A sensitive luminescent assay for the histone methyltransferase NSD1 and other SAM-Dependent enzymes

Assay and Drug Development Technologies

Volumn 12, Issue 5, 2014, Pages 258-271

  Drake, Katherine M ^a   Watson, Venita G ^a,b   Kisielewski, Anne ^a   Glynn, Rebecca ^a,c   Napper, Andrew D ^a  

^a NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

^b Department of Structural Biology   (United States)

^c BUCKNELL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; HISTONE METHYLTRANSFERASE; HYBRID PROTEIN; NSD1 ENZYME; NUCLEOPORIN 98; PRMT1 ENZYME; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SETD7 ENZYME; SURAMIN; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; ENZYME INHIBITOR; METHYLTRANSFERASE; NSD1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL PEPTIDE;

ARTICLE; ENZYME ASSAY; HIGH THROUGHPUT SCREENING; LUMINESCENT ASSAY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DOSE RESPONSE; HUMAN; LUMINESCENCE; METABOLISM; PROCEDURES; STRUCTURE ACTIVITY RELATION; VALIDATION STUDY;

DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ASSAYS; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUMINESCENT MEASUREMENTS; METHYLTRANSFERASES; NUCLEAR PROTEINS; S-ADENOSYLMETHIONINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84902492215     PISSN: 1540658X     EISSN: 15578127     Source Type: Journal    
DOI: 10.1089/adt.2014.583     Document Type: Article

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