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Arterial biology for the investigation of the treatment effects of reducing cholesterol (ARBITER 2). A double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statin
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Vittone F, Chait A, Morse JS, et al. Niacin plus simvastatin reduces coronary stenosis progression among patients with metabolic syndrome despite a modest increase in insulin resistance: a subgroup analysis of the HDL-atherosclerosis treatment study. J Clin Lipidol 2007; 1:203-210. This study demonstrated that chronic use of niacin and simvastatin retards the progression of atherosclerotic cardiovascular disease in patients with dysmetabolic syndrome, suggesting that the overall cardiovascular benefits outweigh the modest adverse effects on insulin resistance and glucose metabolism.
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Vittone F, Chait A, Morse JS, et al. Niacin plus simvastatin reduces coronary stenosis progression among patients with metabolic syndrome despite a modest increase in insulin resistance: a subgroup analysis of the HDL-atherosclerosis treatment study. J Clin Lipidol 2007; 1:203-210. This study demonstrated that chronic use of niacin and simvastatin retards the progression of atherosclerotic cardiovascular disease in patients with dysmetabolic syndrome, suggesting that the overall cardiovascular benefits outweigh the modest adverse effects on insulin resistance and glucose metabolism.
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9
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11
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Nicotinic acid-induced flushing is mediated by activation of epidermal Langerhans cells
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14
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Aspirin reduces cutaneous flushing after administration of an optimized extended-release niacin formulation
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This study described the beneficial effects of aspirin in further reducing niacin flush in patients treated with newly optimized extended-release niacin
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Cefali EA, Simmons PD, Stanek EJ, et al. Aspirin reduces cutaneous flushing after administration of an optimized extended-release niacin formulation. Int J Clin Pharmacol Ther 2007; 45:78-88. This study described the beneficial effects of aspirin in further reducing niacin flush in patients treated with newly optimized extended-release niacin.
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15
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Cheng K, Wu T, Wu KK, et al. Antagonism of the prostaglandin D2 receptor1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A 2006; 103:6682-6687.
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16
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Suppression of niacin-induced vasodilation with an antagonist to prostaglandin D2 receptor subtype 1
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This study examined the effect of DP1 receptor antagonist on niacin flush
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Lai E, DeLepepeire I, Crumley TM, et al. Suppression of niacin-induced vasodilation with an antagonist to prostaglandin D2 receptor subtype 1. Clin Pharmacol Ther 2007; 81:849-857. This study examined the effect of DP1 receptor antagonist on niacin flush.
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Lai, E.1
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MacCubbin DL, Michel Y, Sirah W, et al. Lipid-altering efficacy and tolerability of extended-release niacin/laropiprant in patients with dyslipidemia. Poster presentation. In: 2007 European Society of Cardiology Annual Meeting; 1-5 September 2007; Vienna, Austria: European Society of Cardiology; 2007.
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MacCubin D, Sirah W, Betteridge A, et al. Flushing profile of ER niacin/laropiprant in patients with primary hypercholesterolemia or mixed dyslipidemia. Poster presentation. In: 2007 AHA Scientific Sessions; 4-7 November 2007; Orlando, Florida: AHA; 2007.
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PUMA-G and HM74 are receptors for nicotinic acid and mediate its antilipolytic effect
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