166443 10.1111/j.1742-1241.2008.01938.x 1:CAS:528:DC%2BC3cXktFGntrc%3D
    • D Maccubbin HE Bays AG Olsson, et al. 2008 Lipid-modifying efficacy and tolerability of extended-release niacin/laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia Int J Clin Pract 62 1959 1970 19166443 10.1111/j.1742-1241.2008.01938.x 1:CAS:528:DC%2BC3cXktFGntrc%3D
    • (2008) Int J Clin Pract , vol.62 , pp. 1959-1970
    • MacCubbin, D.1    Bays, H.E.2    Olsson, A.G.3
  • 42
    • 67649372666 scopus 로고    scopus 로고
    • Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease
    • 19576324 10.1016/j.amjcard.2009.02.047 1:CAS:528:DC%2BD1MXotFCitL4%3D
    • D Maccubbin MJ Koren M Davidson, et al. 2009 Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease Am J Cardiol 104 74 81 19576324 10.1016/j.amjcard.2009. 02.047 1:CAS:528:DC%2BD1MXotFCitL4%3D
    • (2009) Am J Cardiol , vol.104 , pp. 74-81
    • MacCubbin, D.1    Koren, M.J.2    Davidson, M.3
  • 43
    • 77949822116 scopus 로고    scopus 로고
    • Safety of extended-release niacin/laropiprant in patients with dyslipidemia
    • 21122637 10.1016/j.jacl.2010.02.002
    • J McKenney H Bays M Koren, et al. 2010 Safety of extended-release niacin/laropiprant in patients with dyslipidemia J Clin Lipidol 4 105 112 21122637 10.1016/j.jacl.2010.02.002
    • (2010) J Clin Lipidol , vol.4 , pp. 105-112
    • McKenney, J.1    Bays, H.2    Koren, M.3
  • 45
    • 0034609562 scopus 로고    scopus 로고
    • Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies
    • 10973834 1:STN:280:DC%2BD3cvls1Knuw%3D%3D
    • J Danesh R Collins R Peto 2000 Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies Circulation 102 1082 1085 10973834 1:STN:280:DC%2BD3cvls1Knuw%3D%3D
    • (2000) Circulation , vol.102 , pp. 1082-1085
    • Danesh, J.1    Collins, R.2    Peto, R.3
  • 46
    • 73549097512 scopus 로고    scopus 로고
    • Genetic variants associated with Lp(a) lipoprotein level and coronary disease
    • 20032323 10.1056/NEJMoa0902604 1:CAS:528:DC%2BC3cXls1Gg This work reports two LPA genetic variants that were strongly and independently associated with both an increased level of Lp(a) lipoprotein and an increased risk of coronary disease, supporting a causal and genetic role for Lp(a) and coronary artery disease
    • R Clarke JF Peden JC Hopewell, et al. 2009 Genetic variants associated with Lp(a) lipoprotein level and coronary disease N Engl J Med 361 2518 2528 20032323 10.1056/NEJMoa0902604 1:CAS:528:DC%2BC3cXls1Gg This work reports two LPA genetic variants that were strongly and independently associated with both an increased level of Lp(a) lipoprotein and an increased risk of coronary disease, supporting a causal and genetic role for Lp(a) and coronary artery disease
    • (2009) N Engl J Med , vol.361 , pp. 2518-2528
    • Clarke, R.1    Peden, J.F.2    Hopewell, J.C.3
  • 47
    • 0035423283 scopus 로고    scopus 로고
    • Effect of niacin and atorvastatin on lipoprotein subclasses in patients with atherogenic dyslipidemia
    • DOI 10.1016/S0002-9149(01)01639-3, PII S0002914901016393
    • JM McKenney LS McCormick EJ Schaefer, et al. 2001 Effect of niacin and atorvastatin on lipoprotein subclasses in patients with atherogenic dyslipidemia Am J Cardiol 88 270 274 11472706 10.1016/S0002-9149(01)01639-3 1:CAS:528:DC%2BD3MXltlOju70%3D (Pubitemid 32721954)
    • (2001) American Journal of Cardiology , vol.88 , Issue.3 , pp. 270-274
    • McKenney, J.M.1    McCormick, L.S.2    Schaefer, E.J.3    Black, D.M.4    Watkins, M.L.5
  • 48
    • 78650041424 scopus 로고    scopus 로고
    • 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
    • 21144964 10.1016/j.jacc.2010.09.001
    • P Greenland JS Alpert GA Beller, et al. 2010 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 56 e50 e103 21144964 10.1016/j.jacc.2010.09.001
    • (2010) J Am Coll Cardiol , vol.56
    • Greenland, P.1    Alpert, J.S.2    Beller, G.A.3
  • 49
    • 11844296800 scopus 로고    scopus 로고
    • Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: A meta-analysis of randomized controlled trials
    • DOI 10.1016/j.jacc.2004.10.031, PII S0735109704020625
    • RS Birjmohun BA Hutten JJ Kastelein, et al. 2005 Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: a meta-analysis of randomized controlled trials J Am Coll Cardiol 45 185 197 15653014 10.1016/j.jacc.2004.10.031 1:CAS:528:DC%2BD2MXkvFaisw%3D%3D (Pubitemid 40094724)
    • (2005) Journal of the American College of Cardiology , vol.45 , Issue.2 , pp. 185-197
    • Birjmohun, R.S.1    Hutten, B.A.2    Kastelein, J.J.P.3    Stroes, E.S.G.4
  • 50
    • 0032530770 scopus 로고    scopus 로고
    • Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia
    • DOI 10.1016/S0002-9149(98)00448-2, PII S0002914998004482
    • JR Guyton AC Goldberg RA Kreisberg, et al. 1998 Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia Am J Cardiol 82 737 743 9761083 10.1016/S0002-9149(98) 00448-2 1:CAS:528:DyaK1cXmsF2ls7k%3D (Pubitemid 28439633)
    • (1998) American Journal of Cardiology , vol.82 , Issue.6 , pp. 737-743
    • Guyton, J.R.1    Goldberg, A.C.2    Kreisberg, R.A.3    Sprecher, D.L.4    Superko, H.R.5    O'Connor, C.M.6
  • 51
    • 41049092899 scopus 로고    scopus 로고
    • Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: The OCEANS study
    • DOI 10.2165/00129784-200808020-00001
    • RH Karas ML Kashyap RH Knopp, et al. 2008 Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: the OCEANS study Am J Cardiovasc Drugs 8 69 81 18422390 10.2165/00129784-200808020-00001 1:CAS:528:DC%2BD1cXns1artLs%3D (Pubitemid 351570857)
    • (2008) American Journal of Cardiovascular Drugs , vol.8 , Issue.2 , pp. 69-81
    • Karas, R.H.1    Kashyap, M.L.2    Knopp, R.H.3    Keller, L.H.4    Bajorunas, D.R.5    Davidson, M.H.6
  • 52
    • 79957829575 scopus 로고    scopus 로고
    • Niacin extended-release therapy in Phase III clinical trials is associated with relatively low rates of drug discontinuation due to flushing and treatment-related adverse events: A pooled analysis
    • 21619381 10.2165/11592560-000000000-00000 1:CAS:528:DC%2BC3MXpvFyntrg%3D
    • EA Brinton ML Kashyap AN Vo, et al. 2011 Niacin extended-release therapy in Phase III clinical trials is associated with relatively low rates of drug discontinuation due to flushing and treatment-related adverse events: a pooled analysis Am J Cardiovasc Drugs 11 179 187 21619381 10.2165/11592560-000000000- 00000 1:CAS:528:DC%2BC3MXpvFyntrg%3D
    • (2011) Am J Cardiovasc Drugs , vol.11 , pp. 179-187
    • Brinton, E.A.1    Kashyap, M.L.2    Vo, A.N.3
  • 53
    • 85047692711 scopus 로고
    • Niacin revisited. A randomized, controlled trial of wax-matrix sustained-release niacin in hypercholesterolemia
    • 2064495 10.1001/archinte.1991.00400070172024 1:STN:280: DyaK3M3ptV2lug%3D%3D
    • JM Keenan PL Fontaine JB Wenz, et al. 1991 Niacin revisited. A randomized, controlled trial of wax-matrix sustained-release niacin in hypercholesterolemia Arch Intern Med 151 1424 1432 2064495 10.1001/archinte. 1991.00400070172024 1:STN:280:DyaK3M3ptV2lug%3D%3D
    • (1991) Arch Intern Med , vol.151 , pp. 1424-1432
    • Keenan, J.M.1    Fontaine, P.L.2    Wenz, J.B.3
  • 54
    • 0026527601 scopus 로고
    • Treatment of hypercholesterolemia: Comparison of younger versus older patients using wax-matrix sustained-release niacin
    • 1727841 1:STN:280:DyaK38%2FptFKmsw%3D%3D
    • JM Keenan CY Bae PL Fontaine, et al. 1992 Treatment of hypercholesterolemia: comparison of younger versus older patients using wax-matrix sustained-release niacin J Am Geriatr Soc 40 12 18 1727841 1:STN:280:DyaK38%2FptFKmsw%3D%3D
    • (1992) J Am Geriatr Soc , vol.40 , pp. 12-18
    • Keenan, J.M.1    Bae, C.Y.2    Fontaine, P.L.3
  • 55
    • 0028057319 scopus 로고
    • A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients
    • 8309029 10.1001/jama.1994.03510330050033 1:STN:280:DyaK2c7kt1Srtw%3D%3D
    • JM McKenney JD Proctor S Harris, et al. 1994 A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients JAMA 271 672 677 8309029 10.1001/jama.1994. 03510330050033 1:STN:280:DyaK2c7kt1Srtw%3D%3D
    • (1994) JAMA , vol.271 , pp. 672-677
    • McKenney, J.M.1    Proctor, J.D.2    Harris, S.3
  • 56
    • 33645771230 scopus 로고    scopus 로고
    • Flush-free niacin": Dietary supplement may be "benefit-free
    • 16407706 10.1111/j.1520-037X.2006.04736.x
    • RB Norris 2006 "Flush-free niacin": dietary supplement may be "benefit-free" Prev Cardiol 9 64 65 16407706 10.1111/j.1520-037X.2006. 04736.x
    • (2006) Prev Cardiol , vol.9 , pp. 64-65
    • Norris, R.B.1
  • 57
    • 0017574089 scopus 로고
    • RICERCHE COMPARATIVE IN ANZIANI NORMOLIPEMICI E DISLIPEMICI CON DUE FORME DI ACIDO NICOTINICO LATENZIATO COME POLIESTERE. PENTAERITRITOLO-TETRANICOTINATO E INOSITOLO-ESANICOTINATO. RISULTATI DI UNA SPERIMENTAZIONE CONTROLLATA IN CROSS-OVER
    • GR Ziliotto G Lamberti A Wagner, et al. 1977 Comparative studies of the response of normolipemic and dyslipemic aged subjects to 2 forms of delayed-action nicotinic acid polyesters. Pentaerythrotol tetranicotinate and inositol hexanicotinate. Results of a controlled cross-over trial Arch Sci Med Torino 134 359 394 345998 1:STN:280:DyaE1c7ktlOrsw%3D%3D (Pubitemid 8271133)
    • (1977) Archivio per le Scienze Mediche , vol.134 , Issue.4 , pp. 359-394
    • Ziliotto, G.R.1    Lamberti, G.2    Wagner, A.3
  • 59
    • 33751087034 scopus 로고    scopus 로고
    • Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells
    • DOI 10.1124/mol.106.030833
    • Z Benyo A Gille CL Bennett, et al. 2006 Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells Mol Pharmacol 70 1844 1849 17008386 10.1124/mol.106.030833 1:CAS:528:DC%2BD28Xht1ylt73I (Pubitemid 44771899)
    • (2006) Molecular Pharmacology , vol.70 , Issue.6 , pp. 1844-1849
    • Benyo, Z.1    Gille, A.2    Bennett, C.L.3    Clausen, B.E.4    Offermanns, S.5
  • 60
    • 60349085760 scopus 로고    scopus 로고
    • Patients' experiences of niacin-induced flushing in clinical practice: A structured telephone interview
    • 19243714 10.1016/j.clinthera.2009.01.011
    • S Kamal-Bahl DJ Watson BM Ambegaonkar 2009 Patients' experiences of niacin-induced flushing in clinical practice: a structured telephone interview Clin Ther 31 130 140 19243714 10.1016/j.clinthera.2009.01.011
    • (2009) Clin Ther , vol.31 , pp. 130-140
    • Kamal-Bahl, S.1    Watson, D.J.2    Ambegaonkar, B.M.3
  • 61
    • 0034191863 scopus 로고    scopus 로고
    • Multiple-dose efficacy and safety of an extended-release form of niacin in the management of hyperlipidemia
    • DOI 10.1016/S0002-9149(00)00703-7, PII S0002914900007037
    • A Goldberg P Alagona Jr DM Capuzzi, et al. 2000 Multiple-dose efficacy and safety of an extended-release form of niacin in the management of hyperlipidemia Am J Cardiol 85 1100 1105 10781759 10.1016/S0002-9149(00)00703-7 1:CAS:528:DC%2BD3cXislaqsbw%3D (Pubitemid 30214256)
    • (2000) American Journal of Cardiology , vol.85 , Issue.9 , pp. 1100-1105
    • Goldberg, A.1    Alagona Jr., P.2    Capuzzi, D.M.3    Guyton, J.4    Morgan, J.M.5    Rodgers, J.6    Sachson, R.7    Samuel, P.8
  • 62
    • 48549100919 scopus 로고    scopus 로고
    • Flushing and the HDL-C response to extended-release niacin
    • 21291745 10.1016/j.jacl.2008.05.002
    • AJ Taylor EJ Stanek 2008 Flushing and the HDL-C response to extended-release niacin J Clin Lipidol 2 285 288 21291745 10.1016/j.jacl.2008. 05.002
    • (2008) J Clin Lipidol , vol.2 , pp. 285-288
    • Taylor, A.J.1    Stanek, E.J.2
  • 63
    • 0025148561 scopus 로고
    • Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus
    • DOI 10.1001/jama.264.6.723
    • A Garg SM Grundy 1990 Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus JAMA 264 723 726 2374275 10.1001/jama.1990.03450060069031 1:STN:280:DyaK3czisFClsQ%3D%3D (Pubitemid 20246864)
    • (1990) Journal of the American Medical Association , vol.264 , Issue.6 , pp. 723-726
    • Garg, A.1    Grundy, S.M.2
  • 64
    • 34249858833 scopus 로고    scopus 로고
    • Relationship between glycemic status and progression of carotid intima-media thickness during treatment with combined statin and extended-release niacin in ARBITER 2
    • AJ Taylor D Zhu LE Sullenberger, et al. 2007 Relationship between glycemic status and progression of carotid intima-media thickness during treatment with combined statin and extended-release niacin in ARBITER 2 Vasc Health Risk Manag 3 159 164 17583186 1:CAS:528:DC%2BD2sXntVSgtbk%3D (Pubitemid 46860725)
    • (2007) Vascular Health and Risk Management , vol.3 , Issue.1 , pp. 159-164
    • Taylor, A.J.1    Zhu, D.2    Sullenberger, L.E.3    Lee, H.J.4    Lee, J.K.5    Grace, K.A.6
  • 65
    • 34447328718 scopus 로고    scopus 로고
    • Niacin plus simvastatin reduces coronary stenosis progression among patients with metabolic syndrome despite a modest increase in insulin resistance: A subgroup analysis of the HDL-Atherosclerosis treatment study
    • DOI 10.1016/j.jacl.2007.05.003, PII S1933287407001407
    • F Vittone A Chait JS Morse, et al. 2007 Niacin plus simvastatin reduces coronary stenosis progression among patients with metabolic syndrome despite a modest increase in insulin resistance: a subgroup analysis of the HDL-Atherosclerosis Treatment Study (HATS) J Clin Lipidol 1 203 210 18591993 10.1016/j.jacl.2007.05.003 (Pubitemid 47055291)
    • (2007) Journal of Clinical Lipidology , vol.1 , Issue.3 , pp. 203-210
    • Vittone, F.1    Chait, A.2    Morse, J.S.3    Fish, B.4    Brown, B.G.5    Zhao, X.-Q.6
  • 66
    • 67349267972 scopus 로고    scopus 로고
    • Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance
    • 19131065 10.1016/j.atherosclerosis.2008.11.026 1:CAS:528: DC%2BD1MXnsFagtL8%3D This work reports the favorable impact of niacin extended-release on lipid parameters, adipocyte size, and insulin sensitivity in patients with impaired glucose tolerance
    • A Linke M Sonnabend M Fasshauer, et al. 2009 Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance Atherosclerosis 205 207 213 19131065 10.1016/j.atherosclerosis.2008. 11.026 1:CAS:528:DC%2BD1MXnsFagtL8%3D This work reports the favorable impact of niacin extended-release on lipid parameters, adipocyte size, and insulin sensitivity in patients with impaired glucose tolerance
    • (2009) Atherosclerosis , vol.205 , pp. 207-213
    • Linke, A.1    Sonnabend, M.2    Fasshauer, M.3
  • 67
    • 42149136762 scopus 로고    scopus 로고
    • Effects of niacin on glucose control in patients with dyslipidemia
    • DOI 10.4065/83.4.470
    • RB Goldberg TA Jacobson 2008 Effects of niacin on glucose control in patients with dyslipidemia Mayo Clin Proc 83 470 478 18380993 10.4065/83.4.470 1:CAS:528:DC%2BD1cXltFWhs78%3D (Pubitemid 351536472)
    • (2008) Mayo Clinic Proceedings , vol.83 , Issue.4 , pp. 470-478
    • Goldberg, R.B.1    Jacobson, T.A.2
  • 68
    • 0028597096 scopus 로고
    • Efficacy and safety of controlled-release niacin in dyslipoproteinemic veterans
    • 7741833 1:STN:280:DyaK2czhtFGgsA%3D%3D
    • DR Gray T Morgan SD Chretien, et al. 1994 Efficacy and safety of controlled-release niacin in dyslipoproteinemic veterans Ann Intern Med 121 252 258 7741833 1:STN:280:DyaK2czhtFGgsA%3D%3D
    • (1994) Ann Intern Med , vol.121 , pp. 252-258
    • Gray, D.R.1    Morgan, T.2    Chretien, S.D.3
  • 69
    • 41149151640 scopus 로고    scopus 로고
    • The safety of niacin in the US Food and Drug Administration adverse event reporting database
    • 18375244 10.1016/j.amjcard.2008.02.027 1:CAS:528:DC%2BD1cXlslWgsbw%3D
    • AA Alsheikh-Ali RH Karas 2008 The safety of niacin in the US Food and Drug Administration adverse event reporting database Am J Cardiol 101 9B 13B 18375244 10.1016/j.amjcard.2008.02.027 1:CAS:528:DC%2BD1cXlslWgsbw%3D
    • (2008) Am J Cardiol , vol.101
    • Alsheikh-Ali, A.A.1    Karas, R.H.2
  • 70
    • 50949133756 scopus 로고    scopus 로고
    • Comparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs simvastatin monotherapy in patients with increased non-HDL cholesterol (from the SEACOAST i study)
    • 18471454 10.1016/j.amjcard.2008.02.092 1:CAS:528:DC%2BD1cXlslyiurs%3D
    • CM Ballantyne MH Davidson J McKenney, et al. 2008 Comparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs simvastatin monotherapy in patients with increased non-HDL cholesterol (from the SEACOAST I study) Am J Cardiol 101 1428 1436 18471454 10.1016/j.amjcard.2008.02.092 1:CAS:528:DC%2BD1cXlslyiurs%3D
    • (2008) Am J Cardiol , vol.101 , pp. 1428-1436
    • Ballantyne, C.M.1    Davidson, M.H.2    McKenney, J.3
  • 71
    • 0842324675 scopus 로고    scopus 로고
    • Safety and tolerability of Simvastatin plus niacin in patients with coronary artery disease and low high-density lipoprotein cholesterol (The HDL Atherosclerosis Treatment Study)
    • DOI 10.1016/j.amjcard.2003.10.009
    • XQ Zhao JS Morse AA Dowdy, et al. 2004 Safety and tolerability of simvastatin plus niacin in patients with coronary artery disease and low high-density lipoprotein cholesterol (The HDL Atherosclerosis Treatment Study) Am J Cardiol 93 307 312 14759379 10.1016/j.amjcard.2003.10.009 1:CAS:528:DC%2BD2cXptFantA%3D%3D (Pubitemid 38167426)
    • (2004) American Journal of Cardiology , vol.93 , Issue.3 , pp. 307-312
    • Zhao, X.-Q.1    Morse, J.S.2    Dowdy, A.A.3    Heise, N.4    Deangelis, D.5    Frohlich, J.6    Chait, A.7    Albers, J.J.8    Brown, B.G.9
  • 72
    • 77950670133 scopus 로고    scopus 로고
    • A "hot" topic in dyslipidemia management-"how to beat a flush": Optimizing niacin tolerability to promote long-term treatment adherence and coronary disease prevention
    • 20360295 10.4065/mcp.2009.0535 1:CAS:528:DC%2BC3cXltlemsro%3D
    • TA Jacobson 2010 A "hot" topic in dyslipidemia management-"how to beat a flush": optimizing niacin tolerability to promote long-term treatment adherence and coronary disease prevention Mayo Clin Proc 85 365 379 20360295 10.4065/mcp.2009.0535 1:CAS:528:DC%2BC3cXltlemsro%3D
    • (2010) Mayo Clin Proc , vol.85 , pp. 365-379
    • Jacobson, T.A.1
  • 73
    • 33744516859 scopus 로고    scopus 로고
    • Clinical evidence for use of acetyl salicylic acid in control of flushing related to nicotinic acid treatment
    • DOI 10.1111/j.1368-5031.2006.00957.x
    • H Oberwittler M Baccara-Dinet 2006 Clinical evidence for use of acetyl salicylic acid in control of flushing related to nicotinic acid treatment Int J Clin Pract 60 707 715 16805757 10.1111/j.1368-5031.2006.00957.x 1:CAS:528:DC%2BD28XntF2ltrY%3D (Pubitemid 43811652)
    • (2006) International Journal of Clinical Practice , vol.60 , Issue.6 , pp. 707-715
    • Oberwittler, H.1    Baccara-Dinet, M.2
  • 74
    • 0026553160 scopus 로고
    • The effect of aspirin on niacin-induced cutaneous reactions
    • 1737967 1:STN:280:DyaK387kvVenug%3D%3D
    • AM Whelan SO Price SF Fowler, et al. 1992 The effect of aspirin on niacin-induced cutaneous reactions J Fam Pract 34 165 168 1737967 1:STN:280:DyaK387kvVenug%3D%3D
    • (1992) J Fam Pract , vol.34 , pp. 165-168
    • Whelan, A.M.1    Price, S.O.2    Fowler, S.F.3
  • 75
    • 0020307552 scopus 로고
    • Aspirin blocks nicotinic acid-induced flushing
    • JK Wilkin O Wilkin R Kapp, et al. 1982 Aspirin blocks nicotinic acid-induced flushing Clin Pharmacol Ther 31 478 482 7060328 10.1038/clpt.1982.63 1:CAS:528:DyaL38XitFSlt7o%3D (Pubitemid 13097390)
    • (1982) Clinical Pharmacology and Therapeutics , vol.31 , Issue.4 , pp. 478-482
    • Wilkin, J.K.1    Wilkin, O.2    Kapp, R.3
  • 77
    • 67650410238 scopus 로고    scopus 로고
    • Novel patent publications on high-affinity nicotinic acid receptor agonists
    • 19552512 10.1517/13543770902991526 1:CAS:528:DC%2BD1MXns1eqtL0%3D
    • HC Shen SL Colletti 2009 Novel patent publications on high-affinity nicotinic acid receptor agonists Expert Opin Ther Pat 19 957 967 19552512 10.1517/13543770902991526 1:CAS:528:DC%2BD1MXns1eqtL0%3D
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 957-967
    • Shen, H.C.1    Colletti, S.L.2


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